Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Publication number: 20160027961
    Abstract: Solid state sources offers potential advantages including high brightness, electricity savings, long lifetime, and higher color rendering capability, when compared to incandescent and fluorescent light sources. To date however, many of these advantages, however, have not been borne out in providing white LED lamps for general lighting applications. The inventors have established that surface recombination through non-radiative processes results in highly inefficient electrical injection. Exploiting in-situ grown shells in combination with dot-in-a-wire LED structures to overcome this limitation through the effective lateral confinement offered by the shell the inventors have demonstrated core-shell dot-in-a-wire LEDs, with significantly improved electrical injection efficiency and output power, providing phosphor-free InGaN/GaN nanowire white LEDs operating with milliwatt output power and color rendering indices of 95-98.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Zetian MI, Hieu Pham TRUNG, Songrui ZHAO
  • Patent number: 9240516
    Abstract: Amongst the candidates for very high efficiency electronics, solid state light sources, photovoltaics, and photoelectrochemical devices, and photobiological devices are those based upon metal-nitride nanowires. Enhanced nanowire performance typically require heterostructures, quantum dots, etc which requirement that these structures are grown with relatively few defects and in a controllable reproducible manner. Additionally flexibility according to the device design requires that the nanowire at the substrate may be either InN or GaN. Methods of growing relatively defect free nanowires and associated structures for group IIIA-nitrides are presented without the requirement for foreign metal catalysts, overcoming the non-uniform growth of prior art techniques and allowing self-organizing quantum dot, quantum well and quantum dot-in-a-dot structures to be formed.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: January 19, 2016
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Zetian Mi, Md Golam Kibria
  • Publication number: 20150376214
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting human farnesyl pyrophosphate synthase or for the treatment or prevention of disease conditions using said compounds;
    Type: Application
    Filed: June 27, 2014
    Publication date: December 31, 2015
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Youla S. TSANTRIZOS, Joris Wim DE SCHUTTER, Yih-Shyan LIN
  • Patent number: 9216045
    Abstract: A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 22, 2015
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, National Research Council of Canada
    Inventors: Paul A. Martineau, Louis-Philippe Lefebvre, Edward J. Harvey
  • Patent number: 9193583
    Abstract: It would be beneficial to integrate MEMS devices with silicon CMOS electronics, package them in controlled environments, e.g. vacuum for MEMS resonators, and provide industry standard electrical interconnections such as solder bumps. However, to do so requires through-wafer via-based electrical interconnections. However, the fragile nature of the MEMS devices, the requirement for vacuum, hermetic sealing, and the stresses placed on metallization membranes are not present in conventional CMOS packaging. Accordingly there is provided a means of reinforcing through-wafer vias for integrated MEMS-CMOS circuits by in-filling the through-wafer electrical vias with low temperature deposited ceramic materials deposited with processes compatible with post-processing of CMOS electronics. Beneficially ceramics such as silicon carbide provide enhanced mechanical strength, enhanced expansion matching, and increased thermal conductivity in comparison to silicon and solder materials.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: November 24, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Mourad El-Gamal, Dominique Lemoine, Paul-Vahe Cicek, Frederic Nabki
  • Patent number: 9186405
    Abstract: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: November 17, 2015
    Assignees: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Janusz Rak, Khalid Al-Nedawi, Brian Meehan, Abhijit Guha
  • Patent number: 9176927
    Abstract: A polar code decoder includes: processing elements each receiving a pair of input values and applying a first or a second predetermined mathematical function depending on a provided function control signal; a first memory that stores at least one of the outputs from processing elements and a plurality of channel values relating to a received polar code to be decoded; a second memory that stores indices of a plurality of frozen bits each representing a bit within an information-bit vector of the polar code being decoded; and a computation block that receives a plurality of inputs from a portion of the processing elements and generates an output that is can be set to a predetermined frozen value or to a calculated value, depending on whether a current index of the bit being decoded is indicated as frozen or not frozen.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: November 3, 2015
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, The Regents of the University of California
    Inventors: Warren Gross, Gabi Sarkis, Alexandre Raymond, Camille Leroux, Ido Tal, Alexander Vardy
  • Publication number: 20150307532
