Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also described herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.
Abstract: Methods for forming electrical contacts with CdTe layers, methods for forming photovoltaic devices, methods for passivating a CdTe surface, and photovoltaic devices are described.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
November 30, 2021
Assignee:
The University of Toledo
Inventors:
Michael J. Heben, Adam B. Phillips, Fadhil K. Alfadhili, Randall J. Ellingson, Ebin Bastola, Dipendra Pokhrel, Kamala Khanal Subedi
Abstract: A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.
Abstract: An equalizer circuit provides both passive and active cell voltage equalization in a battery pack to improve charge and discharge capacity at a low cost. The equalizer circuit is a bilevel circuit that uses both passive equalizers and active equalizers to balance cell voltage. The cells may be grouped into size limited sections which are balanced by passive equalizers. The sections are balanced by active equalizers to promote increased pack charge and discharge capacity. The equalizer circuit can use a current detector or a voltage controlled oscillator to assist in closed loop current control to reduce switching losses and permit use of smaller transistors. The equalizer circuit can use open line protection with capacitors to store excess charge and prevent voltage overload of the switching devices.
Abstract: Methods and kits for the detection of toxic cyanobacteria in a sample by analyzing the sample for the presence antibodies raised in a host, where the presence of antibodies is indicative of toxic cyanobacteria, are described.
Type:
Grant
Filed:
June 27, 2019
Date of Patent:
September 21, 2021
Assignee:
The University of Toledo
Inventors:
David Kennedy, Steven Haller, R. Mark Wooten, Deepa Mukundan, Apurva Lad, John Presloid, Jason Huntley, Bruce Levison
Abstract: Methods for the recovery of lipids, sugars, and proteins from microbial biomass by enzymatic digestion are disclosed. The methods involve treating microalgae with a fungal acid protease, or with a mixture of at least one protease and at least one amylase.
Abstract: Imidazole-based anticancer agents and derivatives thereof, as well as methods of making and methods of using the same, are described. The imidazole-based anticancer agents are HDAC inhibitor compounds having a 1-(1H-imidazol-2-yl)ethan-1-one or 1-(1H-imidazol-2-yl)ethane-1-thione moiety.
Abstract: Compositions, devices, and methods for sensing free radicals such as hydroxyl radicals, involving cerium oxide nanoparticles on a carbon-based substrate, are described.
Type:
Application
Filed:
February 18, 2021
Publication date:
August 19, 2021
Applicant:
The University of Toledo
Inventors:
Ana C. Alba Rubio, Dong-Shik Kim, Surachet Duanghathaipornsuk
Abstract: Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
Type:
Grant
Filed:
February 24, 2017
Date of Patent:
August 10, 2021
Assignees:
The University of Toledo, Washington State University
Abstract: Compounds, compositions, and methods for the treatment of infections, inflammation, cancers, tinnitus, Meniere's disease, hearing loss, or bipolar disorder, or for providing cytoprotection against Clostridium difficile toxins, are disclosed.
Type:
Grant
Filed:
June 21, 2017
Date of Patent:
July 6, 2021
Assignee:
The University of Toledo
Inventors:
Steven Sucheck, Sandeep Thanna, Donald Ronning, Alexander Landgraf
Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.
Type:
Application
Filed:
January 4, 2021
Publication date:
June 10, 2021
Applicants:
The University of Toledo, Washington State University
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
Type:
Application
Filed:
February 10, 2021
Publication date:
June 3, 2021
Applicant:
The University of Toledo
Inventors:
Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
Abstract: Methods of analyzing a sample, diagnosing a cancer, and a treating a patient are described. Various markers for cancers, including triple negative breast cancer, are disclosed.
Type:
Application
Filed:
November 20, 2020
Publication date:
May 27, 2021
Applicant:
The University of Toledo
Inventors:
Mahasin A. Osman, William James Antonisamy
Abstract: Semiconductor layers useable for minimizing or preventing the growth of metal whiskers, as well as devices and methods utilizing the same and kits for making the same, are described. The semiconductor layers may be nickel oxide layers. In some embodiments, an electronic device may include a substrate, a first metal layer on the substrate, a semiconductor layer comprising NiO on the first metal layer, and a second metal layer on the semiconductor layer. In some embodiments, an electronic device may include a substrate, a semiconductor layer comprising NiO directly on the substrate, and a metal layer directly on the semiconductor layer. A method for making an electronic device may include depositing a semiconductor layer comprising NiO on a substrate, and depositing a metal layer on the semiconductor layer, where the semiconductor layer substantially prevents the growth of whiskers on the metal layer.
Type:
Grant
Filed:
April 11, 2019
Date of Patent:
April 6, 2021
Assignee:
The University of Toledo
Inventors:
Vamsi Borra, Daniel G. Georgiev, Srikanth Itapu