Abstract: This shape data generation method include: setting an input shape that has a simple shape that has a same topology as the target shape for a target shape that is a shape of a transformation target identified from image data; identifying first vertices that satisfy a predetermined condition including a first condition that a normal line of a certain vertex of the plural vertices crosses with the target shape, among plural vertices of the input shape; transforming the input shape so that a first vertex is moved in a direction of a normal line of the first vertex by a first distance that is shorter than a distance up to the target shape; and performing the identifying and the transforming a predetermined number of times while changing the input shape after the transforming as the input shape to be processed.

Abstract: A shape data generation method includes: generating a target shape of transformation from plural tomographic images of an object; specifying, from among plural vertices of a first shape that is a reference shape of the object, plural first vertices, each first vertex of which satisfies a condition that a normal line of the first vertex passes through a point that is located on the target shape and is located on a boundary of the object in any one of the plural tomographic images; identifying, for each of the plural first vertices, a second vertex that internally divides a segment between the first vertex and the point; transforming the first shape so as to put each of the plural first vertices on a corresponding second vertex; setting a shape after the transforming to the first shape; and executing the first specifying and the subsequent processings a predetermined number of times.

Abstract: The present invention relates to the new use of the compound 3-(1?-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran for the treatment of diseases or conditions that are associated with ?-amyloid induced toxicity, such as Alzheimer's disease.

Abstract: An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each mRNA contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition.

Abstract: A particle-polymer hybrid material can include: a substance having the structure of Formula 1 Z(Y-FP)m, wherein Z is a particle smaller than 1 mm; m is an integer; Y is a linker including a silicon atom linked to the particle; FP is a functionalized polymer having: a first structure derived from a first norbornene compound linked to the Y; and one or more repeating units linked to the first structure, each unit being derived from a second norbornene compound and having a functional group.

Abstract: The present invention relates to a method and assay useful for determining the sensitivity of the cells of a subject to genetic damage from electromagnetic radiation. The assay may comprise a substrate suitable for mounting a sample of lymphocytes from a subject and an electromagnetic radiation source.

Abstract: A system for wireless power transmission may include one or more charging panels and one or more powered devices. The charging panel may include a pilot analysis circuitry, processor and power transmitter. The pilot analysis circuitry may be configured to analyze the magnitude and phase of a pilot signal from the powered device, based on which the processor may be configured to determine a complex conjugate of the pilot signal. And the power transmitter may be configured to cause radiation of a focused wireless power beam to the powered device in accordance with the complex conjugate of the pilot signal and via one or more antenna elements. The charging panel may be one of a plurality of spatially-distributed charging panels each of which includes respective antenna elements that may form an array of antenna elements configured to collaboratively radiate wireless power as a distributed, retro-reflective beamformer.

Abstract: Apparatus and methods are provided for the management of neural activity in an individual. Nerve activity is sensed and correlated with sensations such as pain. In response and without requiring input from the individual, although external input is contemplated, a signal is transmitted to another component for electrical stimulation that alters neural activity. Also, the modulation of the signals between the sensor and stimulator may be modified by a third component independently, independent of, or including user inputs.

Abstract: Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both.

Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

Abstract: The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.

Abstract: Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists are provided for improving the cognition of a Down syndrome patient.

Abstract: The present invention provides an isolated population of chondrocyte precursor cells wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60, 7% or less of the cells express no collagen II, collagen X, CD105 or Stro-1 and 85% or more of the cells express CBFA1, methods for preparing such cells and uses of chondrocyte cells derived from said precursor cells.

Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression, and uses of the nucleic acid molecule for screening compounds for xenobiotic induction of CYP3A4 expression in cells and animals.

Abstract: A liquid scintillator detector for three-dimensional dosimetric measurement of a radiation beam is provided wherein a volumetric phantom liquid scintillator is exposed to the radiation beam to produce light that is captured by the cameras that provide a three-dimensional image of the beam.

Abstract: Methods for treating and/or preventing skin ulcers are provided featuring administration of pharmaceutical compositions comprising inhibitors of activity or expression Of Lp-PLA2 protein to patients subject to or at risk of developing skin ulcers.

Abstract: The present invention uses digital subcarrier cross-connect switching to accomplish various network processes more efficiently. These processes include interconnecting network components, and performing optical and optoelectronic add/drop operations.

Abstract: The subject invention provides novel soluble PD-1 (sPD-1) proteins, nucleic acids, and fusion constructs thereof, for enhancing humoral and cell-mediated immunity of a subject. Also provided are therapeutic compositions comprising the sPD-1 proteins, nucleic acids, and fusion constructs of the subject invention. In a preferred embodiment, the therapeutic composition is formulated as a vaccine composition. Advantageously, the sPD-1 proteins, nucleic acids, and therapeutic compositions provide protective immunity against pathogenic infection including HIV infection. In addition, the subject invention can be used in the prevention and/or treatment of tumor or cancer.

Abstract: The invention relates to methods, devices, systems and uses of such systems for the generation and detection of electromagnetic fields carrying orbital angular momentum. An electromagnetic wave placed in a resonator having a closed-loop waveguide supporting a guided wave propagating at resonance with angular order, p, and with an angular grating patterned in the closed-loop waveguide, the angular grating having a integer number, q, of grating elements. The angular grating selectively couples the guided wave mode to a free space radiation mode having an OAM quantity, l, and out-of-plane wave vector component, krad,z, and wherein significant coupling to the grating occurs only when the following wave matching condition is satisfied: l=p?mq where: m is the diffraction order of the angular grating, m=1, 2, 3, . . . ,.

Abstract: Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3?UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation.