Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
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Patent number: 10291200Abstract: MEMS based sensors, particularly capacitive sensors, potentially can address critical considerations for users including accuracy, repeatability, long-term stability, ease of calibration, resistance to chemical and physical contaminants, size, packaging, and cost effectiveness. Accordingly, it would be beneficial to exploit MEMS processes that allow for manufacturability and integration of resonator elements into cavities within the MEMS sensor that are at low pressure allowing high quality factor resonators and absolute pressure sensors to be implemented. Embodiments of the invention provide capacitive sensors and MEMS elements that can be implemented directly above silicon CMOS electronics.Type: GrantFiled: July 2, 2015Date of Patent: May 14, 2019Assignee: The Royal Institution for the Advancement of Learning / McGill UniversityInventors: Vamsy Chodavarapu, George Xereas
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Patent number: 10287313Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.Type: GrantFiled: December 29, 2015Date of Patent: May 14, 2019Assignees: The Royal Institution for the Advancement of Learning/McGill University, Wisconsin Alumni Research FoundationInventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Mark Somoza
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Patent number: 10290767Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organizing InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.Type: GrantFiled: June 9, 2016Date of Patent: May 14, 2019Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Zetian Mi, Songrui Zhao, Renjie Wang
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Publication number: 20190118017Abstract: The present disclosure relates to use of rhamnolipid coated nanoparticles of zero valent iron (NZVI), either in its bare form or functionalized with other materials (M) such as trace amounts of a palladium catalyst, for transforming chlorinated solvent pollutants by targeting the non-aqueous phase, which contains said chlorinated solvent pollutants. The method may be useful as water treatment technology for restoration of groundwater resources contaminated with toxic, chlorinated solvent pollutants as well as in the treatment of industrial waste of chlorinated solvents in reactor systems.Type: ApplicationFiled: April 13, 2017Publication date: April 25, 2019Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Subhasis GHOSHAL, Sourjya BHATTACHARJEE
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Patent number: 10206906Abstract: It is provided an anti-microbial composition comprising a phenolic-rich extract such as a phenolic-rich maple syrup extract (PRMSE) and at least one antibiotic and a method of treating a bacterial infection comprising administering to a subject in need thereof a phenolic-rich extract and at least one antibiotic.Type: GrantFiled: May 20, 2016Date of Patent: February 19, 2019Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Nathalie Tufenkji, Vimal Maisuria
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Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers
Patent number: 10208025Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.Type: GrantFiled: October 18, 2016Date of Patent: February 19, 2019Assignees: The Hong Kong Polytechnic University, The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Larry Ming Cheung Chow, Tak Hang Chan, Kin Fai Chan, Iris Lai King Wong, Man Chun Law -
Patent number: 10202420Abstract: An isolated polypeptide comprising a peptide selected from: i) DHX1SDNYT, wherein X1 is L or H (SEQ ID NO:3); ii) a conservative variant of i) iii) a fragment of i) or ii); wherein the conservative variant and/or fragment retains biological activity and the peptide is 15 or less amino acids as well as recombinant cells, and uses thereof.Type: GrantFiled: August 27, 2014Date of Patent: February 12, 2019Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Fackson Mwale, John Antoniou, Lisbet Haglund, Peter J. Roughley, Rahul Gawri, Laura M. Epure, Michael P. Grant
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Patent number: 10197590Abstract: Considerations for selecting capacitive sensors include accuracy, repeatability, long-term stability, ease of calibration, resistance to chemical and physical contaminants, size, packaging, integration options with other sensors and/or electronics, and cost effectiveness. It is beneficial if such sensors are amenable to above-IC integration with associated control/readout circuitry for reduced parasitics and reduced footprint through area sharing. The inventors have established a combined Lorentz force based magnetometer and accelerometer MEMS sensor exploiting a low temperature, above-IC-compatible fabrication process operating without requiring vacuum packaging.Type: GrantFiled: November 17, 2015Date of Patent: February 5, 2019Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Mourad El-Gamal, Mohannad Elsayed, Paul-Vahe Cicek, Frederic Nabki
