Patents Assigned to The University of Toledo
  • Active flow control for ducted fans and fan-in-wing configurations
    Patent number: 11485486
    Abstract: Systems, methods, lift fans, and aircraft involving active flow control of a ducted fan or fan-in-wing configuration are described.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 1, 2022
    Assignee: The University of Toledo
    Inventors: Chunhua Sheng, Qiuying Zhao
  • KITS AND METHODS FOR TESTING FOR LUNCH CANCER RISKS, AND DIAGNOSIS OF DISEASE AND DISEASE RISK
    Publication number: 20220340977
    Abstract: Kits and methods for diagnosing risk of developing lung cancers and uses thereof are described. In a first aspect, described herein are lung cancer risk test kits that include reagents for measurement of multiple low VAF (defined as VAF<1%) mutants in a set of lung cancer driver genes; and, instructions therefor.
    Type: Application
    Filed: September 8, 2020
    Publication date: October 27, 2022
    Applicant: The University of Toledo
    Inventors: James C. Willey, Daniel J. Craig, Thomas M. Blomquist, Erin L. Crawford, Ji-Youn Yeo
  • Assembly of charge mosaic membranes from ionic polymers
    Patent number: 11478758
    Abstract: Charge mosaic membranes useful for desalination applications, and methods of making and using the same, are described.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: October 25, 2022
    Assignee: The University of Toledo
    Inventors: Glenn Lipscomb, Ghazaleh Vaseghi
  • METHODS FOR STANDARDIZED SEQUENCING OF NUCLEIC ACIDS AND USES THEREOF
    Publication number: 20220282303
    Abstract: Methods for controlling for non-systematic error in an amplification-based next generation sequencing (NGS) library preparation are described, which method includes using an internal amplification control (IAC) sharing identical priming sites to a native nucleic acid target template of interest in a NGS library preparation.
    Type: Application
    Filed: April 25, 2022
    Publication date: September 8, 2022
    Applicant: The University of Toledo
    Inventors: James C. Willey, Thomas Blomquist, Erin Crawford
  • Bioactive glass/polymer composite filament, and methods of making
    Patent number: 11433598
    Abstract: Bioactive glass compositions, composites of the bioactive glass compositions with polymers, and 3D printable filaments made from the same, along with methods of making and using the same, are described. In some embodiments, the compositions, composites, and filaments have antibacterial activity.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: September 6, 2022
    Assignee: The University of Toledo
    Inventors: Aisling Coughlan, Emily Krull
  • Minimally invasive thrombectomy
    Patent number: 11419620
    Abstract: A minimally invasive blood clot capturing invention made of nitinol. The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and funnel being delivered to the blood clot by a catheter. The basket and funnel are capable of being collapsed within a catheter, capable of being deployed into a blood vessel, and capable of being retracted into the catheter for removal from the blood vessel.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: August 23, 2022
    Assignee: The University of Toledo
    Inventors: Christopher J. Cooper, Mohammad H. Elahinia, Rajesh Gupta, Hamdy Ibrahim
  • Materials and methods useful to induce cancer cell death via methuosis or autophagy or a combination thereof
    Patent number: 11406626
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 9, 2022
    Assignee: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul W. Erhardt, Piyush Trivedi
  • Architecture for Efficient Monolithic Bifacial Perovskite-CdSeTe Tandem Thin Film Solar Cells and Modules
    Publication number: 20220199845
    Abstract: An optoelectronic device comprising two photovoltaic absorber materials of CdSeTe and perovskite and their functional component layers that are monolithically integrated into a bifacial tandem solar cell structure.
    Type: Application
    Filed: November 18, 2021
    Publication date: June 23, 2022
    Applicant: The University of Toledo
    Inventors: Zhaoning Song, Kamala Khanal Subedi, Randy Ellingson, Yanfa Yan
  • TARGETING LASP1, EIF4A1, EIF4B AND CXC4 WITH MODULATORS AND COMBINATIONS THEREOF FOR CANCER THERAPY
    Publication number: 20220151976
    Abstract: Described herein are compositions, formulations, and methods useful for sensitizing cancer cells to chemotherapeutic agents, for inhibiting expression or translation of oncogenic proteins, for inhibiting eIF4A, for inhibiting c-MYC, for reducing sternness of breast cancer cells, for treating breast cancer, for overcoming drug resistance of drug-resistant cancer cells, and for reducing tumor cell viability, involving one or more inhibitors of eIF4A, LASP1, CXCR4, CXCL8, CXCL12, ROCK1, BIRC5, MDM2, CCND1, and c-MYC.
    Type: Application
    Filed: February 17, 2020
    Publication date: May 19, 2022
    Applicant: The University of Toledo
    Inventors: Dayanidhi Raman, Cory M. Howard, John Nemunaitis, Francis Charles Brunicardi, Shi-He Liu, Amit K. Tiwari
  • PEGYLATED BILIRUBIN FOR THE TREATMENT OF HYPERLIPIDEMIA, OBESITY, FATTY LIVER DISEASE, CARDIOVASCULAR DISEASES AND TYPE II DIABETES
    Publication number: 20220142980
    Abstract: Compositions and methods for the treatment of obesity, hyperlipidemia, fatty liver disease, cardiovascular disease and type II diabetes are described. Also described are compositions and methods for decreasing one or more of body weight, total fat, percent fat mass, visceral fat, epididymal fat, hepatic fat content, fasting blood glucose, decreasing white adipose fat (WAT) adipocyte size, or increasing percent lean mass. The compositions and methods involve PEGylated bilirubin.
