Abstract: Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, ? carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or CBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.

Abstract: A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from degradation of the delivered proteins from cellular proteases. A composition for treat proteins has cation reagents, lipids and enhancers in a carrier. The method can be used in a number of ways including: production of large quantities of properly folded, post-translationally modified proteins using mammalian cell machinery, a in-cell fluorescence spectroscopy and imaging using small molecule fluorophores and a in-cell NMR spectroscopy using living mammalian cells. The method permits cell biology at atomic resolution that is physiologically and pathological relevant and permits protein therapy to treat human diseases. The method can also be used to deliver exogenous protein inside mammalian cells, wherein the exogenous proteins follow a similar secretion pathway as that of the endogenous protein.

Abstract: The invention provides compounds of formula I: and salts thereof wherein R1-R4 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts, and methods for their use in therapy. The compounds have useful antiviral properties.

Abstract: The micropump includes continuous cylindrical separating pipes having at least two alternating stages of pipes of small radius and large radius connected in succession. Each pipe of a large radius has one end as a hot zone, and the opposite end as a cold zone. The pipes alternate straight pipes with a large radius and U-shaped curved pipes with a small radius. The relationship of the large radius (R) to the small radius (r) is in a range of R/r=2 to 10000, while the relationship of the temperature (T2) of a hot zone to the temperature (T1) of a cold zone is T2/T1=1.1 to 3.0. The length and radius measurements of a straight pipe and a U-shaped pipe ensure a given change in temperature of the gas from the temperature of the hot zone to the temperature of the cold zone.

Abstract: Platinum and palladium complexes are disclosed that can be useful as narrow band phosphorescent emitters. Also disclosed are methods for preparing and using the platinum and palladium complexes.

Abstract: A threshold logic element (TLE) is disclosed. The TLE includes a first input gate network, a second input gate network, and a differential sense amplifier. The first input gate network is configured to receive a first set of logical signals and the second input gate network configured to receive a second set of logical signals. The differential sense amplifier is operably associated with the first input gate network and the second input gate network such that the differential sense amplifier is configured to generate a differential logical output in accordance with a threshold logic function. To obfuscate the TLE, any number of obfuscated transmission gates can be provided in one or both of the input gate networks. The obfuscated transmission gates are obfuscated such that obfuscated transmission gates are incapable of effecting the threshold logic function of the TLE and thus hide the functionality of the TLE.

Abstract: Embodiments of the invention provide a fuel cell system including a fuel cell coupled to a controller configured to route power generated by the fuel cell to at least one peripheral device. Embodiments include a hydrogen generator including a reactor vessel enclosed by a housing. The hydrogen generator is fluidly coupled to the fuel cell and configured to deliver hydrogen to the fuel cell. Embodiments include at least one water harvesting system fluidly coupled to the hydrogen generator and configured to deliver water or water vapor to the hydrogen generator using a controller. Some embodiments include at least one waste heat recovery system used to heat harvested water or water vapor delivered to the hydrogen generator. Some embodiments include a fuel cell system fueling method using the hydrogen generator fluidly coupled to the fuel cell including delivery of captured water or water vapor to the hydrogen generator.

Abstract: Some embodiments of the invention include a pagophobic coating assembly including a wick layer coupled an outer layer. The wick layer includes a fluid reservoir with an antifreeze material. The wick can be a hydrophilic or superhydrophilic material, and the outer layer can include a superhydrophobic or omniphobic material. In some embodiments, the wick includes a nylon-based polymer, and the outer layer includes a silicone or siloxane based polymer. In some embodiments of the invention, the antifreeze material includes an alkylene glycol. In some embodiments, the wick layer can enable the antifreeze material to migrate from the wick layer into the outer layer, and the outer layer is configured to enable the antifreeze to migrate to the upper surface of the outer layer. Some embodiments include an article of manufacture including the pagophobic coating assembly. Some further embodiments of the invention include a method of forming the pagophobic coating assembly.

Abstract: A carbon dioxide capture and release method of forming a MOF matrix material including at least one metal-organic-framework crystal that includes at least one metal ion or metal ion cluster coordinated to polydentate organic ligands. The method includes forming a positive moisture swing CO2 host by application of at least a portion of the MOF matrix material to at least a portion of a good, and exposing the good to a feed gas. The method also includes altering the absorption and desorption of CO2 in the CO2 host through a swing absorption/desorption process of moisture content, where an equilibrium pressure of CO2 over the CO2 host is based at least in part on the moisture content. The metal-organic-framework crystal can be UIO-66 including Zr6O4(OH)4(CO2)12 clusters linked by terephthalate acid ligands, and/or Zr6O4(OH)4(CO2)12 clusters linked by amino-terephthalic acid ligands, and/or Zr6O4(OH)4(CO2)12 clusters linked by nitro-terephthalic acid ligands.

Abstract: An antigenic characterization method using polyclonal antibody-based proximity ligation assays (polyPLA). Methods, kits, and other tools disclosed herein are useful in detecting microbial antigenic variants in samples, including clinical samples. The methods and kits have great utility in detecting antigenic variants for pathogenic microbes, including viruses, bacteria, and parasites.

