Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.

Abstract: We provide a wide-field time-resolved imaging apparatus using resonant drive. We also identify ideal configurations of electro-optic (EO) modulator crystals for wide-field imaging. These techniques enable compact and low-cost LIDAR imaging devices. Resonant drive affords modulation of various EO modulators at high voltage by means of resonant voltage enhancement. Further, it enables operation of imaging modulators at high frequencies which would otherwise not be possible with conventional pulsed drivers—this leads to improved LIDAR accuracy and dynamic range. Resonant drive uniquely enables Pockels cell LIDAR beyond normal flash mode by allowing for multiple pulses or multiple cycles of amplitude modulated illumination to be present simultaneously in a scene. This corresponds to illumination and modulation waveforms having a defined phase relationship where time-of-flight is encoded in the phase of the returning light waveform.

Abstract: Systems and methods for generating and evaluating driving scenarios with varying difficulty levels is provided. The disclosed systems and methods may be used to develop a suite of regression tests that track the progress of an autonomous driving stack. A robustness trace of a temporal logic formula may be computed from an always-eventually fragment using a computation graph. The robustness trace may be approximated by a smoothly differentiable computation graph, which can be implemented in existing machine learning programming frameworks. The systems and methods provided herein may be useful in automatic test case generation for autonomous or semi-autonomous vehicles.

Abstract: A metallic glass coating material is composed of an alloy of Fe, B, and one of the metals Nb, Mo, Zr, or W. The ratios of Fe, B, and the metal are predetermined using machine learning predictions and high-throughput experiments. In one example, the material is an alloy of Fe, Nb, Mo and B, of the form Fex(Nb, Mo)yBz, where x is in the range 18-28, y is in the range 35-45, and z is in the range 32-42. In another example, the material may be the alloy Fe23(Nb, Mo)40B37. The alloy may be doped with Zr and/or W, where the Zr and/or W comprises at most 10% of the alloy.

Abstract: Many embodiments describe a scalable scheme for performing quantum computation in a synthetic time dimension which uses a single coherently controlled atom. Quantum operations applied to the atomic qubit can be teleported onto the photonic qubits via projective measurement, and arbitrary quantum circuits can be compiled into a sequence of these teleported gates. The synthetic time dimension can negate the need for many identical quantum emitters to be integrated into a photonic circuit, and the single atom may provide effective all-to-all connectivity between photonic qubits.

Abstract: Disclosed herein are apparatus for a cooler device includes a manifold constructed at least partially of silicon oxide. The manifold includes an array of inlet channels and an array of outlet channels. Each inlet channel has a first depth. The array of outlet channels are interlaced with the array of inlet channels, Each outlet channel has a second depth that is larger than the first depth. Each of the array of outlet channels has a pair of sidewalls separating each outlet channel from adjacent inlet channels of the array of inlet channels.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A method for MR imaging includes acquiring with an MR imaging apparatus undersampled k-space imaging data having one or more temporal dimensions and two or more spatial dimensions; transforming the undersampled k-space imaging data to image space data using zero-filled or sliding window reconstruction and sensitivity maps; decomposing the image space data into a compressed representation comprising a product of spatial and temporal parts, where the spatial part comprises spatial basis functions and the temporal part comprises temporal basis functions; processing the spatial basis functions and temporal basis functions to produce reconstructed spatial basis functions and reconstructed temporal basis functions, wherein the processing iteratively applies conjugate gradient and convolutional neural network updates using 2D or 3D spatial and 1D temporal networks; and decompressing the reconstructed spatial basis functions and reconstructed temporal basis functions to produce a reconstructed MRI image having one or

Abstract: A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte.

Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.

Abstract: An electrochemical device includes an anode having sodium or lithium; a cathode having a carbonaceous material; a separator; and an electrolyte that includes a metal halide, a fluorinated electrolyte compound, and thionyl chloride; wherein the electrochemical device is a primary battery or a secondary battery.

