Abstract: An simpler, cheaper method for enhancing the percentage of eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) from source oils has been discovered. This method hydrolyzes the oil using the lipase enzyme but does not inactivate the lipase enzyme with either added chemicals or increased temperature. The method relies on centrifugation to separate the enzyme from the desired oil and separate the oil from aqueous impurities. The hydrolyzed oil is enhanced with EPA and DHA, and can be further purified by using activated surface adsorbents, e.g., activated alumina, to remove more free fatty acids and impurities.

Abstract: A novel method and apparatus is introduced to provide a new and robust alternative design for linear magnetorheological (MR) brakes, i.e. MR-brakes. The novel embodiments herein combines a serpentine flux path concept to eliminate conventional piston-cylinder arrangements and as a beneficial result when coupled with the linear brake embodiment disclosed herein, significantly reduce off-state friction and facilitates such devices to provide longer stroke length (i.e., infinite stroke lengths) beyond that as provided in conventional systems. The present linear brake embodiments disclosed herein thus provides, for example, for a ratio of the off-state friction force to the maximum force output at about 3% compared to 10% up to about 27% for similar conventional/commercial brake mechanisms. At the same time, the compactness is beneficially improved be being about half the size of a commercially available product.http://en.wikipedia.org/wiki/File:Paul_Patent_2939952_Fig5.

Abstract: A new method is disclosed for recycling waste asphalt shingles in hot mix asphalt, i.e. asphalt pavement construction. Ground asphalt shingles are treated as a binder component instead of as an aggregate component. The recycled asphalt shingles that are blended with virgin binder in a wet process act both as a partial binder replacement and as a binder extender due to the presence of fillers, rubber, and fibers in the processed material.

Abstract: Disclosed are probes, systems, and devices that can be used to assay the presence of a biomarker in the sinus of a patient. The probes, systems, and devices can be used to contact the sinus fluid inside the sinus of a patient with an immunoassay for the presence of a biomarker that is characteristic of sinusitis. The probes can therefore be used to determine the underlying cause of sinusitis in a patient. Also provided are methods of treating sinusitis by administering to a patient a therapeutic regimen selected in view of a biomarker detected in the sinus of the patient. As the biomarker is associated with one or more causative agents of sinusitis, a therapy effective to treat the underlying causative agent can be selected.

Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.

Abstract: This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions.

Abstract: Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.

Abstract: Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group.

Abstract: The present invention provides branched amphipathic peptides and vesicles formed thereof. The peptides comprise a polar/positively charged C-terminal segment, a branch point, and two hydrophobic N-terminal segments extending from the branch point. The vesicles are formed using a plurality of first and second peptides, wherein the first peptide has a different chain length from the second peptide. When a plurality of the first and second peptides are mixed together, they self-assemble to form small spheres defined by a membrane consisting of an interlocking peptide network bilayer and having a liquid-receiving interior space (i.e., hollow core). In the bi-layer, the respective hydrophobic segments of the peptides form beta-sheet structures having a hydrogen bond-stabilized, anti-parallel orientation in which the opposed sequences interlock to form a zipper-like structure in three dimensions. Thus, the peptide assembly (i.e.

Abstract: Automated, standardized and accurate extraction of relationships within text. Automatic extraction of such relationships/information allows the information to be stored in structured form so that it can be easily and accurately retrieved when needed. Such information can be used to build online search engines for highly specific and accurate information retrieval. The current invention discloses a novel approach to extract such information from raw text based on natural language processing (NLP) and graph theoretic algorithm. The novel method can be applied, for example, to extract protein-protein relationships in biomedical literature. The method can be easily extended to extract other biological relationships between biological terms such as proteins, genes, pathways, diseases and drugs. The method can also be applied to other information domains to extract other relationships.

Abstract: The invention provides compounds of the formula: or a pharmaceutically acceptable salt thereof, where m, n, R1, R2, R3 R4, R5, R6, R7 are those defined herein. The invention also provides pharmaceutical compositions comprising a compound of the invention, methods for using compounds and/or pharmaceutical compositions of the invention, and methods for synthesizing compounds of the invention.

Abstract: A wind turbine tower system includes a wind turbine tower with a height of at least 100 meters, said wind turbine tower. The wind turbine tower includes a plurality of hexagonal-shaped or other shapes of vertical columns comprised of a concrete composition and a plurality of panels, each of the plurality of panels extending between adjacent vertical columns. The plurality of vertical columns and the plurality of panels are arranged to provide a hexagonal cross-section for the wind turbine tower.

Abstract: A method is provided for computing network reachability in a computer network. The method includes: identifying each of the subnetworks that comprise a computer network; determining, for each pair of subnetworks, data paths between the two subnetworks; for each identified data path, identifying access control lists implemented along a given data path and formulating a diagram that merges reachability sets derived from the access control lists along the given data path; and, deriving, for each pair of subnetworks, a set of network packets that can traverse between the subnetworks from the formulated diagrams.

Abstract: A vertically integrated reconfigurable and programmable diode/memory resistor (1D1R) and thin film transistor/memory resistor (1T1R) structures built on substrates are disclosed.

Abstract: A gaze direction determining system and method is provided. A two-camera system may detect the face from a fixed, wide-angle camera, estimates a rough location for the eye region using an eye detector based on topographic features, and directs another active pan-tilt-zoom camera to focus in on this eye region. A eye gaze estimation approach employs point-of-regard (PoG) tracking on a large viewing screen. To allow for greater head pose freedom, a calibration approach is provided to find the 3D eyeball location, eyeball radius, and fovea position. Both the iris center and iris contour points are mapped to the eyeball sphere (creating a 3D iris disk) to get the optical axis; then the fovea rotated accordingly and the final, visual axis gaze direction computed.

Abstract: The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.

Abstract: The present invention provides devices and methods for testing the electrical performance of thin-film transistor backplane arrays and protecting thin-films during testing and handling.

Abstract: A method for forming a film on a conductive substrate, comprising immersing a substrate having a conductive portion in a solution comprising a metal ion ceramic precursor for the film and a peroxide; applying a voltage potential to the conductive portion with respect to a counter electrode in the solution, sufficient to protect the conductive portion from corrosion by the solution, and drive formation of a film on the substrate, controlling a pH of the solution while limiting a production of hydrogen by electrolysis of the solution proximate to the conductive portion; and maintaining the voltage potential for a sufficient duration to produce a film on the conductive portion. An electrode may be formed over the film to produce an electrical device. The film may be, for example, insulating, dielectric, resistive, semiconductive, magnetic, or ferromagnetic.

Abstract: One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R.

Abstract: An improved topology is presented for a single phase power source inverter that is designed to minimize double frequency ripple. The inverter circuit includes: a capacitor coupled in parallel across a direct current (DC) voltage source; a bridge circuit having three legs electrically connected in parallel with the voltage source and each other, such that each leg of the bridge circuit being comprised of two switches coupled in series with each other; a low pass filter electrically connected between the bridge circuit and a load; an auxiliary inductor having a first terminal electrically connected to one leg of the bridge circuit and a second terminal electrically connected to another leg of the bridge circuit and the load; and a controller that drives the switches of the bridge circuit in a manner that maintains instantaneous power transfer across the bridge circuit constant.