Abstract: A neat-fuel direct-injected compression ignition engine having a thermal barrier coated combustion chamber, an injection port injects fuel that satisfies a stoichiometric condition with respect to the intake air, a mechanical exhaust regenerator transfers energy from exhaust gas to intake compression stages, an exhaust O2 sensor inputs to a feedback control to deliver quantified fuel, a variable valve actuation (VVA) controls valve positions, an exhaust gas temperature sensor controls exhaust feedback by closing the exhaust valve early according to the VVA, or recirculated to the chamber with an exhaust-gas-recirculation (EGR), heat exchanger, and flow path connecting an air intake, a load command input, and a computer operates the EGR from sensors to input exhaust gas according exhaust temperature signals and changes VVA timing, the load control is by chamber exhaust gas, the computer operates a fuel injector to deliver fuel independent of exhaust gas by the O2 signals.

Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) that provides tissue characterization through simultaneous quantification of water tissue properties and proton density fat fraction (PDFF), by using water-only and fat-only images from MRF. MRF is performed using rosette trajectories scanning k-space to effectively isolate water tissue and fat tissue, by separating these rosette trajectories into individual segments that are then analyzed to enable signals from fat tissue to be distinguished from water.

Abstract: This disclosure provides for compositions and methods that can be used to predict an individual's risk for experiencing a cardiovascular event following a surgical procedure (e.g., a non-cardiac surgical procedure).

Abstract: The present invention provides a compound having the structure: wherein R1 is H or a protecting group; R2 and R3 are each independently H, halo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl-C(O)NHR6, C1-C6 alkyl-C(O)OR6, wherein R6 is H, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl, or R2 and R3 combine to form a 3-7 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and R4 and R5 are each independently halo.

Abstract: Compounds and methods for modulating the activity of receptors are disclosed. Some of the compounds modulate the activity of glycine receptors. Certain embodiments of the compounds are useful for treatment of pain, treatment of opioid addiction, and/or reduction of side effects attributable to opioid use.

Abstract: The present application relates to a bidirectional digital switching power amplifier based on a magnetic suspension drive platform and its multi-step current predictive control method. The control method includes the following steps: establishing a prediction model of a bidirectional digital switching power amplifier; introducing a feedback correction term for a closed loop prediction; calculating an optimal modulation duty cycle through a value function; generating, according to the obtained modulation duty cycle, four PWM drive signals by a pulse width modulation module to control four switch tubes respectively to achieve current prediction control. The present application effectively improves the system control accuracy with small steady-state error, small on-line computation amount, simple algorithm, easy digital realization, and good practical value and application prospect.

Abstract: Disclosed is a high anticoagulation ECMO and extracorporeal circulation consumable, which include the following preparation methods: S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables; S2, activating heparin groups; S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables; S4, modification of enhancer. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.

Abstract: Learning algorithms for oscillatory memristive neuromorphic circuits are described. In one embodiment, a neuromorphic circuit learning network includes a number of neuromorphic circuit nodes, each including a recognition neuron unit and a generative neuron unit. The learning network further includes a plurality of neuromorphic circuit feedforward couplings between the recognition neuron units in the neuromorphic circuit nodes, and a plurality of neuromorphic circuit feedback couplings between the generative neuron units in the neuromorphic circuit nodes. The learning network also includes a learning controller configured to drive activity among the recognition neuron units and train the generative neuron units for learning in one mode and to drive activity among the generative neuron units and train the recognition neuron units for learning in another mode. Various deep learning algorithms can be implemented in the learning network.

Abstract: A cyclical salinity-gradient power generating system based on phase change materials and solar photothermal conversion is provided. The system comprises a solution supplying device, a power generating device and a power output device. The solution supplying device provides seawater with high and low concentration as salinity-gradient energy source of the power generating device; the power generating device implements day-and-night cyclical salinity-gradient power generation; the power output device stores electricity, part of which is used as providing power for the pumps inside the system and part of which is used as system output. A cyclical salinity-gradient power generating method based on phase change materials and solar photothermal conversion is also provided.