    Type: Application
    Filed: February 18, 2020
    Publication date: May 12, 2022
    Applicant: The University of Toledo
    Inventors: Terry D. Hinds, Jr., David E. Stec
  • Methods for standardized sequencing of nucleic acids and uses thereof
    Patent number: 11312987
    Abstract: Methods for controlling for non-systematic error in an amplification-based next generation sequencing (NGS) library preparation are described, which method includes using an internal amplification control (IAC) sharing identical priming sites to a native nucleic acid target template of interest in a NGS library preparation.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: April 26, 2022
    Assignee: The University of Toledo
    Inventors: James C. Willey, Thomas Blomquist, Erin Crawford
  • Materials and methods for joining metal sheets
    Patent number: 11313395
    Abstract: Embodiments of connectors for joining metal sheets, and methods of using the same, are described.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: April 26, 2022
    Assignee: The University of Toledo
    Inventor: Hongyan Zhang
  • Diffusion based ex-situ group V (P, As, Sb, Bi) doping in polycrystalline CdTe thin film solar cells
    Patent number: 11257977
    Abstract: Described herein is a diffusion-based ex-situ group V element doping method in the CdCl2 heat-treated polycrystalline CdTe film. The ex-situ doping using group V halides, such as PCl3, AsCl3, SbCl3, or BiCl3, demonstrated a promising PCE of ˜18% and long-term light soaking stability in CdSe/CdTe and CdS/CdTe devices with decent carrier concentration>1015 cm?3. This ex-situ solution or vapor process can provide a low-cost alternative pathway for effective doping of As, as well as P, Sb, and Bi, in CdTe solar cells with limited deviation from the current CdTe manufacturing process.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: February 22, 2022
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, The University of Toledo
    Inventors: Feng Yan, Yanfa Yan
  • Inexpensive, earth-abundant, tunable hole transport material for CdTe solar cells
    Patent number: 11251385
    Abstract: Hole transport layers, electron transport layers, layer stacks, and optoelectronic devices involving perovskite materials and materials used as precursors, and methods of making the same, are described.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 15, 2022
    Assignee: The University of Toledo
    Inventors: Randall J. Ellingson, Khagendra P. Bhandari, Michael Heben, Suneth Watthage, Zhaoning Song
  • Thermoresponsive injectable microparticles-gel composites with low dose of recombinant BMP-9 and VEGF for bone repair
    Patent number: 11241504
    Abstract: Compositions for delivering one or more active substances, or for repairing a bone, and methods of making and using the same, are described.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: February 8, 2022
    Assignee: The University of Toledo
    Inventors: Ambalangodage C. Jayasuriya, Bipin Gaihre
  • IMMUNOSUPPRESSIVE ANTIGEN-SPECIFIC CHIMERIC ANTIGEN RECEPTOR TREG CELLS FOR PREVENTION AND/OR TREATMENT OF AUTOIMMUNE AND ALLOIMMUNE DISORDERS
    Publication number: 20220008522
    Abstract: Described herein are immunoresponsive cells which are useful for their preventive and therapeutic potential against autoimmune diseases and rejections of solid organ transplants.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 13, 2022
    Applicant: The University of Toledo
    Inventors: Juan C. Jaume, Shahnawaz Imam
  • MATERIALS AND METHODS FOR THE PREVENTION OF RHEUMATOID ARTHRITIS
    Publication number: 20220008503
    Abstract: Compositions and methods for preventing, treating, or delaying the onset of rheumatoid arthritis involving 14-3-3?, are described. Provided is a method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising administering an effective amount of 14-3-3?, or a variant thereof, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 13, 2022
    Applicant: The University of Toledo
    Inventors: Ritu Chakravarti, Bina Joe
  • Collagen enhancing agent made from low acyl gellan gum, methods of making and methods of using the same
    Patent number: 11197885
    Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also described herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: December 14, 2021
    Assignee: The University of Toledo
    Inventors: Joshua J. Park, Dong-Shik Kim
  • PERC-like contact to CdTe solar cells
    Patent number: 11189748
    Abstract: Methods for forming electrical contacts with CdTe layers, methods for forming photovoltaic devices, methods for passivating a CdTe surface, and photovoltaic devices are described.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: November 30, 2021
    Assignee: The University of Toledo
    Inventors: Michael J. Heben, Adam B. Phillips, Fadhil K. Alfadhili, Randall J. Ellingson, Ebin Bastola, Dipendra Pokhrel, Kamala Khanal Subedi
  • Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease
    Patent number: 11186541
    Abstract: Compounds, compositions, and methods for the treatment of Canavan disease are described.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 30, 2021
    Assignee: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang