Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking therebetween, such as an omega-amino-fatty acid residue, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.
Type:
Application
Filed:
December 8, 2011
Publication date:
November 22, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Processes for forming quantum well structures which are characterized by controllable nitride content are provided, as well as superlattice structures, optical devices and optical communication systems based thereon.
Type:
Grant
Filed:
May 28, 2010
Date of Patent:
October 23, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.
Type:
Application
Filed:
June 19, 2012
Publication date:
October 4, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A method for determining similarity between a non-planar probe surface and a non-planar model surface is disclosed. The method comprises calculating an extremal value of an objective function describing embedding of the probe surface into an embedding space having a non-constant sectional curvature; and determining similarity between the probe surface and the model surface based on the extremal value.
Type:
Grant
Filed:
December 17, 2006
Date of Patent:
October 2, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Inventors:
Ron Kimmel, Alexander Bronstein, Michael Bronstein
Abstract: A method for Space-variant polarization manipulation of enhanced nondirectional thermal emission in a narrow spectral peak is disclosed, comprising providing a subwavelength grating irradiating non-directional thermal emission on the grating and discretely controlling the local orientation of the grating.
Type:
Grant
Filed:
May 4, 2006
Date of Patent:
September 25, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Inventors:
Erez Hasman, Nir Dahan, Avi Niv, Gabriel Biener, Vladimir Kleiner
Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Type:
Application
Filed:
May 8, 2012
Publication date:
August 23, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.
Type:
Grant
Filed:
January 11, 2007
Date of Patent:
August 14, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: Disclosed are compositions-of-matter composed of a continuous elastomeric matrix and a liquid; the matrix entrapping the liquid therein in the form of closed-cell droplets dispersed throughout the matrix. The disclosed compositions-of-matter are characterized by a low tensile/compressive modulus and are capable of retaining the liquid for exceedingly long periods of time. Further disclosed are processes for forming the compositions-of-matter and uses thereof.
Type:
Application
Filed:
February 9, 2012
Publication date:
August 9, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A complementary logic circuit contains first and second logic inputs, first and second dedicated logic terminals, a high-voltage terminal configured for connection to a high constant voltage, a low-voltage terminal configured for connection to a low constant voltage, a p-type transistor and an n-type transistor. The p-type transistor and n-type transistor each have a respective outer diffusion connection, gate connection, inner diffusion connection, and bulk connection. The first and second dedicated logic terminals are connected respectively to the outer diffusion connection of the p-type transistor and the outer diffusion connection of the n-type transistor. The inner diffusion connection of the p-type transistor and the inner diffusion connection of the n-type transistor are connected together to form a common diffusion logic terminal.
Type:
Application
Filed:
April 5, 2012
Publication date:
August 2, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A method and system for treating sewage sludge are described herein. A carbonaceous fuel is mixed with sewage sludge, the mixture is then gasified, and the obtained gas is combusted. The method and system may utilize wet sewage sludge.
Type:
Application
Filed:
August 30, 2010
Publication date:
August 2, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Inventors:
Genady Borodyanski, Felix Kirzhner, Yoram Zimmels, Tomer Zimmels
Abstract: A method of manipulating a living cell is disclosed. The method comprises, directing a pulsed optical field to at least one conductive nanoparticle present in the vicinity of the cell, so as to generate cavitations at or near the conductive nanoparticle at sufficient amount to effect at least one cell modification selected from the group consisting of cell-damage and cell-fusion.
Type:
Application
Filed:
January 19, 2012
Publication date:
July 26, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A method for modifying a logic circuit layout to optimize circuit propagation delays for improved circuit operation is presented. The layout includes multiple logic gates connected by conductive segments. An initial layout of a physical electronic logic circuit having the plurality of logic gates is input. A respective size is determined for each of the logic gates in accordance with the initial layout and a circuit propagation delay criterion. The circuit propagation delay criterion is a joint function of properties of at least some of the logic gates and at least some of the conductive segments. A modified logic circuit layout is output. The modified logic circuit layout includes a layout of the logic gates arranged in accordance with the initial layout, where each of the logic gates is modified according to the respective determined size, thereby to obtain a modification of the logic circuit layout incorporating an optimized circuit propagation delay.