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting human farnesyl pyrophosphate synthase or for the treatment or prevention of disease conditions using said compounds;
    Type: Application
    Filed: November 19, 2013
    Publication date: October 29, 2015
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Youla S. TSANTRIZOS, Judes POIRIER, Michael SEBAG, Albert BERGHUIS, Jaeok PARK, Joris WIM DE SCHUTTER
  • Patent number: 9127035
    Abstract: This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof; wherein R1 to R4, R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof; and method of using same for reducing or reversing bacterial resistance to at least one aminoglycoside antibiotic.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: September 8, 2015
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Karine Auclair, Kenward Vong
  • Publication number: 20150236353
    Abstract: A pure and crystalline single-crystal nitrogen-functionalized graphene nano-flake powder comprising from 2 atomic % to at least 35 atomic % of total functionalized nitrogen within the graphene nano-flakes is disclosed. As well, the method of producing the nano-flakes that comprises injecting a carbon source into a thermal plasma system, dissociating the carbon source into carbon atomic species, transporting the carbon atomic species through a controlled nucleation zone to produce a crystalline graphene nano-flake structure, injecting the nitrogen source into the thermal plasma system dissociating the nitrogen source into nitrogen active species, and transporting the nitrogen atomic species to contact the crystalline graphene nano-flakes to produce the crystalline nitrogen-functionalized graphene nano-flakes is also disclosed. Finally, a multilayer composite comprising a carbon substrate and a layer of crystalline nitrogen-functionalized graphene nano-flakes is also described.
    Type: Application
    Filed: June 27, 2013
    Publication date: August 20, 2015
    Applicant: The Royal Institution For The Advancement Of Learning / McGill University
    Inventors: Jean-Luc Meunier, Dimitrios Berk, Ramona Vasilica Pristavita, Dustin Binny, Norma-Yadira Mendoza Gonzalez, Pierre-Alexandre Pascone
  • Publication number: 20150231254
    Abstract: The present disclosure provides a conjugate of formula (I) wherein each wherein each X, Nt, R, n, m and j are as defined herein. There is also provided a process for preparing a substantially monodisperse conjugate, a composition comprising said conjugate, and the use of a conjugate as defined herein in therapy.
    Type: Application
    Filed: February 17, 2015
    Publication date: August 20, 2015
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Hanadi F. SLEIMAN, Christopher J. Serpell, Thomas G.W. Edwardson, Karina M.M. Carneiro
  • Patent number: 9112085
    Abstract: Metal-nitride nanowires are amongst the candidates for very high efficiency electronics, solid state light sources, photovoltaics, photoelectrochemical devices, and photobiological devices. Enhanced performance typically requires heterostructures, quantum dots, etc within structures that are grown with relatively few defects and in a controllable reproducible manner. Additionally device design flexibility requires that the nanowire at the substrate be either InN or GaN. Methods of growing relatively defect free nanowires and associated structures for group IIIA-nitrides are presented without foreign metal catalysts thereby overcoming the non-uniform growth of prior art techniques and allowing self-organizing quantum dot, quantum well and quantum dot-in-a-dot structures to be formed, thereby supporting variety of high efficiency devices.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: August 18, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Zetian Mi, Md Golam Kibria
  • Patent number: 9100153
    Abstract: A method for iteratively decoding a set of encoded samples received from a transmission channel is provided. A data signal indicative of a noise level of the transmission channel is received. A scaling factor is then determined in dependence upon the data signal and the encoded samples are scaled using the scaling factor. The scaled encoded samples are then iteratively decoded. Furthermore, a method for initializing edge memories is provided. During an initialization phase initialization symbols are received from a node of a logic circuitry and stored in a respective edge memory. The initialization phase is terminated when the received symbols occupy a predetermined portion of the edge memory. An iterative process is executed using the logic circuitry storing output symbols received from the node in the edge memory and a symbol is retrieved from the edge memory and provided as output symbol of the node. Yet further an architecture for a high degree variable node is provided.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: August 4, 2015
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Warren J. Gross, Shie Mannor, Saeed Sharifi Tehrani
  • Patent number: 9085598
    Abstract: The present application relates to the compounds of formula I (I) as well as their use for inhibiting at least one of AKT-1, FAK and PKC? and in the treatment and/or prevention of metastatic diseases.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: July 21, 2015
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Ocean University of China
    Inventors: Moulay A. Alaoui-Jamali, Krikor Bijian, Jiang Tao
  • Patent number: 9075235
    Abstract: Optical microscopy of biological specimens, particularly live cells, is difficult as they generally lack sufficient contrast to be studied successfully as typically the internal structures of the cell are colorless and transparent. Commonly, contrast is increased by staining the different structures with selective dyes, but this involves killing and fixing the sample. Staining may also introduce artifacts, apparent structural details caused by the processing of the specimen and are thus not a legitimate feature of the specimen. Further, microscopy of different elements of these biological specimens typically requires multiple microscopy techniques on multiple specimens. According to embodiments of the invention simultaneous imaging techniques are applied to a biological specimen such as fluorescent imaging and dark field imaging by designing an experimental evaluation system and associated illumination system addressing the conflicting demands of these approaches.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 7, 2015
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Dilson Rassier, Albert Kalganov, Aleksander Labuda
  • Patent number: 9057055
    Abstract: It is herewith provided methods of obtaining circulating cancer cells (CCCs)-enriched cellular populations based on the removal of CD45-positive cells from an apheresis product. It is also provided methods of obtaining circulating stem cells (CSCs)-enriched cellular population from a CCCs-enriched cellular population based on a selection either using the specific cellular markers or through culture. It is further provided methods of obtaining circulating tumor cells (CTCs)-enriched cellular population from a CCCs-enriched cellular population based on a selection using the specific cellular markers. It is also provided screening assays for the selection of (chemo)therapeutic agent as well as personalized medicine application based on drug sensitivity/resistance or cancer markers.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: June 16, 2015
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Catalin Mihalcioiu, Richard Kremer, Michael Sebag, Ramy Saleh, Jiarong Li
  • Patent number: 9050294
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: June 9, 2015
    Assignee: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • Publication number: 20150143817
    Abstract: Cryogenic electronics based upon semiconductive devices, superconductive devices, or a combination of the two present opportunities for a wide variety of novel, fast, and low power devices. However, such cryogenic electronics require cooling which is typically achieved through fluid refrigerants such as liquid nitrogen or liquid helium. Solid state refrigeration based upon adiabatic demagnetization in paramagnetic salts offers one alternative but requires that the solid state cooler and cryogenic electronic circuits be different physical elements. The inventors present solid state cooling for semiconductor materials including but not limited to silicon. Beneficially active electronic devices can be integrated monolithically with solid state semiconductor coolers exhibiting magnetic cooling within the whole substrate or predetermined regions of the substrate. Alternatively, active devices may be formed with semiconductor layers integral to them that exhibit magnetic cooling.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 28, 2015
    Applicant: The Royal Institution for the Advancement of Learning.Mcgill University
    Inventors: Guillaume Gervais, Thomas Szkopek, Jonathan Guillemette
  • Patent number: 9041521
    Abstract: The present relates to a system for providing vibration feedback to at least one foot. The system comprises at least one rigid surface for receiving the at least one foot, one vibrotactile actuator for each of the at least one rigid surface, and a suspension mechanism. The vibrotactile actuator is installed underneath the corresponding rigid surface and provides vibration feedback there through. The suspension mechanism supports the at least one rigid surface.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: May 26, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Jeremy Cooperstock, Yon Visell, Alvin Law, Karmen Franinovic
  • Publication number: 20150110216
    Abstract: Cost, electronic circuitry limitations, and communication channel behaviour yield communication systems with strict bandwidth constraints. Hence, maximally utilizing available bandwidth is crucial, for example in wireless networks, to supporting ever increasing numbers of users and their demands for increased data volumes, low latency, and high download speeds. Accordingly, it would be beneficial for such networks to support variable bandwidth allocations such that smaller frequency sub-bands are allocated to users, as their number increases, but the individual users/nodes insert more data-carrying signals in order to compensate pensate for the loss of operating bandwidth arising from the accommodation of more users. It would further be beneficial for transmitters and receivers according to embodiments of such a network architecture to be based upon low cost design methodologies allowing their deployment within a wide range of applications including high volume, low cost consumer electronics for example.
    Type: Application
    Filed: April 29, 2013
    Publication date: April 23, 2015
    Applicant: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Jan Bajcsy, Yong-Jin Kim, Aminata Amadou Garba