Abstract: The present disclosure is directed an air-liquid-interface culture apparatus including a porous support and a polyacrylamide hydrogel layer. The porous support includes a polymer plate having a plurality of pores and a support surface. The polyacrylamide hydrogel layer is deposited onto the support surface of the porous support. The polyacrylamide hydrogel layer includes a polyacrylamide hydrogel having mechanical properties that mimic the extracellular matrix for epithelial cells in the human airway. An air-liquid-interface cell culture system disclosed herein may include the air-liquid-interface culture apparatus disclosed herein with one or more cells deposited on the polyacrylamide hydrogel layer.

Abstract: Prodrugs of antibiotic teixobactin, methods of their synthesis, and methods of their use as antimicrobial treatments are described. The teixobactin prodrugs incorporate one or more O-acyl linkages. The O-acyl linkages can be utilized in substitution of amide peptide bonds between an amino acid containing an alcohol side chain and the immediately preceding amino acid.

Abstract: A molded article with improved mechanical strength properties and thermal properties, and a method for producing the molded article. A composite molded article (C) comprising a cellulosic nanomaterial (A) and a thermoplastic resin (B), an area under a stress-strain curve of the composite molded article (C) (AUC1) being at least two times an area under a stress-strain curve of a melt-molded article (D) having the same composition as that of the composite molded article (C) (AUC2), wherein the stress-strain curve is a curve drawn with strain (unit: %) on the horizontal axis and stress (unit: MPa) on the vertical axis and obtained by subjecting the composite molded article (C) or the melt-molded article (D) to a tensile test, and the area is an area up to the horizontal axis from under a curved portion of the curve that is from the origin (stress: 0) of the stress-strain curve to a fracture of the composite molded article (C) or the melt-molded article (D).

Abstract: The present disclosure provides methods and compositions for the treatment of glycogen storage disorders, such as, for example, Lafora Disease and adult polyglucosan body disease. The methods and compositions of the present disclosure comprise isolated nucleic acid molecules, rAAV vectors and rAAV viral vectors comprising polynucleotide sequences encoding for artificial micro RNAs (amiRNAs) directed against GYS1.

Abstract: A nanoparticle drug based on a small interfering RNA (siRNA) targeting JFK and use thereof are provided. Nucleotide sequences of the sense strand and the antisense strand of the siRNA targeting JFK are set forth in SEQ ID NO: 1 and SEQ ID NO: 2, respectively. Liposomes can be used to encapsulate the complex of the siRNA and a protamine to produce a nanoparticle drug targeting JFK, which may be used to treat a disease related to abnormally-high expression of JFK. In this disclosure, breast cancer 4T1 cell-based tumor-bearing mice serve as the model for evaluating the anti-tumor activity of combined therapy involving the nanoparticle drug targeting JFK and radiotherapy. The results reveal that this combined therapy exhibits superior anti-tumor activity compared to the control group.

Abstract: Provided herein are salts which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of the formula (I) wherein the variables are as defined herein. These salts may be show improved water solubility and/or aqueous stability than free base or other salts of these compounds. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.

Abstract: A method for detecting diaper wetness based on a ratio signal technology comprises: sending a frequency-modulated continuous wave signal to a diaper through a radar device to obtain a transmission signal ST(t) and a return signal SR(t); detecting a static environment factor and a dynamic environment factor, and obtaining continuous radar snapshots; eliminating interference of environmental factors by using a filtering template based on the continuous radar snapshots and object respiration; obtaining an outline of the diaper by using wavelet synchronous compression transformation, and dividing into a training sample set and a testing sample set; and inputting the training sample set and the test sample set into a heuristic mobility network for training until a loss function is converged, obtaining the trained heuristic mobility network, and obtaining diaper wetness of the test sample set.

Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.

Abstract: Apparatuses encode or decode a picture sequence, some having different resolutions, and store a bitstream of encoded video data. The apparatus has a processor, which decodes a first syntax element for specifying a reference size of pictures referring to the high-level syntax structure and a second syntax element for specifying a picture size scaled from the reference size of the pictures referring to the high-level syntax structure. The processor derives at least one offset factor and at least one scale factor representing a scale difference between a current picture including a current block to be decoded and a reference picture referred to by the current block. The processor generates a prediction block of the current block from the reference picture by using the motion vector of the current block, the at least one scale factor, and the at least one offset factor.

