Patents Assigned to The University of Liverpool
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Patent number: 7402852Abstract: A charge coupled device (CCD) is disclosed which has a semiconductor body (20) comprising polymer or oligomer semiconductor material in place of the conventional silicon. A back electrode (22) of the device is electrically coupled to the semi-conductor body through a Schottky junction, reducing the availability of holes in the semiconductor body. Shift electrodes forming a shift register are driven by negative electrical potentials and accumulations of holes in p type semiconductor material represent data.Type: GrantFiled: December 16, 2004Date of Patent: July 22, 2008Assignee: The University of LiverpoolInventor: William Eccleston
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Patent number: 7374903Abstract: The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to facilitate, influence, control or inhibit cell or tissue growth thereon and/or therebetween and the substrate may be used for the study, manipulation or modification of at least one cellular or tissue behavior or response.Type: GrantFiled: June 11, 2002Date of Patent: May 20, 2008Assignee: The University of LiverpoolInventors: Brian G. Cousins, Michael Joseph Garvey, John Fink, Rachel Lucinda Williams, Patrick Joseph Doherty
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Publication number: 20080109102Abstract: An apparatus is disclosed for layer-on-layer manufacture of shaped three dimensional items. The process is controlled by a computer (36). The item is supported upon a build platform (2) and the apparatus additionally includes at least one build station (4) which serves to form upon the item under manufacture a layer of material having a controlled depth, and a shape determined by the computer controller. The build station and/or the build platform is/are mounted and driven to rotate about an axis. In this way the surface of the item under manufacture is repeatedly presented to the build station. The item is thereby built up from multiple layers of material. The rotational motion is advantageous in comparison with the reciprocal relative motion of existing “rapid proto-typing” machines.Type: ApplicationFiled: June 7, 2004Publication date: May 8, 2008Applicant: THE UNIVERSITY OF LIVERPOOLInventor: Christopher Sutcliffe
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Publication number: 20080085279Abstract: The present invention relates to the inhibitors of MDM2 Binding Protein (MTBP) activity that may be used as medicaments. Such medicaments may be used to prevent or treat cancers. A preferred inhibitor is an siRNA molecule that is specific for silencing MTBP expression. The invention further relates to screening methods (e.g. for identifying MTBP inhibitors that may be used to treat cancers).Type: ApplicationFiled: December 22, 2005Publication date: April 10, 2008Applicant: University of LiverpoolInventors: Mark Boyd, Nikolina Vlatkovic, Mark Brady
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Publication number: 20080027594Abstract: A vehicle guidance system comprising: a measurement system; a processor arranged to receive information from the measurement system and convert said information into at least one time-to-contact based parameter; and a control system arranged to receive the at least one time-to-contact based parameter from the processor and use the at least one time-to-contact based parameter to either automatically guide the vehicle or to provide vehicle guidance information to a pilot.Type: ApplicationFiled: July 31, 2006Publication date: January 31, 2008Applicants: The University of Liverpool, The University of EdinburghInventors: Michael Jump, Gareth D. Padfield, David N. Lee
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Publication number: 20070264152Abstract: The present invention relates to a process for producing porous metallic materials comprising the steps of: (a) miming metallic particles with a carbonate additive and a binder, wherein the quantity of carbonate additive in the mixture is in the range 40 to 90 vol % and compressing the mixture beyond the yield strength of the metallic particles; (b) heating the mixture to a first temperature sufficient to evaporate the binder; (c) heating and maintaining the temperature of the mixture to a second temperature sufficient to sinter the metallic particles but insufficient to decompose or melt the carbonate additive; (d) removing the carbonate additive from the sintered porous metallic material; and optionally (e) heating and maintaining the temperature of the porous metallic material to a third temperature greater than the second temperature so as to enhance the sintering. The present invention also relates to metallic materials produced by such a process.Type: ApplicationFiled: May 19, 2005Publication date: November 15, 2007Applicant: THE UNIVERSITY OF LIVERPOOLInventor: Yuyuan Zhao
