Abstract: The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.

Abstract: A safety system is provided for a machine tool which has a frame and a tool. The safety system has a clamping device and a motion device. The clamping device is movable by the motion device from a working position, in which the tool is extended and can be used for working, to a safety position, in which the tool is retracted. The motion device has a first magnetic means connected to or arranged on the tool and a second magnetic means connected to or arranged on the frame, such that movement of the tool by the motion device from the working position to the safety position can be triggered and/or at least partially performed by magnetic force.

Abstract: The invention provides conjugates of cyclic peptides as ligands for cellular surface receptors, in particular, as ligands for ?v?6-integrin. The conjugates further contain effector moieties and are suitable for use as therapeutic agent, diagnostic agent, agent for imaging, targeting moiety and as biomolecular research tool. The invention specifically relates to the use of conjugates with signalling moieties or radionuclides for in-vivo addressing of ?v?6-integrin.

Abstract: The particle sensor device comprises a substrate, a photodetector, a dielectric on or above the substrate, a source of electromagnetic radiation, and a through-substrate via in the substrate. The through-substrate via is exposed to the environment, in particular to ambient air. A waveguide is arranged in or above the dielectric so that the electromagnetic radiation emitted by the source of electromagnetic radiation is coupled into a portion of the waveguide. A further portion of the waveguide is opposite the photodetector, so that said portions of the waveguide are on different sides of the through-substrate via, and the waveguide traverses the through-substrate via.

Abstract: The invention relates to an apparatus and to a method for establishing a connection having material continuity or having material continuity and shaping matching or for separating such a connection of at least one metal or ceramic component and of a component formed from or by a thermoplastic polymer in which the components to be joined together can be pressed together by a pressing device having a counterholder and a plunger. A heating device is present at the plunger and/or at the counterholder or acts there.

Abstract: The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure.

Abstract: A method for the preparation of isocyanates in which: (i) a first organosilicon compound having at least one silicon atom Si1 and a unit of formula G-I bound thereto is converted to a third organosilicon compound having a unit of formula G-II by silylation of the NH group of the unit of formula G-I with a second organosilicon compound having one silicon atom Si2; and (ii) the third organosilicon compound is reacted to an isocyanate by thermolysis, whereby the unit of formula G-II is converted to an isocyanate group.

Abstract: An articulating robotic arm for minimally invasive surgery, comprising a proximal arm segment extending along a longitudinal axis of the robotic arm and a distal arm segment connected to the proximal arm segment, pivotable about a pivot axis orthogonal to the longitudinal axis. The distal arm segment comprises a pinion segment formed with pinion teeth arranged about the pivot axis in the form of a pinion. A rack element is arranged on the proximal arm segment such that the rack element is movable in the longitudinal direction of the rack element parallel to the longitudinal axis by means of a translation, and rack teeth formed on the rack element are engaged with the pinion teeth so that a movement of the rack element in the longitudinal direction via the rack teeth and the pinion teeth is converted into a rotational movement of the distal arm segment about the pivot axis, and so that the distal arm segment pivots relative to the proximal arm segment about the pivot axis.

Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit CXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.

Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.

Abstract: The invention relates to an assembly for damping vibrations of a structure (I), having a wall element (5a, 5b, 5c, 5d) to be fitted in a upright position, a casing element (Sa, Sb, Sc, 8d) and a damping device (22a, 22b, 22c, 22d), which is connected to the casing element (Sa, Sb, Sc, 8d) and to the wall element (5a, 5b, 5c, 5d) such that a relative movement between the wall element (5a, 5b, 5c, 5d) and the casing element (Sa, Sb, Sc, 8d) is transmitted to the damping device (22a, 22b, 22c, 22d). The damping device (22a, 22b, 22c, 22d) is designed to damp a vibrating movement of the wall element (5a, 5b, 5c, 5d) in a damping direction and is arranged such that the damping device is oriented substantially parallel to a surface of the wall element (5a, 5b, 5c, 5d). The invention further relates to a method for damping vibrations of a structure.

Abstract: A fluorescent probe includes one or more metal binding functional group, such as phosphonic acid group and an arsonic acid group, in which the functional group is covalently linked to a fluorescent core via a sp2-carbon atom of the fluorescent core. In embodiments, the fluorescent core is an organic fluorescent compound/moiety, that can be a tetrapyrrole derivative, such as porphyrin or phthalocyanine, acridine, BODIPY, cyanine or cyanine derivatives, carbazole, coumarine or coumarine derivatives, xanthene or xanthene derivatives such as fluorescein or rhodamine. The fluorescent probe can bind to calcium and/or a calcification, such as hydroxyapatite (HAP). In a further aspect, a fluorescent probe is used in a method of detecting calcium, such as a calcification or HAP, in a bodily tissue. The use of the fluorescent probe is also provided for detecting calcium, a calcification and/or HAP, such as calcium depositions in a bodily tissue.

Abstract: A rotary cutting disc (10) comprising two coaxial mutually opposed disc-shaped elements (12a, 12b) each having a circumferential edge, wherein circumferential edges (14a, 14b) of the disc-shaped elements (12a, 12b) are joined together forming a cutting edge (16) of the cutting disc (10); wherein each of the disc-shaped elements (12a, 12b) comprises one or more at least partly curved elongated deformation lines (30), wherein the one or more deformation lines (30) have a radial distance from the centre (26) of the cutting disc (10) that increases along at least a part of the length of the deformation line (30). The rotary cutting disc (10) has an increased critical speed that allows improving the efficiency of a cutting operation with a cutting disc while maintaining acceptable levels of quality, cutting precision and safety.

Abstract: The present invention relates to a method for preparing oligosaccharides which can be used among others as food additives to reduce calorie content, to sweeten food products, to increase the fiber content of food products, to improve the texture of food products and to stimulate the gut microbiome bacteria. Furthermore they can be applied in the fields of animal feed, or other applications. More particularly, this invention is directed to a high temperature hydrolysis of xyloglucan polysaccharide to defined xyloglucan oligosaccharides. The invention further relates to oligosaccharide hydrolysates produced with the method of the invention and to the use of said oligosaccharide hydrolysates in human and/or animal nutrition, as prebiotic or other uses. Further provided are novel endoglucanases for use in the method of the invention as well as in other applications.

Abstract: In a method for coating a base body, a first target and a second target are arranged in a vacuum chamber. A base body to be coated is arranged in the vacuum chamber is heated to a coating temperature of less than 600° C. During sputtering with sputter gas ions, first target particles are liberated from the first target and second target particles are liberated from the second target and are deposited as coating particles on the base body. A first sputter rate is specified for the first target and a second sputter rate is specified for the second target such that, during the sputtering process, the coating is generated as an A15 phase with an intended stoichiometric ratio of the first target particles to the second target particles. A functional element has a base body and a coating of Nb3Sn applied directly on the surface of the base body.

Abstract: A toothed belt includes at least one tension member and a plastics material matrix which at least partially encases the tension member. The at least one tension member extends in the plastics material matrix in a running direction and teeth of the toothed belt are formed transversely to the running direction in the plastics material matrix. The tension member is formed from an electrically conductive material and the plastics material matrix is formed from an electrically insulating material. The toothed belt has at least one electronic component which is embedded in the plastics material matrix and has at least one sensor which detects data on a condition parameter of the toothed belt. The at least one electronic component is coupled to the tension member via at least two voltage taps to tap a voltage induced in the tension member to supply the at least one electronic component with power.

Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from. the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The operation of a hybrid powertrain system is optimized with respect to a desired state-of-charge trajectory, taking account of the estimated anticipated vehicle drive power. The hybrid powertrain system has an internal combustion engine and an electrically operated torque machine. The internal combustion engine and the torque machine are controlled by a control device and are connected to an output element via a hybrid transmission. Before the start of the prediction period ?t, an experience-based state-of-charge trajectory for the anticipated route, covering at least the prediction period ?t, is retrieved from an external database. The desired state-of-charge trajectory is established based on the experience-based state-of-charge trajectory by modifying it with at least one optimization constraint.

Abstract: A method of preparing a mesoporous carbon composite material having a mesoporous carbon phase and preformed metal nanoparticles located within the mesoporous carbon phase. The present invention also relates to a mesoporous carbon composite material and to a substrate having a film of such mesoporous carbon composite material.