Abstract: Methods for inducing plasticity in effector T cells or intermediate Treg cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the simultaneous/synergistic inhibition of eIFSA and Notch signaling. Also described are compositions and kits including an eIPSA inhibitor and a Notch signaling inhibitor.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.

Abstract: A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient. A method of 3D printing nitinol to create a patient-specific device to facilitate the establishment of a normal stress-strain trajectory in grafted bone.

Abstract: Materials and methods for improving the stability of perovskites are described.

Abstract: An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure.

Abstract: HDAC inhibitor compounds having trifluoromethylpyruvamides or hydrates thereof, and methods of making and using the same, are described. The HDAC inhibitor compounds are useful for inhibiting HDAC activity and inhibiting growth of cancer cells.

Abstract: A pressure ulcer boot includes a boot body formed from a layer of flexible material, an array of selectively inflatable and deflatable air pockets mounted to a portion of the boot body, an air pump in fluid communication with the array of air pockets, and a micro-processor operative to control the air pump to selectively inflate and deflate the air pockets and to apply pressure via the air pockets at regular intervals to increase circulation and relieve pressure in a portion of a patient's body with which the pressure ulcer boot is in contact.

Abstract: Adjustable gravity simulators, mechanical loading devices, and methods for simulating gravitational loads and cell culturing are described. Further provided is an adjustable gravity simulator having a simulator chamber and a mechanical loading device configured to apply a mechanical load to samples in the simulator chamber while the simulator chamber experiences a microgravity or partial gravity simulation. Advantageously, the adjustable gravity simulator as described herein can address the challenges associated with cell culturing in simulated microgravity or partial gravity.

Abstract: Provided is a device comprising a phantom comprising a solid water material, having a square cross-sectional shape, and having a width that varies monotonically along a height of the solid phantom; and an array of radiation detectors disposed within the phantom; wherein the array of radiation detectors is configured to detect radiation within the phantom. Further provided is a linear accelerator having a gantry and comprising the device as described herein installed in a treatment head of the gantry. In certain embodiments, the linear accelerator further comprises software to interface the device with the linear accelerator.

Abstract: Coacervate compositions, tie layers, coatings, moldable viscoelastic materials, sustained release materials, kits for making coacervate compositions, and methods of using and making the same are described. A coacervate composition may include a complex between a surfactant and a polyelectrolyte in a solvent, where the surfactant includes a cis double bond.

Abstract: An automatic fraction collector, methods of using the same, and systems including the same are described. The automatic fraction collector includes a sensor assembly able to detect liquid drops passing therethrough with light, where the sensor assembly is in the fluid flow path between a column and the point of collection of the liquid drops.

Abstract: Methods for inducing plasticity in effector T cells or intermediate Treg cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the synergstic inhibition of eIF5A and Notch signaling. Also described are compositions and kits including an eIF5A inhibitor and a Notch signaling inhibitor.

Abstract: Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described. Provided are exosomes useful for delivering drugs to desired targets. The exosomes comprise drugs, such as chemotherapeutic drugs, encapsulated in their core. The targets include pancreatic cancer cells.

Abstract: Sustainable methods to separate and recover polypropylene (PP) and polyethylene (PE) from mixed plastic wastes are described. The method utilize a class of green solvents, namely, oils, which can selectively dissolve PP, but not PE or other polymers. When re-precipitated, the recovered PP has properties similar to virgin PP.

Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.

Abstract: Combination treatments for cancers involving inhibiting cis-ATR, as well as biomarkers for cancer diagnosis and prognosis, and transgenic animals, are described.

Abstract: An aortic punch includes a cylindrical barrel, a cylindrical plunger movably mounted within the barrel, a blade shaft movably mounted within a distal end of the barrel and having a first cutting tool at a distal end thereof, the first cutting tool configured to form a first cut in a wall of a blood vessel, and a cylindrical punch body movably mounted within a distal end of the barrel and about the blade shaft and having a second, circular cutting tool configured to form a circular hole in the wall of a blood vessel around the first cut.

Abstract: A fixation/reconstruction system for treating syndesmotic ankle fractures includes a screw guide assembly configured to align the cannulated screw for insertion into, and securing within, the patients bone; and, a tension band alignment assembly configured to insert at least one tension band through a transverse opening in the patient s leg, and to secure the tension band.

Abstract: Adjustable gravity simulators, mechanical loading devices, and methods for simulating gravitational loads and cell culturing are described.