Abstract: The present invention relates to a method of producing a heterologous polypeptide of interest in a host cell, wherein the method comprises expressing a fusion protein comprising the heterologous polypeptide of interest and a fluorescent fusion partner in a host cell modified to include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein is under control of an RNA thermometer. Also provided are E. coli cells which express the fusion protein and include a nucleic acid encoding a lytic protein operably linked to a promoter, wherein translation of the lytic protein regulated by an RNA thermometer.
Type:
Grant
Filed:
November 16, 2021
Date of Patent:
December 24, 2024
Assignee:
Stellenbosch University
Inventors:
Anton Du Preez van Staden, Carine Smith, Dominic Nicholas, Leon Milner Theodore Dicks, Ross Rayne Vermeulen
Abstract: Disclosed are an artificial intelligence algorithm-based wireless power transmitter, wireless power receiver, and wireless power charging system that are capable of high-speed response to environmental changes and that can optimize the power efficiency of a wireless power receiver, estimate a dynamic location from a signal received from the wireless power receiver using artificial intelligence technology, and dynamically transmit wireless power to a prioritized wireless power receiver according to a power state.
Type:
Grant
Filed:
April 29, 2022
Date of Patent:
December 24, 2024
Assignees:
SKAIChips Co., Ltd., Research & Business Foundation SUNGKYUNKWAN UNIVERSITY
Inventors:
Kang Yoon Lee, Jong Wan Jo, Dong Gyun Kim, Sung Jun Byun, Jae Bin Kim, Joon Mo Yoo, Young Gun Pu, Yeon Jae Jung, Hyung Ki Huh
Abstract: Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.
Type:
Grant
Filed:
June 10, 2022
Date of Patent:
December 24, 2024
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Mark H. Schoenfisch, Mona Jasmine R. Ahonen, Lei Yang, Haibao Jin, Evan Scott Feura, Sara Elizabeth Maloney
Abstract: Disclosed herein is a tricyclic octacationic cyclophane and complexes comprising the tricyclic octacationic cyclophane and a perylene diimide dye complexed therein and methods of using and making the cyclophane and complexes.
Abstract: A zero-watermarking method and device for BIM data, and a medium are provided, which relate to the field of watermarking information security technologies. Aiming at existing zero-watermarking method for the BIM data cannot resist primitive attacks, vertical stability of a model is used to construct a mapping relationship between primitive clusters and watermarking bits, calculate norms of primitives in each primitive cluster of the primitive clusters, take positivity and negativity of norm skewness measurement of the primitives as eigenvalues to construct a binary sequence, and performs an XOR process on the binary sequence and an original watermarking sequence to construct the zero-watermarking for the BIM data. Experimental results indicate that the zero-watermarking method has uniqueness, robustness and security.
Type:
Grant
Filed:
June 4, 2024
Date of Patent:
December 24, 2024
Assignees:
The Third Surveying and Mapping Institute of Hunan Province, Nanjing Normal University
Inventors:
Xingxiang Jiang, Qianwen Zhou, Changqing Zhu, Hua Sun, Luanyun Hu, Sheng Chen, Xi Liu, Tan Chen, Yujing Liu, Na Ren
Abstract: A method of producing polycrystalline Y3Ba5Cu8Oy (Y-358) whereby powders of yttrium (III) oxide, a barium (II) salt, and copper (II) oxide are pelletized, calcined at 850 to 950° C. for 8 to 16 hours, ball milled under controlled conditions, pelletized again and sintered in an oxygen atmosphere at 900 to 1000° C. for up to 72 hours. The polycrystalline Y3Ba5Cu8Oy thus produced is in the form of elongated crystals having an average length of 2 to 10 ?m and an average width of 1 to 2 ?m, and embedded with spherical nanoparticles of yttrium deficient Y3Ba5Cu8Oy having an average diameter of 5 to 20 nm. The spherical nanoparticles are present as agglomerates having flower-like morphology with an average particles size of 30 to 60 nm. The ball milled polycrystalline Y3Ba5Cu8Oy prepared under controlled conditions shows significant enhancement of superconducting and flux pinning properties.
Abstract: The invention relates to an on-chip optical waveguide comprising an input or output facet, the facet comprising an array of unit-cells; each unit cell is a recess that gradually narrows in the direction from the outer of the waveguide towards the interior of the waveguide.
Type:
Grant
Filed:
January 19, 2021
Date of Patent:
December 24, 2024
Assignee:
B.G. Negev Technologies and Applications LTD., at Ben-Gurion University
Abstract: A three-dimensional (3D) magnetic particle imaging (MPI) method and system without rotating a field-free line (FFL) are disclosed. In accordance with the method, an FFL is generated such that magnetic particles in a region far from the FFL enter a magnetic saturation state. Further, a non-uniform mixed-frequency excitation magnetic field parallel to the FFL is applied to generate intermodulation response signals. In addition, the intermodulation response signals are acquired, amplified and filtered. Moreover, the intermodulation response signals are transmitted to a digital signal processing unit and an image reconstruction unit, and an encoding matrix is constructed. Additionally, a one-dimensional (1D) concentration distribution of the magnetic particles is reconstructed based on the encoding matrix and an actually measured voltage signal. The FFL is driven for line-by-line scanning along a vertical plane of the FFL, thereby achieving 3D imaging.
