Abstract: Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6?-glucuronide are provided.
Type:
Application
Filed:
January 10, 2014
Publication date:
May 8, 2014
Applicant:
The Research Foundation of State University of New York
Inventors:
George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
Abstract: The present invention provides compositions and methods of altering/improving Durum wheat phenotypes. Furthermore, methods of breeding Durum wheat and/or other closely related species to produce plants having altered or improved phenotypes are provided.
Abstract: Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
Type:
Application
Filed:
January 8, 2014
Publication date:
May 8, 2014
Applicant:
North Carolina State University
Inventors:
Christian Melander, John Cavanagh, Robert W. Huigens, III, T. Eric Ballard, Justin J. Richards
Abstract: A novel IFN-?/? independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-?1, IFN-?2, IFN-?3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-? proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-?R1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-?R1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection.
Type:
Grant
Filed:
October 5, 2010
Date of Patent:
May 6, 2014
Assignee:
Rutgers, The State University of New Jersey
Abstract: A avian cell line that supports replication of animal or human viruses, which cell line is adapted to animal-product free growth. The cell line is useful for propagating a virus suitable as a live or a killed vaccine and for virus isolation and diagnostic assays.
Type:
Grant
Filed:
April 23, 2009
Date of Patent:
May 6, 2014
Assignee:
Board of Trustees of Michigan State University
Inventors:
Paul Michael Coussens, Kristen Ann Smith Pabst, Patty Sue Dickerson-Weber
Abstract: A passive sampling apparatus and method for measuring the cumulative mass of a selected gas being transported through a known cross-sectional area, for example, a soil surface, during a chosen period of time, using absorbent material, are described. Two quantities of absorbent material are disposed in a hollow container, such as a pipe section, and spaced apart such that they may be readily separated for analysis. The absorbent material closest to the soil captures the gas leaving the soil. Under reversed flow conditions, for example when the ambient air enters the ground because of fluctuations in atmospheric pressure, the upper absorbent material captures the component of interest entering the apparatus, thereby preventing this gas from entering the lower material and disturbing the measurement. The apparatus can therefore sequester the component of interest without being affected by the direction of gas transport.
Type:
Grant
Filed:
August 3, 2011
Date of Patent:
May 6, 2014
Assignees:
Colorado State University Research Foundation, Chevron U.S.A. Inc.
Inventors:
Julio A. Zimbron, Thomas C. Sale, Mark Lyverse
Abstract: A high sensitivity desorption electrospray ionization mass spectrometry system that employs a heated platform, along with means for directing a liquid stream containing an analyte of interest onto a target location on the heated platform to heat the stream, an electrospray emitter for generating an electrospray and directing the electrospray at the target location on the heated platform to produce an ionized, desorbed analyte, and a mass spectrometer for receiving and detecting the ionized, desorbed analyte.
Abstract: An OPO is disclosed capable of rapid frequency tuning by non-mechanical means. The OPO includes a resonant cavity including one or more non-linear crystals in an optical path thereof. A pump laser pulse is transmitted into the resonant cavity simultaneously with a seed beam having a desired wavelength. The output beam from the resonant cavity has the same center wavelength as the seed beam. The wavelength of the seed beam may be modulated at a frequency larger than the pulse rate of the pump laser or larger than the inverse of the pulse duration. The OPO disclosed may be used to perform DIAL analysis wherein intra-pulse modulation of an output beam is used to obtain measurements of absorption at multiple frequencies for each pulse of a pump beam.
Type:
Grant
Filed:
June 15, 2011
Date of Patent:
May 6, 2014
Assignee:
Utah State University Research Foundation
Abstract: Disclosed are methods for producing esterified propoxylated glycerols and eutectic mixtures containing one or more esterified propoxylated glycerols and one or more digestible fats. Food products containing the eutectic mixtures are also disclosed.
Type:
Grant
Filed:
June 21, 2012
Date of Patent:
May 6, 2014
Assignees:
Choco Finesse LLC, Kansas State University Institute for Commercialization
Inventors:
Leopold Strecker, David Stewart Rowe, James Louis Flowers, Dana Overman
Abstract: The present invention disposes a membrane between two electrical conductive walls having a height at least as great as the thickness of the membrane. The conductive walls are fabricated on an electrically insolative chip base. The chip base has one or more through hole between the electrically conducting walls. The chip is placed inside a container having a well below the through hole of the electrically insolative base. At least one passageway extends from the well to the periphery of the container. This invention probes changes of the membrane as an in-plane electric field is applied between the conductive walls. The well may include various compounds while-other compounds can be placed in contact with the top of the membrane. The passageways are used to introduce substances into and out of the well.
Abstract: The present invention relates to a method and system for detecting biologically relevant structures in a hierarchical fashion, beginning at a low-resolution and proceeding to higher levels of resolution. The present invention also provides probabilistic pairwise Markov models (PPMMs) to classify these relevant structures. The invention is directed to a novel classification approach which weighs the importance of these structures. The present invention also provides a fast, efficient computer-aided detection/diagnosis (CAD) system capable of rapidly processing medical images (i.e. high throughput). The computer-aided detection/diagnosis (CAD) system of the present invention allows for rapid analysis of medical images the improving the ability to effectively detect, diagnose, and treat certain diseases.
