Patents Assigned to State University
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Patent number: 8729090Abstract: Embodiments of the invention include compositions effective for inhibiting collagen production and related methods. A preferred method comprises contacting at least one cell capable of producing collagen with a composition effective for inhibiting collagen production thereby. The composition comprises one or more of the compounds effective for inhibiting collagen production disclosed herein.Type: GrantFiled: October 5, 2012Date of Patent: May 20, 2014Assignee: The Florida State University Research Foundation, Inc.Inventor: Branko Stefanovic
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Patent number: 8729233Abstract: A nanowire comprising a purified protein filament, such as a pilus, isolated from a bacterium, such as Geobacter sulfurreducens, is provided. Such a purified pilus can contain peptide subunits capable of assembling into the protein filament and establishing an electrical connection with an insoluble electron acceptor. The novel nanowires can be produced via a novel single step. Such nanowires are useful in applications requiring rectifying behavior.Type: GrantFiled: August 30, 2011Date of Patent: May 20, 2014Assignee: Board of Trustees of Michigan State UniversityInventors: Gemma Reguera, Stuart Tessmer, Joshua Veazey, Sanela Lampa-Pastirk
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Patent number: 8728578Abstract: A method for preparing a graphene sheet greater than 1 ?m in length that includes: combining graphitic oxide with a solvent having a ratio of from about 50:50 to about 80:20 deionized water and ethanol to form a graphitic oxide solution; mixing a solution of NaBH4 and deionized water and the graphitic oxide solution to form a mixture having a concentration of from 10 mmolar to 20 mmolar NaBH4; depositing the mixture on a substrate to form a sheet; and heating the mixture at a temperature of from 25° C. to 85° C. for from 3 to 30 minutes.Type: GrantFiled: May 12, 2011Date of Patent: May 20, 2014Assignee: The Research Foundation for the State University of New YorkInventors: Miriam Rafailovich, Rebecca Isseroff, Paul Masih Das
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Patent number: 8729060Abstract: The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n? and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.Type: GrantFiled: August 1, 2008Date of Patent: May 20, 2014Assignee: Rutgers, the State University of New JerseyInventors: Edmond J. LaVoie, Joseph E. Rice, Satyanarayana Mavurapu
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Patent number: 8729246Abstract: The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.Type: GrantFiled: August 10, 2012Date of Patent: May 20, 2014Assignees: Alcatel Lucent, Rutgers, The State University of New JerseyInventors: Noshir A. Langrana, David C. Lin, Bernard Yurke
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Patent number: 8729024Abstract: Techniques are provided for targeting a pharmaceutically active compound using, as a carrier, a molecule (or molecules) having greater affinity for a particular site in a living organism's body than for other sites therein. A compound of the formula B-L-A is provided, where B represents the residue of a small synthetic molecule, preferably one that is approved for human use, having a greater affinity for a particular site in a patient's body than for other sites in the patient's body, L represents a direct bond or a linking group, and A represents the residue of a pharmaceutically active compound.Type: GrantFiled: February 28, 2007Date of Patent: May 20, 2014Assignee: The Resesarch Foundation of State University of New YorkInventors: Alfred Stracher, Leo Kesner, Abraham Shulman
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Patent number: 8729171Abstract: A biodegradable nanocomposite and a method of forming a biodegradable nanocomposite are provided. In one aspect, the biodegradable nanocomposite includes a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid. The biodegradable nanocomposite further includes a plurality of pores formed in the nanocomposite, the plurality of pores having an average pore size greater than about 100 ?m.Type: GrantFiled: January 20, 2011Date of Patent: May 20, 2014Assignees: Wayne State University, William Beaumont HospitalInventors: Rangaramanujam M. Kannan, Kevin C. Baker, Robert Bellair, Mihai Manitiu, Harry Herkowitz
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Patent number: 8728478Abstract: The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine. In still further embodiments, the invention relates to the treatment of constipation using the disclosed methods and compositions.Type: GrantFiled: September 3, 2009Date of Patent: May 20, 2014Assignee: Board of Trustees of Michigan State UniversityInventor: A. Mahdi Saeed
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Patent number: 8729502Abstract: Microfluidics has made great progress in integrating many aspects of biological analysis and testing into the microscale. One aspect which has proven challenging to miniaturize has been fluorescence testing, as a complete fluorescence system requires an integrated light source, detector and filters to filter out the excitation light (from the light source) from the detector. Here we demonstrate that with polarization filtering of the excitation light and multiple dye sources modulated at different frequencies, a high-sensitivity, multi-dye system with one detector can be realized. Simultaneous detection and quantition of a mixture of two different dyes is demonstrated with no physical change in the measurement setup. The degree of interaction of the dyes is measured. This system is readily adaptable to integrated lab-on-a-chip microfluorescence.Type: GrantFiled: October 21, 2011Date of Patent: May 20, 2014Assignee: The Research Foundation for The State University of New YorkInventor: David Klotzkin
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Patent number: 8728359Abstract: Fire retardant materials are provided that contain carbon nanotubes and particles capable of endothermically reacting when exposed to elevated temperatures. The carbon nanotubes may be a buckypaper. Methods also are provided for making a fire retardant material and for improving the fire retardation capabilities of a material.Type: GrantFiled: December 16, 2013Date of Patent: May 20, 2014Assignee: Florida State University Research Foundation, Inc.Inventors: Changchun Zeng, Chuck Zhang, Ben Wang, Richard Liang, Chase Knight
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Patent number: 8731130Abstract: A power module assembly includes a reactor vessel containing a reactor core surrounded by a primary coolant. A containment vessel is adapted to be submerged in a containment cooling pool and to prohibit a release of the primary coolant outside of the containment vessel. A secondary cooling system is configured to remove heat generated by the reactor core. The heat is removed by circulating liquid from the containment cooling pool through the primary coolant.Type: GrantFiled: April 23, 2012Date of Patent: May 20, 2014Assignee: The State of Oregon Acting by and Through the State Board of Higher Education on Behalf of Oregon State UniversityInventors: Jose N. Reyes, Jr., John T. Groome
