Patents Assigned to The University
  • Methods and compositions for modulating RAD51 and homologous recombination
    Patent number: 9198914
    Abstract: The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: December 1, 2015
    Assignee: The University of Chicago
    Inventors: Philip P. Connell, Douglas K. Bishop, Ralph R. Weichselbaum
  • Displacement devices and methods for fabrication, use and control of same
    Patent number: 9202719
    Abstract: Displacement devices comprise a stator and a moveable stage. The stator comprises a plurality of coils shaped to provide pluralities of generally linearly elongated coil traces in one or more layers. Layers of coils may overlap in the Z-direction. The moveable stage comprises a plurality of magnet arrays. Each magnet array may comprise a plurality of magnetization segments generally linearly elongated in a corresponding direction. Each magnetization segment has a magnetization direction generally orthogonal to the direction in which it is elongated and at least two of the magnetization directions are different from one another. One or more amplifiers may be connected to selectively drive current in the coil traces and to thereby effect relative movement between the stator and the moveable stage.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: December 1, 2015
    Assignee: The University of British Columbia
    Inventors: Xiaodong Lu, Irfan-Ur-Rab Usman
  • System and method for retrofitting application code
    Patent number: 9202044
    Abstract: Disclosed is a system and method for retrofitting defensive technology that transforms potentially dangerous computer programs into safe programs. The present disclosure involves applying software rewriting and/or randomization algorithms to monitored application launches and/or API calls. The present disclosure provides systems and methods for understanding and manipulating how untrusted software will behave upon execution, thereby thwarting any chance the untrusted software could launch and/or institute a weaponized malicious software attack. The present disclosure can apply a light-weight binary rewriting and in-lining system to tame and secure untrusted binary programs. The disclosed systems and methods can also implement binary stirring by imbuing native code of software with the ability to self-randomize its instruction addresses each time it is launched.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: December 1, 2015
    Assignee: The Board of Regents, The University of Texas System
    Inventor: Kevin William Hamlen
  • Modulation of angiogenesis
    Patent number: 9198981
    Abstract: This invention relates to compounds, compositions, and methods for the treatment of traits, diseases and conditions that respond to the modulation of angiogenic growth factor bioavailability or biological activity.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: December 1, 2015
    Assignee: The University of Kentucky
    Inventors: Balamurali Krishna Ambati, Jayakrishna Ambati, Nirbhai Singh
  • Single-axis flexure bearing configurations
    Patent number: 9200689
    Abstract: Flexure bearing systems and configurations guide translational motion along a single-axis in micro and macro applications such as micro-electro-mechanical system (MEMS) devices including sensors and actuators like electrostatic comb-drive actuators. The flexure bearing systems and configurations described herein provide an improved constraint against movement (i.e., stiffness) of the primary mover in non-motion axes such as a bearing axis.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: December 1, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Shorya Awtar, Siddharth Sood, Mohammad Olfatnia
  • Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus
    Patent number: 9198596
    Abstract: Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 1, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventor: Thomas E. Milner
  • Self-repairing cyclic oxide-substituted chitosan polyurethane networks
    Patent number: 9200089
    Abstract: Thermosetting polymeric compositions, such as polyurethane compositions, and related methods are provided. The invention relates to coating and polymer compositions and related methods derived from a biodegradable natural polysaccharide compound such as chitosan, pectin, heparin, and combinations thereof reacted to a cyclic oxide compound, such as an oxetane, oxolane or oxepane compound. The compositions and methods of the present invention exhibit self-repairing properties upon exposure to ultraviolet (UV) light. The compositions and methods of the present invention can be used in many coating applications, such as the transportation, packaging, fashion, and biomedical industries.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: December 1, 2015
    Assignee: The University of Southern Mississippi
    Inventors: Marek W. Urban, Biswajit Ghosh
  • Clusterin antisense therapy for treatment of cancer
    Patent number: 9200285
