Abstract: An 2-amino-4-(4-bromophenyl)-6-methoxypyridine-3.5-dicarbonitrile compound, its synthesis, and its use as an antibacterial agent.

Abstract: Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

Abstract: An 2-(5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetic acid compound, its synthesis, and its use as an antimicrobial agent.

Abstract: The present invention relates to modified proteins e.g. oxygen-carrying proteins, with improved or enhanced, in comparison to a reference protein, reduction of a metal ion associated with the modified protein. The present invention also relates to methods of using such modified proteins and compositions comprising such proteins e.g. in therapy.

Abstract: A ceiling fan airflow diffuser apparatus and system that creates elevated air speeds indoors for cooling occupants, improving room air circulation, and reducing energy use by the cooling system of the building. The apparatus has a diffuser support structure and diffuser body oriented below the blades of a ceiling fan. The diffuser body has an outer rim with an annular opening and a top surface forming a shroud for the fan blades. A smaller concentric inner ring positioned coaxially in relation to the outer rim is joined to the outer rim with struts. The inner ring has a frustoconical shape with a central opening. The outer rim and inner ring may also have directional visible light sources to provide flicker-free lighting, or an integrated UV-C light source oriented in an upward direction to inhibit airborne pathogens exposed to the light source.

Abstract: Disclosed is a method of desorbing an adsorbed material by subjecting to energy a diazirine adsorbed on a solid surface or a layer on the solid surface, which causes the diazirine to form a carbene and nitrogen gas; and using the energy of the resultant nitrogen gas to desorb the adsorbed material from the solid surface or a layer on the same. Also disclosed is a method of reacting the resultant carbene with (a) a material in the gas phase proximal to the first solid surface; (b) a material adsorbed on a second solid surface proximal to the first solid surface; or (c) a second solid surface proximal to the first solid surface.

Abstract: A visible-light communication and illumination array includes a substrate and plural surface-emitting superluminescent diodes, SLDs, distributed across the substrate. A first set of SLDs of the plural SLDs generates a first light beam having substantially a first wavelength, a second set of SLDs of the plural SLDs generates a second light beam having substantially a second wavelength, and a third set of SLDs of the plural SLDs generates a third light beam having substantially a third wavelength. The array further includes a controller configured to encode at least one of the first light beam, the second light beam and the third light beam to transmit information. A combination of the first light beam, the second light beam and the third light beam produces white light.

Abstract: One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.

Abstract: There is disclosed an improved additive manufacturing method and system for the production of components and structures, which integrates real-time monitoring and integrity diagnosis systems directly into the manufacturing process. The method introduces smart slicing technique by which smart sensor network layers (SNL) are embedded into sliced layers of a 3-D model at critical points during component design. The critical points are identified by structural analyses of the component using Finite Element Analysis (FEA). A Smart Extrusion and Mixing Module (SEMM) produces both primary printing material and conductive material for SNL layers. The SEMM operates in a direct extrusion mode for primary material and in a mixing and extrusion mode for conductive material. An Artificial Intelligence Single Board Computer (AISBC) manages the printing process and communication with SNL layers. Defect detection occurs in real-time during manufacturing, aided by a scanning module powered by an AI algorithm.

Abstract: A phase locked loop (PLL) includes a phase detector configured to receive a reference signal and a feedback signal, wherein the reference signal has a reference frequency, sample the feedback signal, and output a phase detection signal indicative of a phase of the feedback signal. A voltage controlled oscillator is configured to generate an output signal based on the phase detection signal. The output signal has an output frequency greater than the reference frequency. Feedback circuitry is configured to detect a signal edge of the output signal and selectively supply, once per cycle of the reference signal, the detected signal edge of the output signal as the feedback signal.

Abstract: A pyrazole metal complex for absorption of carbon dioxide, a method for preparing the pyrazole metal complex, and a method for absorbing carbon dioxide are provided; wherein the product produced by reacting pyrazole metal complex and carbon dioxide may be transformed into several economically valuable compounds.

