Abstract: A new and distinct cultivar of Azalea plant named ‘Stewla#1’, characterized by its globe to broad columnar plant form; freely branching habit; terminal truss flower arrangement; pure white hose-in-hose flowers with some yellow-green flecking in the throat of the petals; green-yellow flower buds; and hardiness in USDA zone 6a.
Abstract: Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.
Type:
Application
Filed:
December 16, 2013
Publication date:
June 19, 2014
Applicant:
The Research Foundation of State University of New York
Abstract: Identifying pathways that are significantly impacted in a given condition is a crucial step in the understanding of the underlying biological phenomena. All approaches currently available for this purpose calculate a p-value that aims to quantify the significance of the involvement of each pathway in the given phenotype. These p-values were previously thought to be independent. Here, we show that this is not the case, and that pathways can affect each other's p-values through a “crosstalk” phenomenon that affects all major categories of existing methods. We describe a novel technique able to detect, quantify, and correct crosstalk effects, as well as identify novel independent functional modules. We assessed this technique on data from four real experiments coming from three phenotypes involving two species.
Abstract: Nanowire apparatus and methods of using the same are disclosed. The apparatus include nanowires that are attached to and extend from varying substrates and can be used in the manipulation of cells and/or sensing of cellular and subcellular characteristics. The methods include using the apparatus to sense forces exerted by a single cell or using the apparatus to manipulate one or more cells.
Type:
Application
Filed:
February 21, 2014
Publication date:
June 19, 2014
Applicant:
Kansas State University Research Foundation
Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Type:
Application
Filed:
August 30, 2013
Publication date:
June 19, 2014
Applicant:
The Ohio State University Research Foundation
Inventors:
Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
Abstract: The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1.
Type:
Application
Filed:
December 12, 2013
Publication date:
June 19, 2014
Applicant:
The Research Foundation for The State University of New York
Inventors:
Natasha M. NESBITT, Roger A. JOHNSON, Elizabeth M. BOON
Abstract: Identifying pathways that are significantly impacted in a given condition is a crucial step in the understanding of the underlying biological phenomena. All approaches currently available for this purpose calculate a p-value that aims to quantify the significance of the involvement of each pathway in the given phenotype. These p-values were previously thought to be independent. Here, we show that this is not the case, and that pathways can affect each other's p-values through a “crosstalk” phenomenon that affects all major categories of existing methods. We describe a novel technique able to detect, quantify, and correct crosstalk effects, as well as identify novel independent functional modules. We assessed this technique on data from four real experiments coming from three phenotypes involving two species.
Abstract: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such assays.
Type:
Grant
Filed:
July 26, 2006
Date of Patent:
June 17, 2014
Assignee:
Rutgers, The State University of New Jersey
Inventors:
David S. Perlin, Steven Park, Cameron M. Douglas, Jennifer Nielsen Kahn, Stephen A. Parent, Rosemarie Kelly
Abstract: The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective concentration of a dihydropyrimidinone compound; and contacting the at least one cell with a sub-effective concentration of a proteasome inhibitor, wherein the sub-effective concentration of the dihydropyrimidinone compound and the sub-effective concentration of the proteasome inhibitor have a synergistic effect upon the at least one cell.
Type:
Grant
Filed:
August 15, 2008
Date of Patent:
June 17, 2014
Assignees:
The Research Foundation of State University of New York, University of Pittsburgh—of the Commonwealth System of Higher Education
Abstract: A method of constructing a phosphorous adsorbing structure includes creating a design model that indicates a percentage of phosphorous removed from a water supply per an amount of a predetermined adsorbent exposed to the water supply based upon an original concentration of phosphorous in the water supply and a retention time of water in the adsorbing structure.
Type:
Grant
Filed:
April 16, 2012
Date of Patent:
June 17, 2014
Assignee:
The Board of Regents for Oklahoma State University
Abstract: A removable intraoral device is useful for longitudinal in vivo biofilm research. The device is adapted to allow it to be retained in the oral cavity long enough for biofilm to form and to affect the oral mucosa. The device is readily removable to facilitate longitudinal observations. The device is biostable. The device does not interfere with the animal's daily activities such as eating and drinking. The device can be fabricated and maintained at low cost.
