Abstract: Methods and assays for diagnosing cholemia are described. The methods and assays utilize the discovery that cholemic blood is resistant to osmotic lysis.
Type:
Application
Filed:
March 8, 2023
Publication date:
March 6, 2025
Applicant:
The University of Toledo
Inventors:
Matam Vijay-Kumar, Beng San Yeoh, Ahmed Abokor
Abstract: An IVC filter retrieval device useful for removing an IVC filter from a blood vessel, and useful for removing a tilted IVC filter causing the hook to be embedded in the side (wall) of a blood vessel from the blood vessel, and methods for using the same are described. The IVC retrieval device can be used to retrieve other foreign bodies such as, but not limited to, catheters and wires that may become detached from their devices and released into the blood vessels.
Type:
Grant
Filed:
September 14, 2022
Date of Patent:
February 25, 2025
Assignee:
The University of Toledo
Inventors:
Munier Nazzal, Abdullah Nasif, Mohamed Fikri Mohamed Osman, Ayman Ahmed, Sakeena Davis, Soheila Alidad, Zahra Alzaher, Ghayth M. Ansarei
Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
Abstract: Compositions and methods for preventing, treating, or delaying the onset of rheumatoid arthritis involving 14-3-3?, are described. Provided is a method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising administering an effective amount of 14-3-3?, or a variant thereof, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.
Abstract: A bore embolization catheter comprising a catheter main body extending from a catheter junction to a distal end and housing a first lumen, a second lumen, and a third lumen; a detachment zone on the catheter main body configured to allow the catheter main body to be broken; an agent delivery hole on the catheter main body between the detachment zone and the distal end; an end port at the distal end; an inflatable balloon on the catheter main body between the agent delivery hole and the distal end; and a first port in communication with the inflatable balloon through the first lumen, a second port in communication with the agent delivery hole through the second lumen, and a third port in communication with the end port through the third lumen.
Abstract: Flushable wet wipes, and methods of making and using the same, are described. The flushable wet wipes include a biopolymer comprising a carrageenan and optionally a monovalent or multivalent salt on a substrate.
Type:
Application
Filed:
June 18, 2024
Publication date:
December 26, 2024
Applicant:
The University of Toledo
Inventors:
Yakov Lapitsky, Kunal Choudhuri, Umberto A. Kober
Abstract: A minimally invasive blood clot capturing invention made of nitinol. The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and funnel being delivered to the blood clot by a catheter. The basket and funnel are capable of being collapsed within a catheter capable of being deployed into a blood vessel, and capable of being retracted into the catheter for removal from the blood vessel.
Type:
Grant
Filed:
August 22, 2022
Date of Patent:
December 17, 2024
Assignee:
The University of Toledo
Inventors:
Christopher J. Cooper, Mohammad H. Elahinia, Rajesh Gupta, Hamdy Ibrahim
Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
Abstract: A fenestration device for fenestrating an endograft material, a retrievable vessel marker, and methods of using the same are described. The fenestration device includes a needle-like tip with cutting edges configured to make a perforation in an endograft material and blades configured to enlarge the perforation. The retrievable vessel marker includes a wire with a helical portion having four radiopaque markers thereon and blades extendable from the needle-like tip configured to be heated by an external heat source to enlarge the perforation in the endograft material.
Type:
Application
Filed:
August 30, 2022
Publication date:
December 5, 2024
Applicant:
The University of Toledo
Inventors:
Ayman Eltayeb Elhag Ahmed, Mohamed Fikri Mohamed Osman
Abstract: Exosomes that express peptides in CD9 proteins, and smart exosomes that co-express two peptides incorporated into CD9 proteins to home delivery of the exosomes to a desired target and evade phagocytosis by macrophages, are described.
Abstract: Methods for inducing plasticity in effector T cells or intermediate Treg cells to exhibit a regulatory T cell phenotype, treating an autoimmune disease, enriching Treg cells, and preparing a subject for an organ transplant are described. The methods involve the simultaneous/synergistic inhibition of eIFSA and Notch signaling. Also described are compositions and kits including an eIPSA inhibitor and a Notch signaling inhibitor.
Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
Abstract: A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient. A method of 3D printing nitinol to create a patient-specific device to facilitate the establishment of a normal stress-strain trajectory in grafted bone.
Type:
Grant
Filed:
January 18, 2023
Date of Patent:
November 12, 2024
Assignees:
OHIO STATE INNOVATION FOUNDATION, THE UNIVERSITY OF TOLEDO
Inventors:
Howard David Dean, Mohammad H. Elahinia, Christoph Haberland, Michael J. Miller, Alok Sutradhar, Narges Shayesteh Moghaddam, Jason M. Walker, Roman Skoracki
Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.
Type:
Grant
Filed:
January 4, 2021
Date of Patent:
November 12, 2024
Assignees:
The University of Toledo, Washington State University
Abstract: An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure.
Type:
Grant
Filed:
November 18, 2021
Date of Patent:
November 5, 2024
Assignee:
The University of Toledo
Inventors:
Zhaoning Song, Kamala Khanal Subedi, Randy Ellingson, Yanfa Yan
Abstract: HDAC inhibitor compounds having trifluoromethylpyruvamides or hydrates thereof, and methods of making and using the same, are described. The HDAC inhibitor compounds are useful for inhibiting HDAC activity and inhibiting growth of cancer cells.
Type:
Application
Filed:
February 23, 2024
Publication date:
October 31, 2024
Applicant:
The University of Toledo
Inventors:
Endri Karaj, Liyanaaratchige V. Tillekeratne, Riddhidev Banerjee, William R. Taylor
Abstract: A pressure ulcer boot includes a boot body formed from a layer of flexible material, an array of selectively inflatable and deflatable air pockets mounted to a portion of the boot body, an air pump in fluid communication with the array of air pockets, and a micro-processor operative to control the air pump to selectively inflate and deflate the air pockets and to apply pressure via the air pockets at regular intervals to increase circulation and relieve pressure in a portion of a patient's body with which the pressure ulcer boot is in contact.
Type:
Application
Filed:
April 19, 2024
Publication date:
October 24, 2024
Applicant:
The University of Toledo
Inventors:
Munier Nazzal, Abdullah Nasif, Karen Bauer, Mohamed Osman, Josh N. Moskall, Raelyn E. Nyren, Mathieu K. Holt, Logan K. Simmons