Abstract: Systems, methods, and other embodiments described herein relate to improving controls in a device according to risk. In one embodiment, a method includes, in response to receiving sensor data about a surrounding environment of the device, identifying objects from the sensor data that are present in the surrounding environment. The method includes generating a control sequence for controlling the device according to a risk-sensitivity parameter to navigate toward a destination while considering risk associated with encountering the objects defined by the risk-sensitivity parameter. The method includes controlling the device according to the control sequence.
Type:
Grant
Filed:
December 31, 2020
Date of Patent:
November 7, 2023
Assignees:
Toyota Research Institute, Inc., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Haruki Nishimura, Boris Ivanovic, Adrien David Gaidon, Marco Pavone, Mac Schwager
Abstract: A method for scarless genome editing is disclosed. In particular, the method provides scarless genome modification by using homology directed repair (HDR) steps to genetically modify cells and remove unwanted sequences. This method can be used for genome editing, including introducing mutations, deletions, or insertions at any position in the genome without leaving silent mutations, selection marker sequences, or other additional undesired sequences in the genome.
Type:
Application
Filed:
May 18, 2023
Publication date:
November 2, 2023
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Systems and methods for predicting a future cardiovascular event are provided. Electrocardiogram waveform data can be acquired and utilized in a trained computational model to predict a future cardiovascular event. Clinical interventions, clinical surveillance, and clinical treatments can be performed based on a future cardiovascular event prediction.
Type:
Application
Filed:
April 28, 2023
Publication date:
November 2, 2023
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
John Weston Hughes, James Zou, Euan A. Ashley, Marco V. Perez
Abstract: The present disclosure provides meta-optical elements and image sensors using a meta-pattern and apparatuses including the image sensors. In an embodiment, an image sensor includes a plurality of pixels. Each pixel of the plurality of pixels includes a photoelectric conversion layer including at least one photoelectric conversion element, and a color routing meta-structure layer provided at a position facing the photoelectric conversion layer. The color routing meta-structure layer includes a meta-structure having a symmetrical structure with respect to a center of a corresponding pixel, and a multi-layer structure having a refractive index that varies in a direction perpendicular to a light-incident surface.
Type:
Application
Filed:
May 2, 2023
Publication date:
November 2, 2023
Applicants:
SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors:
Sungmo AHN, Sangeun Mun, Shanhui Fan, Peter Bert Catrysse, Hongkyu Park, Minwoo Lim, Choonlae Cho
Abstract: A battery electrolyte solution is that includes an organic electrolyte solution, a lithium-sulfur (Li2S) compound, soluble lithium polysulfide (Li2Sx) microparticles, and a redox mediator comprising a soluble quinone derivative.
Type:
Grant
Filed:
February 6, 2019
Date of Patent:
October 31, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior
University
Inventors:
Zhenan Bao, Yi Cui, Yuchi Tsao, Min Ah Lee
Abstract: Systems and methods for coordinating distributed energy storage in accordance with embodiments of the invention are illustrated. One embodiment includes a power distribution network, including a set of nodes, wherein a node includes a controllable load, an uncontrollable load, and a local controller, a substation connected to each node in the set of nodes by a set of distribution lines, and a global controller including a processor, a memory, and a communications device, wherein the global controller obtains load parameters from at least one node, calculates coordination parameters for each node based on the obtained load parameters, and asynchronously provides the coordination parameters to each of the nodes in the set of nodes, and wherein each node independently obtains coordination parameters, and controls the operation of its controllable load using the local controller based on the coordination parameters and a local load profile describing at least the uncontrollable load.
Type:
Grant
Filed:
May 7, 2018
Date of Patent:
October 31, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Kyle Anderson, Abbas El Gamal, Ram Rajagopal
Abstract: The present disclosure provides variant light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a variant light-responsive polypeptide of the present disclosure.
Type:
Grant
Filed:
September 14, 2016
Date of Patent:
October 31, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Karl A. Deisseroth, Andre Berndt, Soo Yeun Lee, Charu Ramakrishnan
Abstract: Methods of deconvolving a feature profile of a physical system are provided herein. The present method may include: optimizing a regression between a) a feature profile of a first plurality of distinct components and b) a reference matrix of feature signatures for a second plurality of distinct components, wherein the feature profile is modeled as a linear combination of the reference matrix, and wherein the optimizing includes solving a set of regression coefficients of the regression, wherein the solution minimizes 1) a linear loss function and 2) an L2-norm penalty function; and estimating the fractional representation of one or more distinct components among the second plurality of distinct components present in the sample based on the set of regression coefficients. Systems and computer readable media for performing the subject methods are also provided.
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
October 31, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: An acoustic biometric touch scanner device and method is disclosed. In one aspect, an acoustic fingerprint sensing device includes an array of ultrasonic transducers configured to transmit an ultrasound signal having a frequency in a range from 50 megahertz (MHz) to 500 MHz. The acoustic fingerprint ultrasonic transducers include a piezoelectric film. The acoustic fingerprint sensing device further includes a receiving surface configured to receive a finger. The acoustic fingerprint sensing device further includes a processor configured to generate an image of at least a portion of a fingerprint of the finger based on a reflection of the ultrasound signal from the finger.
Type:
Grant
Filed:
December 29, 2021
Date of Patent:
October 31, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Morten Fischer Rasmussen, Gerard Touma, Butrus T. Khuri-Yakub
Abstract: Provided herein are Cas proteins and guide RNA molecules engineered to exhibit increased activity in eukaryotic cells. The provided Cas proteins and RNA molecules are particularly useful for applications where modulation of eukaryotic nucleic acids with relatively small molecules is advantageous. Also provided are nucleic acids and vectors encoding the disclosed Cas proteins and guide RNA molecules, pharmaceutical compositions including the Cas proteins and guide RNA molecules, and methods for using the disclosed materials.
