Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.
Type:
Grant
Filed:
January 18, 2013
Date of Patent:
November 25, 2014
Assignees:
Cellceutix Corporation, Rutgers, The State University of New Jersey
Inventors:
Richard W. Scott, Katie Freeman, Haizhong Tang, Gill Diamond
Abstract: The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.
Type:
Application
Filed:
September 13, 2012
Publication date:
November 20, 2014
Applicants:
Behalf of Arizona State University
Inventors:
Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall
Abstract: One embodiment is a pressure sensitive adhesive construct comprising: (a) a backing substrate; and (b) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive composition includes a product made from (i) at least one epoxidized vegetable oil and; (ii) a dimer acid or anhydride thereof, a trimer acid or anhydride thereof, a polymerized fatty acid or anhydride thereof, or a mixture thereof.
Abstract: Systems and methods for single wavelength with dual channels for control signal and Internet data transmission are disclosed. According to an aspect, a network unit may include a communications module configured to receive a single wavelength signal having first and second channels. The first channel may carry Internet data. The second channel may carry power grid control and monitoring data. Further, the network unit may include a multiplexer configured to multiplex the Internet data and the power grid control and monitoring data.
Type:
Application
Filed:
March 10, 2014
Publication date:
November 20, 2014
Applicant:
North Carolina State University
Inventors:
Leda M. Lunardi, Subhashish Bhattacharya, Tie Wu
Abstract: A method for order prioritization includes calculating a cycle time for a product order of a plurality of product orders using an artificial neural network, determining a first order priority of the product order based on a priority index using an analytic hierarchy process, determining a second order priority of the product order based on event based simulation model, and determining a shipping date for the product order based on the second order priority. The artificial neural network calculates the cycle time based upon product order type and a plurality of component counts. The analytic hierarchy process determines a first order priority based upon a plurality of product order attributes. The simulation model determines a second order priority and completion time based upon the first order priority, product model, product type, a plurality of component counts, manufacturing capacity and inventory data, and production time data for historical product orders.
Type:
Application
Filed:
May 17, 2013
Publication date:
November 20, 2014
Applicant:
The Research Foundation of State University of New York
Inventors:
Faisal Aqlan, Keila Y. Martinez Camacho, Sarah S. Lam
Abstract: The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E. ewingii (EE) polypeptides, isolated polynucleotides encoding EE polypeptides, probes, primers, isolated antibodies and methods of their production, immunogenic compositions and vaccines, as well as methods of using the EE polypeptides, antibodies, probes, and primers for the purpose of diagnosis, therapy and production of vaccines against E. ewingii.
Type:
Application
Filed:
June 11, 2014
Publication date:
November 20, 2014
Applicant:
The Ohio State University Research Foundation
Abstract: A method is disclosed for stabilizing histone stem-loop-containing mRNA by the addition of a chain-terminating nucleoside. The novel, synthetic mRNA contains a 3? histone stem-loop sequence. At the 3? end of the mRNA a chain-terminating nucleoside is incorporated, for example 3?-deoxyadenosine (cordycepin). The chain-terminating nucleoside blocks the addition of a 3?-terminal oligo(U) sequence to the mRNA containing the histone stem-loop. When the 3?-terminal oligo(U) sequence cannot be added, degradation of the mRNA is retarded. The mRNA then remains available to the translational machinery for a longer time, resulting in higher levels of protein synthesis.
Type:
Application
Filed:
January 3, 2013
Publication date:
November 20, 2014
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Robert E. Rhoads, Wei Su, William F. Marzluff
Abstract: The present invention relates to a thermoplastic block copolymer comprising at least one PA block and at least one PB block. The PA block represents a polymer block comprising one or more units of monomer A, and the PB block represents a polymer block comprising one or more units of monomer B. Monomer A is a vinyl, acrylic, diolefin, nitrile, dinitrile, acrylonitrile monomer, a monomer with reactive functionality, or a crosslinking monomer. Monomer B is a radically polymerizable triglyceride or mixtures thereof, typically in the form of a plant or animal oil. The present invention also relates to a method of preparing a thermoplastic block copolymer or novel thermoplastic statistical copolymers by polymerizing a radically polymerizable monomer with a radically polymerizable triglyceride or mixtures thereof via reversible addition-fragmentation chain-transfer polymerization (RAFT), in the presence of an free radical initiator and a chain transfer agent.
Type:
Application
Filed:
May 20, 2014
Publication date:
November 20, 2014
Applicant:
Iowa State University Research Foundation, Inc.
Inventors:
Eric W. COCHRAN, Ronald Christopher WILLIAMS, Nacu HERNANDEZ, Andrew CASCIONE
Abstract: Disclosed are encapsulated zinc compounds, together with methods for preparing and use the same. Also disclosed are methods for mixing the encapsulated zinc mixtures with a cement, and the resulting concrete compositions.
Type:
Grant
Filed:
March 23, 2012
Date of Patent:
November 18, 2014
Assignees:
Board of Regents of the University of Texas System, Kansas State University Research Foundation
Inventors:
Maria C. G. Juenger, Sarah Clare Taylor Lange, Kyle Riding
Abstract: The invention is embodied in methods for finding gene expression signatures of circulating melanoma cells, ovarian, breast, colorectal cancer cells, and circulating endothelial progenitor cells, which signatures are effective in distinguishing the circulating cancer cell from normal circulating cells and can also distinguish between different types of circulating cancer cells.