    Abstract: A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising administering from 40 to 640 mg anti-clusterin antisense oligonucleotide to a patient in need of treatment for a cancer expressing clusterin is provided. The method may include administering chemotherapeutic agent or agents, radiotherapy, and/or hormone ablation therapy. The invention also encompasses pharmaceutical compositions formulated to provide a dosage of 40 to 640 mg, and use of antisense in formulating a medicament.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: December 1, 2015
    Assignee: The University of British Columbia
    Inventors: Martin E. Gleave, Scott D. Cormack
  • Photonic analog-to-digital converter
    Patent number: 9201287
    Abstract: A photonic analog-to-digital converter is provided that includes a tunable light source, an optical sampling clock source, an optical splitter and a plurality of optical signal processing channels. The tunable light source produces an optical signal at a variable wavelength corresponding to analog levels of an electrical input signal. The optical sampling clock source produces an optical sampling clock signal that defines a sequence of sampling periods. The optical splitter is operably coupled to the tunable light source. The optical splitter splits the optical signal produced by the tunable light source for supply to the plurality of optical signal processing channels. Each one of the optical signal processing channels includes a photonic filter and corresponding optoelectronic thyristor comparator that is operably coupled to the optical sampling clock source.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: December 1, 2015
    Assignees: Opel Solar, Inc., The University of Connecticut
    Inventor: Geoff W. Taylor
  • Methods and compositions involving fibrillizing polypeptides for nanofibers
    Patent number: 9200082
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a ?-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 1, 2015
    Assignee: The University of Chicago
    Inventors: Joel Collier, Gregory Hudalla
  • Methods and compositions for targeting sites of neovascular growth
    Patent number: 9198975
    Abstract: Compositions and methods for targeted delivery to and detection of sites of neovascular growth, including tumor vasculature, are provided. Compositions include polypeptides conjugated to or complexed with a bioactive compound, wherein the polypeptide is capable of binding to an OEC or a circulating progenitor thereof. Methods for identifying additional polypeptides with the same binding characteristics are further provided. Methods for targeted delivery of a bioactive compound to a site of neovascular growth are provided in which polypeptides capable of binding OECs or progenitors thereof are conjugated to or complexed with the bioactive compound and administered to a subject in need thereof. Methods for detecting neovascular growth are also provided, wherein the polypeptides conjugated to or complexed with a detectable label are administered to a subject and the label is detected.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: December 1, 2015
    Assignees: The University of North Carolina at Chapel Hill, North Carolina State University
    Inventors: Cam Patterson, Anka N. Veleva
  • Haematopoietic-prostaglandin D2 synthase inhibitors
    Patent number: 9199976
    Abstract: The present invention generally relates to compounds that inhibit haematopoietic-prostaglandin D2 synthase (H-PGDS), to compositions containing them and to their use in treating or preventing conditions and diseases associated with H-PGDS, such as allergies and inflammation.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: December 1, 2015
    Assignee: The University of Queensland
    Inventors: Mark Leslie Smythe, Jack Urquhart Flanagan
  • Adenovirus vaccine vector and methods of use
    Patent number: 9198959
    Abstract: Ad40-based polynucleotides, viral vectors, methods of making such polynucleotides and viral vectors, pharmaceutical compositions that includes such polynucleotides and viral vectors, and uses of such compositions are disclosed herein. Generally, the Ad40-based polynucleotide includes an Ad40-based vector that includes a genetic modification that decreases expression of an E1 coding region and a heterologous polynucleotide.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: December 1, 2015
    Assignee: Regents of The University of Minnesota
    Inventor: Masato Yamamoto
  • Catalysts compositions for use in fuel cells
    Patent number: 9203094
    Abstract: The present invention generally relates to the generation of electrical energy from a solid-state fuel. In one embodiment, the present invention relates to a solid-oxide fuel cell for generating electrical energy from a carbon-based fuel, and to catalysts for use in a solid-oxide fuel cell.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: December 1, 2015
    Assignee: The University of Akron
    Inventor: Steven S. C. Chuang
  • Digital light processing hyperspectral imaging apparatus and method
    Patent number: 9198578