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Patent number: 10193578Abstract: Modern communication systems must cope with varying channel conditions and differing throughput constraints. Polar codes despite being the first error-correcting codes with an explicit construction to achieve the symmetric capacity of memoryless channels are not currently employed against other older coding protocols such as low-density parity check (LDPC) codes as their performance at short/moderate lengths has been inferior and their decoding algorithm is serial leading to low decoding throughput. Accordingly techniques to address these issues are identified and disclosed including decoders that decode constituent codes without recursion and/or recognize classes of constituent directly decodable codes thereby increasing the decoder throughput. Flexible encoders and decoders supporting polar codes of any length up to a design maximum allow adaptive polar code systems responsive to communication link characteristics, performance, etc. while maximizing throughput.Type: GrantFiled: July 10, 2015Date of Patent: January 29, 2019Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITYInventors: Warren Gross, Gabi Sarkis, Pascal Giard, Camille Leroux
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Patent number: 10112871Abstract: A building product is made from granular material and a binder that includes steel slag. A process for making the building product includes combining the granular material and the binder and then curing the combined granular material and binder with carbon dioxide. A building material includes a mixture of steel slag and a silica-rich material. The steel slag and silica-rich material is treated by heating. The silica-rich material may be waste glass and/or fly ash. A process for making the building material includes mixing the steel slag and silica-rich material and further heating the mixture.Type: GrantFiled: March 23, 2015Date of Patent: October 30, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Yixin Shao, Mehrdad Mahoutian, Zaid Ghouleh
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Patent number: 10104827Abstract: A vehicle guidance system for an agricultural vehicle is described which includes an optical imaging device collecting information of field characteristics, and a steering control device receiving the information of field characteristics transmitted from the optical imaging device. The steering control device having a steering actuator including a motor operatively connected to a hub adaptor. The hub adaptor is removably mountable to a central hub of a steering wheel of the agricultural vehicle in fixed rotary engagement, wherein when the hub adaptor is engaged to the central hub of the steering wheel, rotation of the hub adaptor by the motor causes corresponding rotation of the steering wheel. The steering control device thereby autonomously rotates the central hub of the steering wheel in response to the information of field characteristics received by the steering control device and the vehicle guidance system thereby steers the agricultural vehicle.Type: GrantFiled: July 8, 2016Date of Patent: October 23, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Viacheslav Adamchuk, Antoine Pouliot, Trevor Stanhope
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Patent number: 10099203Abstract: A method for the preparation of a metal-organic compound is provided. This method comprises the steps of (a) providing at least one metal precursor, (b) providing at least one bridging organic ligand, and (c) exposing together the metal precursor and the ligand to liquid CO2 or supercritical CO2 as a reaction medium, thereby producing said metal-organic compound.Type: GrantFiled: February 22, 2016Date of Patent: October 16, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Tomislav Friscic, Chao-Jun Li, Simon Girard, Cristina Mottillo, Christopher Walter Nickels
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Publication number: 20180290887Abstract: The present disclosure relates to a reversible hydrogen transfer process and storage system using visible light to photocatalytically generate hydrogen from compounds comprising saturated or partially saturated carbocyclic residue and catalytically hydrogenate compounds comprising at least one carbocyclic aromatic residue.Type: ApplicationFiled: May 19, 2016Publication date: October 11, 2018Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Chao-Jun LI, Zetian MI, Lu LI
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Patent number: 10093971Abstract: A heating mechanism for use in DNA applications such as DNA amplification, extraction and sterilization is provided. Nanoparticles having photo-thermal properties are put in contact with a reaction mixture and irradiated with an activation light beam to activate these photo-thermal properties, thereby releasing heat. Nanoparticles of several types may be used. Use of the same nanoparticles or of different one to monitor the reaction using a different light beam is also presented.Type: GrantFiled: September 29, 2017Date of Patent: October 9, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Philip Roche, Andrew Kirk, Lenore Beitel, Miltiadis Paliouras, Mark Trifiro, Vamsy Chodavarapu, Mohamed Najih, Joachim Thiemann
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Patent number: 10075193Abstract: Herein provided are methods and systems for decoding polar codes. A data flow graph relating to a predetermined polar code is converted to a tree graph comprising rate-zero nodes, rate-1 nodes, and rate-R nodes. A rate-R node within the binary tree is replaced with a maximum likelihood node when predetermined conditions are met thereby replacing a sub-tree of the tree graph with a single maximum likelihood node.Type: GrantFiled: November 3, 2015Date of Patent: September 11, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Warren Gross, Gabi Sarkis