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Patent number: 7258236Abstract: The present invention is concerned with the adsorption of chiral molecules at surfaces or interfaces, with the arrangement and properties of adsorbed chiral molecules, and with devices and methods based thereupon. In particular, an apparatus allows the influence of the magnetic environment of the adsorbed chiral molecules by means of a magnetic field. The new observed orientation of the adsorbed chiral molecules caused by the chiro-magnetic effect, and the possible applications, are disclosed too.Type: GrantFiled: November 23, 2004Date of Patent: August 21, 2007Assignee: The University of LiverpoolInventor: Rasmita Raval
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Publication number: 20070166709Abstract: An immunoassay utilizing the polymerase chain reaction to detect biological molecules in a sample. In one embodiment, the method employs a plurality of nucleic acid templates with varying annealing temperatures when annealed to a detectable probe.Type: ApplicationFiled: January 21, 2004Publication date: July 19, 2007Applicant: THE UNIVERSITY OF LIVERPOOLInventors: David McCreavy, William Fraser, James Gallagher
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Publication number: 20070142477Abstract: The present invention concerns compounds derived from the anaesthetic propofol that are useful as analgesics and methods of using the same. The compounds act as co-activators of strychnine-sensitive glycine receptors and may have greater activity at those glycine receptors than at GABAA.Type: ApplicationFiled: December 19, 2006Publication date: June 21, 2007Applicants: THE UNIVERSITY OF LIVERPOOL, THE UNIVERSITY OF DUNDEE, MEDIZINISCHE HOCHSCHULE HANNOVERInventors: Martin Leuwer, Gertrud Haeseler, Jeremy Lambert, Delia Belelli
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Publication number: 20070135528Abstract: The present invention relates to a method for producing a porous material comprising the steps of; (a) providing a C/W emulsion comprising an aqueous phase, a matrix building material, a surfactant and liquid CO2 phase; (b) at least partially freezing the aqueous phase; (c) gasifying CO2 from the liquid CO2 phase to form an intermediate porous material; (d) venting gasified CO2 from the intermediate porous material; and (e) freeze drying the intermediate porous material at least substantially to remove the aqueous phase and form the porous material. The present invention also relates to a porous material obtainable by the method.Type: ApplicationFiled: July 29, 2004Publication date: June 14, 2007Applicant: THE UNIVERSITY OF LIVERPOOLInventors: Rachel Butler, Andrew Cooper
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Publication number: 20070031815Abstract: A screening method for identifying and/or analysing Hsp90 inhibitors and/or Hsp90 agonists comprises the steps of contacting a compound with at least two of yeast strains A-E wherein each yeast strain comprises expression vectors from which a pair of binding partners for a yeast two-hybrid assay are expressed. The binding partner pairs comprise: A: Hsp90-targeting protein; B: Hsp90-Hsp90; C: Hsp90-p23; D: Hsp90-E3 ligase; E: Hsp90-Client. Inhibition and/or promotion of dimerisation between the binding partners is then measured.Type: ApplicationFiled: April 28, 2004Publication date: February 8, 2007Applicant: University of LiverpoolInventors: John Jenkins, William Greenhalf, David O'Connor
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Patent number: 7132431Abstract: The present invention relates to pharmaceutical compounds for use in the treatment or porphylaxis of malaria having the general formula: where: R is selected from the group consisting of dimethylamino, diethylamino, di-N-propylamino, diisopropylamino, di-N-butylamino, di-sec-butylamino, piperidinyl, piperizinyl, ethylamino, tert-butylamino; and X is selected from the group consisting of chloro, fluoro, iodo, bromo, trifluoromethyl, methoxy and methyl.Type: GrantFiled: March 14, 2002Date of Patent: November 7, 2006Assignee: The University of LiverpoolInventors: Brian Kevin Park, Paul Michael O'Neill, Stephen Andrew Ward, Paul Anthony Stocks
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Publication number: 20060240473Abstract: Novel methodologies for producing saccharide libraries are provided as well as the libraries themselves.Type: ApplicationFiled: July 17, 2003Publication date: October 26, 2006Applicant: The University of LiverpoolInventors: Andrew Powell, Jeremy Turnbull, Edwin Yates
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Publication number: 20060068384Abstract: A method to detect biological molecules in a sample which is an immuno polymerase chain reaction assay which comprises the detection of a complex which includes a ligand: nucleic acid conjugate bound to at least one biological molecule. The complex is detected by the addition of a second nucleic acid molecule which is adapted to anneal to the nucleic acid of the conjugate.Type: ApplicationFiled: December 4, 2002Publication date: March 30, 2006Applicant: UNIVERSITY OF LIVERPOOL Senate HouseInventors: David McCreavy, William Fraser, James Gallagher
