Abstract: A cable termination utilizing liquid and gaseous cryogen. The liquid cryogen maintains cryogen temperatures of all dielectric surfaces exposed to gaseous cryogen and to high voltage potential. The invention further includes capacitive grading, minimizing the electric field on the surface of the bushing in the vapor phase of the cryogen used in the liquid cryogen compartment. The cross-section of the conductor within the cable termination is adjusted along its axis enabling thermal optimization for reduction in the loss of liquid cryogen. Heat sink, for helium gas cooling of superconducting power devices, is surrounded by a metal of high thermal conductivity and placed near the area needed to be cooled. Cryogenic gaseous coolant flows through two tubes connected to the heat sink. Fins inside heat sink increase metal surface in contact with the coolant. The coolant flows from first tube, passes through the finned are and exits through the second tube.
Type:
Application
Filed:
May 9, 2013
Publication date:
June 12, 2014
Applicant:
The Florida State University Research Foundation, Inc.
Inventors:
Lukas Graber, Horatio Rodrigo, Danny G. Crook, Sastry Pamidi, Steinar Dale, Bianca Trociewitz
Abstract: Cell lines harboring a range of polymorphisms using recombinant cytochrome P450 or other chemical-metabolizing enzymes in a parent cell line that is minimally expressing or devoid of its own cytochrome P450 protein or other chemical-metabolizing enzymes of interest can be placed into an array format to enable high throughput screening of one or more chemicals for CYP450 or other enzyme-dependent metabolism (FIG. 9). Processing of the cells can be automated, done en-masse through use of an array having a substrate upon which a plurality of cell lines with exogenous chemical-metabolizing enzymes are coupled, and both relative and quantitative metabolism rates determined using mass spectrometry over time. Thus, methods are disclosed to measure, for example, the effects of cytochrome P450 polymorphisms on clinical drug metabolism in a high throughput manner for drug development and genetically personalized diagnostics and treatment regimens.
Type:
Application
Filed:
July 27, 2012
Publication date:
June 12, 2014
Applicant:
Arizona Board of Regents of behalf of Arizona State University
Abstract: A method of determining antimicrobial activity of an agent can include providing a well, wherein the well contains at least one antimicrobial agent, the well further including at least two electrodes. A sample of a microbe can be added into the well and a voltage pulsed between the electrodes. An electrical property can be sampled and recorded. In another aspect, a method of identifying at least one microbe includes taking a sample containing the at least one microbe, isolating the at least one microbe from the sample, dividing the at least one microbe into at least one well, wherein each well contains at least one antimicrobial agent and at least two electrodes. A voltage is pulsed between the at least two electrodes, an electrical property is sampled during the pulsing and recorded. In another aspect, a diagnostic device for detecting at least one microbe is presented.
Type:
Application
Filed:
December 4, 2013
Publication date:
June 12, 2014
Applicants:
Texas State University, Telemedicine Up Close, Inc. dba DxUpClose
Inventors:
Cynthia S. NICKEL, Clois E. POWELL, James R. BIARD, William A. STAPLETON, Gary M. ARON, Jeanette HILL, Ray G. COOK, Daniel M. JUSTISS, Frederick J. STRIETER, Andrei M. MANOLIU
Abstract: A solder alloy includes Sn, optional Ag, Cu, and Al wherein the solder alloy composition together with the solder alloy superheat temperature and rapid cooling rate from the superheat temperature are controlled to provide a dispersion of fine hard Cu—Al intermetallic particles in an as-solidified solder alloy microstructure wherein the particles are retained even after multiple solder reflow cycles often used in modern electronic assembly procedures to provide a particle strengthening to the solder joint microstructure as well as exert a grain refining effect on the solder joint microstructure, providing a strong, impact- and thermal aging-resistant solder joint that has beneficial microstructural features and is substantially devoid of Ag3Sn blades.
Type:
Application
Filed:
February 6, 2014
Publication date:
June 12, 2014
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
Type:
Grant
Filed:
February 25, 2013
Date of Patent:
June 10, 2014
Assignee:
The Research Foundation for the State University of New York
Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.
Type:
Grant
Filed:
October 24, 2012
Date of Patent:
June 10, 2014
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
Inventors:
Yanqing Tian, Weiwen Zhang, Deirdre Meldrum, Hongguang Lu, Yuguang Jin, Mark Holl
Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
Type:
Grant
Filed:
November 10, 2009
Date of Patent:
June 10, 2014
Assignees:
Battelle Memorial Institute, Institute for Systems Biology, The Ohio State University Research Foundation
Inventors:
David Galas, Richard Evan Gelinas, Clay Braden Marsh, Melissa Garnet Piper, Kai Wang, Shile Zhang
Abstract: A powertrain is adapted to drive ground-engaging elements disposed along longitudinally-opposing sides of a vehicle. The powertrain includes at least one engine, a first electric machine, a second electric machine, a third electric machine, a first differential mechanism and a second differential mechanism. The engine and first electric machine are operatively connected to the first and second differential mechanisms. The second electric machine is operatively connected to the first differential mechanism and the third electric machine is operatively connected to the second differential mechanism. The first and second differential mechanisms are each operatively connected to drivable engage one or more ground-engaging elements disposed on a different one of the longitudinally-opposing sides of the associated vehicle. A vehicle including such a powertrain as well as methods of using the same are also included.
Type:
Grant
Filed:
October 2, 2013
Date of Patent:
June 10, 2014
Assignee:
The Ohio State University Research Foundation
Inventors:
Codrin-Gruie Cantemir, Gabriel G. Ursescu, Georgio Rizzoni
Abstract: In accordance with the present teachings, a method of producing composite having a 3A Q3D reinforcement phase is disclosed. The method of producing the composite provides producing a three-dimensionally woven configuration where a first fiber from a first sheet of reinforcement phase is interwoven or mechanically linked with at least one of an adjacent second layer and then back into the first sheet. The linking fibers are passed between layers at an acute angle generally less than about 10 degrees. The method includes impregnating the woven construction with a curable polymer such as epoxy.
