Patents Assigned to State University
  • Patent number: 8729090
    Abstract: Embodiments of the invention include compositions effective for inhibiting collagen production and related methods. A preferred method comprises contacting at least one cell capable of producing collagen with a composition effective for inhibiting collagen production thereby. The composition comprises one or more of the compounds effective for inhibiting collagen production disclosed herein.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: May 20, 2014
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic
  • Patent number: 8729233
    Abstract: A nanowire comprising a purified protein filament, such as a pilus, isolated from a bacterium, such as Geobacter sulfurreducens, is provided. Such a purified pilus can contain peptide subunits capable of assembling into the protein filament and establishing an electrical connection with an insoluble electron acceptor. The novel nanowires can be produced via a novel single step. Such nanowires are useful in applications requiring rectifying behavior.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: May 20, 2014
    Assignee: Board of Trustees of Michigan State University
    Inventors: Gemma Reguera, Stuart Tessmer, Joshua Veazey, Sanela Lampa-Pastirk
  • Patent number: 8728578
    Abstract: A method for preparing a graphene sheet greater than 1 ?m in length that includes: combining graphitic oxide with a solvent having a ratio of from about 50:50 to about 80:20 deionized water and ethanol to form a graphitic oxide solution; mixing a solution of NaBH4 and deionized water and the graphitic oxide solution to form a mixture having a concentration of from 10 mmolar to 20 mmolar NaBH4; depositing the mixture on a substrate to form a sheet; and heating the mixture at a temperature of from 25° C. to 85° C. for from 3 to 30 minutes.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: May 20, 2014
    Assignee: The Research Foundation for the State University of New York
    Inventors: Miriam Rafailovich, Rebecca Isseroff, Paul Masih Das
  • Patent number: 8729060
    Abstract: The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n? and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: May 20, 2014
    Assignee: Rutgers, the State University of New Jersey
    Inventors: Edmond J. LaVoie, Joseph E. Rice, Satyanarayana Mavurapu
  • Patent number: 8729246
    Abstract: The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: May 20, 2014
    Assignees: Alcatel Lucent, Rutgers, The State University of New Jersey
    Inventors: Noshir A. Langrana, David C. Lin, Bernard Yurke
  • Patent number: 8729024
    Abstract: Techniques are provided for targeting a pharmaceutically active compound using, as a carrier, a molecule (or molecules) having greater affinity for a particular site in a living organism's body than for other sites therein. A compound of the formula B-L-A is provided, where B represents the residue of a small synthetic molecule, preferably one that is approved for human use, having a greater affinity for a particular site in a patient's body than for other sites in the patient's body, L represents a direct bond or a linking group, and A represents the residue of a pharmaceutically active compound.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: May 20, 2014
    Assignee: The Resesarch Foundation of State University of New York
    Inventors: Alfred Stracher, Leo Kesner, Abraham Shulman
  • Patent number: 8729171
    Abstract: A biodegradable nanocomposite and a method of forming a biodegradable nanocomposite are provided. In one aspect, the biodegradable nanocomposite includes a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid. The biodegradable nanocomposite further includes a plurality of pores formed in the nanocomposite, the plurality of pores having an average pore size greater than about 100 ?m.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: May 20, 2014
    Assignees: Wayne State University, William Beaumont Hospital
    Inventors: Rangaramanujam M. Kannan, Kevin C. Baker, Robert Bellair, Mihai Manitiu, Harry Herkowitz
  • Patent number: 8728478
    Abstract: The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine. In still further embodiments, the invention relates to the treatment of constipation using the disclosed methods and compositions.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 20, 2014
    Assignee: Board of Trustees of Michigan State University
    Inventor: A. Mahdi Saeed
  • Patent number: 8729502
    Abstract: Microfluidics has made great progress in integrating many aspects of biological analysis and testing into the microscale. One aspect which has proven challenging to miniaturize has been fluorescence testing, as a complete fluorescence system requires an integrated light source, detector and filters to filter out the excitation light (from the light source) from the detector. Here we demonstrate that with polarization filtering of the excitation light and multiple dye sources modulated at different frequencies, a high-sensitivity, multi-dye system with one detector can be realized. Simultaneous detection and quantition of a mixture of two different dyes is demonstrated with no physical change in the measurement setup. The degree of interaction of the dyes is measured. This system is readily adaptable to integrated lab-on-a-chip microfluorescence.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: May 20, 2014
    Assignee: The Research Foundation for The State University of New York
    Inventor: David Klotzkin
  • Patent number: 8728359
    Abstract: Fire retardant materials are provided that contain carbon nanotubes and particles capable of endothermically reacting when exposed to elevated temperatures. The carbon nanotubes may be a buckypaper. Methods also are provided for making a fire retardant material and for improving the fire retardation capabilities of a material.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: May 20, 2014
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Changchun Zeng, Chuck Zhang, Ben Wang, Richard Liang, Chase Knight
  • Patent number: 8731130
    Abstract: A power module assembly includes a reactor vessel containing a reactor core surrounded by a primary coolant. A containment vessel is adapted to be submerged in a containment cooling pool and to prohibit a release of the primary coolant outside of the containment vessel. A secondary cooling system is configured to remove heat generated by the reactor core. The heat is removed by circulating liquid from the containment cooling pool through the primary coolant.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: May 20, 2014
