Patents Assigned to The University
  • TREATMENTS OF OXIDATIVE STRESS CONDITIONS
    Publication number: 20150157686
    Abstract: The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, a subject having pulmonary fibrosis. In some embodiments, an inhibitor of ERp57 (for example, thiomuscimol) and/or an inhibitor of GSTP (for example, TLK-199) may be used to treat the subject. Also provided in certain aspects of the present invention are kits for such therapies, methods for promoting such therapies, and the like.
    Type: Application
    Filed: June 20, 2013
    Publication date: June 11, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Yvonne M. Janssen-Heininger, Vikas Anathy
  • APPARATUS AND METHOD FOR GENERATING SHAPE DATA
    Publication number: 20150161297
    Abstract: A shape data generation apparatus includes a detection unit and a generation unit. With reference to model information indicating the thicknesses and the positions of both ends of a plurality of elements each having a cylindrical surface, the detection unit detects a connection point where two or more elements are connected to each other, on the basis of the positions of both ends of the elements. The generation unit generates a curved surface collectively covering the connecting ends of the two or more elements, on the basis of the thicknesses and the positions of both ends of the two or more elements connected at the connection point.
    Type: Application
    Filed: December 1, 2014
    Publication date: June 11, 2015
    Applicants: FUJITSU LIMITED, The University of Tokyo
    Inventors: Tadashi ATAKA, Masahiro WATANABE, Satoshi FUCHIKAMI, Yoshimasa KADOOKA, Toshiaki HISADA, Seiryo SUGIURA, Takumi WASHIO, Jun-ichi OKADA
  • SOLAR THERMAL CONCENTRATOR AND METHOD OF FORMING SAME
    Publication number: 20150159915
    Abstract: A concentrator tube comprises a reflector portion having two walls; and an aperture closing an opening to the reflector portion. The aperture and the reflector portion extend longitudinally. The aperture is substantially flat relative to curvature of the reflector portion.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 11, 2015
    Applicant: The Regents of The University of California
    Inventors: Roland Winston, Lun Jiang
  • Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse
    Patent number: 9051334
    Abstract: The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: June 9, 2015
    Assignee: The University of Bath
    Inventors: John Lewis, Stephen Husbands
  • Measurement of depth and energy of buried trap states in dielectric films by single electron tunneling force spectroscopy
    Patent number: 9052339
    Abstract: A single electron tunneling force spectroscopy (SETFS) system (10) can perform a series of surface potential charge measurements at an array of voltages (V) and tip-sample heights (Z). These measurements are combined with a tunneling model that includes the dependence of the tunneling probability on trap state depth and energy. Simultaneous measurement of the depth and energy of individual trap states in a sample, such as a dielectric film, with an atomic scale of spatial resolution can be achieved. When combined with two-dimensional trap state imaging, such techniques provide for three-dimensional imaging of electronic defect states with atomic scale spatial resolution.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: June 9, 2015
    Assignee: The University of Utah Research Foundation
    Inventors: Clayton Covey Williams, Jon Paul Johnson
  • Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
    Patent number: 9051551
    Abstract: The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: June 9, 2015
    Assignee: The University of Western Australia
    Inventors: Peter Jeffery Leedman, Keith Michael Giles, Felicity Caris Kalinowski
  • Photolithographically defined contacts to carbon nanostructures
    Patent number: 9053941
    Abstract: Methods for the fabrication of nanostructures, including nanostructures comprised of carbon nanotubes, and the nanostructures, devices, and assemblies prepared by these methods, are described.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: June 9, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ryan A. Jones, Samuel M. Khamis
  • Osmolyte mixture for protein stabilization
    Patent number: 9052323
    Abstract: An osmolyte composition comprising 4 M glycerol and 4M urea for stabilizing previously transient protein folding intermediates as long-lived stable forms. A method to search for other possible stabilizing osmolyte mixtures using a screening array is also provided. These additional osmolyte mixtures may complement or augment the successful 4M glycerol/4 M urea mixture.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: June 9, 2015
    Assignee: The University of Kansas
    Inventors: Mark T. Fisher, Hiroo Katayama
  • Surgical applications for BMP binding protein
    Patent number: 9050300
    Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: June 9, 2015
    Assignees: The Regents of The University of California, The United States of America Represented by The Department of Veterans Affairs
    Inventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
  • NSchelate-targeting ligand conjugates
    Patent number: 9050378
    Abstract: The invention provides, in a general sense, a new labeling strategy employing compounds that are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor angiogenesis targeting ligand, a tumor apoptosis targeting ligand, a disease receptor targeting ligand, amifostine, angiostatin, monoclonal antibody C225, monoclonal antibody CD31, monoclonal antibody CD40, capecitabine, a COX-2 inhibitor, deoxycytidine, fullerene, herceptin, human serum albumin, lactose, leuteinizing hormone, pyridoxal, quinazoline, thalidomide, transferrin, or trimethyl lysine. The present invention also pertains to kits employing the compounds of interest, and methods of assessing the pharmacology of an agent of interest using the present compounds.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: June 9, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: David J. Yang, Dong-Fang Yu, Chang-Sok Oh, Jerry L. Bryant, Jr.