Abstract: Systems and method for light field imaging with mirror arrays in accordance with embodiments of the invention are illustrated. One embodiment includes a light field imaging system, including a mirror array where each mirror in the mirror array is positioned to reflect light from a target object towards a lens such that a different view of the target object is visible in each mirror from the viewpoint of the lens. The system further includes a lens configured to focus the reflected light, a sensor configured to capture an image depicting a plurality of reflections of the target object, a processor, and a memory containing a light field imaging application that directs the processor to obtain the captured image, extract a light field of the target object based on the plurality of reflections of the target object, and construct a three-dimensional model of the target object based on the light field.

Abstract: This document describes techniques for radio frequency (RF) based micro-motion tracking. These techniques enable even millimeter-scale hand motions to be tracked. To do so, radar signals are used from radar systems that, with conventional techniques, would only permit resolutions of a centimeter or more.

Abstract: In some embodiments, a device for generating mid-infrared radiation is provided. The device may include a thin film quadratic nonlinear waveguide formed on a mid-infrared transparent cladding by a thin film material of a predetermined film thickness, the waveguide having a predetermined etch depth and a predetermined top width. At least one of the predetermined film thickness, the predetermined etch depth, and the predetermined top width may be tuned for the device to generate a coherent idler wave as a mid-infrared radiation from a fixed pump wave and a tunable signal wave.

Abstract: An apparatus and method for extracting nitrogen including compounds from wastewater is disclosed herein. The methods and apparatus use molecularly designed selective electrocatalysts, electrolytes, and separation reactors to enable automated, distributed ammonia manufacturing with minimal environmental impacts. In some embodiments, a method of nitrogen reduction of wastewater is provided. The method includes: providing an apparatus including: a first chamber comprising a salt solution; a second chamber comprising a wastewater source; a third chamber comprising a salt solution and a third electrode, wherein the second chamber is positioned between the first chamber and the third chamber; an anion exchange membrane positioned between the first chamber and the second chamber; and a cation exchange membrane positioned between the second chamber and the third chamber; applying a potential bias between any two of the first chamber, the second chamber, and the third chamber.

Abstract: A non-reciprocal microwave network is provided that includes an in-line ferromagnetic element with adjoining polarizing adapters to achieve directivity via a multi-mode interaction at or near the ferrite to act as new class of 4-port circulator or 2-port isolator, with standard waveguide inputs for assembly in larger networks.

Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.

Abstract: A method of producing para-hydroxybenzoic acid (pHBA) or a derivative thereof includes culturing the recombinant microorganism in a fermentation broth, wherein said recombinant microorganism comprising a genetically engineered pathway expressing at least one nucleic acid sequence encoding a polypeptide selected from: an exogenous chorismate pyruvate lyase of EC 5.4.4.2 or EC 4.1.3.40; an exogenous 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase of EC 4.1.2.15, or EC 2.5.1.54; an exogenous shikimate kinase of EC 2.7.1.71; or an exogenous 3-dehydroquinate dehydratase (DHQ) of EC 4.2.1.10; adding a carbon source to the fermentation broth; and isolating the pHBA from the fermentation broth.

Abstract: Systems and methods for increasing hypnotizability in accordance with embodiments of the invention are illustrated. One embodiment includes a method of treating a recipient using hypnotherapy, including applying neurostimulation to a recipient's brain such that functional connectivity between an anterior cingulate cortex (ACC) and a dorsolateral prefrontal cortex (DLPFC) of the recipient's brain is increased, and activity in the ACC is decreased, and applying hypnotherapy in order to treat a condition of the recipient. In a further embodiment, the condition is selected from the group consisting of depression, anxiety, phobia, pain, stress, disordered eating, sleep disorders, posttraumatic stress, and addiction.

Abstract: A method for treating a subject suffering from a disease is provided. The method includes diagnosing the subject as suffering from a disease; upregulating the cathelicidin gene CAMP in the subject; and administering to the subject at least one treatment for the disease.