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Publication number: 20050245466Abstract: The present invention relates to the use of a first agent that attenuates topoisomerase II (Topo II) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.Type: ApplicationFiled: March 28, 2003Publication date: November 3, 2005Applicant: THE UNIVERSITY OF LIVERPOOLInventor: John Jenkins
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Publication number: 20050239720Abstract: The present invention relates to the use of a first agent that attenuates Topoisomerase I (Topo I) activity and a second agent that inhibits Heat Shock Protein 90 (HSP90) for use in chemotherapy. The agents are particularly useful in the treatment of cancer and destruction of micro-organisms. The invention also relates to screening methods, diagnostic methods and methods for evaluating or monitoring chemotherapy regimens.Type: ApplicationFiled: April 15, 2003Publication date: October 27, 2005Applicant: UNIVERSITY OF LIVERPOOL Senate HouseInventor: John Jenkins
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Patent number: 6875429Abstract: The invention relates to metastasis inducing DNA's, a method of identifying such DNA's and their use in diagnosis and therapy. It includes a method of screening and recovering met-DNA comprising the steps of: (i) transferring fragments of human DNA from malignant, metastatic cancer cells into a cell line that produces only benign, non-metastasizing tumors when injected into a syngeneic animal; (ii) injecting the transformed cells into the syngenic animal; (iii) selecting those animals in which metastasizing tumors have been identified; and (iv) recovering the met-DNA therefrom.Type: GrantFiled: January 10, 1997Date of Patent: April 5, 2005Assignee: University of LiverpoolInventors: Philip S Rudland, Roger B Barraclough
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Patent number: 6852995Abstract: A polymer-based or silicon-based accumulation type, depletion mode field effect transistor, suitable as a driver for load. Optionally, the load is another accumulation type, depletion mode field effect transistor. The transistor may be of the TFT type, either lateral or vertical. Optionally, it may have Schottky diode contacts to source and drain electrodes, possibly with a reverse biased Schottky junction, or it may have a negatively charged gate dielectric.Type: GrantFiled: November 9, 2000Date of Patent: February 8, 2005Assignee: The University of LiverpoolInventors: William Eccleston, Giles Christian Rome Lloyd
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Patent number: 6853127Abstract: A manufacture and methods are provided for a field emission cathode and field emission display comprising a conjugated polymer material. The manufacture of the invention comprises a conjugated polymer material, which may include substituted polythiophene, polyalkylthiophene, and poly-3-octylthiophene. A polymer material layer may be formed by distributing a conjugated polymer material and a solvent onto a substrate. The solvent may be evaporated under a vacuum. The polymer layer may be molded to include projections to promote field emission. Additionally, the polymer material may be doped with an electron donor material. Methods according to the invention include the steps of forming a polymer layer comprising conjugated polymer material on a substrate, distributing a polymer solution including a solvent onto the substrate, evaporating the substrate, and shaping the surface of the polymer layer by use of a mould.Type: GrantFiled: March 15, 1999Date of Patent: February 8, 2005Assignee: The University of LiverpoolInventors: William Eccleston, Gehan Anil Joseph Amaratunga, Ismail Musa
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Patent number: 6818486Abstract: A method of fabricating an electronic component is disclosed in which an electrically conductive layer (4) is provided upon a substrate (2). A mask (6) having a window (8) is provided upon the layer and by etching, preferably chemically, through the window an opening (10) the conductive layer. Conductive material is deposited, preferably by vapor deposition, through the window to form an island in the opening. The etching of the conductive layer is carried out such that the conductive layer is undercut at the periphery of the window with the result that the periphery of the island is spaced apart from the periphery of the opening. Also disclosed is a thin film transistor structure well suited to fabrication by the above described method.Type: GrantFiled: March 31, 2003Date of Patent: November 16, 2004Assignee: The University of LiverpoolInventor: William Eccleston