Type:
Grant
Filed:
May 19, 2011
Date of Patent:
June 17, 2014
Assignee:
Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
Abstract: A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease selected from the list in Table 6. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays of claim 4, the software including analyzing means for analyzing the arrays.
Type:
Grant
Filed:
June 20, 2011
Date of Patent:
June 17, 2014
Assignee:
Wayne State University
Inventors:
Michael Tainsky, Sorin Draghici, Madhumita Chatterjee
Abstract: A method of treating or inhibiting hepatitic C virus (HCV). The method comprises administering an effective amount of at least one pokeweed antiviral protein (PAP) mutant alone or in combination with other anti-HCV agents.
Type:
Grant
Filed:
January 18, 2008
Date of Patent:
June 17, 2014
Assignee:
Rutgers, The State University of New Jersey
Abstract: The disclosure provides compositions that can be used to make films to increase the efficiency of producing plants and plant parts. The films are designed in part to be environmentally friendly and/or edible. Also provided are methods of using such compositions as well as plants and plant parts comprising such compositions.
Type:
Grant
Filed:
April 22, 2010
Date of Patent:
June 17, 2014
Assignee:
State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
Abstract: The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of the present invention are also provided. The invention also provides methods for inhibiting, preventing or improving the pathological or clinical manifestations of cancer or an inflammatory disease or disorder in a subject, comprising administering a peptide of the invention.
Type:
Grant
Filed:
January 27, 2011
Date of Patent:
June 17, 2014
Assignee:
The Research Foundation for the State University of New York
Abstract: Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic bacterium that is not modified with respect to the genes of interest.
Type:
Grant
Filed:
October 19, 2007
Date of Patent:
June 17, 2014
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A process for producing hydrogen comprising the steps of: (i) gasifying a fuel into a raw synthesis gas comprising CO, hydrogen, steam, sulfur and halide contaminants in the form of H2S, COS, and HX, wherein X is a halide; (ii) passing the raw synthesis gas through a water gas shift reactor (WGSR) into which CaO and steam are injected, the CaO reacting with the shifted gas to remove CO2, sulfur and halides in a solid-phase calcium-containing product comprising CaCO3, CaS and CaX2; (iii) separating the solid-phase calcium-containing product from an enriched gaseous hydrogen product; and (iv) regenerating the CaO by calcining the solid-phase calcium-containing product at a condition selected from the group consisting of: in the presence of steam, in the presence of CO2, in the presence of synthesis gas, in the presence of H2 and O2, under partial vacuum, and combinations thereof.
Type:
Application
Filed:
May 13, 2013
Publication date:
June 12, 2014
Applicant:
The Ohio State University Research Foundation
Abstract: Provided are an apparatus and method for load-balancing of a three-phase electric power distribution system having a multi-phase feeder, including obtaining topology information of the feeder identifying supply points for customer loads and feeder sections between the supply points, obtaining customer information that includes peak customer load at each of the points between each of the feeder sections, performing a phase balancing analysis, and recommending phase assignment at the customer load supply points.
Type:
Application
Filed:
December 10, 2013
Publication date:
June 12, 2014
Applicant:
The Research Foundation for the State University of New York
Inventors:
Thomas G. ROBERTAZZI, Steven SKIENA, Kai WANG
Abstract: This disclosure relates generally to systems and methods for simulating physical active semiconductor components using in silico active semiconductor components. To simulate charge degradation effect(s) in a circuit simulation, a simulated defect signal level is produced. More specifically, the simulated defect signal level simulates at least one charge degradation effect in the in silico active semiconductor component as a function of simulation time and a simulated input signal level of a simulated input signal. As such, the charge degradation effect(s) are simulated externally with respect to the in silico active semiconductor component. In this manner, the in silico active semiconductor component does not need to be reprogrammed in order to simulate charge degradation effects.
Type:
Application
Filed:
December 9, 2013
Publication date:
June 12, 2014
Applicants:
Arizona State University
Inventors:
Hugh James Barnaby, Ivan Sanchez Esqueda
Abstract: A magnetic graphene-like nanoparticle or graphitic nano- or microparticle exhibits a high relaxivity, and is useful as a MRI contrast agent. A composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. Methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. Methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle.
Type:
Application
Filed:
May 7, 2012
Publication date:
June 12, 2014
Applicant:
The Research Foundation for The State University of New York