Abstract: Unsymmetrical bisazides containing chelating and non-chelating azido groups undergo chemoselective three-component copper(I)-catalyzed azide-alkyne conjugation reactions with two different alkyne molecules. In conjunction with the reactivity gap between aromatic and aliphatic alkynes, a bistriazole molecule can be generated with an excellent regioselectivity by mixing two alkynes and a bisazide in a single reaction container. This method is applicable in aqueous solutions at neutral pH, which may lend utilities in bioconjugation applications.

Abstract: Wireless devices in proximity are securely paired with one another autonomously by generating a common cryptographic key directly from a time-varying wireless environment shared among the wireless devices. The shared key can be used by the wireless devices to authenticate each wireless device's physical proximity and then to facilitate confidential communication between the wireless devices. The algorithm used to create the shared key is secure against a computationally unbounded adversary and its computational complexity is linear in the size of the shared key.

Abstract: This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.

Abstract: Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.

Abstract: The invention provides a method of reducing infarct size and/or limiting, decreasing and/or inhibiting reperfusion injury and/or ameliorating heart failure in a patient comprising administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to the patient. The compound capable of inhibiting AC5 is particularly effective when administered during or after reperfusion in patients suffering from an ischemic injury.

Abstract: The performance of a radio frequency identification (RFID) system is improved by a protocol that eliminates collisions between signals generated by a) RFID tags that the RFID reader has already identified as being in its interrogation zone and b) RFID tags that are newly arrived and thus that the reader has not yet identified. This is illustratively accomplished by the use of separate identification and access frames. It is during the identification frame that newly arrived tags become identified by the reader. Although there may be collisions during the identification frame, those collisions are only among newly arrived tags. The already-identified tags communicate with the reader during respective time slots of the access frame, so that they neither collide with each other nor with the newly arrived tags.

Abstract: A method for preparing 1,4-biscarboxylic acid esters of benzene is provided.

Abstract: The invention provides methods for identifying cell binding and/or lytic polypeptides that permit production of specific polypeptide therapeutics in a high throughput manner.

Abstract: The invention provides a compound of formula I: or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1-R12 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

Abstract: The invention discloses methods for making photonic bandgap structures and photonic bandgap structures made by those processes. In one embodiment, the photonic bandgap structure is flexible. In another photonic bandgap structure, the structure has a graded, periodic grating. One embodiment of a method according to the present invention comprises the steps of preparing a pre-polymer mixture, positioning that mixture between two slides, exposing the mixture to electromagnetic radiation, curing the mixture, and discarding at least one of the slides. In another embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a prism. In one embodiment of the method, the pre-polymer mixture is exposed to the electromagnetic radiation through a lens. In one embodiment of the invention, the photonic bandgap structure is used as a filter in a multispectral imaging device comprising a imaging device, the filter, a processor, and an electronic image storage device.

Abstract: Various embodiments of the present invention provide a lure composition, lure arrangement, and/or method for attracting and capturing bed bugs and the like. In some embodiments, the present invention combines a collection structure with a chemical lure composition that has improved efficacy due to a synergistic combination of elements. The present invention reduces the need for sprayed or broadcast attractants. In one aspect of the invention, a lure composition for attracting bed bugs and the like is provided. The 5-chemical lure mixture comprises a combination of Nonanal, 1-octen-3-ol, L-lactic acid, spearmint oil, and coriander Egyptian oil. In another embodiment of the invention, the mixture comprises a 4-chemical lure mixture Nonanal, 1-octen-3-ol, spear mint oil, and coriander Egyptian oil.

Abstract: A method of making dispersion-strengthened alloy particles involves melting an alloy having a corrosion and/or oxidation resistance-imparting alloying element, a dispersoid-forming element, and a matrix metal wherein the dispersoid-forming element exhibits a greater tendency to react with a reactive species acquired from an atomizing gas than does the alloying element. The melted alloy is atomized with the atomizing gas including the reactive species to form atomized particles so that the reactive species is (a) dissolved in solid solution to a depth below the surface of atomized particles and/or (b) reacted with the dispersoid-forming element to form dispersoids in the atomized particles to a depth below the surface of said atomized particles. Bodies made from the dispersion strengthened solidified particles exhibit enhanced fatigue and creep resistance and reduced wear as well as enhanced corrosion and/or oxidation resistance at high temperatures.

Abstract: Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided.

Abstract: The invention is directed to network management systems and methods that provide substantially real-time network management and control capabilities of multimedia streaming traffic in telecommunications networks. The invention provides pre-emptive and autonomous network management and control capabilities, and may include shared intelligence of embedded systems—Heterogeneous Sensor Entities (HSE) and the Sensor Service Management (SSM) system. HSEs are distributed real-time embedded systems provisioned in various network elements. HSEs performs fault, configuration, accounting, performance and security network management functions in real-time; and real-time network management control activations and removals. SSM facilitates automated decision making, rapid deployment of HSEs and real-time provisioning of network management and control services. The service communication framework amongst various HSEs and the SSM is provided by the Heterogeneous Service Creation system.

Abstract: A new and distinct cultivar of Corylus plant named ‘York’ characterized by globose plant habit and moderate vigor, green developing and fully expanded leaves during the spring and summer, resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller, presence of random amplified polymorphic DNA markers 152-800 and AA12-850, expression of incompatibility alleles S2 and S21 in the styles, and DNA fingerprints at 10 of 23 microsatellite marker loci that differ from both parents OSU 479.027 and OSU 504.065, and from one parent at an additional 11 marker loci.

Abstract: A new and distinct cultivar of Corylus plant named ‘Felix’ characterized by an upright plant habit and high vigor, green developing and fully expanded leaves during the spring and summer, resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Wüller, presence of random amplified polymorphic DNA markers 152-800 and AA12-850, expression of incompatibility alleles S15 and S21 in the styles, and DNA fingerprints at 14 of 24 microsatellite marker loci differ from both parents OSU 384.095 and ‘Delta’, and from one parent at an additional 6 marker loci.

Abstract: A new and distinct cultivar of Lagerstroemia crapemyrtle plant named ‘CREC-0052’, characterized by its light pink color flowers and large growth habit.

Abstract: A new and distinct cultivar of Lagerstroemia crapemyrtle plant named ‘CREC-0030’, characterized by its deep purple color flowers and small to medium growth habit.

Abstract: A new and distinct cultivar of Lagerstroemia crapemyrtle plant named ‘CREC-0060’, characterized by its deep purple color flowers and small to medium growth habit.