Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.

Abstract: In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.

Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.

Abstract: Systems and methods for controlling power amplifier (PA) performance metrics such as linearity and stability based on out-of-band feedback are presented. Various embodiments provide for synthesizing negative baseband termination using a feedback network between the drain and gate bias paths of the PA, so that the intermodulation distortion (IMD) is suppressed without an increase in system complexity. Other embodiments include a feedback network topology between the drain and gate bias paths of the PA that provides stability enhancement of the PA without the need for conventional stability networks in the radio frequency (RF) path. The out-of-band feedback nature of the approach means that the continuous wave (CW) RF performance is not perturbed, enabling conventional design techniques to be used for the input and output matching networks while enhancing aspects of the PA performance.

Abstract: Integrated circuit structures, arrangements, and manufacturing processes are discussed herein. In one example, a method of forming a transistor structure includes forming a dielectric layer onto a gate element and forming a corrugated surface into the dielectric layer using at least an atomic layer etching (ALE) process to remove portions of the dielectric layer. The method also includes forming a semiconductor layer onto the corrugated surface and forming a source element and a drain element onto the semiconductor layer.

Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.

Abstract: A device and method for treatment of post-operative surgical site wounds. Device includes an elongated hollow shaft that spans from the wound closure to the deep wound area, the internal end abutting a wound dressing and the external end connecting to a device that can provide negative-pressure suction and irrigation. Device providing one or more of irrigation, suction, and/or local antibiotic delivery to deep infections through a closed-wound. The method for removal includes narrowing a removal element relative to the long axis, collapsing the wound dressing; removing the wound dressing through the elongated shaft; and removing the device through a closed wound, avoiding a second removal surgery.

Abstract: The present application provides agents that specifically inhibits the IGFBP7/CD93 signaling pathway, such as agents that specifically block the interaction between CD93 and IGFBF7, methods of using said agents and methods of identifying said agents.

Abstract: A computer-implemented method for identifying tongue movement comprises detecting an electroencephalography (“EEG”) signal from an EEG sensor. The EEG sensor is configured to sense the EEG signal generated by a brain in association with a tongue movement. The method also comprises detecting the EMG signal from the EMG sensor. The EMG sensor is configured to sense the EMG signal generated by cranial nerve stimulation of muscles associated with the tongue movement. The method also includes identifying the tongue movement based on the EEG signal and the EMG signal. The method then includes correlating the tongue movement with one of a plurality of tongue location areas.

Abstract: The present disclosure relates to a composition that includes a perovskite crystal, where the perovskite crystal is in the form of a powder, and the perovskite crystal is semiconducting and photovoltaically active.

Abstract: Tools and techniques for estimating and/or predicting a patient's current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patient's blood pressure value. In particular cases, derived parameters, such as a patient's compensatory reserve index (“CRI”) can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.

Abstract: The present invention provides a light-weight wearable sensor that can capture electroencephalogram (EEG or brain signals), electromyography (EMG or muscle signal), and electrooculography (EOG or eye movement signal) using a pair of modified off-the-shelf earplugs. The present invention further provides a supervised non-negative matrix factorization learning algorithm to analyze and extract these signals from the mixed signal collected by the sensor. The present invention further provides an autonomous and whole-night sleep staging system utilizing the sensor's outputs.

Abstract: Implementations include herein are visual navigation strategies and systems for lumen center tracking comprising a high-level state machine for gross (i.e., left/right/center) region prediction and curvature estimation and multiple state-dependent controllers for center tracking, wall-avoidance and curve following. This structure allows a navigation system to navigate even under the presence of significant occlusion that occurs during turn navigation and to robustly recover from mistakes and disturbances that may occur while attempting to track the lumen center. This system comprises a high-level state machine for gross region prediction, a turn estimator for anticipating sharp turns, and several lower level controllers for heading adjustment.

Abstract: Described herein are devices incorporating Casimir cavities, which modify the quantum vacuum mode distribution within the cavities. The Casimir cavities can create energy differences within layers or device to drive energy from or to a portion of a layer disposed adjacent to or contiguous with the Casimir cavity by modifying the quantum vacuum mode distribution incident on one portion of the layer to be different from the quantum vacuum mode distribution incident on another portion of the layer. Additionally, Casimir cavities in which the cavity layer comprises a conductor that can be used to carry a flow of electrical power induced by the presence of the Casimir cavity.

Abstract: Methods of treating or preventing microbial infection in a subject in need of treatment by administering a therapeutically effective amount of ergothioneine, or functional analog, or prodrug, or salt thereof. Ergothioneine may be advantageously administered in conjunction with lactoferrin.

Abstract: The present disclosure provides a high-power-density power converter topology with a common neutral between its input and output AC ports while having a single DC bus. The topology may also be embodied as an online uninterruptible power supply (UPS). The presently-disclosed topology enables high power density by utilizing half-bridge switch structures suitable for MHz-frequency operation.

Abstract: Methods for inducing the regeneration of non-cancerous tissues in a cancer patient undergoing radiotherapy and/or chemotherapy using continuous administration of tyrosine kinase inhibitors for at least 90 days following a cancer treatment in the patient.

Abstract: An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. The connection interface is separate from and non-contiguous with the plurality of outer plates, according to various embodiments.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: A low-cost, magnetically-driven device that enables visualization and quantification of dynamic changes in cell behavior during mechanical stretch. Using this device, it was observed that nuclei of mouse embryonic skin fibroblasts underwent rapid but divergent responses to strain magnitude, showing nuclear area increase and chromatin decompaction during 5% (low) strain, but nuclear area decrease and chromatin condensation during 20% (high) strain. Only responses to low strain were dependent on calcium, while actin inhibition abrogated any nuclear response and increased stretch-induced DNA damage. Stretch-activation revealed a shift in actin filaments away from (low strain) or towards (high strain) the nuclear periphery. The findings suggest that different pathways control strain level-dependent cell behavior and that mechanical confinement of nuclei through actin may be a protective mechanism during high strain loads.