Abstract: The invention relates generally to oligosaccharide compounds and the use of these compounds as pharmaceuticals for treating diseases or conditions in which it is desirable to inhibit ?-secretase.

Abstract: Provided are methods of detecting cancer or pre-cancerous conditions in patients comprising assaying a patient sample for an elevated level of target molecules representative of expression of nucleosome assembly protein 1-like 1 (NAP1L1), wherein elevated levels of expression of NAP1L1 are indicative of a cancer of the colon, or a precancerous condition of the colon. Also provided are similar methods using panels of biomarkers such as HMGB1; PHB; RPL6; NAP1L1 and CK18. The invention also provides a method for assessing effectiveness of a therapy or putative therapy, methods of staging cancer and assessing progression of a cancer and methods of determining an appropriate cancer treatment regimen.

Abstract: The present invention relates to a branched vinyl polymer carrying dendrons made from monofunctional vinyl monomers and branched by virtue of difunctional vinyl monomers so that there is on average one branch or fewer per polymer chain to avoid gelation. The polymer may be made by chain-growth polymerization of predominantly monofunctional vinyl monomers in the presence of difunctional vinyl monomers and dendron units.

Abstract: The present invention relates to a mixed metal oxide exhibiting perovskite-type structural characteristics in which there are cations of Ba, Ca or Sr, a rare earth metal and Fe, Cr, Cu, Co or Mn present in three different coordination sites or a composition thereof, to a cathode composed of the mixed metal oxide or composition thereof and to a solid oxide fuel cell comprising the cathode.

Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a boundary is prepared. A space including the porous CAD volume is populated with unit cells. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. The space is populated with at least one elongated fixation element extending beyond the boundary to produce an interlocking feature enabling assembly or engagement with a mating structure.

Abstract: The present invention relates to a process for fabricating a quadrupole mass spectrometer (QMS) component, to a monolithic quadrupole mass spectrometer or a component thereof, to a quadrupole mass filter (QMF) or quadrupole ion trap (QIT) capable of generating a hyperbolic electric field and to a modular quadrupole mass spectrometer (QMS) assembly.

Abstract: A structure for bending transversal elastic waves around a zone to isolate of a plate, has an anisotropic Young's modulus and/or a heterogeneous mass density. The wavelengths of the elastic waves to bend are large with respect to the thickness of the plate and small with respect to the other dimensions of the plate. The structure is made by defining a meshing of a peripheral zone surrounding the zone to isolate; dividing the peripheral zone into several elementary rings and several elementary angular sectors; and forming, in each mesh delimited by an elementary angular sector and an elementary ring, a structural element in a material having a Young's modulus and/or a mass density different than those of the material forming the plate, the dimensions of the meshes and of the structural elements in the plane of the plate being less than half the wavelengths of the elastic waves to bend.

Abstract: The present invention relates to a branched vinyl polymer carrying dendrons made from monofunctional vinyl monomers and branched by virtue of difunctional vinyl monomers so that there is on average one branch or fewer per polymer chain to avoid gelation. The polymer may be made by chain-growth polymerization of predominantly monofunctional vinyl monomers in the presence of difunctional vinyl monomers and dendron units.

Abstract: Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.

Abstract: The present invention relates to an electrochemical cell comprising a vibratile electrode (eg a vibratile microelectrode).

Abstract: The present invention relates to a dental implant and to a process for fabricating the dental implant.

Abstract: The present invention relates to a cathode composed of a perovskite-type or fluorite-type mixed metal oxide containing molybdenum, to a composite comprising the mixed metal oxide and to a solid oxide fuel cell comprising the cathode. The cathode mixed metal oxide has an empirical formula unit: EaTbMocOn wherein: T is one or more transition metal elements other than Mo; E is one or more metal elements selected from the group consisting of lanthanide metal elements, alkali metal elements, alkaline earth metal elements, Pb and Bi; and a, b, c, and n are non-zero numerals which may be the same or different for each element.

Abstract: This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessment and/or diagnosis of organ (e.g. liver) or tissue (e.g. skin) injury.

Abstract: The present invention relates to a mixed metal oxide of formula SrM1-xTixO3 wherein x is 0>x>1 and M is Hf or Zr, such as a strontium-hafnium-titanium oxide orstrontium-zirconium-titanium oxide, and to a functional device comprising the mixed metal oxide.

Abstract: A vehicle guidance system comprising: a measurement system; a processor arranged to receive information from the measurement system and convert said information into at least one time-to-contact based parameter; and a control system arranged to receive the at least one time-to-contact based parameter from the processor and use the at least one time-to-contact based parameter to either automatically guide the vehicle or to provide vehicle guidance information to a pilot.

Abstract: Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.

Abstract: The present invention relates to an electrochemical cell comprising a vibratile electrode (eg a vibratile microelectrode).

Abstract: The present invention relates to a process for fabricating a composite functional body/substrate, either by melting with an energy beam or by spin coating. The functional material is preferably a piezoelectric material (PVDF). The energy beam is preferably a laser beam.

Abstract: Apparatus for non-orthogonal monitoring of a variable measurand in a system or process, comprising: means defining at least three sources having limited spectral widths and non-orthogonal spectral outputs; a modulator means which is adapted to modulate the outputs of said sources in response to said variable measurand; at least three detectors which have non-orthogonal responsivities in the measurement domain and which receive the modulated outputs of said sources; and a processor which converts the detector outputs algorithmically into primary chromatic parameters.

Abstract: The invention provides a method of enhancing the effectiveness of pesticides, as well as pesticidal formulations. Furthermore, it also provides the means for the de novo rational design of pesticides. The present invention also relates to a method of screening agents for potential use in insecticides, particularly against mosquitoes.