Type:
Grant
Filed:
December 1, 2008
Date of Patent:
July 17, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Inventors:
Arkadiy Morgenshtein, Ran Ginosar, Avinoam Kolodny, Eby G. Friedman
Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
Type:
Grant
Filed:
April 11, 2011
Date of Patent:
July 17, 2012
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these lipospmes.
Type:
Application
Filed:
August 26, 2010
Publication date:
June 28, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A system for measuring one or more characteristics of light of a photon energy Eph from a light source, that can be determined from measuring three-photon absorption events, the system comprising: a) a detector having a band gap material characterized by gap energy between 2.1 and 3 times Eph; b) an optical element configured to concentrate a beam of light from the light source on the detector; c) a signal amplifier that amplifies an output signal indicative of when three photons produced by the light source undergo a three-photon absorption event in the band gap material; and d) an analyzer that analyzes the output signal to count or measure a rate of the three-photon absorption events, and determines the one or more characteristics of the light from the light source.
Type:
Application
Filed:
December 28, 2011
Publication date:
June 28, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating CD105+, CD73+ and/or CD105+/CD73+ cells from embryoid bodies and optionally by enriching the cells with CD31? cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor cells from embryoid bodies, and methods of differentiating same for various therapeutic applications. In addition, the invention provides an isolated pericyte progenitor cell having an expression marker signature of CD105+/CD73+CD31?/alpha SMA?/CD133?/Flk-1?.
Type:
Application
Filed:
August 17, 2010
Publication date:
June 14, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Inventors:
Ayelet Dar-Oaknin, Joseph Itskovitz-Eldor
Abstract: A method of separating a mixture of a plurality of molecular analytes having different isoelectric points (pIs). The method comprises placing a solution containing a mixture of a plurality of molecular analytes in a separation volume, generating a pH profile having a plurality of pH zones across an axis of the separation volume, and adjusting a profile of the pH profile to induce a migration of a first molecular analyte along the axis apart from a second molecular analyte. The first and second molecular analytes having different pIs.
Type:
Application
Filed:
August 18, 2010
Publication date:
June 14, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A device for isoelectric focusing. The device comprises a focusing container configured to contain an electrolyte solution and having a longitudinal axis and at least one electrolysis unit mounted in a close proximity to the longitudinal axis. Each electrolysis unit injects an ion flow into the focusing container so as to create a pH gradient having a plurality of steps in the electrolyte solution, along the longitudinal axis. Each step has a substantially uniform pH level and the pH gradient is defined by at least one pH ramp between every two sequential steps of the plurality of steps.
Type:
Application
Filed:
August 18, 2010
Publication date:
June 7, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: Disclosed is a novel family of macrocyclic compounds, coined calixurenes, which comprises linear and cyclic oligomers composed of alternating moieties of an aromatic unit and a ureatic unit, linked to one another via a bridging moiety. The disclosed calixurenes feature multiple heteroatom-containing groups, and can be designed so as to feature other functionalities, and can thus be used in a variety of applications. Further disclosed are processes of preparing the calixurenes, articles containing same and uses thereof.
Type:
Application
Filed:
August 12, 2010
Publication date:
June 7, 2012
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: A complementary logic circuit contains a first logic input, a second logic input, a first dedicated logic terminal, a second dedicated logic terminal, a high-voltage terminal configured for connection to a high constant voltage a low-voltage terminal configured for connection to a low constant voltage, a p-type transistor, and an n-type transistor. The p-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection. The n-type transistor has an outer diffusion connection, a gate connection, an inner diffusion connection, and a bulk connection.
Type:
Grant
Filed:
July 7, 2011
Date of Patent:
May 29, 2012
Assignee:
Technion Research & Development Foundation Ltd.