Type:
Application
Filed:
February 24, 2023
Publication date:
October 26, 2023
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2R? and IL-2R?. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
Type:
Application
Filed:
September 16, 2022
Publication date:
October 26, 2023
Applicants:
Pfizer Inc., The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Isaac J. Rondon, Natasha Crellin, Paul Bessette, Eleonora Trotta, Jeffrey A. Bluestone, Lauren K. Ely, Kenan C. Garcia
Abstract: Provided are methods for determining the presence or absence of donor specific antibodies in a biological sample. The methods include mixing a cellular sample from a donor with a biological sample from a recipient under conditions sufficient for recipient immune antibodies, if present, to bind to donor cell surface antigen (Ag) to form an immune antibody-Ag complex, contacting the mixture with beads comprising an antibody that specifically binds the immune antibody-Ag complex (e.g., the Ag or immune antibody) on a surface thereof, adding under lysis conditions a detectably-labeled antibody that specifically binds the immune antibody-Ag complex bound to the beads, and detecting the presence or absence of the detectably-labeled antibody bound to the immune antibody-Ag complex to determine the presence or absence of donor specific antibodies in the biological sample from the recipient. Systems and kits for practicing the subject methods are also provided.
Type:
Grant
Filed:
August 17, 2020
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Adaptable and customizable truss-like robots are provided. The robotic truss has robotic roller modules configured to translate along one or more pliable member and therewith control the shape or design of the robot.
Type:
Grant
Filed:
September 10, 2020
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Allison M. Okamura, Sean Follmer, Elliot W. Hawkes, Zachary Hammond, Nathan Scot Usevitch, Mac Schwager, James Ballard
Abstract: Inducible promoters for the coordinated expression of at least one heterologous gene in yeast and methods of using them are disclosed. In particular, the invention relates to sets of inducible promoters derived from S. cerevisiae and related species that can be induced in the presence of nonfermentable carbon sources.
Type:
Grant
Filed:
February 20, 2020
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Colin Harvey, Ulrich Schlecht, Maureen Elizabeth Hillenmeyer
Abstract: Systems and methods for radiology image classification from noisy images in accordance with embodiments of the invention are illustrated. One embodiment includes noisy image classification device, including a processor, camera circuitry, and a memory containing a noisy image classification application, where the noisy image classification application directs the processor to obtain image data describing a first image taken of a second image using the camera circuitry, where the second image was produced by a medical imaging device, and where the first image is a noisy version of the second image, classify the image data using a neural network trained to be robust to noise, generate an investigation recommendation based on the classification, and provide the investigation recommendation via a display.
Type:
Grant
Filed:
September 18, 2020
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Sharon Zhou, Andrew Y. Ng, Pranav Rajpurkar, Mark Sabini, Chris Wang, Nguyet Minh Phu, Amirhossein Kiani, Jeremy Irvin, Matthew Lungren
Abstract: A method for optimization of photonic devices is disclosed. The method includes receiving a set of unconstrained latent variables; mapping the set of unconstrained latent variables to a constrained space to generate a constrained device; calculating the permittivity across each element of the constrained device; determining a permittivity-constrained width gradient based at least partially on the permittivity across each element; and optimizing the set of unconstrained latent variables by at least partially using the permittivity-constrained width gradient.
Type:
Grant
Filed:
May 11, 2021
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Jonathan Fan, Jiaqi Jiang, Mingkun Chen
Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.
Type:
Grant
Filed:
April 24, 2019
Date of Patent:
October 17, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A distributed sensor network for soft growing robots is provided. Sensor bands are distributed at discrete intervals along the length of the flexible tube, and the sensor bands each are wrapped circumferentially around the diameter of the flexible tube. Each sensor band has one or more sensors and one or more semi-rigid islands containing a self-contained microcontroller, and one or more communication lines to an aggregator microcontroller located at the base of the soft growing robot communicatively connecting signals from the sensor bands. A casing laminates the distributed sensor network. In one example the encasing has cavities or a tooth geometry to allow bending. The casing is flexible to not hinder the growth of the soft growing robot, yet protecting the distributed sensor network.
Type:
Grant
Filed:
December 10, 2021
Date of Patent:
October 17, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior
University
Inventors:
Alexander M. Gruebele, Andrew C. Zerbe, Margaret M. Coad, Mark R. Cutkosky
Abstract: Provided are bifunctional molecules that include a first moiety that specifically binds a cell surface molecule or extracellular molecule, and a second moiety that specifically binds a lysosomal targeting molecule. The bifunctional molecules find use, e.g., for targeted degradation of cell surface and extracellular molecules (e.g., proteins) via the endosomal/lysosomal pathway. Also provided are compositions and kits that include the bifunctional molecules, as well as methods of using the bifunctional molecules. Methods of making bifunctional molecules are also provided.
Type:
Grant
Filed:
October 12, 2021
Date of Patent:
October 17, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Carolyn Bertozzi, Steven Banik, Kayvon Pedram, Green Ahn
Abstract: A stacked three-dimensional (3D) metasurface includes a first layer with a first kernel configured to apply a first convolution on a first frequency of an incident polarized light, and a second layer with a second kernel different than the first kernel. The second kernel is configured to apply a second convolution different than the first convolution on a second frequency of the incident polarized light and the second frequency is different than the first frequency such that the stack 3D metasurface provides at least two independent convolutions on the incident polarized light.
Type:
Application
Filed:
April 8, 2022
Publication date:
October 12, 2023
Applicants:
Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Shanhui Fan, Ercan Mehmet Dede, Sean P. Rodrigues, Haiwen Wang