Type:
Application
Filed:
May 20, 2013
Publication date:
June 5, 2014
Applicant:
Board of Trustees of Michigan State University
Abstract: A method for generating a model for epithelial ovarian cancer is presented, comprising the steps of obtaining a mass spectrum for each of a plurality of samples, segmenting each of the mass spectra into “bins,” and determining a plurality of relationships between two or more bins. One are more statistically significant factors are identified according to the determined plurality of relationships, and a predictive model is generated as a function of the one or more identified factors. A method of the present invention may further comprise the step of obtaining one or more nuclear magnetic resonance spectra of each of the samples, which are segmented into a plurality of bins. Combinations of mass spectra and NMR spectra may be used to determine the plurality of relationships. In other embodiments, methods for identifying the presence of EOC indicated by a biological sample of an individual are presented.
Type:
Application
Filed:
July 27, 2012
Publication date:
June 5, 2014
Applicant:
The Research Foundation of State University of New York
Inventors:
Thomas Szyperski, Christopher Andrews, Dinesh K. Sukumaran, Adekunle Odunsi
Abstract: An active catheter device is provided. At least one elongate catheter segment includes an elongate flexible tube member defining an axis, and a pair of ferrule members operably engaged with and spaced apart along the tube member. The ferrule members are not rotatable about the axis relative to each other. At least one articulation member is operably engaged with and extends at least between the ferrule members along the tube member. Each articulation member is configured to be actuatable to cause a change in a distance between the ferrule members so as to articulate the tube member. Associated systems and methods are also provided.
Type:
Application
Filed:
March 28, 2012
Publication date:
June 5, 2014
Applicant:
North Carolina State University
Inventors:
Gregory Dale Buckner, Arun Shankar Veeramani, Stephen B. Owen, Shaphan R. Jernigan
Abstract: A reaction-based process developed for the selective removal of CO2 from a multicomponent gas mixture to provide a gaseous stream depleted in CO2 compared to the inlet CO2 concentration. The proposed process effects the separation of CO2 from a mixture of gases by its reaction with metal oxides. The Calcium based Reaction Separation for CO2 (CaRS—CO2) process consists of contacting CO2 laden gas with CaO in a reactor such that CaO captures CO2 by the formation of CaCO3. CaCO3 is regenerated by calcination leading to the formation of fresh CaO sorbent and the evolution of a concentrated stream of CO2. The “regenerated” CaO is then recycled for the further capture of CO2. This carbonation-calcination cycle forms the basis of the CaRS—CO2 process. This process also may use a mesoporous CaCO3 structure that attains >90% conversion over multiple carbonation and calcination cycles.
Abstract: This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.
Type:
Application
Filed:
May 18, 2012
Publication date:
June 5, 2014
Applicant:
Rutgers, The State University of New Jersey
Inventors:
Michele Vittadello, Kamil Woronowicz, Manish Chhowalla, Paul G. Falkowski
Abstract: The present invention is directed to methods and compositions for blocking the effect of the intronic inhibitory splicing region of intron 7 of the SMN2 gene. The compositions and methods of the instant invention include short oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target sites in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The short target regions are 8-mers and 5-mers and also include the identification of a single nucleotide base that is essential for initiating a long distance stearic inhibitory interactions as well as novel targets distant from intron 7 which block the intronic inhibitory splicing of the same. These short target regions and concomitant inhibitory blocking oligonucleotides are less expensive and easier to manufacture and are small enough to cross the blood brain barrier.
Type:
Application
Filed:
December 19, 2013
Publication date:
June 5, 2014
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: An inspection probe for directly measuring a transmission spectrum of a solvent oil in a transformer includes a tube having a plurality of apertures spaced along a side of the tube to allow oil to pass therethrough, and first and second optical collimators disposed at opposing ends of the tube. The first and second collimators are aligned by the tube such that incident light is transmitted through the first collimator, the tube, and the second collimator to a spectrometer.
Type:
Grant
Filed:
May 16, 2012
Date of Patent:
June 3, 2014
Assignee:
Virginia Polytechnic Institute & State University
Abstract: An apparatus and method for transmission of laser pulses with high output beam quality using large core step-index silica optical fibers having thick cladding, are described. The thick cladding suppresses diffusion of modal power to higher order modes at the core-cladding interface, thereby enabling higher beam quality, M2, than are observed for large core, thin cladding optical fibers. For a given NA and core size, the thicker the cladding, the better the output beam quality. Mode coupling coefficients, D, has been found to scale approximately as the inverse square of the cladding dimension and the inverse square root of the wavelength. Output from a 2 m long silica optical fiber having a 100 ?m core and a 660 ?m cladding was found to be close to single mode, with an M2=1.6.
Type:
Grant
Filed:
August 25, 2011
Date of Patent:
June 3, 2014
Assignee:
Colorado State University Research Foundation
Abstract: Methods and devices for treatment of biomass comprised of crystalline structures are described that provide a combined mechanical, chemical and thermal effect (i.e., nano-hybrid pretreatment) to synergistically break down the crystalline structures. Such nano-hybrid mixing provides efficient, and cost-effective breakdown which enhances enzymatic accessibility to lignocellulosic materials. Methods and devices shown can be used to produce products such as pulp, chemicals, or biofuels.
Type:
Grant
Filed:
July 29, 2011
Date of Patent:
June 3, 2014
Assignee:
Board of Trustees of Michigan State University