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Patent number: 10009668Abstract: As photonics evolves closer and closer to the electronic processing elements in order to meet the demands of speed, latency of evolving data communications networks and data centers the inventors, rather than seeking direct monolithically integrated CMOS based processing photonic and electronic elements, have established a different route. Namely replace the computer hubs/electrical bridges interconnecting the multiple core logic chipset elements with a photonic bridge. In this manner high risk chip-to-chip photonic point-to-point links are replaced with photonic SOCs that leverage photonics bandwidth density attribute rather than its bandwidth distance attributes. An SOI based Electronic Embedded Photonic Switching Fabric is presented supporting, for example, N×MGb/s interconnections exploiting N channels of MGb/s wherein each channel of exploits S WDM channels of TGb/s. Embodiments of the invention also support high density optical interconnection via vertical grating couplers and multicore fibers.Type: GrantFiled: December 1, 2015Date of Patent: June 26, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITYInventors: Odile Liboiron-Ladouceur, Md. Shafiqul Hai, Monireh Moayedi Pour Fard, Chunshu Zhang, Meer Sakib
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Patent number: 9991370Abstract: High electron mobility leads to better device performance and today is achieved by fabricating “gated devices” within a high-mobility two-dimensional electron gas (2DEG. However, the fabrication techniques used to form these devices lead to rapid degradation of the 2DEG quality which then can limits the mobility of the electronic devices. Accordingly, it would be beneficial to provide a process/technique which circumvents this processing and 2DEG layer damage. By exploiting a flip-chip methodology such damaging processing steps are separated to a second die/wafer which is then coupled to the 2DEG wafer. Extensions of the technique with two or more different semiconductor materials or material systems may be employed in conjunction with one or more electronic circuits to provide 2DEG enabled circuits in 2D and/or 3D stacked configurations. Further semiconductor materials providing EG elements may incorporate one or more of 2DEG, 1DEG, and “zero” DEG structures.Type: GrantFiled: December 9, 2015Date of Patent: June 5, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Guillaume Gervais, Keyan Bennaceur
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Patent number: 9969755Abstract: A compound of formula (I) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in photodynamic therapy comprising this compound. Finally, there are provided a method of killing cells under oxidative stress conditions and a method for the selective delivery of singlet oxygen (1O2) to cells having an increased reactive oxygen species (ROS) concentration, these methods comprising the steps of contacting such cells with a compound of formula (I), and exposing the cells to light.Type: GrantFiled: January 12, 2017Date of Patent: May 15, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Gonzalo Cosa, Andres M. Durantini, Lana E. Greene, Richard Lincoln
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Publication number: 20180126389Abstract: An electrocyclonic particle collector (EPC) for removing particulate matter from a gas includes an EPC gas inlet, an EPC gas outlet, and an EPC gas flow path between the EPC gas inlet and the EPC gas outlet. A first section is downstream of the EPC gas inlet and includes a first cyclonic particle collector in the gas flow path for cyclonically removing particles from the gas. A second section is in series with the first section and includes a rotational flow chamber in the gas flow path, and at least a first electrode in the gas flow path for facilitating electrostatic removal of particles from the gas stream in the rotational flow chamber.Type: ApplicationFiled: January 12, 2016Publication date: May 10, 2018Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITYInventors: MARK LEFSRUD, YVES ROY, JENNIFER ASHFIELD, LUC ROY
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Patent number: 9951039Abstract: Filamenting temperature-sensitive mutant Z (FtsZ) protein plays a crucial role in the bacterial cell division machinery and is a validated drug target for antibacterial agents. The present invention relates to FtsZ-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine scaffold. Some of these compounds possess potent anti-staphylococcal properties and potent antibacterial activities against clinically isolated MRSA strains. Compounds have been identified to exhibit low spontaneous frequency of resistance, low toxicity as well as the ability to rescue G. mellonella larvae infected with lethal dose of the MRSA ATCC 43300 strain. Characterization by saturation transfer difference NMR, light scattering assay and GTPase hydrolysis assay with purified S. aureus FtsZ protein verified the interaction of 2,4,6-trisubstituted pyrimidine with the FtsZ protein, further confirmed by observations of iconic filamentous cell phenotype and mislocalization of the Z-ring formation.Type: GrantFiled: September 29, 2016Date of Patent: April 24, 2018Assignees: THE HONG KONG POLYTECHNIC UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITYInventors: Kwok-yin Wong, Tak-Hang Chan, Kin-Fai Chan