Abstract: The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.

Abstract: A coalescing filter includes a coalescing filter medium having an entrance face and an exit face and a surface energy, the coalescing filter also having a drainage channel in the coalescing filter medium, the drainage channel being a woven or non-woven fiber construct having a pore size greater than the pore size of said coalescing filter medium and having a surface energy that is lower than the surface energy of the coalescing filter medium, the drainage channel extending at a downward angle relative to the direction from the entrance face to the exit face.

Abstract: An improved reference current generator is provided. A voltage difference generator generates two voltages that are separated by a relatively small electrical potential. The two closely separated voltages are applied across a resistive element with relatively large impedance value resulting in a small and stable reference current. The result is a power efficient, temperature compensated reference current generator.

Abstract: A graphene nano-sensor with a suspended graphene flake electrically connected to metal electrodes. The graphene nano-sensor is capable of detecting single molecules in an atmosphere through a change in electrical conductance through the graphene flake.

Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.

Abstract: A sensor for detecting the presence of unsaturated compounds, the sensor comprising: a semiconductor material doped with a metal halide in electrical connection with a monitoring device.

Abstract: A hierarchical control system (203) for supervising operations of an autonomous operator located within a defined geographical region containing a localized zone having an operation-defined boundary. The control system (203) has a primary controller (604) associated with the defined geographical region and a secondary controller (605) associated with the localized zone. The secondary controller (605) is responsive to the supervisory control of the primary controller (604). The autonomous operator, if located within the localized zone, is responsive to the supervisory control of the secondary controller (605).

Abstract: A method, wireless device and computer program product for expanding the coverage of a cellular network. A wireless device (e.g., cellular telephone) is able to communicate with a base station in a cell of the cellular network over a non-cellular interface via another wireless device in the cell through the use of multi-hopping. A wireless device may request permission to communicate with the base station over a non-cellular interface via hopping off another wireless device when its signal strength is below a threshold. Alternatively, a wireless device may receive a request to communicate with the base station over a non-cellular interface via hopping off the wireless device that sent the request when that wireless device has excess capacity in its bandwidth with the base station. By enabling wireless devices to communicate with a base station in such a manner, the effective coverage area of the cellular network is expanded and the effective capacity of the cellular network is improved.

Abstract: The present invention provides a broad response single-stranded DNA-graphene chemical sensor device. The present invention also provides methods for improving the ability of graphene to work as a chemical sensor by using single-stranded DNA as a sensitizing agent.

Abstract: Biomarkers for pre-Diabetes, Diabetes and/or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q subcomponent subunit B, sulfhydryl oxidase 1 and apolipoprotein A-IV.

Abstract: The present invention relates to methods, systems, and compositions for treating and preventing cancer in a subject with the combination of radiation therapy and antigen presenting cells that have been exposed cancer stem cells or a portion thereof. In certain embodiments, the antigen presenting cells are dendritic cells that have been pulsed with ALDHhigh cancer stem cells.

Abstract: The invention relates to methods for the diagnosis, prognosis, and treatment of non-dermal fibrosis, including lung (or pulmonary) fibrosis.

Abstract: Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided.

Abstract: An apparatus for analyzing free flight of a body including an inertial measurement unit having at least one accelerometer continuously measuring three orthogonal axes of acceleration and outputting data representative thereof and a processing unit operably receiving the data and determining three components of an angular velocity of the body during free flight.

Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: The present invention pertains to a protein having the characteristics of a serine protease having an amino acid sequence according to SEQ ID NO 2 for use as a medicament. The invention also pertains to this protein for use in a vaccine to protect an animal against an infection with a micro organism that secretes said protein, and to the corresponding antibodies directed against the protein.

Abstract: This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P).

Abstract: The invention is directed to long lasting crosslinked water-soluble swellable polymers, methods for making same, and their uses. More particularly, the invention relates to a composition comprising expandable polymeric particles having cationic sites as well as labile crosslinkers and stable crosslinkers, said particle mixed with a fluid. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric particles are injected into a target zones in the reservoirs and when the heat and/or a suitable pH in the reservoir cause degradation of the labile crosslinker and when the particle expands, the cationic sites in the polymer adsorb to negative sites of the rock in the formation, thus diverting water to lower permeability regions and improving oil recovery. However, many other uses are possible.

Abstract: The present invention provides methods for stimulating or enhancing the conversion of coal to methane. The methods of the current invention subject coal to an oxidation step, for example ozonolysis, thereby converting at least a portion of the coal to partially-oxidized and water-soluble forms of organic matter. Subsequent contact of the oxidized coal components with a suitable inoculum containing a methanogenic microbial community produces methane.

Abstract: Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their salts or pro-drug, or compositions containing the compounds, salts, or pro-drug, to modify the activity of CB1 and CB2 receptors and treat conditions mediated by these receptors.