Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Publication number: 20150087072
    Abstract: A soil analysis apparatus includes at least one sensor element for measuring a property of the soil; a blade assembly having at least one blade and being displaceable between a raised position and an excavation position, the at least one blade being operable to excavate the soil at a test location when the blade assembly is in the excavation position, the blade assembly being further operable to enter a sensor permitting configuration; and a first actuator operable to displace the at least one sensor element between an initial position and a sensing position along a sensor displacement path, the sensor element being proximate the soil at the test location when in the sensing position.
    Type: Application
    Filed: September 24, 2014
    Publication date: March 26, 2015
    Applicant: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Viacheslav Adamchuk, Nandkishor Dhawale, Frédéric René-Laforest, Shiv Prasher, Antoine Pouliot
  • Patent number: 8979911
    Abstract: A bone screw is described which includes a one-piece threaded screw body composed at least partially of a rigid foam. The screw body is headless and includes a bore extending therethrough to define a cannula and thereby providing the screw body with an annular shape defining a radial wall thickness. At least a central portion of the screw body is formed of the rigid foam which defines a matrix having a plurality of inter-connected pores therein. The inter-connected pores are disposed throughout the complete radial wall thickness of the screw body from an outer surface of the screw body to an inner surface thereof within the cannula, such as to permit bone in-growth through the complete radial wall thickness of the annular screw body. The inter-connected pores and the cannula thereby respectively allow bone in-growth through the complete radial wall thickness and the full axial length of the screw body.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: March 17, 2015
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, National Research Council of Canada
    Inventors: Paul A. Martineau, Louis-Philippe Lefebvre, Edward J. Harvey
  • Patent number: 8974795
    Abstract: The present invention relates to a new process for producing a doped synthetic monodispersed hematin anhydride (HA) crystals useful as a slow release vehicle and immune modulator. As the preparation comprises embedded in the crystals one or more antigens and/or one or more biologically active entities, the preparation can be useful in numerous medical indications such as vaccine or any therapy where it is desired that a biologically active entity maintains its activity over time due to its slow-release. The process comprises the steps of (i) providing a substantially pure iron(III) protoporphyrin-IX, in solution in an alkaline solution substantially free of oxygen (ii) adjusting the pH of the solution to an acidic pH of between about 4.0, by slowly adding a medium strong organic acid, (iii) during step b) above, adding one or more antigens and/or one or entities having a biological activity, at a pH of about 5.0.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: March 10, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Martin Olivier, Marie-Josée Bellemare
  • Patent number: 8975104
    Abstract: A method of providing microelectromechanical structures (MEMS) that are compatible with silicon CMOS electronics is provided. The method providing for processes and manufacturing sequences limiting the maximum exposure of an integrated circuit upon which the MEMS is manufactured to below 350° C., and potentially to below 250° C., thereby allowing direct manufacturing of the MEMS devices onto electronics, such as Si CMOS circuits. The method further providing for the provisioning of MEMS devices with multiple non-conductive structural layers such as silicon carbide separated with small lateral gaps. Such silicon carbide structures offering enhanced material properties, increased environmental and chemical resilience while also allowing novel designs to be implemented taking advantage of the non-conductive material of the structural layer.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: March 10, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Mourad El-Gamal, Frederic Nabki, Paul-Vahe Cicek
  • Patent number: 8935195
    Abstract: Portable wireless devices are ubiquitous in modern society and many of these have integral sensors such as accelerometers, microphones, and Global Positioning Systems (GPS) that can collect data. This creates potential for intelligent applications to recognize the user, or aspects of the user and take appropriate action. According to embodiments of the invention there are presented techniques for representing such time series data which reduce the memory and computational complexity of performing the analysis and classifying the results. The techniques exploit time-delay embedding is to reconstruct the state and dynamics of an unknown dynamical system, Geometric Template Matching to build nonparametric classifiers, and algorithms to address the problem of selecting segments of data from which to build the time-delay models for classification problems.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: January 13, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Doina Precup, Jordan Frank, Shie Mannor
  • Patent number: 8933742
    Abstract: Time-Mode Signal Processing (TMSP) offers a means for offsetting some of the challenges for analog circuit designs when exploiting CMOS circuit processes designed for digital applications. It would therefore be beneficial to provide a digital method for the storage, addition and subtraction of Time-Mode variables as these offer significant benefit to providing TMSP techniques and expanding their exploitation within devices, systems, and applications. While driven by CMOS process challenges the TM circuits outlined may exploit essentially any digital circuit technology since they are based upon delay. The inventors present an approach to TM variables wherein a switched delay unit is exploited and adopted such that the instantaneous phase difference between two rising signal edges can be latched and used to perform various arithmetic operations. Beneficially, the technique allows analog sampled-data signal processing to be implemented within digital circuitry.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: January 13, 2015
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Gordon Roberts, Mohammad Ali Bakhshian
  • Publication number: 20140378541
    Abstract: Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 25, 2014
    Applicants: WAYNE STATE UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, HONG KONG POLYTECHNIC UNIVERSITY
    Inventors: Tak-Hang Chan, Sreedhar Pamu, Qing Ping Dou, Di Chen
  • Patent number: 8898537
    Abstract: Low-Density Parity-Check (LDPC) codes offer error correction at rates approaching the link channel capacity and reliable and efficient information transfer over bandwidth or return-channel constrained links with data-corrupting noise present. LDPC codes also offer error correction performance approaching channel capacity exponentially fast in terms of the code length, linear processing complexity, and parallelism that scales with the code length. They also offer challenges relating to the decoding complexity of the binary error-correction codes themselves and error floors limiting achievable bit-error rates. A new Relaxed Half-Stochastic (RHS) decoding algorithm is presented that reduces decoding complexity for high decoding throughput applications. The RHS algorithm uses an approach based on stochastic decoding algorithms but differs significantly from the conventional approaches of LDPC decoder implementation.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: November 25, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Warren Gross, Francois Leduc-Primeau, Saied Hemati, Shie Mannor
  • Publication number: 20140343124
    Abstract: The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 20, 2014
    Applicant: The Royal Institution for The Advancement of Learning/McGill University
    Inventors: Kevin PETRECCA, Masad DAMHA, Glen DELEAVEY
  • Patent number: 8886578
    Abstract: Stabilizing the visual system for any sighted mobile system increases immunity of the mobile system's gaze and reduces information processing task complexity. Two human reflexes are the optokinetic reflex and vestibulo-ocular reflex (VOR). The VOR stabilizes retinal images during head movement by producing eye movements in the opposite direction. Improved analysis of the VOR in humans would improve the diagnosis/treatment of patients, provide improvements in visual prosthesis performance for patients, and also vision systems performance for mobile robotic systems. However, an important issue for prior art mathematical analysis techniques is the requirement to classify the nystagmus segments before applying any analysis techniques, wherein this classification should be preferably performed non-subjectively. Accordingly the inventors overcome these limitations by performing classification, i.e.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: November 11, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Henrietta Galiana, Atiyeh Ghoreyshi
  • Publication number: 20140329767
    Abstract: Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, such as Onaway, Russet Burbank, Purple Valley or Bora Valley cultivars. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.