Type:
Grant
Filed:
July 3, 2024
Date of Patent:
December 24, 2024
Assignee:
Beihang University
Inventors:
Jie Tian, Yanjun Liu, Yu An, Guanghui Li
Abstract: Disclosed is a Brillouin-optical coherence-speckle based multi-mode elasticity measurement device, including a Brillouin-optical coherence elastography common-path scanning unit, a Brillouin scattering elastography system, an optical coherence elastography system, a speckle elastography system, and a time sequence controller, where the Brillouin scattering elastography system and the optical coherence elastography system share the Brillouin-optical coherence elastography common-path scanning unit.
Type:
Grant
Filed:
January 11, 2023
Date of Patent:
December 24, 2024
Assignee:
Nanchang Hangkong University
Inventors:
Xingdao He, Jiulin Shi, Yubao Zhang, Zhongqi Hao, Gang Shi, Jin Xu
Abstract: A system and method for matching conformers of different molecule are provided. The methods for matching conformers of different molecule include calculating average electron density (AED) values corresponding to a most electronegative group of the different molecules, and matching conformers of the different molecules based on a common AED.
Abstract: A deep learning fault diagnosis method includes the following steps: a fault diagnosis data set X is processed based on sliding window processing, to obtain a picture-like sample data set {tilde over (X)}, and obtain an attention matrix A of the picture-like sample data set {tilde over (X)}; and a 2D-CNN model is constructed to process the picture-like sample data set {tilde over (X)} to obtain a corresponding feature map F, and in the meantime, the feature map F is processed based on channel-oriented average pooling and channel-oriented maximum pooling to obtain an output P1 of the average pooling and an output P2 of the maximum pooling, and a weight matrix W is obtained based on the attention matrix A, the output P1 of the average pooling, and the output P2 of the maximum pooling, so that an output of the model is a feature map {tilde over (F)} based on an attention mechanism, where {tilde over (F)}=WF.
Abstract: The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed.
Type:
Grant
Filed:
July 3, 2023
Date of Patent:
December 24, 2024
Assignee:
WILLIAM MARSH RICE UNIVERSITY
Inventors:
Jordan Miller, Anderson Ta, Bagrat Grigoryan
Abstract: An intensification mechanism analysis and anthropogenic climate change signal identification method for terrestrial water cycle (TWC) in dry and wet regions, includes: identifying dry regions and wet regions worldwide with observed data; quantifying a precipitation increasing rate; calculating a regional warming rate and a precipitation response warming rate, and investigating a difference between dry regions and wet regions; identifying a fingerprint pattern of a precipitation increase in dry regions and wet regions in response to global warming, and calculating a signal-to-noise ratio (SNR) to quantify a possibility of an anthropogenic climate change signal in dry regions and wet regions; and detecting different external forcing signals in a precipitation change of dry regions and wet regions with an optimal fingerprinting method, and quantifying a contribution of each of the different external forcing signals to the precipitation change.
Type:
Grant
Filed:
April 26, 2024
Date of Patent:
December 24, 2024
Assignee:
CHINA UNIVERSITY OF GEOSCIENCES (WUHAN)
Inventors:
Xihui Gu, Yansong Guan, Lunche Wang, Xiang Zhang, Yanhui Zheng, Jie Gong, Dongdong Kong
Abstract: A method for direct recycling of degraded lithium-ion battery (LIB) cathodes includes relithiating degraded lithium nickel cobalt manganese oxide (NCM) by mixing the cathode particles with a eutectic molten-salt solution and heating the mixture at ambient pressure over a period of time, followed by a short-time thermal annealing. Combining low-temperature relithiation using the eutectic molten-salt solution with thermal annealing provides successful regeneration and full recovery of the LIB to its original storage capacity, cycling stability and rate capability to the levels of the pristine materials. The method is useful to recycle and remanufacture degraded cathode materials for LIB or sodium-ion batteries.
Type:
Grant
Filed:
March 11, 2020
Date of Patent:
December 24, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: An 3-(4,5-bis(4-bromophenyl)-2-(4-chlorophenyl)-1H-imidazol-1-yl)propanoic acid compound, its synthesis, and its use as an antimicrobial agent.
Type:
Grant
Filed:
January 29, 2024
Date of Patent:
December 24, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
Abstract: This invention presents a projection embedded discrete fracture model integrating a TPFA and MFD hybrid approach, creating a pEDFM framework for various anisotropic two-phase flow situations. It specifies the distribution of extra pressure freedoms on matrix grids for MFD implementation, maintains f-f connections in TPFA through a standard pEDFM workflow, and introduces a low-conductivity fracture treatment for MFD. It also outlines the derivation of numerical flux calculation formulas for effective m-m and m-f connections. The mixed TPFA-MFD design applies to numerical flux estimation across both K-orthogonal and non-K-orthogonal grids, enhancing computational efficiency and facilitating the spatial discretization of continuity equations for matrix and fracture grids under anisotropic permeability conditions.
Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of a TLR agonist and a chimeric CD154 polypeptide. Also provided herein are methods of enhanced immune function.
Type:
Grant
Filed:
April 11, 2018
Date of Patent:
December 24, 2024
Assignees:
MEMGEN, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Willem Overwijk, Manisha Singh, Patrick Hwu, Mark Cantwell
Abstract: Provided is a fuel cell catalyst composition comprising a C12A7:X? inorganic material having a structure in which oxygen anions of C12A7 are replaced by halogen (X) anions, or comprising a C12A7:X?-based inorganic material which is a C12A7:X? partially converted to electride. A fuel cell comprising the fuel cell catalyst composition in a catalyst layer is also provided. Also provided is a method of producing a fuel cell catalyst composition, comprising a step of heat-treating C12A7:X? at temperature of 1000-1300° C. for at least 20 hours under a nitrogen atmosphere.