Abstract: A 2-[(1H-benzimidazol-2-yl)imino]-5,5-diphenylimidazolidin-4-one compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A N?-(2-naphthoyloxy)-2-(benzo[d]oxazol-2-yl)acetimidamide compound, its synthesis, and its use as an antimicrobial agent.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: An adaptive, large graph-oriented unified memory management method is proposed; according to the order of priorities of different types of graph data structure in a graph computing application, whether the current GPU memory is full is sequentially determined by means of GPU memory checking; whether the size of current graph data exceeds the available memory capacity of the GPU is determined by means of data overflow checking; and then a unified memory management policy is configured; the method uses different graph algorithms based on the characteristics of graph data structure and the size of the available GPU memory; the method can significantly improve the performance of processing large graphs, which exceed the video memory capacity under a unified memory architecture, including improving GPU bandwidth utilization, reducing the number of page faults and the overhead of processing page faults, and speeding up the execution of graph computing programs.

Abstract: According to an aspect of the present disclosure, a method executed by an information processing apparatus in order to cause a neural network to learn a Tth task corresponding to a Tth learning set is provided. The method includes: for each of a plurality of units, determining an importance degree of the unit in the Tth task; for each of a plurality of layers, determining dissimilar tasks from among a first task to a (T?1)th task, the dissimilar tasks being not similar to the Tth task in terms of behaviors in the layer; and in learning that uses the Tth learning set, suppressing updating of weight parameters of the plurality of units included in the plurality of layers in accordance with importance degrees in the dissimilar tasks determined for each of the plurality of layers.

Abstract: An 6-(4,5-bis(4-bromophenyl)-2-(4-methoxyphenyl)-1H-imidazol-1-yl)hexanoic acid compound, its synthesis, and its use as an antimicrobial agent.

Abstract: Various perovskite solar cell embodiments include a flexible metal substrate (e.g., including a metal doped TiO2 layer), a perovskite layer, and a transparent electrode layer (e.g., including a dielectric/metal/dielectric structure), wherein the perovskite layer is provided between the flexible metal substrate and the transparent electrode layer. Also, various tandem solar cell embodiments including a perovskite solar cell and either a quantum dot solar cell, and organic solar cell or a thin film solar cell.

Abstract: A mold capable of preparing a cellular or acellular construct includes a block including a three-dimensional cavity for a sample, a base, and a removable sheet inserted between the block and the base. The sheet may be coated with silicone grease prior to insertion of the sheet between the block and the base. Mechanical constraints may be included at each end of the cavity to constrain cell driven contraction and to allow for gripping the sample after the sample is removed from the mold. The sample may be prepared by partially filling the cavity with gel, filling the remaining portion of the cavity with culture media, and allowing a three-dimensional sample to culture within the cavity for a time. The sample may be transported to a bioreactor and ejected from the mold by removing the sheet and applying pressure to the mechanical constraints.

Abstract: The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of the present technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection.

Abstract: An embodiment in accordance with the present invention provides a method for accurate and objective quantification of stone fragment size. The method includes intraoperative measurement of objects during URS. The method analyzes URS procedures for ureteral and renal stones during basket extraction of fragments. An instrument is passed through an instrument channel of the ureteroscope and advanced until it is adjacent to the stone fragment to be measured. The measurement of stone fragment size is based on the known distance of a tip of the instrument in the ureteroscope's visual field.

Abstract: Described herein are technologies for concentrating rare-earth elements from a heavy fraction of grit in gangue produced in kaolin mining. In some examples, grit is separated as a non-clay fraction of gangue produced in a kaolin mining operation. The grit is separated into a heavy mineral grit sub-fraction and a light mineral grit sub-fraction. Rare-earth elements, particularly heavy rare-earth elements, are thereafter extracted from the heavy mineral grit sub-fraction using various extraction technologies.

Abstract: The disclosure provides human toll-like receptor modulators of general Formula (II), wherein R1, R2, R3, R4, R5, R6, R7, R8 are defined herein.

