Patents Assigned to The University
  • Patent number: 9216977
    Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: December 22, 2015
    Assignees: The University of North Carolina at Chapel Hill, National Taiwan University
    Inventors: Kuo-Hsiung Lee, Xiaoming Yang, Qian Shi, Kenneth F. Bastow, Che-Ming Teng, Tse-Ming Hong, Pan-Chyr Yang, Shuenn-Chen Yang
  • Patent number: 9216217
    Abstract: A novel constrained peptide epitope derived from A?, wherein the eptitope comprises the amino acid sequence SNK, related antibody compositions and methods of use. An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope which comprises the amino acid sequence SNK and corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric A? is described. An antigenic peptide comprising an epitope having a constrained cyclic configuration, which comprises the amino acid sequence SNK and corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric A? is also described. Methods of treating, preventing and diagnosing Alzheimer's disease are also described.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: December 22, 2015
    Assignee: The University of British Columbia
    Inventor: Neil R. Cashman
  • Patent number: 9217696
    Abstract: Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a fresh tissue is sliced to prepare a tissue specimen, (ii) a hardening module that hardens the tissue specimen, (iii) an impregnating module that impregnates the tissue specimen that was hardened, and (iv) an embedding module that embeds a tissue specimen that was hardened and impregnated. Fresh (i.e., not fixed or frozen) tissue, which was excised to diagnose disease or to assess surgical treatment, is grossed to about 0.6 mm. Preferably, the hardening of fresh tissue is initiated, but not completed, during grossing by contact with a chemical admixture. Preferably, dry ice, a thermoelectric device, or a gas condenser cools a metal mold containing the embedded specimen.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: December 22, 2015
    Assignee: The University of Miami
    Inventor: Azorides Morales
  • Patent number: 9219215
    Abstract: The invention provides for a nanostructure, or an array of such nanostructures, each comprising a rough surface, and a doped or undoped semiconductor. The nanostructure is an one-dimensional (1-D) nanostructure, such a nanowire, or a two-dimensional (2-D) nanostructure. The nanostructure can be placed between two electrodes and used for thermoelectric power generation or thermoelectric cooling.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: December 22, 2015
    Assignee: The Regents of The University of California
    Inventors: Peidong Yang, Arunava Majumdar, Allon I. Hochbaum, Renkun Chen, Raul Diaz Delgado
  • Patent number: 9215983
    Abstract: A novel contrast mechanism for imaging blood flow using magneto-motive optical Doppler tomography (MM-ODT), Optical Coherence Tomography, and Ultrasound. MM-ODT, OCT, and ultrasound combined with an externally applied temporally oscillating high-strength magnetic field detects erythrocytes moving according to the field gradient.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: December 22, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventor: Thomas E. Milner
  • Publication number: 20150363947
    Abstract: An apparatus and method of reconstructing a computed tomography (CT) image using multiple datasets of projective measurements, wherein the method of image reconstruction favors spatial correlations among the images respectively reconstructed from each of the corresponding multiple datasets. The multiple data sets each contain projective measurements of the same object taken in close temporal proximity, but taken with different detector type or configurations (e.g., different spectral components in spectral CT or different detector types in hybrid 3rd- and 4th-generation CT scanners). Reconstructed images minimizing a vectorial total variation norm satisfies the criteria of favoring images exhibiting spatial correlations among the reconstructed images and favoring a sparse gradient-magnitude image (i.e., edge enhancing image) for each reconstructed image.
    Type: Application
    Filed: June 16, 2014
    Publication date: December 17, 2015
    Applicants: The University of Chicago, Toshiba Medical Systems Corporation
    Inventors: David Rigie, Patrick La Riviere, Adam Petschke
  • Patent number: 9211506
    Abstract: Disclosed is a membrane surface modification method. The method is applicable to a variety of hydrophobic membranes by doping selected inorganic particles. One act of the method involves the in-situ embedment of the inorganic particles onto the membrane surface by dispersing the particles in a non-solvent bath for polymer precipitation. Further membrane surface modification can be achieved by hydrothermally growing new inorganic phase on the embedded particles. The embedment of particles is for the subsequent phase growth.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: December 15, 2015
    Assignee: The University of Hong Kong
    Inventors: Kaimin Shih, Xiao-Yan Li, Xiao-Mao Wang, Tong Zhang
  • Patent number: 9211537
    Abstract: A microfluidic device comprising a plurality of reaction chambers in fluid communication with a flow channel formed in an elastomeric substrate, a vapor barrier for preventing evaporation from the plurality of reaction chambers, and a continuous phase fluid for isolation of each of the plurality of reaction chambers.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: December 15, 2015
    Assignee: The University of British Columbia
    Inventors: Carl Lars Genghis Hansen, Carolina Tropini
  • Patent number: 9212261
    Abstract: A method for the manufacture of a polymer is provided, the method comprising: Providing a first monomer, the first monomer comprising a bicyclic diamine moiety, a first nucleophilic group provided on a carbon atom of an aromatic moiety, and a second nucleophilic group provided on a carbon atom of an aromatic moiety; Providing a bridging compound comprising at least two sites vulnerable to nucleophilic attack; and Contacting the first monomer with the bridging compound. Polymers made by said method and uses of such polymers are also disclosed.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: December 15, 2015
    Assignee: The University Court of the University of Edinburgh
    Inventors: Neil Bruce McKeown, Mariolino Carta
  • Patent number: 9211096
    Abstract: A clinical decision support system for patient treatment that incorporates patient data to display information in readily identifiable icons for vital organs and medical systems, and in a useable, real-time, updated fashion that extracts data from the medical history, the current medical management, the current physiologic monitors, and associated medical systems to produce warnings and alerts to enable caregivers to be made aware of physiologic systems at risk. These data are not only presented, but also use real-time queries and calculations to enable caregivers to have the types of data that would traditionally assist them in patient care but only be available by reviewing the medical literature and/or doing retrospective individual calculations while providing patient care.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: December 15, 2015
    Assignee: The Regents Of The University Of Michigan
    Inventors: Kevin K. Tremper, Justin Adams
  • Patent number: 9211419
    Abstract: Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: December 15, 2015
    Assignees: Nanospectra Biosciences, Inc., Board of Regents, The University of Texas System
    Inventors: Sunil Krishnan, Parmeswaran Diagaradjane, Jon Alexander Schwartz, James Chunjay Wang
  • Patent number: 9213945
    Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: December 15, 2015
    Assignees: National Research Council of Canada, The Governors of The University of Alberta
    Inventors: Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
  • Patent number: 9213889
    Abstract: An apparatus and method for calculating athlete speed non-invasively, on the field/court of play using data from a torso-mounted inertial measurement unit. The method complements existing, GPS-based methods for calculating athlete speed by enabling use in environments where GPS signal is unavailable (i.e. indoors).