Type:
Grant
Filed:
September 19, 2008
Date of Patent:
November 18, 2014
Assignee:
The Research Foundation for The State University of New York
Abstract: A nuclear reactor module includes a reactor vessel containing coolant, a reactor core submerged in the coolant, and a heat exchanger configured to remove heat from the coolant. The nuclear reactor module further includes one or more heaters configured to add heat to the coolant during a startup operation and prior to the reactor core going critical.
Type:
Grant
Filed:
June 10, 2008
Date of Patent:
November 18, 2014
Assignee:
State of Oregon Acting by and Through The State Board of Higher Education on Behalf or Oregon State University, The Oregon State University
Inventors:
Jose N. Reyes, Jr., John T. Groome, Qiao Wu, Brian G. Woods, Todd S. Palmer
Abstract: The stability of an animal joint, especially a knee, is assessed with an arrangement having track arranged about perpendicular to the axis of the distal portion; a cart slidably engaged to the track; a fork positioned on the cart; a support adapted to receive the distal linear portion, the support connected to the fork; a lever arm connected to the support, the lever arm positioned to rotate the support about the axis of the distal portion; and at least one instrumented handle, the instrumented handle detachably engages at least one of the cart and the lever arm. In some embodiments, the fork can rotate freely on the cart. Additionally, in various embodiments, the cart may be selectively locked at a position along the length of the track. In various embodiments, the arrangement further comprises: a bracket rigidly attached to the distal portion and positioned between the support and the joint; and the at least one instrumented handle detachably engages the bracket.
Type:
Grant
Filed:
July 14, 2011
Date of Patent:
November 18, 2014
Assignee:
The Ohio State University
Inventors:
Robert A. Siston, Thomas L. Maack, Cornel C. Van Gorp, Horst E. Maack
Abstract: A highly dislocation free compound semiconductor, e.g. AlxInyGa1-x-yN (0?x, y?1), is formed on a lattice mismatched substrate, e.g. Si, by first depositing a polycrystalline buffer layer on the substrate. A defective layer is then created at or near the interface of the substrate and the polycrystalline buffer layer, e.g. through ion implantation. A monocrystalline template layer of the compound semiconductor is then created on the buffer layer, and an epilayer of the compound semiconductor is grown on the template layer. A compound semiconductor based device structure may be formed in the epilayer.
Type:
Grant
Filed:
January 27, 2006
Date of Patent:
November 18, 2014
Assignee:
The Research Foundation of State University of New York
Inventors:
Fatemeh Shahedipour-Sandvik, Di Wu, Jamil Kahn Muhammad
Abstract: The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present invention encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and a regulated rfc nucleic acid, while additional embodiments encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and at least one nucleic acid encoding at least one exogenous antigen.
Type:
Grant
Filed:
January 21, 2011
Date of Patent:
November 18, 2014
Assignee:
The Arizona Board of Regents for an on Behalf of Arizona State University
Abstract: The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer.
Type:
Grant
Filed:
August 8, 2011
Date of Patent:
November 18, 2014
Assignee:
Rutgers, The State University of New Jersey
Abstract: The present invention provides methods of improving growth performance, improving the efficiency of feed utilization, increasing feed digestibility, and decreasing mortality of immature and developing animals receiving animal feed. Methods of producing a crude keratinise enzyme extract and animal feed supplements for achieving the same are also provided.
Abstract: A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer.
Type:
Grant
Filed:
June 10, 2010
Date of Patent:
November 18, 2014
Assignee:
Wayne State University
Inventors:
Rangaramanujam M. Kannan, Sujatha Kannan, Roberto Romero, Raghavendra S. Navath
Abstract: The disclosure describes use of flagellin polypeptides to induce tolerance to gram negative bacteria, such as Pseudomonas aeruginosa, in order to alleviate the effects of the inflammatory response to bacterial infection in a patient. Also described are methods and compositions for treating and preventing keratitis, cystic fibrosis, asthma, and other diseases and conditions in which inflammation contributes to the pathology and symptoms.
Type:
Grant
Filed:
February 15, 2007
Date of Patent:
November 18, 2014
Assignee:
Wayne State University
Inventors:
Fu-shin X. Yu, Ashok Kumar, Jing Zhang, Linda D. Hazlett, Jia Yin
Abstract: A method of producing pristine graphene particles through a one-step, gas-phase, catalyst-free detonation of a mixture of one or more carbon-containing compounds hydrocarbon compounds and one or more oxidizing agents is provided. The detonation reaction occurs very quickly and at relatively high temperature, greater than 3000 K, to generate graphene nanosheets that can be recovered from the reaction vessel, such as in the form of an aerosol. The graphene nanosheets may be stacked in single, double, or triple layers, for example, and may have an average particle size of between about 35 to about 250 nm.
Type:
Application
Filed:
May 8, 2014
Publication date:
November 13, 2014
Applicant:
Kansas State University Research Foundation
Inventors:
Christopher Sorensen, Arjun Nepal, Gajendra Prasad Singh
Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
Type:
Application
Filed:
February 24, 2014
Publication date:
November 13, 2014
Applicants:
Iowa State University Research Foundation, Inc., Regents of the University of Minnesota
Inventors:
Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang