Patents Assigned to Thermo Finnigan LLC
  • Patent number: 12007359
    Abstract: Adjusting compensation voltage (CV) parameters of an ion mobility device is described. In one instance, the CV parameters are adjusted to reflect a different CV range, a number of CV steps, or a CV step size to increase throughput of a mass spectrometer.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: June 11, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Bennett S. Kalafut, Dhruva D. Kulkarni, Satendra Prasad, Michael W. Belford
  • Patent number: 12002669
    Abstract: A method comprises: obtaining, from a series of mass spectra including a most recent mass spectrum and a plurality of previously-acquired mass spectra, an elution profile comprising a plurality of detection points each representing intensity of ions accumulated over an accumulation time and detected by a detector as a function of time; classifying, based on a subset of detection points included in the plurality of detection points, a current signal state of the elution profile; and setting, for a next acquisition of a mass spectrum, the accumulation time based on the classified current signal state of the elution profile.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: June 4, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Jesse D. Canterbury
  • Patent number: 11988652
    Abstract: Packed-tip electrospray ionization (ESI) emitters for mass spectrometry are described. In one aspect an ESI emitter stores a first type of particle. A liquid chromatography (LC) column is coupled with the emitter via a junction. The LC column stores a different type of particle than the ESI emitter to facilitate better chromatographic and ESI performance.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: May 21, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Dale Lindseth, Gary A. Schultz, Eloy R. Wouters, Michael L. Poltash, Brandon Howard Robson
  • Patent number: 11988635
    Abstract: An ion mobility analyser is disclosed having a gas flow directed along the ion travel axis and a set of electrodes to which DC voltages are applied to establish a DC field. The opposing forces of the gas flow and DC field cause ions to be trapped within a separation region in axial regions determined by their ion mobilities. A gas recirculator, having inlet and outlet ends respectively located downstream and upstream of the separation region, supplies at least fifty percent of the gas flow within the separation region, thereby reducing vacuum pumping requirements.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: May 21, 2024
    Assignees: Thermo Finnigan LLC, Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Mikhail V. Ugarov, Vladimir Gurevich, Pablo Nieto Ramos, Alexander A. Makarov
  • Patent number: 11990330
    Abstract: An ion separation apparatus comprises: (a) first and second ion carpets, each comprising: a substrate having first and second faces; and a set of electrodes disposed on or beneath the first face, wherein a configuration of a first plurality of the set of electrodes defines at least one group of circle sectors; (b) an ion exit aperture passing through one ion carpet; and (c) one or more power supplies configured to provide radio frequency voltages to a first subset of the electrodes of each ion carpet, to provide electrical potential differences across electrodes of the first subset of electrodes of each ion carpet, and to provide time-varying voltages to the first plurality of electrodes of each ion carpet that migrate through the sectors as a traveling wave, wherein the ion carpets are disposed parallel to one another with a gap therebetween, the first faces facing one another across the gap.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: May 21, 2024
    Assignee: Thermo Finnigan LLC
    Inventor: Michael W. Senko
  • Patent number: 11984307
    Abstract: A mass spectrometer support apparatus includes a peak shape logic to determine one or more peak shapes using a calibration mass spectrum and known peak locations; and a tuning logic to adjust instrument parameters to achieve a selected peak width. A method for tuning a quadrupole-based mass spectrometer includes determining one or more peak shapes using a calibration mass spectrum and known peak locations; and adjusting instrument parameters to achieve a selected peak width.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: May 14, 2024
    Assignee: Thermo Finnigan LLC
    Inventor: Johnathan W. Smith
  • Patent number: 11982654
    Abstract: Determining a level of a liquid in a container is described. In one aspect, a container includes a calibrant liquid used for calibrating a mass spectrometer. A conductive layer is placed to float upon the calibrant liquid, and a circuit board with electrodes is arranged around the container. A controller circuit then drives and measures various electrodes to first identify which two electrodes the level of the calibrant liquid is between, and then subsequently identify a more precise location for the level between the two electrodes.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: May 14, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Raman Mathur, Thi Le, David E. Minkler
  • Publication number: 20240153751
    Abstract: A method of performing mass spectrometry includes obtaining, based on a series of mass spectra of detected ions derived from components eluting from a chromatography column, a plurality of extracted ion chromatograms (XICs), each XIC comprising a plurality of detection points representing detected intensity for a distinct selected m/z as a function of time; detecting, based on the series of mass spectra, precursor ions of each distinct selected m/z of the plurality of XICs; and determining, for each XIC based on a set of detection points of the XIC, a predicted next detection point to be obtained based on a next mass spectrum to be acquired.
    Type: Application
    Filed: January 15, 2024
    Publication date: May 9, 2024
    Applicant: Thermo Finnigan LLC
    Inventors: Philip M. REMES, Jesse D. CANTERBURY
  • Patent number: 11942315
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.
