Abstract: The present invention relates to a method for producing shaped bodies (5) from a building material, in which a layered structure of a shaped body (5) takes place by successively solidifying layers of the building material by exposure to electromagnetic radiation in a layer area having a contour specified for the respective layer. The method provides that together with the shaped body (5), a sleeve-like frame (6) surrounding the shaped body at a distance is constructed layer by layer from the building material, and that in addition, a plurality of pin-like connections (10) are constructed integral with the frame (6) and the shaped body (5), which are distributed around the shaped body (5) and which connect the shaped body (5) with the frame (6).

Abstract: The invention relates to a computer-implemented method for the optical sensing, the detection and the quantification of relevant conditions and/or their changes with respect to at least one target object, wherein at least one target object is temporarily positioned opposite an optical sensor device, and wherein the fault conditions of the fault classes deviate from the optimal condition. The method is characterized particularly in that the background and the target object are distinguished by means of a higher rate of change of the image information of the background in comparison with the rate of change of the image information of the target object.

Abstract: The present invention relates to a method for preparing oligosaccharides which can be used among others as food additives to reduce calorie content, to sweeten food products, to increase the fiber content of food products, to improve the texture of food products and to stimulate the gut microbiome bacteria. Furthermore they can be applied in the fields of animal feed, or other applications. More particularly, this invention is directed to a high temperature hydrolysis of xyloglucan polysaccharide to defined xyloglucan oligosaccharides. The invention further relates to oligosaccharide hydrolysates produced with the method of the invention and to the use of said oligosaccharide hydrolysates in human and/or animal nutrition, as prebiotic or other uses. Further provided are novel endoglucanases for use in the method of the invention as well as in other applications.

Abstract: The invention provides methods for specifically altering the DNA sequence in a genome, in particular for genome editing by deleting or replacing a sequence of interest. Advantageously, the invention uses two non-identical sequences naturally occurring in a genome as target sites two which DNA-recombining enzymes are generated. The invention is in particular useful for medicine, in particular to repair a mutation in a genome or to delete predefined genetic material from cells or tissue and to cure diseases. An advantage of the invention is that it allows precise site directed altering of DNA without engaging host DNA repair pathways and thereby works without inducing random insertions and deletions (indels).

Abstract: The 3D printing method disclosed here for the production of vascularized tissues and organs requires a droplet printer to produce photorealistic high-resolution prints and a device for applying non-directional or directional electromagnetic waves. The process uses a new type of capillary ink that crosslinks or undergoes a layer-forming reaction only in the edge area of the ink drops. Unbound capillary ink components are removed. The resulting cavities form a capillary network with diameters of up to approx. 10 ?m. Also disclosed is a novel printer table for supplying the printed tissue with medium during printing and a printer head supply unit for individually mixing the bio-inks from cell concentrate and various ink concentrates.

Abstract: The present invention relates to an improved methanation process, wherein energy released during the methanation process is used to drive a turbocharger to drive and/or maintain the process. The present invention is further concerned with a system for the production of methane-enriched gas and power from hydrogen and carbon-containing starting materials comprising at least one methanation reactor and at least one turbocharger.

Abstract: A method for determining the joint positions of a kinematic chain uses only an imaging sensor and a computing unit. Characteristic features on the links and joints of the kinematic chain are identified and the joint positions are calculated from these visual measurements. The robot can be controlled without the use of joint encoders. A sensor system for monitoring the status of a kinematic chain includes a computing unit and an imaging sensor. The imaging sensor may be mounted to the kinematic chain or in the surroundings of the kinematic chain and monitors the kinematic chain and/or the surroundings of the kinematic chain. The computing unit determines a pose and/or movement parameters of at least one element of the kinematic chain by analyzing an output signal of the imaging sensor, in particular by analyzing characteristic features and determines a rotational joint position by analyzing the characteristic features.

Abstract: High affinity macrocyclic FKB51-Inhibitors (HAM-FKB51-Inhibitors), which enable the selective inhibition of FK506-binding proteins (FKBPs). The molecules are useful for the treatment of psychiatric disorders, metabolic disorders, pain diseases, and cancers.

Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.

