Abstract: A device used in conjunction with fixation hardware to provide a two-stage process to address the competing needs of immobilization and re-establishment of normal stress-strain trajectories in grafted bone. A method of determining a patient-specific stress/strain pattern that utilizes a model based on 3D CT data of the relevant structures and cross-sectional data of the three major chewing muscles. The forces on each of the chewing muscles are determined based on the model using predetermined bite forces such that a stiffness of cortical bone in the patient's mandible is determined. Based on the stiffness data, suitable implantation hardware can be designed for the patient by adjusting external topological and internal porous geometries that reduce the stiffness of biocompatible metals to thereby restore normal bite forces of the patient.

Abstract: Methods for extracting and analyzing a sample, and methods for predicting or diagnosing thyroid cancers and disorders, are described.

Abstract: Sensor systems, sensors, and methods for detecting a presence and a phase of a medium on a surface are described. The sensor system has a power source providing a voltage; a sensing element in electrical communication with the power source, the sensing element including: two electrodes, wherein a gap is defined between the two electrodes, and a temperature measurement device disposed between the two electrodes; a fixed resistor in electrical communication with the power source and the sensing element; and a data acquisition system in electrical communication with the power source, the sensing element, and the fixed resistor. The sensor system measures the electrical resistance of the medium, and the temperature of the surface, and identifies the phase of the medium.

Abstract: A locking fixation device for treating extra-articular fractures includes a connector assembly connected to two end plates. Rotation of the connector assembly about an axis extending therethrough converts rotational motion to linear motion, and advances the end plates in a linear direction away from (lengthening) or toward (compression) each other.

Abstract: Described herein are compositions for, and methods of treating, Raynaud's phenomenon. The compositions comprise a TRPM-8 antagonist formulated in a topical formulation in an amount effective to treat Raynaud's phenomenon.

Abstract: A superacid polymeric catalyst having both Lewis acidity and Brønsted acidity is described, along with methods of making and methods of using the same.

Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.

Abstract: Crosslinked membranes for anion exchange applications, and methods of making and using the same, are described.

Abstract: A female urethral catheter guide includes a guide body defining a first body portion having a first end and a second body portion having a second end. The first body portion includes a longitudinally extending catheter support groove formed in a surface thereof, and the second body portion includes a radially outwardly extending tunnel portion having a catheter tunnel formed therein, wherein the catheter tunnel is connected to the catheter support groove and the second end of the second body portion is rounded and defines a vaginal support end.

Abstract: Artificial intelligence-based systems and methods for learning management are described.

Abstract: Materials that exhibit stress-induced porosity, and methods of making and using the same, are described.

Abstract: A three-way urology catheter stopcock includes a stopcock body defining a longitudinally extending fluid flow passage, the body having three connector mounting openings in a wall thereof, an on/off selector movably mounted within the fluid flow passage of the body, the on/off selector including a longitudinally extending, cylindrical selector body having an open end, a closed end, and three fluid flow openings in a wall of the selector body, wherein the closed second end includes one of a plurality of fluid flow indicator members and fluid flow indicia, two first connectors mounted in opposing connector mounting openings of the stopcock body, and a second connector mounted in the connector mounting opening that is between the openings in which the two first connectors are mounted.

Abstract: Compounds and methods for inhibiting cofilin activity or reducing total cofilin, improving motor deficits, attenuating LPS-induced microglial activation and inflammation, reducing microglial migration and proliferation, reducing TNF-?, reducing NF-?B, and improving motor deficits in a subject are described.

Abstract: Compositions and methods for inhibiting brain tumor proliferation, or for inhibiting or halting TM formation, invasion, and/or proliferation, or for rendering brain tumor cells sensitive to chemotherapy or radiation, or for treating a brain tumor, or for inducing cell death, involving mDia agonists such as IMM01 and IMM02, are described.

Abstract: A minimally invasive blood clot capturing invention made of nitinol. The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and fennel being delivered to the blood clot by a catheter. The basket and funnel are capable of being collapsed within a catheter, capable of being deployed into a blood vessel, end capable of being retracted into the catheter for removal from the blood vessel.

Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

Abstract: Described herein are kits and methods for quantifying the amount of at least one nucleic acid of interest in a sample. The kits include a mixture of synthetic spike-in internal standards (IS) reagents, where the spike-in IS reagents comprise a complexity calibration ladder (CCL) that includes synthetic internal standard competitors for at least one target gene.

Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.

Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.

Abstract: Methods and systems for creating emulsions are described. Also described are the emulsions created by the methods or with the systems.