Type:
Grant
Filed:
September 3, 2009
Date of Patent:
May 6, 2014
Assignees:
Trustees of the University of Pennsylvania, Rutgers, The State University of New Jersey
Inventors:
Anant Madabhushi, James Monaco, John Tomaszewski, Michael Feldman, Ajay Basavanhally
Abstract: Embodiments of content addressable memories for internet protocol devices and operations are described herein. Other examples and related methods are also disclosed herein.
Type:
Grant
Filed:
May 26, 2010
Date of Patent:
May 6, 2014
Assignee:
Arizona Board of Regents, for and on Behalf of Arizona State University
Inventors:
Satendra Kumar Maurya, Lawrence T. Clark
Abstract: Compounds of the hydroxytolan family kill tumor cells, inhibit tumor growth and development, and are thus useful in method for treating a tumor or cancer in subjects in need thereof. These compounds are also active in preventing or treating a variety of skin diseases and conditions. The most preferred hydroxytolan compounds are 4,4?-dihydroxytolan. (KST-201), 4 hydroxy 4? trifluoromethyltolan or 4? hydroxy 4 trifluoromethyltolan (KST-213), 3,4?,5-trihydroxytolan or 3?,4,5?-trihydroxytolan (KST-301) and 3,3?,5,5?-tetrahydroxytolan (KST-401). The compounds and methods of using them alone and in combination with ascorbate and certain cyclic compounds to inhibit the development, growth or metastasis of tumor/cancer or preneoplastic cells, or to prevent or treat skin disorders in a subject are disclosed.
Abstract: Compositions, methods, and kits for repair and production of extracellular matrix are provided. In the broad aspect, the composition comprises a ligand of ?5?1 integrin attached to a surface of a nanoparticle composed of a protein, with a proviso that the protein is not fibronectin.
Type:
Grant
Filed:
July 11, 2007
Date of Patent:
May 6, 2014
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Prabhas V. Moghe, Ram Sharma, Marian Pereira Guelakis
Abstract: Various embodiments of ion detection systems, devices, and associated methods of operation are described herein. In one embodiment, a method for ion detection includes separating a target species from other species in an ionized sample of a first polarity, generating ions of a second polarity opposite the first polarity, and contacting ions of the second polarity with the ionized sample to generate emissions after separating the target species from other species in the ionized sample. The method also includes detecting the generated emissions when combining the ionized sampled of the first polarity with the ions of the second polarity.
Type:
Grant
Filed:
March 26, 2013
Date of Patent:
May 6, 2014
Assignee:
Washington State University
Inventors:
Herbert H Hill, Jr., Eric J. Davis, William F. Siems
Abstract: In some embodiments, a wastewater treatment system may reduce contaminants in water. A system may include one or more bioreactors which include a substrate that supports a biofilm. The bacteria used to form the biofilm may be selected to maximize the reduction of contaminants in water. Various components of the wastewater treatment system may be optimized to improve the efficiency and energy consumption of the wastewater system.
Type:
Grant
Filed:
November 8, 2012
Date of Patent:
May 6, 2014
Assignee:
Sam Houston State University
Inventors:
R. Gavin Jones, Kenneth Wilson, Sabin Holland, Michael D. Rainone
Abstract: One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death.
Type:
Grant
Filed:
December 27, 2006
Date of Patent:
May 6, 2014
Assignees:
Kansas State University Research Foundation, The Board of Regents of the University of Nebraska, Cornell Research Foundation, Inc., The United States of America as Represented by the Secretary of Agriculture
Inventors:
James R. Alfano, Alan Collmer, Samuel W. Cartinhour, David J. Schneider, Xiaoyan Tang
Abstract: Certain embodiments of the invention provide a copolymer having a backbone, wherein the backbone comprises a) one or more units that comprise a group that will yield a biologically active agent upon hydrolysis of the backbone; and b) one or more units of formula (II): wherein y is 1 or more. Other embodiments of the invention provide a therapeutic method for treating a wound in an animal comprising administering to an animal in need of such therapy, an effective amount of a copolymer as described herein.
Type:
Application
Filed:
October 23, 2013
Publication date:
May 1, 2014
Applicant:
Rutgers, The State University of New Jersey
Abstract: Compositions of nanoparticles and targeting moieties for imaging and treating Chlamydial infection are provided, including nanoparticles conjugated to folic acid and comprising at least one antibiotic effective against Chlamydia.
Type:
Application
Filed:
January 2, 2014
Publication date:
May 1, 2014
Applicant:
Wayne State University
Inventors:
Jayanth Panyam, Judith A. Whittum-Hudson, Alan P. Hudson
Abstract: A process for preparing polymeric composite particles includes the steps of preparing an oil phase containing a biodegradable polymer and a water phase containing a hydrophilic compound or nanoparticle and emulsifying the oil phase in the water phase to form emulsions. Then solvent is removed from the emulsions to prepare the particles in the form of capsules and spheres in sizes from 0.01 ?m (10 nm) to 50 ?m.
Type:
Application
Filed:
October 24, 2013
Publication date:
May 1, 2014
Applicant:
Board of Trustees of Michigan State University