    Type: Grant
    Filed: March 3, 2022
    Date of Patent: March 26, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
  • Patent number: 11933770
    Abstract: A Liquid Chromatography Mass Spectrometry system comprises: a chromatograph; a mass spectrometer configured to ionize separated fractions of a sample received from the chromatograph; and a programmable processor operable to repeatedly execute the steps of: (i) causing the mass spectrometer to perform a data-independent analysis of the precursor ion species using a mass analyzer of the mass spectrometer; (ii) calculating one or more degree-of-matching scores that relate to detection of an internal standard; and (iii) if each of the degree-of-matching scores meets a respective degree-of-matching condition, performing a quantitative tandem mass spectrometric analyses of both the internal standard and the analyte; the programmable processor further operable to calculate a quantity of the analyte in the sample by comparison between intensities of one or more mass spectral signals generated by the quantitative tandem mass spectrometric analyses of the analyte and the internal standard.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: March 19, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, David A. Sarracino, Sebastien F. Gallien
  • Patent number: 11908670
    Abstract: A method of performing mass spectrometry includes accessing a series of mass spectra of detected ions derived from components eluting from a chromatography column; obtaining, based on the series of mass spectra, an elution profile including a plurality of detection points representing intensity of at least a set of the detected ions as a function of time; and determining, based on a set of detection points included in the plurality of detection points, a predicted next detection point of the elution profile to be obtained based on a next mass spectrum to be acquired subsequent to acquisition of the series of mass spectra.
    Type: Grant
    Filed: May 16, 2022
    Date of Patent: February 20, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Jesse D. Canterbury
  • Patent number: 11906408
    Abstract: A method for preparing a protein-containing sample for analysis by mass spectrometry includes introducing the sample into a reaction vessel. The reaction vessel contains a reagent mixture including pre-measured quantities of an immobilized proteolytic enzyme, a reducing agent and an alkylating agent. The contents of the reaction vessel are activated by heating or by sonication.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: February 20, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Daniel Lopez Ferrer, Aaron M. Robitaille, Michael O. Krawitzky, Greg A. Foster
  • Patent number: 11892433
    Abstract: An electrospray ionization system used in mass spectrometry provides for improved current measurement. The system includes a fluid union, a fluid column coupled with a first port of the fluid union, a power source coupled with the fluid union and configured to apply a voltage potential to the fluid union, and an electrospray emitter coupled with a second port of the fluid union. The power source is coupled with the first port and configured to apply the voltage potential to the first port to restrict current leakage from the fluid union. The current sensing circuit is configured to determine an electrical current flow between the power source and the at least one of the fluid union and the first port.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: February 6, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Dale Lindseth, Joshua A. Silveira, Michael L. Poltash, Eloy R. Wouters, David E. Minkler
  • Patent number: 11879897
    Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, the elapsed search time can be monitored. If the elapsed search time of the identification of the candidate peptide is completed before reaching a maximum value, then the mass spectrometer can perform further actions.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: January 23, 2024
    Assignee: Thermo Finnigan LLC
    Inventor: Derek J. Bailey
  • Patent number: 11875981
    Abstract: A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: January 16, 2024
    Assignee: THERMO FINNIGAN LLC
    Inventors: Michael W. Senko, Philip M. Remes
  • Patent number: 11854777
    Abstract: A metal-channel conversion dynode comprises: a wafer comprising a first face and a second face parallel to the first face and having a thickness less than 1000 ?m; and a plurality of channels passing through the wafer from the first face to the second face at an angle to a plane of the first face and a plane of the second face. In some embodiments, each inter-channel distance may be substantially the same as the wafer thickness. In some embodiments, the wafer is fabricated from tungsten. In some other embodiments, the wafer comprises a non-electrically conductive material that is fabricated by three-dimensional (3D) printing or other means and that is coated, on its faces and within its channels, with a metal or suitably conductive coating that produces secondary electrons upon impact by either positive or negative ions.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: December 26, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Oleg Silivra, Alan E. Schoen, Johnathan W. Smith, Berg A. Tehlirian
  • Patent number: 11841352
    Abstract: Methods are described for the automatic determination and correction of retention time shift of a MS data set relative to a control data set, to correct for retention time drifts endemic to targeted LCMS analyses. In an embodiment, a 2D grid of periodic MS spectra versus time is collected for a control experiment, and RT windows are determined with an additional set of unscheduled mass spectral analyses. During successive experiments, spectra from periodic MS scans are used to determine the correspondence between the current time and the time in the control experiment. The active set of MSn scans to be acquired by the instrument is then determined as the scans with adjusted retention time windows that bracket the corrected retention time.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: December 12, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Ping F. Yip
  • Patent number: 11837451
    Abstract: A method for cleaning an electrospray emitter of a mass spectrometer comprises the steps of: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude, |V|, of a voltage applied between a counter electrode and the electrospray emitter; and (b) changing the mode of operation of the electrospray emitter from the dripping mode or the pulsating mode of operation to the stable jet mode of operation by increasing the magnitude, |V|, of the applied voltage; wherein the repetitions are performed at a predetermined frequency that depends on one or more of liquid flow rate, an emitter internal diameter, and liquid properties.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: December 5, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Publication number: 20230369036
    Abstract: A method of performing mass spectrometry includes accessing a series of mass spectra of detected ions derived from components eluting from a chromatography column; obtaining, based on the series of mass spectra, an elution profile including a plurality of detection points representing intensity of at least a set of the detected ions as a function of time; and determining, based on a set of detection points included in the plurality of detection points, a predicted next detection point of the elution profile to be obtained based on a next mass spectrum to be acquired subsequent to acquisition of the series of mass spectra.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 16, 2023
    Applicant: Thermo Finnigan LLC
    Inventors: Philip M. REMES, Jesse D. CANTERBURY
  • Patent number: 11810773
    Abstract: A mass spectrometry method comprises: introducing a first packet of ions into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the introducing of the first packet, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; introducing a second packet of ions into the mass analyzer through the set of lenses, wherein, during the introducing of the second packet, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: November 7, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Jesse D. Canterbury, Michael W. Senko