    Assignee: The State of Oregon Acting by and Through the State Board of Higher Education on Behalf of Oregon State University
    Inventors: Jose N. Reyes, Jr., John T. Groome
  • Patent number: 8730268
    Abstract: A system for generating an output image based on an original image via an imaging application can comprise a parsing module, an optical flow displacement module, and a new pixel generation module. The parsing module can establish a magnified resolution lattice from an original resolution lattice of the original image. The optical flow displacement module can establish optical displacement vectors extending, within the magnified resolution lattice, between original pixels and optical displacement locations, the optical displacement vectors based on one-dimensional optical flow brightness constraint calculations for the original pixels. The new pixel generation module can generate new pixels in the magnified resolution lattice via one or more interpolations based on the optical displacement vectors. Other embodiments and related methods are also disclosed herein.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: May 20, 2014
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
    Inventors: Christine M. Zwart, David H. Frakes
  • Patent number: 8729492
    Abstract: A multiple-deflection blanker for charged particle beam lithography includes a support structure, a first pair of electrodes mounted to the support structure and providing a first electric field, a second pair of electrodes mounted to the support structure and providing a second electric field, at least a third pair of electrodes mounted to the support structure and providing a third electric field, and a surface, such as, an aperture or knife edge, positioned to obstruct a charged particle beam passed through the electric fields. The blanker may include at least a fourth pair of electrodes providing a fourth electric field and apparatus for regulating the time of the excitation of the electric fields. Methods for exposing media to charged particles and aperture holders are also provided.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: May 20, 2014
    Assignee: The Research Foundation for The State University of New York
    Inventors: Junru Ruan, John G. Hartley, Gregory Denbeaux
  • Patent number: 8729128
    Abstract: Lipoxin A4 and its analogs have been discovered to promote the cell proliferation of cornea endothelial cells, and thus promote the proper functioning of the labile tissue layer of cornea endothelial cells. These lipoxin compounds can be administered alone or in combination with other known compounds as a solution that can be topically administered to decrease the swelling of the cornea or maintain the clarity of the cornea. Lipoxin A4 or its analogs can also be combined with other known nutritive compounds to form a solution for storage of a cornea prior to transplantation.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: May 20, 2014
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Nicolas G. Bazan, Jiu-Cheng He, Haydee E. P. Bazan
  • Publication number: 20140134439
    Abstract: A method for solvent-less adhesive bonding is provided comprising depositing thin, functional, polymeric films on one or more substrates and bonding the substrates to each other or to other substrates. Depositing the polymeric films, including, for example, chemically reactive polymers and thermoplastics with adhesive qualities, may be accomplished using an initiated chemical vapor deposition technique compatible with a variety of monomers, including monomers with chemically functional moieties such as amine and epoxy groups. The technique allows for deposition of polymeric films on a wide variety of substrates/devices and provides an alternative for other coating/deposition methods that are incompatible with certain substrates/devices and/or do not provide adequate control over the resulting polymeric film. The provided method is advantageous in that it is applicable to fabrication of hybrid devices and is compatible with microfabrication technology, including that in clean-room settings.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 15, 2014
    Applicant: The Research Foundation for the State University of New York
    Inventor: Magnus Bergkvist
  • Publication number: 20140135375
    Abstract: Compositions and methods for delivery of therapeutic RNA molecules are disclosed.
    Type: Application
    Filed: April 2, 2012
    Publication date: May 15, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventor: Eric Lam
  • Publication number: 20140135387
    Abstract: Equol (7-hydroxy-3(4?hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5?-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 15, 2014
    Applicants: Brigham Young University, Children's Hospital Center, Colorado State University Research Foundation
    Inventors: Edwin Douglas Lephart, Trent D. Lund, Kenneth David Reginald Setchell, Robert J. Handa
  • Publication number: 20140137298
    Abstract: A 23 amino acid peptide, AtPep1, plays an important role as a signaling component of the innate immune system of Arabidopsis. The peptide precursor gene is transcribed in response to elicitors generated by pathogens, and AtPep1 is produced to amplify the signaling pathways. Seven paralogs of the AtproPep1 gene have been identified in the Arabidopsis genome, and orthologs have been identified in species of several agriculturally important families. AtPep1 and its paralogs and orthologs play important roles as endogenous signals to amplify innate immunity. The sequences of two AtPep1 receptors from Arabidopsis are also provided.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 15, 2014
    Applicant: Washington State University Research Foundation
    Inventors: Clarence A. Ryan, Gregory L. Pearce, Alisa Huffaker, Yube Yamaguchi
  • Publication number: 20140135404
    Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 15, 2014
    Applicant: Kansas State University Research Foundation
    Inventors: Govindsamy Vediyappan, Duy H. Hua
  • Publication number: 20140134661
    Abstract: Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds that inhibit autophagy. Cell lines that may be used in the methods of identification are also disclosed.
    Type: Application
    Filed: May 16, 2013
    Publication date: May 15, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Eileen White, Anne Marie Storhecker, Robin Mathew, Cristina Karp