    Abstract: A hyperspectral imaging system having an optical path. The system including an illumination source adapted to output a light beam, the light beam illuminating a target, a dispersing element arranged in the optical path and adapted to separate the light beam into a plurality of wavelengths, a digital micromirror array adapted to tune the plurality of wavelengths into a spectrum, an optical device having a detector and adapted to collect the spectrum reflected from the target and arranged in the optical path and a processor operatively connected to and adapted to control at least one of: the illumination source; the dispersing element; the digital micromirror array; the optical device; and, the detector, the processor further adapted to output a hyperspectral image of the target.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: December 1, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Karel J. Zuzak, Jeffrey A. Cadeddu, Rafael Ufret-Vincenty, Robert P. Francis, Edward Livingston
  • Method for producing differentiated cells
    Patent number: 9200254
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: December 1, 2015
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • One Dimensional Photonic Crystals for Enhanced Fluorescence Based Sensing, Imaging and Assays
    Publication number: 20150338345
    Abstract: Techniques for enhanced fluorescence include a functionalized substrate for a target optical frequency comprising a one dimensional photonic crystal that is functionalized with a bioactive target molecule that has an affinity for a particular analytic. The one dimensional photonic crystal includes a plurality of dielectric layers including a plurality of high index of refraction layers alternating with a plurality of low index of refraction layers. The thickness of each layer is within a factor of four of a wavelength of the optical frequency in the layer. For emissions from a fluorophore bound to the target molecule and excited by incident light, there is an emission intensity maximum centered at an angle independent of the direction of the incident light.
    Type: Application
    Filed: May 21, 2015
    Publication date: November 26, 2015
    Applicant: The University of Maryland, Baltimore
    Inventors: Joseph R. Lakowicz, Ramachandram Badugu
  • Stimulation signal generation device and stimulation signal generation method
    Patent number: 9192768
    Abstract: Implementation including a brain activity data acquisition unit configured to acquire data on brain activity of a human body; a generator configured to generate a stimulation signal based on predetermined stimulation parameters or stimulation parameters determined from the data acquired by the brain activity data acquisition unit, the stimulation signal being to be applied, for activity of a specific brain region to be activated in order to move a joint of the human body, to a nerve corresponding to the specific brain region; and an output unit configured to output the stimulation signal generated by the generator.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: November 24, 2015
    Assignees: The University of Electro-Communications, The University of Tokyo, National University Corporation University of Fukui
    Inventors: Hiroshi Yokoi, Ryu Kato, Tatsuhiro Nakamura, Soichiro Morishita, Osamu Yamamura
  • Method for the preparation of poly(disulfide) polymers and gels
    Patent number: 9193680
    Abstract: High molecular weight disulfide polymers are synthesized in aqueous media by exposing dithiol compounds to a mild oxidizing environment in the presence of a tertiary amine catalyst. The unique oxidizing system polymerizes monomers through the formation of sulfur-sulfur bonds between dithiol compounds. The same oxidizing system may be used to make disulfide-crosslinked gels from compounds containing multiple thiol groups. The oxidizing system is comprised of oxygen at atmospheric concentration and dilute hydrogen peroxide. A filler such as carbon black may be incorporated into the polymer or cross-linked gel during polymerization. A polydisulfide polymer is provided having a weight average molecular weight of greater than about 100,000 g/mol and a polydispersity index of about 2 or less. A tetrathiol composition results from a reaction of a diacrylate with a trithiol.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: November 24, 2015
    Assignee: The University of Akron
    Inventors: Judit E. Puskas, Emily Q. Rosenthall
  • Flow cells for electron microscope imaging with multiple flow streams
    Patent number: 9196457
    Abstract: Provided are flow cell devices—referred to as nanoaquariums—that are microfabricated devices featuring a sample chamber having a controllable height in the range of nanometers to micrometers. The cells are sealed so as to withstand the vacuum environment of an electron microscope without fluid loss. The cells allow for the concurrent flow of multiple sample streams and may be equipped with electrodes, heaters, and thermistors for measurement and other analysis devices.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: November 24, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Joseph M Grogan, Haim H Bau