Abstract: The invention pertains to an inducible CRISPR system for controlling expression of a CRISPR complex with an inducible fusion promoter. One embodiment of the invention provides HIV LTR-minimal Drosophila hsp70 fusion promoter that can be used for inducible co-expression of gRNA and Cas9 in HIV-infected cells to target cellular cofactors such as Cyclin T1. A single introduction of such embodiment leads to sustained suppression of HIV replication in stringent, chronically infected HeLa-CD4 cell lines as well as in T-cell lines. In another embodiment, the invention further relates to enhancement of HIV suppression by incorporating cis-acting ribozymes immediately upstream of the gRNA in the inducible CRISPR system construct. The inducible fusion promoter is adaptable for other tissue- or cell-type specific expression of the inducible CRISPR system.

Abstract: The embodiments of the present disclosure disclose an evaluation apparatus and a method for seal integrity of a wellbore in a full life cycle. The apparatus may include an oil pipe temperature and pressure simulation assembly, an oil casing annular temperature and pressure simulation assembly, a formation confining pressure simulation assembly, a casing-cement sheath-formation combination preparation assembly, a blowby characteristic detection assembly, and a monitoring system. The present disclosure may crustal stress quickly complete scanning of cement slurry system and maintenance and preparation of casing-cement sheath-formation combination, intelligent monitor blowby pressure of cement sheath in real time, test the critical blowby pressure curve of cement sheath of oil and gas wells under various production conditions throughout the life cycle for evaluating the seal integrity of wellbore, and provide technical support for the formulation of wellbore safeguard measures.

Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) by obtaining magnetic resonance data over a main field-of-view (FOV) and resulting from providing a magnetic resonance fingerprinting pulse sequence to a sample. The pulse sequence includes gradient waveforms and radio frequency (RF) pulses that have pulse sequence parameters specifically tailored for scanning, not the entire main FOV but rather a reduced portion of that main FOV. The methods and systems further include comparing the magnetic resonance data from the sample to a fingerprint dictionary of signal profiles that specifically correspond to the reduced portion of the main FOV and generating tissue property maps that correspond only to that reduced portion.

Abstract: The present disclosure relates to a data processing method, and more specifically, to a digital image processing method to enable a rapid noise-suppressed contrast enhancement in an optical linear or nonlinear microscopy imaging application. The disclosed method digitally mimics a hardware-based feedback-driven adaptive or controlled illumination technique by means of digitally resembling selective laser-on and laser-off states so as to selectively optimize the signal strength and hence the visibility of the weak-intensity morphologies while mostly preventing saturation of the brightest structures.

Abstract: A dynamic crack leaking stoppage evaluation experiment device includes a crack simulation experiment instrument having a dynamic crack simulation mechanism. The dynamic crack leaking stoppage evaluation experiment device can simulate a dynamic change process of a crack from a closed state to an open state. An experiment method can be applied to study a variation range of the width of the crack that have been subjected to self-adaptive leaking stoppage with various combinations of leaking stoppage materials and under different increments, and the method can also be applied to quantitatively study on effecting patterns of rheological parameters and hydraulic parameters of well drilling fluid on stability of a leaking stoppage layer in the dynamic crack, so that enabled is not only simulation of leaking stoppage process of a dynamic crack, but also real-time monitoring and evaluation on leaking stoppage effect and leaking stoppage location inside the dynamic crack.

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

Abstract: The present disclosure provides a method of biocementation comprising contacting a granular, cohesionless soil with a solution, wherein the solution comprises urea, urease, a source of calcium ions, and a source of non-urease proteins, wherein the urea, urease, source of calcium ions, and source of non-urease proteins are provided in effective amounts suitable to cause crystallization of calcium carbonate.

Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.

Abstract: Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.

Abstract: A method and device for generating a wind turbine generator set simulation model, equipment and a medium, wherein the method includes: clustering a plurality of pieces of historical operation data of a wind turbine generator set, so as to obtain a predetermined number of target data sets, wherein wind speeds contained in each piece of the historical operation data in a target data set fall within a wind speed range corresponding to the target data set; different target data sets correspond to different wind speed ranges; training an initial simulation model by using each target data set, so as to obtain a segmented pneumatic simulation model corresponding to each target data set; constructing a transmission generation simulation model for a transmission system and a generator system, based on the historical operation data; concatenating the segmented pneumatic simulation model corresponding to each wind speed range and the transmission generation simulation model.

Abstract: A nanobandage solution having Faidherbia albida nanoparticles, olibanum gum, and polyvinyl alcohol and methods of making the nanobandage solution and topically applying the nanobandage to a subject in need thereof are provided.