  • Cellular seeding and co-culture of a three dimensional fibroblast construct
    Patent number: 9051550
    Abstract: The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: June 9, 2015
    Assignee: Arizona Board of Regents, on Behalf of The University of Arizona
    Inventors: Jordan Lancaster, Steve Goldman
  • Covalently functionalized particles for synthesis of new composite materials
    Patent number: 9051402
    Abstract: The present invention includes compositions and methods for synthesis of composite materials involving gas phase plasma polymerization to covalently plasma graft an organic molecule onto inorganic particles; covalently binding an organic monomer to the functionalized inorganic particles; and, polymerizing the organic monomers into inorganic/organic hybrid polymer composite materials.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: June 9, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Richard B. Timmons, Dattatray Wavhal, Dhiman Bhattacharyya, Narayan Mukherjee
  • Fluorescent substrate for detection of enzymatic activity of nitrile-related enzyme
    Patent number: 9051597
    Abstract: The object of the invention is to provide a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme and compound represented by formula (I) and a fluorescent substrate for detecting the enzymatic activity of a nitrile-related enzyme, which includes the compound.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: June 9, 2015
    Assignees: Mitsubishi Rayon Co., Ltd., The University of Tokyo
    Inventors: Yasuteru Urano, Tetsuo Nagano, Tomoe Ohta, Fujio Yu
  • Wheelchair attachments
    Patent number: 9050230
    Abstract: Attachments for a manual wheelchair are provided for navigating a wheelchair over obstacles and uneven terrain, such as a typical curb on a street. The attachments provide for regulating the movement of the wheelchair as the wheelchair descends the curb and to prevent the wheelchair from flipping over during such movement. The attachments include a belt support frame, at least two rollers mounted on the belt support frame and a belt mounted around the at least two rollers. The belt support frame is adapted for mounting on the frame of the wheelchair such that as the wheelchair descends from the upper surface to the lower surface, the belt engages an edge of the upper surface and rolls around the at least two rollers slowing a descent of the wheelchair from the upper surface to the lower surface.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: June 9, 2015
    Assignees: Montefiore Medical Center, The University of Hartford
    Inventors: Avital Fast, Devdas Shetty, Moshe Raz, Giora Rothman
  • Method for height control for single electron tunneling force spectroscopy and dynamic tunneling force microscopy
    Patent number: 9052337
    Abstract: Height control systems and/or methods are implemented for dynamic force tunneling microscopy and single electron tunneling force spectroscopy to improve their accuracy.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: June 9, 2015
    Assignee: The University of Utah Research Foundation
    Inventors: Clayton Covey Williams, Jon Paul Johnson
  • DATA SEARCH APPARATUS AND METHOD FOR CONTROLLING THE SAME
    Publication number: 20150154282
    Abstract: A storage section stores positional information and a physical amount for each of a plurality of physical amount set points arranged in a three-dimensional model. A division section generates division data corresponding to each of a plurality of second regions obtained by dividing a first region including the three-dimensional model so as to make the number of physical amount set points included in each second region equal. When a position in the three-dimensional model is designated, a search section acquires from the storage section a physical amount for a physical amount set point corresponding to the designated position of physical amount set points which division data corresponding to a second region, of the plurality of second regions, including the designated position includes.
    Type: Application
    Filed: November 12, 2014
    Publication date: June 4, 2015
    Applicants: FUJITSU LIMITED, The University of Tokyo
    Inventors: Masahiro WATANABE, Satoshi FUCHIKAMI, Yoshimasa KADOOKA, Toshiaki HISADA, Seiryo SUGIURA, Takumi WASHIO, Jun-ichi OKADA
  • METHOD FOR DETERMINING COMPLETE RESPONSE TO ANTICANCER THERAPY
    Publication number: 20150152504
    Abstract: Methods for identifying patients with molecular or complete remission of colorectal cancer following therapy a fluorocytidine derivative and a COX-2 enzyme inhibitor by quantifying CD 133 expression levels. Methods for detecting cancer stem cells by quantifying serum CD 133 RNA levels are also provided.
    Type: Application
    Filed: May 1, 2013
    Publication date: June 4, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventor: Edward H. Lin
  • SUPEROLEOPHOBIC SURFACES AND METHODS OF MAKING SAME
    Publication number: 20150153642
    Abstract: Disclosed herein is a substrate having a surface modified to impart multi-scale roughness, thereby providing superhydrophobic and/or superoleophobic properties. The surface comprises a pattern of microscale pillars topped by a plurality of nanoparticles having a re-entrant convex shape. The area fraction of the surface is also selected to provide the desired superoleophobic properties. Also disclosed herein is a process for creating the modified surface comprising photolithography, optionally followed by vapour deposition. The substrates may be formed into useful articles or applied to pre-formed articles.
    Type: Application
    Filed: June 18, 2013
    Publication date: June 4, 2015
    Applicant: The University of Western Ontario
    Inventors: Jun Yang, Tingjie Li, Maxim Paliy, Xiaolong Wang, Natalie Suhan
  • METHOD AND COMPOSITION FOR DELIVERING A COMPOUND THROUGH A BIOLOGICAL BARRIER
    Publication number: 20150150788
    Abstract: A method for delivering a compound through a biological barrier including applying a force to a plurality of microparticles on a surface of the barrier so that at least some of the microparticles penetrate the biological barrier to facilitate delivery of the compound therethrough.
    Type: Application
    Filed: June 21, 2013
    Publication date: June 4, 2015
    Applicant: The University of Queensland
    Inventors: Tarl W. Prow, H. Peter Soyer
  • COILED AND NON-COILED TWISTED NANOFIBER YARN TORSIONAL AND TENSILE ACTUATORS
    Publication number: 20150152852
    Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional and/or tensile actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize non-coiled or coiled yarns and can be either neat or comprising a guest. Devices comprising these artificial muscles are also described.
    Type: Application
    Filed: January 30, 2015
    Publication date: June 4, 2015
    Applicant: The Board of Regents, The University of Texas System
    Inventors: Na Li, Carter S. Haines, Marcio D. Lima, Monica Jung De Andrade, Shaoli Fang, Jiyoung Oh, Mikhail E. Kozlov, Dongseok Suh, Ray H. Baughman