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: December 15, 2015
    Assignee: The Regents Of The University Of Michigan
    Inventors: Noel C. Perkins, Ryan S. McGinnis
  • Patent number: 9214822
    Abstract: The present invention generally relates to a device and method for the management of a collection of battery cells. In one embodiment, the present invention permits the management of a collection of battery cells composed of an overall battery pack manager unit, individual cell manager units, and wireless communication links between these units. In another embodiment, the present invention relates to a device and method for the management of a collection of battery cells in the field of rechargeable batteries, such as batteries based on lithium-based chemistries, nickel-based chemistries, and lead-acid chemistries. In still another embodiment, the present invention is directed to a method that permits the maximization of battery pack capacity during a charge-discharge cycle and/or permits the maximization of the total number of charge-discharge cycles.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: December 15, 2015
    Assignee: The University of Akron
    Inventors: Thomas T. Hartley, Benjamin W. Magistro, Courtney A. Gras, Rick Clester, Andrew Faulstick
  • Patent number: 9212219
    Abstract: The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: December 15, 2015
    Assignee: The University of Chicago
    Inventors: Olaf Schneewind, Alice Cheng, Dominique M. Missiakas, Hwan Keun Kim
  • Patent number: 9212199
    Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: December 15, 2015
    Assignee: The University of Liverpool
    Inventors: Dinesh Talwar, Weijun Tang, Chao Wang, Barbara Villa Marcos, Jianliang Xiao
  • Patent number: 9214590
    Abstract: A photovoltaic device includes an electron accepting material and an electron donating material. One of the electron accepting or donating materials is configured and dimensioned as a first component of a bulk heterojunction with a predetermined array of first structures, each first structure is substantially equivalent in three dimensional shape, has a substantially equivalent cross-sectional dimension, and where each first structure of the array of first structures has a substantially equivalent orientation with respect to adjacent first structures of the predetermined array forming a substantially uniform array.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: December 15, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Joseph M. DeSimone, Ginger Denison Rothrock, Zhilian Zhou, Edward T. Samulski, Meredith Earl, Stuart Williams
  • Patent number: 9213176
    Abstract: An embodiment of the present invention is an imaging arrangement that includes imaging optics, a fiducial light source, and a control system. In operation, the imaging optics separate light into first and second tight by wavelength and project the first and second light onto first and second areas within first and second detector regions, respectively. The imaging optics separate fiducial light from the fiducial light source into first and second fiducial light and project the first and second fiducial light onto third and fourth areas within the first and second detector regions, respectively. The control system adjusts alignment of the imaging optics so that the first and second fiducial light projected onto the first and second detector regions maintain relatively constant positions within the first and second detector regions, respectively. Another embodiment of the present invention is a microscope that includes the imaging arrangement.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: December 15, 2015
    Assignee: The Regents of The University of California
    Inventors: Alexandros Pertsinidis, Steven Chu
  • Publication number: 20150352206
    Abstract: In some embodiments, the methods involve the use of a combination of at least two of the following: an inhibitor of indoleamine-2,3-dioxygenase (IDO), an inhibitor of the PD-L1/PD-1 pathway, an inhibitor of CTLA-4, an inhibitor of CD25, or IL-7. The inventors particularly observed a major synergistic effect of combining anti-CTLA-4 with either an IDO inhibitor, with anti-PD-L1 mAb, or with CD-25 depletion. Such combinations have been found to demonstrate a synergistic effect in treating cancer and tumors, for example by reducing tumor size, increasing the percentage of antigen-specific T cells, and increasing T cell function.
    Type: Application
    Filed: October 25, 2013
    Publication date: December 10, 2015
    Applicant: The University of Chicago
    Inventors: Thomas F. Gajewski, Stefani Spranger, Michael Leung
  • Publication number: 20150357090
    Abstract: An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities.
    Type: Application
    Filed: March 13, 2014
    Publication date: December 10, 2015
    Applicant: The University of Houston System
    Inventors: Goran Majkic, Venkat Selvamanickam