Abstract: Systems and methods for battery-based vehicle diagnostics are provided. Various embodiments include a battery-based diagnostics system that guards vehicles against anomalies with a cyber-physical approach. The diagnostics system can be implemented as an add-on module of commodity vehicles attached to automotive batteries, thus providing vehicles an additional layer of protection. The automotive battery can operate in strong dependency with many physical components of the vehicle, which is observable as correlations between battery voltage and the vehicle's corresponding operational parameters, e.g., a faster revolutions-per-minute (RPM) of the engine, in general, leads to a higher battery voltage. These embodiments exploit such physically induced correlations to diagnose vehicles by cross-validating the vehicle information with battery voltage and may be based on a set of data-driven norm models constructed online.

Abstract: Systems and methods for a shape-memory in-ear biosensor for polysomnography and monitoring physiological signals are provided. Various embodiments include an earpiece made from a shape memory or temperature-dependent phase transition material embedded into polydimethylsiloxane elastomer body. The earpiece can use electrodes to detect physiological signals by making direct contact with a user's skin and without the use of electrically conductive gel. When heated above the glass transition temperature of the shape memory polymer, various embodiments of the biosensor may be folded. When cooled, the biosensor will maintain the folded shape. The folded biosensor may then be inserted into the ear canal of a user where, in response to heating by the user's body, it partially unfolds to conform to the shape of the ear canal.

Abstract: Disclosed is a tongue strengthening device that includes a handle on one end and a bulb structure on the other end. The bulb is resiliently flexible, and enables a user to exercise their tongue by repeatedly compressing and releasing the bulb. Provided is a system or kit that includes multiple tongue strengthening devices having different compression specifications that allow a patient to graduate to devices which are harder to compress as the patient gains tongue strength.

Abstract: Described herein are systems incorporating a Casimir cavity, such as an optical Casimir cavity or a plasmon Casimir cavity. The Casimir cavity modifies the zero-point energy density therein as compared to outside of the Casimir cavity. The Casimir cavities are paired in the disclosed systems with product generating devices and the difference in zero-point energy densities is used to directly drive the generation of products, such as chemical reaction products or emitted light.

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.

Abstract: The present disclosure discloses a method and apparatus for generating an optical frequency comb. The specific generation method comprises: receiving a pump laser that matches a thermally stable state of a nonlinear optical resonant cavity and causing the pump laser to oscillate in the nonlinear optical resonant cavity, such that a Brillouin gain corresponding to the pump laser coincides with a target longitudinal mode in the nonlinear optical resonant cavity; continuously generating a Brillouin laser at the target longitudinal mode in the case that a pump power of the pump laser exceeds a threshold for generating the Brillouin laser; and generating an optical frequency comb by using the Brillouin laser through a Kerr nonlinear four-wave mixing process. According to the technical solution of the present disclosure, the nonlinear optical resonant cavity with the Brillouin gain can generate an optical frequency comb in its thermally stable region.

Abstract: An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

Abstract: A device and method for drilling a pilot hole within an object at a predetermined angle. The device includes a spacer having a lateral surface established by a first surface and a second surface and at least a portion of the lateral surface includes an extension. The extension having a proximal end and a distal end where the proximal end abuts the lateral surface and the distal end is configured to coupled to a first end of a body. A guide body is also provided and is coupled to the device. The guide member includes a bore extending from a first end to a second end. Subsequent to disposing the spacer within the object, a drilling instrument may be disposed within the guide body thereby drilling out the pilot hole at the prescribed angle.

Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.

Abstract: Technology is disclosed herein that the enhances the measurability and scalability of qubits in a quantum computing environment. In an implementation, a superconducting amplifier device comprises a parametric amplifier and a tunable coupling between the parametric amplifier and a readout cavity external to the superconducting amplifier device. The tunable coupling allows an entangled signal, associated with a qubit in the readout cavity, to transfer from the readout cavity to the parametric amplifier. The parametric amplifier amplifies the entangled signal to produce an amplified signal as output to a measurement sub-system.