Abstract: The invention provides antibodies, antibody-based fragments or antibody fragments (antigen-binding fragments), as well as derivative molecules such as bispecific T-cell engagers, antibody-drug conjugates (ADCs) and chimeric antigen receptors (CARs), that specifically recognize Siglec-6 and related compositions. Also provided in the invention are methods of using such antibodies in various diagnostic and therapeutic applications.

Abstract: New antibodies and methods of use are described.

Abstract: Methods and FSP27 compositions for increasing muscle performance and/or regulating lipid droplet dynamics to store triglycerides in the muscles, and regulating their breakdown via lipolysis are described.

Abstract: Disclosed is a method for preparing a cemented carbide with dual gradients by graphene-induced Co migration. The method includes: subjecting a WC—Co cemented carbide powder to first vacuum hot-pressed sintering to obtain a prefabricated WC—Co cemented carbide; subjecting the prefabricated WC—Co cemented carbide to first ultrasonic treatment and second ultrasonic treatment in sequence to obtain a graphene/WC—Co cemented carbide, wherein the first ultrasonic treatment is conducted in anhydrous ethanol, and the second ultrasonic treatment is conducted in a graphene dispersion; and subjecting the graphene/WC—Co cemented carbide to second vacuum hot-pressed sintering to obtain the WC cemented carbide with dual gradients.

Abstract: There is provided a method for generating an emotion cause pair based on conversation. The method comprises receiving a plurality of utterance texts converted from a voice conversation between a plurality of speakers; classifying each of the plurality of utterance texts for each emotion and detecting at least one of emotion utterance texts among the plurality of utterance texts; generating candidate emotion cause pairs each including a pair of an emotion utterance text selected from among the at least one of the emotion utterance texts and a cause utterance text corresponding to the selected emotion utterance text; and determining the emotion cause pair from the plurality of generated candidate emotion cause pairs.

Abstract: The present disclosure provides inhibitors of bunyavirus of the formula: wherein the variables are defined herein.

Abstract: An object of the present invention is to make control for friction compensation executed in a master-slave system more appropriate. A control system includes a master device, a slave device, and a control device. Furthermore, the control device includes a friction compensation control unit and a tactile force transmission unit. The friction compensation control unit calculates a force for assisting an operation in the master device with respect to friction generated in the slave device on the basis of a moving average of velocity of a movable portion in the slave device. The tactile force transmission unit assists the operation in the master device with a force calculated by the friction compensation control unit and controls tactile force transmission in the master device and the slave device.

Abstract: The present disclosure relates to compositions and methods for preventing and/or treating corneal scarring. The present disclosure further provides kits for performing such methods.

Abstract: A compound represented by formula (I), its racemic form, or their salt, wherein X represents an oxygen atom, a nitrogen atom or a sulfur atom; R1 represents an unsaturated aliphatic hydrocarbon group; R2 represents a saturated or unsaturated aliphatic hydrocarbon group; and R3 represents choline, ethanolamine, inositol or serine.

Abstract: An electric field emission device includes a vacuum vessel configured to include a vacuum chamber; an emitter positioned on one side in an axial direction of the chamber and including an electron generation portion facing another side in the axial direction; a target positioned on the other side of the chamber and facing the emitter; a guard electrode that is a cylindrical body, is fixed to the vacuum vessel, and has an opening portion; a support to move the emitter in the axial direction on an inner side of the guard electrode; and an electric field shield body formed of a conductor connected to the guard electrode. The electric field shield body partially overlaps the opening portion on a projection plane in the axial direction, and is formed in a shape partitioning the opening portion into a plurality of areas.

Abstract: In a method for discriminating deposit types by using tourmaline elemental components, contents of Sn, Li, Ga, and V trace elements are determined by collecting hydrothermal tourmaline samples in a deposit, and deposit type discrimination is performed with F1, F2, and F3 as discriminant factors, in combination with the characteristics that a porphyry type Cu—Mo—Au deposit has lower contents of Sn+Li, and further, a porphyry type Cu—Mo deposit has higher contents of Ga*V, while a porphyry type Au deposit has relatively low contents of Ga*V; a granite-related Sn—W deposit has relatively high contents of Sn+Li; while an IOCG deposit has relatively high contents of Sn+Li and Ga*V, realizing quick discrimination of the deposit types during prospecting and exploration, shortening the exploration period and reducing the exploration cost, and the method can be used for identification of 4 different types of deposits.