Patents Assigned to The University of Toledo
  • Patent number: 11197885
    Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also described herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: December 14, 2021
    Assignee: The University of Toledo
    Inventors: Joshua J. Park, Dong-Shik Kim
  • Patent number: 11189748
    Abstract: Methods for forming electrical contacts with CdTe layers, methods for forming photovoltaic devices, methods for passivating a CdTe surface, and photovoltaic devices are described.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: November 30, 2021
    Assignee: The University of Toledo
    Inventors: Michael J. Heben, Adam B. Phillips, Fadhil K. Alfadhili, Randall J. Ellingson, Ebin Bastola, Dipendra Pokhrel, Kamala Khanal Subedi
  • Patent number: 11186541
    Abstract: Compounds, compositions, and methods for the treatment of Canavan disease are described.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 30, 2021
    Assignee: The University of Toledo
    Inventors: Ronald E. Viola, Bharani Thangavelu, Vinay Mutthamsetty, Qinzhe Wang
  • Patent number: 11142739
    Abstract: A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: October 12, 2021
    Assignee: The University of Toledo
    Inventors: Gayathri Subramanian, Mostafa Elsaadany, Eda Yildirim-Ayan
  • Patent number: 11139661
    Abstract: An equalizer circuit provides both passive and active cell voltage equalization in a battery pack to improve charge and discharge capacity at a low cost. The equalizer circuit is a bilevel circuit that uses both passive equalizers and active equalizers to balance cell voltage. The cells may be grouped into size limited sections which are balanced by passive equalizers. The sections are balanced by active equalizers to promote increased pack charge and discharge capacity. The equalizer circuit can use a current detector or a voltage controlled oscillator to assist in closed loop current control to reduce switching losses and permit use of smaller transistors. The equalizer circuit can use open line protection with capacitors to store excess charge and prevent voltage overload of the switching devices.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: October 5, 2021
    Assignee: The University Of Toledo
    Inventor: Thomas A. Stuart
  • Patent number: 11125750
    Abstract: Methods and kits for the detection of toxic cyanobacteria in a sample by analyzing the sample for the presence antibodies raised in a host, where the presence of antibodies is indicative of toxic cyanobacteria, are described.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: September 21, 2021
    Assignee: The University of Toledo
    Inventors: David Kennedy, Steven Haller, R. Mark Wooten, Deepa Mukundan, Apurva Lad, John Presloid, Jason Huntley, Bruce Levison
  • Patent number: 11104920
    Abstract: Methods for the recovery of lipids, sugars, and proteins from microbial biomass by enzymatic digestion are disclosed. The methods involve treating microalgae with a fungal acid protease, or with a mixture of at least one protease and at least one amylase.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: August 31, 2021
    Assignee: The University of Toledo
    Inventors: Agasteswar Vadlamani, Patricia A. Relue, Sridhar Viamajala, Heng Shao, Sasidhar Varanasi
  • Patent number: 11098038
    Abstract: Imidazole-based anticancer agents and derivatives thereof, as well as methods of making and methods of using the same, are described. The imidazole-based anticancer agents are HDAC inhibitor compounds having a 1-(1H-imidazol-2-yl)ethan-1-one or 1-(1H-imidazol-2-yl)ethane-1-thione moiety.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 24, 2021
    Assignee: The University of Toledo
    Inventors: Viranga Tillekeratne, Ayad Al-Hamashi, Samkeliso Dlamini, Abdulateef Saeed S. Alqahtani, Endri Karaj
  • Publication number: 20210255132
    Abstract: Compositions, devices, and methods for sensing free radicals such as hydroxyl radicals, involving cerium oxide nanoparticles on a carbon-based substrate, are described.
    Type: Application
    Filed: February 18, 2021
    Publication date: August 19, 2021
    Applicant: The University of Toledo
    Inventors: Ana C. Alba Rubio, Dong-Shik Kim, Surachet Duanghathaipornsuk
  • Patent number: 11084836
    Abstract: Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: August 10, 2021
    Assignees: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • Patent number: 11053236
    Abstract: Compounds, compositions, and methods for the treatment of infections, inflammation, cancers, tinnitus, Meniere's disease, hearing loss, or bipolar disorder, or for providing cytoprotection against Clostridium difficile toxins, are disclosed.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: July 6, 2021
    Assignee: The University of Toledo
    Inventors: Steven Sucheck, Sandeep Thanna, Donald Ronning, Alexander Landgraf
  • Publication number: 20210171553
    Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.
    Type: Application
    Filed: January 4, 2021
    Publication date: June 10, 2021
    Applicants: The University of Toledo, Washington State University
    Inventors: Kenneth Hensley, Travis Denton
  • Publication number: 20210163431
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 3, 2021
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • Publication number: 20210156864
    Abstract: Methods of analyzing a sample, diagnosing a cancer, and a treating a patient are described. Various markers for cancers, including triple negative breast cancer, are disclosed.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Applicant: The University of Toledo
    Inventors: Mahasin A. Osman, William James Antonisamy
  • Publication number: 20210154197
    Abstract: Thieno-pyrimidin-4-yl-hydrazinylidene compounds, and methods of using the same, are described.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Angelique Nyinawabera
  • Patent number: 11015167
    Abstract: Methods and systems for efficient culturing of algae in open ponds are described.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: May 25, 2021
    Assignee: The University of Toledo
    Inventors: Brahmaiah Pendyala, Agasteswar Vadlamani, Sridhar Viamajala, Sasidhar Varanasi, Mohammadmatin Hanifzadeh
  • Patent number: 11007256
    Abstract: Single molecules useful in vaccine compositions, and methods of making and using the same, are described.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: May 18, 2021
    Assignee: The University of Toledo
    Inventors: Abhishek R. Vartak, Steven J. Sucheck, Katherine Ann Wall, Anthony Quinn, Marcia F. Mcinerney
  • Patent number: 11001515
    Abstract: Materials and methods for degrading a microcystin compound, and filtering microcystin from water, are described.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: May 11, 2021
    Assignee: The University of Toledo
    Inventors: Jason F. Huntley, Alison Thees
  • Publication number: 20210104686
    Abstract: Materials and methods for improving the stability of perovskites are described.
    Type: Application
    Filed: September 30, 2020
    Publication date: April 8, 2021
    Applicant: The University of Toledo
    Inventors: Yanfa Yan, Chongwen Li, Baicheng Weng
  • Patent number: 10967463
    Abstract: Semiconductor layers useable for minimizing or preventing the growth of metal whiskers, as well as devices and methods utilizing the same and kits for making the same, are described. The semiconductor layers may be nickel oxide layers. In some embodiments, an electronic device may include a substrate, a first metal layer on the substrate, a semiconductor layer comprising NiO on the first metal layer, and a second metal layer on the semiconductor layer. In some embodiments, an electronic device may include a substrate, a semiconductor layer comprising NiO directly on the substrate, and a metal layer directly on the semiconductor layer. A method for making an electronic device may include depositing a semiconductor layer comprising NiO on a substrate, and depositing a metal layer on the semiconductor layer, where the semiconductor layer substantially prevents the growth of whiskers on the metal layer.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: April 6, 2021
    Assignee: The University of Toledo
    Inventors: Vamsi Borra, Daniel G. Georgiev, Srikanth Itapu