    Type: Application
    Filed: May 1, 2014
    Publication date: November 6, 2014
    Applicant: The Royal Institution For The Advancement Of Learning/McGill University
    Inventors: Stanley Kubow, Danielle Donnelly, Andre Piccolomini, Luis Agellon
  • Publication number: 20140323535
    Abstract: The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, FLORIDA INSTITUTE OF TECHNOLOGY
    Inventors: William S. POWELL, Joshua ROKACH
  • Patent number: 8860939
    Abstract: Two dimensional (2D) optical spectroscopy, wherein the spectrum has an excitation and an emission axis, reveals information formerly hidden in one-dimensional (1D) optical spectroscopy. However, current two dimensional optical spectroscopy systems are complex laboratory arrangements and accordingly limited in deployment. According to embodiments of the invention a monolithic platform providing significantly reduced complexity and increased robustness is provided allowing for “black-box” modules allowing commercial deployment of 2D optical spectroscopy instruments. Additionally, the invention supports high pulse repetition rates as well as one quantum and two quantum measurements under electronic control.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: October 14, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Patanjali Kambhampati, Jonathan Saari, Pooja Tyagi
  • Patent number: 8855215
    Abstract: A method and a circuit are provided for providing phase or frequency synthesis using sigma-delta modulation bit-stream techniques in which data is encoded utilizing sigma-delta modulation and then digital-to-time conversion (DTC) or digital-to-frequency conversion (DFC). In some embodiments this encoded data stream is further subjected to phase or frequency domain filtering, which in some embodiments is carried out by a higher-order phase-locked loop (PLL).
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: October 7, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Gordon Roberts, Sadok Aouini
  • Publication number: 20140265720
    Abstract: Monolithically integrated capacitive micromachined transducers (CMTs) offer combined process steps, shared layers, simplified packaging, and reduced die size by overlapping the CMTs with the integrated circuit (IC) electronics. Moreover, a CMT array directly above the electronics also allows for varying the excitation signal phase to each CMT element thereby enabling beam-forming techniques. Above-IC integration is particularly attractive by not requiring any alteration of the semiconductor fabrication process and allowing subsequent implementation independent of IC fabrication. Naturally, this scheme requires that the CMT technology limit itself to IC compatible materials and chemicals, as well as process step temperatures within a specific thermal budget.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Mourad El-Gamal, Qing Zhang, Paul-Vahe Cicek, Frederic Nabki
  • Patent number: 8835345
    Abstract: There is provided a catalyst comprising metal nanoparticles supported on nanocrystalline cellulose and a homogeneous catalyst system comprising this catalyst colloidally suspended in a fluid. There is also provided a method of producing this catalyst and various uses thereof.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: September 16, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Audrey Moores, Ciprian M. Cirtiu
  • Publication number: 20140256926
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Application
    Filed: August 23, 2012
    Publication date: September 11, 2014
    Applicants: Hong Kong Polytechnic University, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • Patent number: 8815942
    Abstract: The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., Plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: August 26, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Philippe Gros, Gundula Min-Oo, Anny Fortin
  • Patent number: 8816082
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting human farnesyl pyrophosphate synthase or for the treatment or prevention of disease conditions using said compounds;
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: August 26, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Youla S. Tsantrizos, Joris Wim De Schutter, Yih-Shyan Lin
  • Publication number: 20140230547
    Abstract: Micromachined gyroscopes, such as those based upon microelectromechanical systems (MEMS) have the potential to dominate the rate-sensor market mainly due to their small size, low power and low cost. As MEMS gyroscopes are resonant devices requiring active excitation it would be beneficial to improve the resonator Q-factor reducing the electrical drive power requirements for the excitation circuitry. Further, many prior art MEMS gyroscope designs have multiple resonances arising from design and manufacturing considerations which require additional frequency tuning and control circuitry together with the excitation/sense circuitry. It would therefore be beneficial to enhance the bandwidth of the resonators to remove the requirement for such circuitry. Further, to address the relatively large dimensions of MEMS gyroscopes it would be beneficial for the MEMS gyroscopes to be fabricated directly above the CMOS electronics thereby reducing the die dimensions and lowering per die cost.
    Type: Application
    Filed: October 1, 2013
    Publication date: August 21, 2014
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Mourad El-Gamal, Mohannad Elsayed, Paul-Vahe Cicek, Frederic Nabki