Abstract: The present invention is based, in part, on our studies of molecular pathways that include the deubiquitinase CYLD. Accordingly, the present invention features, inter alia, nucleic acid constructs that express CYLD or a biologically active variant thereof (e.g., a variant including the catalytic domain), nucleic acids that inhibit the expression of a negative regulator of CYLD (e.g., PDE4B or LNK2), nucleic acids that modulate the expression of downstream CYLD targets (e.g., Akt, by inhibiting or promoting the expression of the downstream target), compositions including one or more of these types of constructs (e.g., pharmaceutical compositions), kits including one or more of the compositions described herein and instructions for use, screening methods to identify therapeutic agents {e.g., anti-inflammatory agents) that upregulate CYLD, downregulate a negative regulatory of CYLD, or modulate (e.g., inhibit) a downstream CYLD target (e.g.

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

Abstract: A significant fraction of short fibers (fines) is produced while recycling Old Corrugated Containerboards (OCC), which are usually rejected as solid waste stream, requiring landfilling and posing environmental problems. The major component of these fines rejects are primarily cellulose that can be hydrolyzed into sugars for possible fermentation into biofuels, bioplastics or other sugar based products. Use of fines also offers benefits such as negative costs and production of fermentable sugars without requiring complex pretreatment processes, now required to hydrolyze and eliminate inhibitors from hydrolyzate. Enzymatic hydrolysis of reject fines from a recycled OCC mill, employing different strains of cellulases, were investigated. Fillers (up to 30 mass %) in the fines increases the required dosage of enzymes and costs. Enzyme loading can be lowered by addition of surfactants to reduce their inhibitory activity. The nonionic surfactant Triton X-80 improved hydrolysis yields by up to 10 percent points.

Abstract: Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.

Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.

Abstract: Systems, methods, and computer-readable media for generating a data set are provided. One method includes generating a data set based on input data using a plurality of brokers. The method further includes receiving a request from a user and determining whether the request can be fulfilled using data currently in the data set. When the request can be fulfilled using data currently in the data set, the data is accessed using broker(s) configured to provide access to data within the data set. When the request cannot be fulfilled using data currently in the data set, at least one new broker is spawned using existing broker(s) and additional data needed to fulfill the request is added to the data set using the new broker. The method further includes generating a response to the request using one or more of the plurality of brokers.

Abstract: Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. Methods for determining ovarian cancer recurrence in an ovarian cancer patient. A method for isolating antibodies specific for ovarian cancer by their affinity to the polypeptide marker antigens, and antibodies isolated by that method.

Abstract: The present application focuses on systems and methods that utilize one or more carbon dioxide (CO2) sorbent substrates and a swing cycle, e.g., a moisture swing cycle, to increase the partial pressure of the CO2 in a gaseous feedstock, which is delivered through a membrane to a bioreactor, such as a membrane carbonation photobioreactor. Such systems and processes offer an effective means for concentrating and capturing CO2 obtained from air and delivering the concentrated CO2 to a photobioreactor through a membrane.

Abstract: Photo-active devices including a substrate, a first electrode, an active layer including an organic salt or salt mixture that selectively or predominantly harvests light from the near infrared or infrared regions of the solar spectrum, and a second electrode. The devices are either visibly transparent or visibly opaque and can be utilized in single- or multi-junction devices.

Abstract: The present disclosure provides synthetic repressor constructs and the proteins encoded therein, as well as synthetic repressible promoter constructs for use in combination with the synthetic repressor constructs/synthetic repressors disclosed herein. Various combinations of synthetic repressor constructs and synthetic repressible promoter constructs are also provided in synthetic genetic circuits for modifying expression of a protein of interest in a plant cell.

Abstract: Systems and methods for making ice utilize self-demolding ice molds. Responsive to freezing of water in the mold into ice, an ejection apparatus is compressed. Via a force arising from the compression, the ejection apparatus ejects the ice from the mold. Ice machines may utilize multiple molds, and water filling a first mold may be utilized to at least partially melt ice in a second mold to facilitate ejection of the ice from the second mold.

Abstract: The high thermal conduction resistances of a lithium-ion battery (LIB) severely limit the effectiveness of a conventional external thermal management system (TMS). A method for a new thermal management system for lithium-ion batteries that utilizes a multi-functional electrolyte (MFE) to remove heat locally inside the cell by evaporating a volatile component of the MFE is disclosed. These new electrolyte mixtures comprise a high vapor pressure co-solvent. The characteristics of a previously unstudied high vapor pressure co-solvent HFE-7000 (65 kPa at 25° C.) in an MFE (1 M LiTFSI in 1:1 HFE-7000/EMC), and other possible MFE compositions that can be utilized in a custom electrolyte boiling facility, are disclosed.

Abstract: A system and method is provided for simultaneous ion current sensing and gas analysis. The system acquires an ion current signal and analyzes the composition of a corresponding gas sample.

Abstract: Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based adjuvants are provided. The peptide adjuvants comprise a peptide having a hydrophobic region, a turning region, and a hydrophilic region. The turning region comprises amino acid residues GSII (SEQ ID NO: 10). The peptide adjuvants can be used to immunopotentiate active agents by improving the immune response to the active agent.

Abstract: Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting.

Abstract: The invention relates to plants that contain higher proportions of mannans. Such plants express transcription factors that increase the expression of CSLA9, a mannan synthase.

Abstract: An omnibus process of pulping and bleaching lignocellulosic materials in which a charge of a lignocellulosic material is biopulped and/or water extracted prior to pulping and bleaching. The lignocellulosic material may be mechanically pulped and bleached in the presence of an enzyme that breaks lignin-carbohydrate complexes.

Abstract: Dendritic polypeptides useful for the delivery of therapeutic agents into cells are disclosed, together with their methods of preparation. These dendritic polypeptides serve as carriers of drugs, siRNA, aptamers and plasmid DNA in the treatment of various diseases, including cancer.

Abstract: The present invention provides compositions and methods of altering/improving Durum wheat phenotypes. Furthermore, methods of breeding Durum wheat and/or other closely related species to produce plants having altered or improved phenotypes are provided.

Abstract: The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.