Abstract: Functional nanoparticles may be formed using at least one nano-lithography step. In one embodiment, sacrificial material may be patterned on a multi-layer substrate using an imprint lithography system. The pattern may be further etched into the multi-layer substrate. Functional material may then be deposited on multi-layer substrate and solidified. At least a portion of the functional material may then be removed to provide a crown surface exposing pillars. Pillars may be removed from multi-layer substrate forming functional nanoparticles.

Abstract: A method is provided for identifying documents that include a searchable form relevant to a topic. A document is received. If the received document comprises a form is determined. A form includes a field presented to a user requesting information from the user. If the received document is determined to comprise a form, a determination is made concerning whether or not the form is a searchable form. A searchable form returns non-trivial information to a requester in response to a submission of the form. If the form is determined to be a searchable form, a determination is made concerning whether or not the form is relevant to an identified topic. If the form is determined to be relevant to the identified topic, the document is identified as a searchable form relevant to the identified topic.

Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

Abstract: A real-time method for controlling a system, the system including a plurality of controlling means each having at least one variable parameter (q) and a controlled element having a trajectory which is controlled by the controlling means, wherein the trajectory is related to the variable parameters by a variable matrix, the method comprising defining a control transfer matrix (K) relating the variable parameters dq to the trajectory dx, and using a feedback loop in which a feedback term is computed that is dependent on an error (e) which is the difference between the desired trajectory (dxd) which can have an arbitrary dimension specified as (m) and a current trajectory (dx).

Abstract: An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.

Abstract: A system is provided for use in brachytherapy where a central tube permits passage of a radioactive source therethrough to deliver a prescribed dosage of radiation. One or more balloons are coaxially positioned around the central tube. At least one balloon includes one or more peripheral tubes extending along at least a portion of the balloon. The peripheral tube is also attached to the high dose rate brachytherapy unit in order to permit passage of a radioactive source therethrough.

Abstract: An optoelectronic semiconductor component includes a semiconductor layer sequence having at least one active layer, and a photonic crystal that couples radiation having a peak wavelength out of or into the semiconductor layer sequence, wherein the photonic crystal is at a distance from the active layer and formed by superimposition of at least two lattices having mutually different reciprocal lattice constants normalized to the peak wavelength.

Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Use of the composition in methods of reducing triglycerides or reducing C-reactive protein levels are also provided.

Abstract: An apparatus and method for mineralising demineralised and hypo-mineralised biological material such as tooth or bone. The apparatus has a probe electrode for receiving a mineralisation agent and a counter electrode. It is also provided with a controller to control the electrical signal provided to the probe such that the extent of mineralisation of the biological material is controlled by modulating or changing the electrical signal provided by the probe based upon the measured output of the circuit formed from the probe, counter electrode and biological material. The electrical output provides a measure of the extent of mineralisation of the biological material which is compared with data from a reference technique which gives 3D structural information on an area of interest in the biological material.

Abstract: Disclosed are sheaths that comprise a first sheath member having a first passageway, a first length, and a first proximal end defined by a first valve apparatus configured to seal the first passageway, the first passageway having a first passageway diameter at a location in the first passageway; and a second sheath member coupled to the first sheath member, the second sheath member having a second passageway and a second length, the second passageway having a second passageway diameter at a location in the second passageway; where the first passageway and the second passageway are separate from each other and not co-axial, the first length is different from the second length, and the first and second sheath members are positioned beside each other for a portion of their first and second lengths.

Abstract: A pulse generator is disclosed. The pulse generator can include an ac source for providing an ac signal. A pulsed switch can be connected to an ac output of the ac source that is adapted or configured to generate a pulsed output from the ac signal and a non-linear frequency multiplier adapted or configured to shorten the pulses of the pulsed output. The pulsed switch can include a mixer.

Abstract: Systems and methods for determining one or more attributes and their associated values for a user, by mining the user's social network profiles. The systems and methods determine if the value of an attribute of interest for a user is specified on one or more social networking websites. If so, the systems and methods set the attribute value for the user to the specified attribute value. If not, the systems and methods retrieve, from the social networking websites, attribute values for the attribute of interest for friends of the user to form a group of possible attribute values for the user. The method, selects a value from the group of possible attribute values, and then sets the selected value as the attribute value for the user.

Abstract: The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.

Abstract: The present invention describes a system for controlling a thin flexible thermoplastic catheter. The system includes a plurality of shape memory alloy filaments attached to the distal end of the catheter, each filament having a phase and a temperature; a means for receiving a strain value for at least one of the filaments; a means for determining the phase change that will results in the strain value, whereby the phase change is dependent on the temperature and the temperature is dependent on a voltage; and a means for setting the voltage in each filament thereby resulting in movement of the catheter. In addition, a three-degrees of freedom force sensor measures the magnitude and direction of the force exerted on the tip of the catheter. The catheter can be autonomously guided or it can be interfaced to a haptic device. The catheter can also be fitted with microtools.

Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

Abstract: Binary Offset Carrier (BOC) is the agreed modulation for signals of next generation Global Navigation satellite systems (GNSS). Compared to current phase shift keying (PSK) modulation by a code, there is a further modulation by a sub-carrier. There is a known major difficulty with BOC called ‘false lock’ where early/late gates settle on the wrong peak of the multi-peaked correlation function. This invention eliminates the problem by eliminating that correlation. Instead, a two dimensional correlation is tracked independently to realize a dual estimate. An unambiguous lower accuracy estimate derived from the code phase is used to make an integer correction to a higher accuracy but ambiguous independent estimate based on the sub-carrier phase. The actual receiver may adopt a triple loop, instead of the usual double loop, where carrier phase, sub-carrier phase and code phase are tracked independently but interactively.

Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

Abstract: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.

Abstract: A behavior analysis device has an object extraction portion that processes a frame image of an imaging area being imaged by an imaging device and extracts an object being imaged, a position detection portion that detects a position in the imaging area, for each object extracted by the object extraction portion, a posture estimation portion that estimates an posture of the object, for each object extracted by the object extraction portion, and a behavior determination portion that determines a behavior of the object, for each object extracted by the object extraction portion, based on the position in the imaging area that is detected by the position detection portion and the posture estimated by the posture estimation portion.

Abstract: The present invention relates to compounds that are useful as metal ligands and which contain a moiety capable of binding to a biological entity and methods of making these compounds. These compounds are of interest as they can be bound to a biological entity and then coordinated with a suitable metallic radionuclide. The coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging.