Abstract: A drill bit for a drill includes a body clearance extending helically along the drill bit, a margin also extending helically along the drill bit, adjacent to and projecting radially beyond the body clearance, and a flank at which the body clearance and the margin terminate at a tip of the drill bit. The margin has a variable width along its helical extension.

Abstract: A method for controlling a combustion apparatus having a combustion state in which a parameter related to the combustion state reflects a chaotic behavior is provided. The method includes the steps of measuring the parameter and determining a time series of the parameter, shifting the time series by a variable time delay for determining a time-shifted signal, and forming a difference between the time-shifted signal and the time series for determining a time dependent first signal, so that a norm of the difference is lowest. A time dependent second signal is determined, wherein determining the time dependent second signal includes at least one of using a frequency of a desired oscillating combustion state, and shifting the time series by a set time delay. The first signal and the second signal are combined to determine a control signal. The control signal is used to influence the combustion apparatus.

Abstract: The present invention refers to a mutein of the ?-subunit of human Interleukin 27 and of human heterodimeric Interleukin 27 according to the present invention. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention further refers to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing a said muteins.

Abstract: A sensor (10) comprises a waveguide (20) having a longitudinal axis and an end face (21), the waveguide (20) comprising a Bragg grating (23). The sensor comprises at least one reflector (24) on the end face (21) of the waveguide (20). An optical resonator (25) is formed by the Bragg grating (23), the at least one reflector (24), and an inner portion of the optical resonator (25) between the Bragg grating (23) and the at least one reflector (24). The inner portion of the optical resonator (25) extends within a portion of the waveguide (20). The sensor (10) comprises a detector (32) configured to detect at least one spectral characteristic of the optical resonator (25) or a change of at least one spectral characteristic of the optical resonator (25).

Abstract: The present invention provides the modular design and assembly of novel targeting bio-conjugates, exclusively assembled by means of biotin-biotin binding element conjugation, comprising mono-biotinylated cell binding component, a tetrameric biotin-binding element, and mono-biotinylated payload for therapeutic and diagnostic purposes. In addition, there is provided a method of delivering the payload, such as therapeutic oligonucleotides, via mono-biotinylated targeting devices, such as antibodies or ligands, into eukaryotic cells by means of receptor-mediated endocytosis. The targeting bio-conjugates are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: The present invention relates to compounds which bind and/or inhibit prostate-specific membrane antigen (PSMA) comprising at least one group electron dense substituent (EDS), and at least one moiety which is amenable to radiolabeling; and therapeutic and diagnostic uses thereof.

Abstract: The present invention relates to peptides, in particular amyloid inhibitory peptides, and to pharmaceutical compositions comprising such peptides. Furthermore, the present invention relates to such peptides, in particular such amyloid inhibitory peptides, for use in methods of treating or diagnosing neurodegenerative diseases such as Alzheimer's disease, or for use in a method of treating or diagnosing type 2 diabetes. Furthermore, the present invention also relates to a kit for the in-vitro or in-vivo detection and, optionally, quantification of amyloidogenic polypeptides, amyloid fibrils or amyloid aggregates, and/or for the diagnosis of Alzheimer's disease or type 2 diabetes in a patient.

Abstract: The invention relates to alkaline secondary batteries. The secondary battery contains a cathode, an anode and an electrolyte, said secondary battery being arranged between the cathode and anode and comprises an alkali metal ion conductive contact to the cathode and to the carbon layer of the anode. The anode contains or consists of a carbon layer, whereby the carbon layer, alone or in combination with an electrically conductive substrate, forms with an electrically conductive contact.

Abstract: A light-curable composition is provided which may be used as a photopolymerizable material in an additive manufacturing process. The additive manufacturing process involves heating the light-curable composition which has a viscosity at 20° C. of at least 20 Pa·s. The light-curable composition includes a photopolymerizable matrix material, at least one thermoplastic polymer dissolved therein, and at least one photoinitiator. Polycaprolactone or a derivative thereof is used as the dissolved thermoplastic polymer.

Abstract: A Gunn diode is disclosed which comprises a first contact layer (110), a second contact layer (120), and an active layer (130) based on a gallium nitride (GaN) semiconductor material having a base surface (132) and a side surface (135) non-parallel thereto. Optionally, related materials such as aluminum indium gallium nitride (AlInGaN) materials may also be used as the active layer. The first contact layer (110) electrically contacts the side surface (135) to form a side contact (115). The second contact layer (120) forms an electrical contact for the base surface (132), so that a maximum of the electric field strength is formed when an electric voltage is applied between the first contact layer (110) and the second contact layer (120) at the side contact (115).

Abstract: The invention relates to a device and a method for UV antisepsis, in particular for intracorporeal in vivo UV antisepsis on the human and animal body in the event of colonization with multiresistant pathogens (MRPs) such as methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). The device comprises a light emitting diode chip, LED chip, configured to emit radiation in the UVC spectral range, wherein the LED chip forms a light emitting diode, LED, with a package; a spectral filter element set up to limit the radiation emitted by the LED chip substantially to wavelengths below 235 nm; and an optical element for directional emission of the radiation emitted by the LED.

Abstract: The application relates to a method for zigzag folding a material web, the method having the following steps: continuously feeding a material web to be folded into a folding apparatus along a feed direction, alternately gripping the material web in a proximal region of the folding apparatus by means of gripping devices, holding and conveying the material web by means of the gripping devices into a distal region of the folding apparatus, the material web being zigzag folded thereby, and releasing the material web from the gripping devices and depositing the material web in a stack (9) with folds in the distal region, a distance between adjacent gripping devices (4, 5) being equal to a fold length. Furthermore, the application also relates to an apparatus for zigzag folding a material web.

Abstract: The present invention relates to a method and a device for monitoring the process for a welding seam formed by means of collision welding, in which a first joining partner (1) and a second joining partner (2) are moved toward one another by an introduction of energy and are welded to one another to form the welding seam. A light flash between the first joining partner (1) and the second joining partner (2) is detected during the welding by an optical capture unit (6), which measures in a time-resolved manner, having at least one detector (19, 20, 24) and an actual value of a beginning of the light flash, a duration of the light flash, an intensity of the light flash, and/or an intensity distribution over time of the light flash is determined by an analysis unit (16) and compared to a respective target value of the beginning of the light flash, the duration of the light flash, the intensity of the light flash, and/or the intensity distribution over time of the light flash.

Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.

Abstract: The present invention relates to a method for the synthesis of a two-dimensional or quasi-two-dimensional polymer comprising a surfactant, the two-dimensional or quasi-two-dimensional polymer film and the use for the production of membranes, electronic devices or catalysts.

Abstract: A process for polymerizing ?-butyrolactone that includes contacting racemic ?-butyrolactone or an enantiomer thereof with a catalyst/initiator system which includes a rare earth metal, a chiral ligand, at least one nucleophilic ligand, optionally at least one solvent ligand, and optionally an alkali based co-catalyst. The chiral ligand is an enantiomer of a unit of formula I Each Rz independently is substituted or unsubstituted linear C1-C20 alkyl, or substituted or unsubstituted branched, or cyclic C3-C20 alkyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C5-C20 heteroaryl, or halogen. Each Ra independently is H, Me+, (MeZ)+, wherein Z is a charge equalizing anion, or wherein two Ra together are alkaline earth metal, wherein Me+ is alkali metal or alkaline earth metal.

Abstract: The invention relates to a method for the tamper-proof storing of data in a bidirectionally linked blockchain structure. The method comprises the steps of creating an additional block Bi to extend the blockchain structure which comprises the data to be stored as payload data creating a bidirectional linking of the additional block Bi to a predefined number of preceding blocks, wherein creating the bidirectional linking comprises performing a backward linking of the additional block to the predefined number of preceding blocks and performing a forward linking of the predefined number of preceding blocks to the additional block.

Abstract: A device and a method for training a model are disclosed, wherein the method of training the model includes: first classifying a plurality of data packets using the model, wherein a first class is assigned to each data packet of a plurality of data packets, wherein the first class is associated with a receiver of a plurality of receivers; second classifying the plurality of data packets, wherein a second class is assigned to each data packet of the plurality of data packets, wherein the second class is associated with a receiver of the plurality of receivers; and training the model using the plurality of first classes and the plurality of second classes assigned to the plurality of data packets.

Abstract: The present invention relates to an enzymatic process for the modification of free fatty acids (FFAs) derived from renewable feedstocks of bio-based oils. Specifically, the invention describes the hydrolysis of any bio-based oil, such as high oleic sunflower oil (HOSO), to FFAs, containing high amounts of oleic acid (OA), which is further hydrated to 10-hydroxystearic acid (10-HSA).

Abstract: The present invention relates to novel inhibitors of adipose triglyceride lipase (ATGL) having an improved inhibitory activity against human ATGL (hATGL) as well as pharmaceutical compositions comprising these inhibitors, and their therapeutic use, particularly in the treatment or prevention of a lipid metabolism disorder, including, e.g., obesity, non-alcoholic fatty liver disease, type 2 diabetes, insulin resistance, glucose intolerance, hypertriglyceridemia, metabolic syndrome, cardiac and skeletal muscle steatosis, congenital generalized lipodystrophy, familial partial lipodystrophy, acquired lipodystrophy syndrome, atherosclerosis, or heart failure.