Abstract: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.

Abstract: The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C5-C10)cycloalkyl and (C2-C10)heterocyclyl. Fused ring A is substituted with (R1)1-8 and fused ring B is substituted with —(OC(O)R?C(O)R2)1-8. At each occurrence R? is independently chosen from (C2-C10)alkanylene, (C2-C10)alkenylene, (C2-C10)alkynylene, C5-C20(arylene), and (C1-C20)heteroarylene, wherein R? is unsubstituted or substituted. At each occurrence R1 is independently selected from —OH, —OR3, and —OC(O)R?C(O)R2. At each occurrence R2 is independently chosen from —OH, —OR3, —NH2, —NHR3, and —NR32. At each occurrence R3 is independently chosen from (C1-C10)alkanyl, (C2-C10)alkenyl, (C2-C10)alkynyl, C5-C20(aryl), and (C1-C20)heteroaryl, wherein R3 is unsubstituted or substituted.

Abstract: Systems and methods for detection of an amphiphile at a liquid crystal interface include the production of circular polarized light. A system 100 for detecting an amphiphile at a liquid crystal interface comprises a source of white collimated light. A circular polarizer is included for circularly polarizing incoming white light. Polarized white light passes through to an LC grid including a suspended LC film and a solution in contact with the LC grid at a surface. A spectrophotometer optically detects the presence of an amphiphile at the surface by determining a change in birefringence exhibited by the suspended LC film. A method for detecting amphiphiles at a liquid crystal water interface comprises shining collimated white light on an LC cell including an LC film, polarizing the white light with a circular polarizer, adding an amphiphile to a solution in contact with the LC film, and optically detecting the presence of the amphiphile by measuring a change in birefringence exhibited by the LC film.

Abstract: A diffraction grating comprises a liquid crystal (LC) cell configured to apply an electric field through a cholesteric LC material that induces the cholesteric LC material into a heliconical state with an oblique helicoid director. The applied electric field produces diffracted light from the cholesteric LC material within the visible, infrared or ultraviolet. The axis of the heliconical state is in the plane of the liquid crystal cell or perpendicular to the plane, depending on the application. A color tuning device operates with a similar heliconical state liquid crystal material but with the heliconical director axis oriented perpendicular to the plane of the cell. A power generator varies the strength of the applied electric field to adjust the wavelength of light reflected from the cholesteric liquid crystal material within the visible, infrared or ultraviolet.

Abstract: Applicants have successfully generated heritable phenotypes in plants making them resistant to bacterial blight. TAL effector binding elements, (EBEs) of bacterial pathogen disease susceptibility genes are modified to prevent induction of expression associated with disease states caused by the bacterial pathogens. Surprisingly, Applicants have found that modifications may be made in the EBEs of these genes which prevent bacterial pathogen induction, but still allow for normal plant development and seed production. Nucleic acid sequences for generating such plants, amino acid sequences, cells, vectors and expression constructs are included as well as resistant plants, seeds and lines.

Abstract: In some embodiments, a wastewater treatment system may reduce contaminants in water. A system may include one or more bioreactors which include a substrate that supports a biofilm. The bacteria used to form the biofilm may be selected to maximize the reduction of contaminants in water. Various components of the wastewater treatment system may be optimized to improve the efficiency and energy consumption of the wastewater system.

Abstract: A configurable ME MTJ XOR/XNOR gate includes an insulator separating a top and bottom FM layer, a top ME layer with a first boundary magnetism at an interface of the top ME layer and the top FM layer, a bottom ME layer with a second boundary magnetism at an interface of the bottom ME layer and the bottom FM layer, and a top electrode coupled to the top ME layer and a bottom electrode coupled to the bottom ME layer. A voltage between the top electrode and FM layer is a first input, a voltage between the bottom electrode and FM layer is a second input, and a resistance between the top and bottom FM layer is indicative of the XOR or the XNOR of the inputs. The configurable ME MTJ XOR/XNOR gate has reduced energy consumption, smaller area, faster switching times, is non-volatile, and is configurable.

Abstract: A direct-write lithography apparatus includes a polarization selector stage configured to vary a polarization orientation angle of light from a light source, a focusing element configured to focus the light from the light source into a spot at a focal plane thereof, and a scanning stage configured to scan the spot in at least two dimensions along a surface of a polarization-sensitive recording medium that is arranged proximate to the focal plane such that neighboring scans substantially overlap. The polarization selector stage and the scanning stage are configured to be operated independently of one another. Related fabrication methods of and optical elements fabricated thereby are also discussed.

Abstract: A method, a computer readable medium and an apparatus for optimizing a cellular network architecture are disclosed. For example, the method obtains network traffic data for a plurality of different endpoint device types, wherein the network traffic data comprises network traffic data for each of the plurality of different endpoint device types, and predicts a future traffic pattern for one of the plurality of different endpoint device types based on the network traffic data. The method then adjusts a parameter of the cellular network architecture in response to the future traffic pattern predicted for the one of the plurality of different endpoint device types.

Abstract: Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.