Abstract: Embodiments disclosed herein relate to systems and methods for securing a drug delivery component to an intraocular lens (IOL) assembly. The systems generally include a support base and a plunger. The support base includes a first portion configured to accommodate a drug delivery component; and a second portion configured to act as a plunger guide. The plunger can be inserted into the plunger guide such that the plunger is positioned to interface with a drug delivery component and an IOL assembly during use. The plunger includes an elongated body and a tip, wherein the tip can include a ramp configured to interface with a fixation loop of a drug delivery component during use and a compartment configured to interface with a haptic of an IOL assembly during use.

Abstract: A serpentine delay-line waveguide feeding an array of grating couplers can be fabricated in a silicon photonic chip, or tile, with the grating couplers emitting light at an angle that varies with wavelength and delay between the couplers imparted by the waveguide. The beam-steering tile can be used to transmit or receive light from a scene. The tile can be arrayed with one or more other tiles for bistatic radar-lidar operation. A tile in the array may transmit probe and frequency-shifted reference beams, while another tile may receive a return at a heterodyne frequency giving a range to the scene. The pitch of the serpentine delay line may be different for transmitting and receiving tiles to suppress returns from unwanted directions. Pairs of phase-cohered tiles may illuminate a spot in the scene with fringe patterns, producing oscillating returns that can be processed to form a high-resolution sub-image by Fourier synthesis.

Abstract: Embodiments disclosed herein generally relate to a stabilized intraocular drug delivery system for implantation into an eye of a subject. The system can include an intraocular lens (IOL) assembly and a drug delivery component. The IOL assembly can include a lens and a haptic. The haptic can include an outer end, an inner end opposite the outer end, a retention tab at the inner end, and a connection tab positioned between the outer end and the inner end and adjoining the lens. The drug delivery component can include at least one therapeutic agent and a fixation portion having an opening to receive the haptic and secure the drug delivery component to the IOL assembly. The fixation portion of the drug delivery component can be secured to the connection tab of the haptic such that the retention tab inhibits movement of the drug delivery component relative to the IOL assembly.

Abstract: The present disclosure relates to an intracranial guide for use in a medical procedure, such as to evacuate a subdural hematoma or to relieve an intracerebral hemorrhage. The intracranial guide generally includes a guide cannula to be received within a portion of a cranial port. The cranial port is configured to be anchored in a burr hole to be formed in the patient's cranium. The guide cannula includes at least one channel that may be used to guide a catheter to a targeted portion of the patient's anatomy or to apply a suction force within the patient's cranium.

Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures, and a cold collection system comprising a plurality of the polymer-based selective radiative cooling structures.

Abstract: The invention includes compositions and methods for promoting gas mixtures separations, such as a carbon dioxide and methane mixture. The composition of the invention is based on a curable polymerized room-temperature ionic liquid [poly(RTIL)].

Abstract: Embodiments of the instant disclosure relate to novel compositions and methods for treating a subject having genetic homocystinuria (HCU or other form of genetic homocystinuria). In some embodiments, compositions and methods disclosed herein concern improving efficacy of standard treatments (e.g. trimethylglycine) to reduce dietary compliance requirements and improve outcomes. In accordance with these embodiments, a subject having or suspected of developing classical cystathionine beta-synthase deficient homocystinuria (HCU) or other genetic form of homocystinuria can be treated with a polyamine or diamine or a precursor thereof or a combination thereof for example, in combination with trimethylglycine (e.g. betaine) or other genetic homocystinuria treatment.

Abstract: An operational environment is disclosed herein that includes a cryogenic environment and a signal source. The cryogenic environment includes a signal target, an optical link, signal converter devices, and an electrical link. Outside of the cryogenic environment, the signal source generates an electric signal. An electric-to-optical converter converts the electrical signal into an optical signal. The optical link delivers the optical signal into the cryogenic environment. Inside the cryogenic environment, an optical-to-electrical converter converts the optical signal back into an electrical signal. The optical-to-electrical converter transfers the electric signal to the signal target.