Abstract: A single-atom catalyst for use in a water splitting process includes at least one support material and at least one metal catalyst deposited on the surface of the at least one support material. The at least one support material is made of tungsten carbide obtained from a tungstate-metal-aryl compound precursor, and the at least one metal catalyst is selected from a group including Fe, Ni, Mn, Co, Cu, Zn, V, Ru, Ir, Ca, Pd, Pt or combinations thereof.

Abstract: A device is presented for an absorption refrigerator or an absorption heat pump having a heat exchanger through which a working medium flows. The device includes a distribution apparatus for a sorbent which is designed to apply the sorbent to a heat exchange surface of the heat exchanger in a refrigerant environment such that the sorbent, which forms a working pair with the refrigerant, at least partially absorbs the refrigerant from the refrigerant environment and emits heat released in the process to the heat exchanger, or at least partially desorbs the refrigerant from the sorbent in the form of one or more jets onto the heat exchange surface, forming turbulent flows of the sorbent on the heat exchange surface.

Abstract: It is provided an albidicin derivatives, in particular to amid bond isosteres compound according to general formula (1) and (2).

Abstract: The present invention provides the modular design and assembly of novel targeting bio-conjugates, exclusively assembled by means of biotin-biotin binding element conjugation, comprising mono-biotinylated cell binding component, a tetrameric biotin-binding element, and mono-biotinylated payload for therapeutic and diagnostic purposes. In addition, there is provided a method of delivering the payload, such as therapeutic oligonucleotides, via mono-biotinylated targeting devices, such as antibodies or ligands, into eukaryotic cells by means of receptor-mediated endocytosis. The targeting bio-conjugates are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: A fuel cell system comprising at least one fuel cell arranged for a reformation of a hydrocarbon and a hydrocarbon generation unit connected to an anode outlet of the fuel cell for generating the hydrocarbon from carbon monoxide and hydrogen included in a partially unconverted exhaust stream of the anode outlet of the fuel cell, where the fuel cell is thermally decoupled from the hydrocarbon generation unit so that the exothermal hydrocarbon generation reaction and the endothermal reformation reaction proceed without one reaction thermally interfering the other.

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

Abstract: A hybrid drive device for a motor vehicle with an internal combustion engine includes a first electric motor and a second electric motor. A transmission includes a first partial transmission connected to the first electric motor and a second partial transmission connected to the second electric motor, each being connectable to an output shaft. The internal combustion engine can selectively be uncoupled from the transmission or can be connected in a form-fit manner to the first or the second partial transmission. The first electric motor is connected at a constant gear ratio to a first drive shaft of the first partial transmission, and the second electric motor is connected at a constant gear ratio to a second drive shaft of the second partial transmission. The internal combustion engine can also be connected in a form-fit manner to the output shaft by way of a direct gear-change means.

Abstract: A hydrogen bonded organic framework (HOF) includes at least one kind of organic linker with at least one functional group forming a hydrogen-bonded network, the functional group includes a hydroxyl group and a central atom of tetrahedral geometry, the HOF is semi-conductive, proton-conductive and porous, and can even be microporous. In some embodiments, the at least one functional group is phosphonic acid, phosphinic acid, arsonic acids, arsinic acids, phosphonate, arsonate and/or esters thereof including at least one hydroxylgroup. A covalent organic framework (COF), is also provided based on an HOF for transforming the hydrogen bonds between the functional groups into covalent anhydride bonds via a condensation reaction or reactions known to form anhydrides.

Abstract: An apparatus for additively manufacturing a heterogeneous structure (50) using a plastic fiber (10) and an energy transfer material (20) is disclosed. Additive manufacturing is performed in a vertical direction (z) perpendicular to a horizontal plane (x-y). The apparatus comprises: a nozzle device (110) adapted to provide the plastic fiber (10) for additive manufacturing; a feeding device (120) adapted to move the energy transfer material (20) back and forth in a vertical direction (z); and moving device (130) adapted to independently move (or rotate) the feeding device (120) and the nozzle device (110) in the horizontal plane (x-y) to fabricate the heterogeneous structure (50) in the horizontal plane (x-y).

Abstract: An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources.

Abstract: A device and a method for computer-aided processing of data are disclosed, the method including: providing configuration data of an application, determining a first application identification, wherein the first application identification is assigned to the application, determining a configuration identification, wherein the configuration identification is assigned to the configuration data of the application, individualizing the data by means of a second application identification, wherein the second application identification is determined using the first application identification and the configuration identification.