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Patent number: 8730268Abstract: A system for generating an output image based on an original image via an imaging application can comprise a parsing module, an optical flow displacement module, and a new pixel generation module. The parsing module can establish a magnified resolution lattice from an original resolution lattice of the original image. The optical flow displacement module can establish optical displacement vectors extending, within the magnified resolution lattice, between original pixels and optical displacement locations, the optical displacement vectors based on one-dimensional optical flow brightness constraint calculations for the original pixels. The new pixel generation module can generate new pixels in the magnified resolution lattice via one or more interpolations based on the optical displacement vectors. Other embodiments and related methods are also disclosed herein.Type: GrantFiled: February 4, 2011Date of Patent: May 20, 2014Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State UniversityInventors: Christine M. Zwart, David H. Frakes
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Patent number: 8729492Abstract: A multiple-deflection blanker for charged particle beam lithography includes a support structure, a first pair of electrodes mounted to the support structure and providing a first electric field, a second pair of electrodes mounted to the support structure and providing a second electric field, at least a third pair of electrodes mounted to the support structure and providing a third electric field, and a surface, such as, an aperture or knife edge, positioned to obstruct a charged particle beam passed through the electric fields. The blanker may include at least a fourth pair of electrodes providing a fourth electric field and apparatus for regulating the time of the excitation of the electric fields. Methods for exposing media to charged particles and aperture holders are also provided.Type: GrantFiled: July 20, 2011Date of Patent: May 20, 2014Assignee: The Research Foundation for The State University of New YorkInventors: Junru Ruan, John G. Hartley, Gregory Denbeaux
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Patent number: 8729128Abstract: Lipoxin A4 and its analogs have been discovered to promote the cell proliferation of cornea endothelial cells, and thus promote the proper functioning of the labile tissue layer of cornea endothelial cells. These lipoxin compounds can be administered alone or in combination with other known compounds as a solution that can be topically administered to decrease the swelling of the cornea or maintain the clarity of the cornea. Lipoxin A4 or its analogs can also be combined with other known nutritive compounds to form a solution for storage of a cornea prior to transplantation.Type: GrantFiled: October 30, 2008Date of Patent: May 20, 2014Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical CollegeInventors: Nicolas G. Bazan, Jiu-Cheng He, Haydee E. P. Bazan
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Publication number: 20140134439Abstract: A method for solvent-less adhesive bonding is provided comprising depositing thin, functional, polymeric films on one or more substrates and bonding the substrates to each other or to other substrates. Depositing the polymeric films, including, for example, chemically reactive polymers and thermoplastics with adhesive qualities, may be accomplished using an initiated chemical vapor deposition technique compatible with a variety of monomers, including monomers with chemically functional moieties such as amine and epoxy groups. The technique allows for deposition of polymeric films on a wide variety of substrates/devices and provides an alternative for other coating/deposition methods that are incompatible with certain substrates/devices and/or do not provide adequate control over the resulting polymeric film. The provided method is advantageous in that it is applicable to fabrication of hybrid devices and is compatible with microfabrication technology, including that in clean-room settings.Type: ApplicationFiled: November 12, 2013Publication date: May 15, 2014Applicant: The Research Foundation for the State University of New YorkInventor: Magnus Bergkvist
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Publication number: 20140135375Abstract: Compositions and methods for delivery of therapeutic RNA molecules are disclosed.Type: ApplicationFiled: April 2, 2012Publication date: May 15, 2014Applicant: Rutgers, The State University of New JerseyInventor: Eric Lam
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Publication number: 20140135387Abstract: Equol (7-hydroxy-3(4?hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5?-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.Type: ApplicationFiled: May 28, 2013Publication date: May 15, 2014Applicants: Brigham Young University, Children's Hospital Center, Colorado State University Research FoundationInventors: Edwin Douglas Lephart, Trent D. Lund, Kenneth David Reginald Setchell, Robert J. Handa
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Publication number: 20140137298Abstract: A 23 amino acid peptide, AtPep1, plays an important role as a signaling component of the innate immune system of Arabidopsis. The peptide precursor gene is transcribed in response to elicitors generated by pathogens, and AtPep1 is produced to amplify the signaling pathways. Seven paralogs of the AtproPep1 gene have been identified in the Arabidopsis genome, and orthologs have been identified in species of several agriculturally important families. AtPep1 and its paralogs and orthologs play important roles as endogenous signals to amplify innate immunity. The sequences of two AtPep1 receptors from Arabidopsis are also provided.Type: ApplicationFiled: January 31, 2014Publication date: May 15, 2014Applicant: Washington State University Research FoundationInventors: Clarence A. Ryan, Gregory L. Pearce, Alisa Huffaker, Yube Yamaguchi
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Publication number: 20140135404Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Applicant: Kansas State University Research FoundationInventors: Govindsamy Vediyappan, Duy H. Hua
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Publication number: 20140134661Abstract: Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds that inhibit autophagy. Cell lines that may be used in the methods of identification are also disclosed.Type: ApplicationFiled: May 16, 2013Publication date: May 15, 2014Applicant: Rutgers, The State University of New JerseyInventors: Eileen White, Anne Marie Storhecker, Robin Mathew, Cristina Karp