Abstract: A novel process of preparing tridentate ligands containing a diarylphosphine electron donating group are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed.

Abstract: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.

Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.

Abstract: New antimicrobial polymeric agents which are designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same.

Abstract: The present invention provides IA derivative compounds of the formula: where the variables are described herein.

Abstract: A method of generating light is disclosed. The method comprises irradiating a substance with first optical field of a first frequency and second optical field of a second frequency. The second frequency being higher than a cutoff frequency of a harmonics generation spectrum characterizing the interaction of the substance with the first optical field.

Abstract: A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.

Abstract: Methods and devices for detecting and collection analytes fractionated based on pI, separating analytes via electrophoresis and pI, and purifying a target molecule using pI focusing and subsequent crystallization are provided.

Abstract: A method for signal processing includes distributing an analog input signal to a plurality of processing channels. In each processing channel, the input signal is mixed with a respective periodic waveform including multiple spectral lines, so as to produce a respective baseband signal in which multiple spectral slices of the input signal are superimposed on one another. The baseband signal produced in each of the processing channels is digitized, to produce a set of digital sample sequences that represent the input signal.

Abstract: An immuno-molecule which comprises a soluble human MHC class I effector domain; and an antibody targeting domain which is linked to the soluble human MHC class I effector domain, methods of making same and uses thereof.

Abstract: A method for generating induced pluripotent stem (iPS) cells from isolated hair follicles is disclosed. The method comprises: a. culturing isolated hair follicle keratinocytes on a layer of feeder cells, so as to generate colonies of hair follicle keratinocytes; b. detaching the colonies of hair follicle keratinocytes from the feeder cells so as to generate detached keratinocytes; c. infecting the detached keratinocytes with a virus comprising a nucleic acid molecule encoding at least one dedifferentiation factor so as to generated infected keratinocytes; and d. culturing the infected keratinocytes on a layer of feeder cells in a culture medium until iPS cells are formed, thereby generating iPS cells. Populations and uses of the iPS cells are also disclosed.

Abstract: A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.

Abstract: Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated GAD autoantigenic peptide; and isolated high affinity entities comprising an antigen binding domain capable of specifically binding the complex, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated GAD autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.

Abstract: A method for reconstructing a holographic projection including providing a single hologram, providing at least one cyclic shift of at least a portion of the single hologram in the space domain, and reconstructing a cyclically shifted hologram by applying said cyclic shift on said portion and providing at least one cyclic shift comprises computing the cyclic shift; wherein computing at least one cyclic shift includes creating an array of shifting points in a g-h plane of the single hologram and calculating a distance vector from an origin of the plane to the shifting point.

Abstract: An isolated primate embryonic cell is provided as well as cell cultures and cell lines derived therefrom. Also provided are methods of generating and using such cells.

Abstract: Methods for producing p-doped organic semiconductor material with a fullerene derivative having at least one electron-withdrawing substituent covalently attached thereto, and semiconductor compositions prepared thereby are provided. Also provided are electronic devices, such as transistors, solar-cells, illuminating devices, OLEDs and detectors, comprised of these p-doped organic semiconductor materials.

Abstract: A computerized method of creating a presentation of multidimensional objects in a multidimensional presentation space. The method comprises providing a core element which applies any of functions on a multidimensional object in a multidimensional presentation space, providing a plurality of adaptation components each contains instructions for converting any media object of another of different media types each to a multidimensional object in the multidimensional presentation space, receiving a media object, identifying a matching adaptation component from the adaptation components according to a respective media type of the media object, converting the media objects into a multidimensional object in the multidimensional presentation space using the matching adaptation component, and applying any of the functions on the multidimensional object, using the core element, according to a user selection.

Abstract: Anti CMV antibodies are provided. Thus an antibody of the present invention comprises an antigen recognition domain capable of binding an MHC molecule being complexed with a cytomegalovirus (CMV) pp65 or pp64 peptide, wherein the antibody does not bind said MHC molecule in an absence of said complexed peptide, and wherein the antibody does not bind said peptide in an absence of said MHC molecule. Also provided are methods of using the antibodies.

Abstract: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.

Abstract: A method of operating a multi focused acoustic wave source. The method comprises providing the multi focused acoustic wave source, providing a plurality of target acoustic pressures to be applied on a plurality of regions of interest (ROIs) in at least one cellular tissue, computing a transmission pattern of multi-focal acoustic energy according to the plurality of target acoustic pressures, and operating the multi focused acoustic wave source according to the transmission pattern.