Abstract: A gold(III) complex of formula (I) or formula (II) wherein R1 and R2 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, or an optionally substituted aryl; R3 and R4 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted alkoxy, a hydroxyl, a halo, a nitro, a cyano, a N-monosubstituted amino group, or a N,N-disubstituted amino group; and X is Cl, Br, or I. A pharmaceutical composition containing the gold(III) complex of formula (I) or (II), and a method of treating cancer are included.

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

Abstract: The present invention discloses a magnetic resonance fingerprinting imaging method with variable number of echoes, in addition to conventional MRF coding such as changing the excitation pulse angle, the method also introduces the change of the number of echoes, so that quantitative maps of B0, B1+, T1 and T2* can be obtained in a single scan. Further, if the echo time corresponding to the in-phase, opposed-phase and in-phase of water and fat is set for three consecutive echoes, the present invention can also image water and fat, and achieve the accurate quantification of B0, B1+, T1w, T1F, [T2*]w and [T2*]F. Through in vivo experiments and simulations, the effectiveness of the present invention has been proved. Therefore, the present invention can provide multiple information representations for common brain diseases (glioma) and fatty diseases (such as lipoma, fatty liver, etc.), which is conducive to clinical diagnosis and treatment.

Abstract: The present invention discloses a double-crosslinked thermal phase transition gel temporary plugging agent and an application thereof, and relates to the technical field of oil and gas field development. The gel temporary plugging agent comprises the following components in percentage by weight: 5.8-18.3% of acrylic acid, 2.8-6.5% of 2-acrylamide-2-methylpropanesulfonic acid, 2.8-7.0% of hydroxyethyl acrylate, 0.2-1.0% of a degradable crosslinking agent, 0.4-1.2% of borax or boric acid, 0.2-0.8% of a high-temperature initiator, 2.6-4.5% of palygorskite attapulgite, 1.5-3.1% of a urea-formaldehyde resin, and the balance of water, wherein the gel temporary plugging agent is formed by underground gelation. The gel temporary plugging agent is applied to oil and gas reservoirs with a temperature of 100-150° C., can automatically be subjected to gelation and degradation, and has a low filtration loss before gelation.

Abstract: A bilirubin concentration measurement system including: a sensor device attachable to a subject; and a terminal device capable of wirelessly communicating with the sensor device. The sensor device includes: a light emitting diode that emits blue light; a light emitting diode that emits green light; a light detection diode that detects reflected light that is the blue light having been incident on skin of the subject and reflected, and detects reflected light that is the green light having been incident on the skin of the subject and reflected; and a communication unit that wirelessly transmits information about intensities of the reflected light detected by the photodiode. The terminal device includes: a communication unit that receives the information about the intensities of the reflected light transmitted from the sensor device; and a computing unit that calculates a bilirubin concentration using the information about the intensities of the reflected light.

Abstract: A polymer-assisted 3D printing method and ink compositions are used to manufacture magnetocaloric devices having many applications including in heat pumps, refrigerators, etc. The ink compositions and printing methods can produce compositionally graded, anisotropically aligned magnetocaloric architectures with designed pores and channels, to bring forth significant improvement in heat exchange efficiency.

Abstract: The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers.

Abstract: A file fragmentation removal method includes collecting input/output system call information of a plurality of file input/output system calls by an application of at least one target file used by an application operating on an arbitrary filesystem, generating a file range list of items comprising information on a start point, an end point, and an access count of input/output based on the input/output system call information, selecting a plurality of fragmentation target items based on the file range list and a predetermined threshold, and selectively removing fragmentation based on whether individual items of the plurality of fragmentation target items are fragmented.

Abstract: This disclosure provides systems and methods for storing and preserving an implantable device. The system comprises a first sealable container; a second sealable container housed within the first sealable container; and a storage solution comprising a zinc compound contained in the second sealable container. The storage solution exhibits antimicrobial activity of inhibiting or controlling growth of microbial organisms and is capable of maintaining the implantable device in a hydrated state.