Abstract: The disclosure concerns oil drilling technology, and specifically an all-metal intelligent control motor (AMIM). The AMIM comprises an electric control module, a power module and a transmission module. The electric control module determines the axial position of the connecting rod valve through an electromagnet and controls the connection between the connecting rod valve and the piston through an electric motor. The hydraulic pressure of drilling fluid and the spring reaction force in the power module push a double worm to move axially and circumferentially under the action of internal teeth on the inner surface of shell. A one-way bearing ensures that the power module only transmits unidirectional motion. The transmission module axially limits the power module through TC bearings and transmits circumferential motion, drilling pressure and torque to the lower drilling tool. The AMIM is suitable for all kinds of deep well exploration, with a stronger drilling force, a lower cost and a higher applicability.

Abstract: The present disclosure is directed towards systems and methods built for predictively timing the inflation and/or deflation of an intra-aortic balloon pump. A controller operates in three states: (1) initialization state, (2) learning state, and (3) peak detection state. The controller decomposes a patient's electrocardiogram signal to a power signal. It then learns characteristics of the patient's electrocardiogram signal during the learning state and computes adaptive threshold parameter values. During the peak detection state, the controller applies the learnt threshold parameter values on a current electrocardiogram signal to identify occurrence and timings of R peaks in the electrocardiogram signal. The R-to-R peak timings are then used to trigger inflation of an intra-aortic balloon pump.

Abstract: A system for monitoring potential damage to a tissue within a patient caused by tissue retraction during a surgical procedure, the system comprising: a housing body; an attachment mechanism for attaching the housing body to a tip of a surgical retractor; a force sensor; an inertial sensor; a feedback module; and a control module configured to: track force applied by the retractor tip to the tissue based on force signals received from the force sensor; detect the force applied approaching a force threshold, the force threshold based on a relationship between force applied by the retractor tip to the tissue and orientation of the retractor tip against the tissue; in response to the force applied approaching the force threshold, generating a first warning prompt indicating a possibility of damage to the tissue; and outputting the first warning prompt via a feedback module.

Abstract: A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.

Abstract: The present disclosure provides ?2?-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an ?2?-1 C-terminal domain peptide which blocks binding of ?2?-1 to the glutamate receptors NMDAR and AMPAR.

Abstract: Memristor devices are provided. In an embodiment, a memristor device comprises a top electrode; a bottom electrode; a dielectric material between the top and bottom electrodes; and an ion-implanted conductive region embedded within the dielectric material, the ion-implanted conductive region comprising the dielectric material. The ion-implanted conductive region forms an interface with the dielectric material such that a voltage applied across the top and bottom electrodes causes electrons to cross the interface as they move between the top and bottom electrodes so that the memristor device exhibits memristance.

Abstract: The present invention discloses a crystalline aluminum phosphite, preparation and an application thereof. The compound has the following structural formula (I): where, x is an integer of 1-6; n, y and p are an integer of 1-4; M is Ca, Mg, Al, Zn, Fe, Sn or Ti. The preparation method includes: after dissolving phosphorous acid and hydrogen phosphite into water, adding concentrated phosphoric acid for reaction at 80-90° C., then performing drying at low temperature, dehydration reaction at high temperature, washing and drying. The compound has very high thermal decomposition temperature, high phosphorus content, and good flame retardant property, low water absorption and low acidity; moreover, the compound can serve as a halogen-free flame retardant component of high polymer materials.

Abstract: A method of determining oxygen concentration, metabolic activity, and/or the effects of a test substance on the metabolic activity of a live cell sample by photoluminescence quenching technique employing a photoluminescent probe that self-loads sans any loading reagent into the cells of the cell sample. The probe comprises a plurality of polymeric particles each comprising an amphiphilic cationic polymer matrix having a hydrophobic core and a hydrophilic positively charged surface provided by quaternary amino groups, and a hydrophobic oxygen-sensitive photoluminescent dye embedded in the hydrophobic core.