Patents Assigned to Thermo Finnigan LLC
  • Patent number: 10903064
    Abstract: A method of performing mass spectrometric analyses, comprises: (a) passing a stream of ions through a quadrupole mass analyzer; (b) intercepting a flux of ions emitted from an exit aperture of the quadrupole mass analyzer at a front face of a stack of multichannel plates and emitting a flux of electrons in response to the intercepted flux of ions at a rear face of the stack of multichannel plates; (c) intercepting the flux of electrons at a front surface of a scintillator comprising a phosphorescent material and emitting a flux of photons in response to the intercepted flux of ions at a rear surface of the scintillator; (d) receiving the flux of photons at a photo-imager; and (e) repositioning at least one of the scintillator and the stack of microchannel plates during the execution of one or more of the steps (a) through (d).
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: January 26, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventor: Tsung-Chi Chen
  • Patent number: 10895578
    Abstract: A method includes applying distinct isobaric tags to each of a plurality of samples; combining the samples; performing a separation of species within the combined samples; isolating and fragmenting labeled parent ions within a m/z range to produce a plurality of reporter ions, each reporter ion corresponding to one of the isobaric tags; determining intensities of the plurality of reporter ions and ions representative of a parent species at a plurality of points along a peak; and fitting the intensity of the ions representative of a parent species and the plurality of reporter ions at the plurality of points to obtain a relative abundance of the parent species in each of the plurality of samples.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 19, 2021
    Assignee: THERMO FINNIGAN LLC
    Inventor: Michael W. Senko
  • Patent number: 10886118
    Abstract: A magnet assembly for an ion source comprising a first magnet of a first magnet type; a second magnet of a second magnet type; a heat shield located between the first magnet and the second magnet; and a heat sink coupled to the heat shield; wherein the first magnet type having a higher Curie temperature than the second magnet type.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: January 5, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Deven L. Shinholt
  • Patent number: 10878944
    Abstract: A method for generating a searchable small-molecule tandem mass spectrometry library comprises: (a) generating, by theoretical calculation and for each of a plurality of small-molecule compounds, a list of ion species, including fragment-ion species that are predicted, by the theoretical calculations, to be generated by tandem mass spectrometry (MSn) analyses, where n?2; (b) comparing at least a subset of the predicted ion species to entries in a database that includes a list of experimentally observed ion species; (c) matching a predicted mass-to-charge ratio (m/z) value of each of one or more of the predicted fragment-ion species to a respective experimentally measured m/z value of an experimentally observed fragment-ion species for which information is tabulated in the database; and (d) updating the predicted list of ion species based on information derived from the matched predicted and experimentally measured m/z values.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: December 29, 2020
    Assignees: Thermo Finnigan LLC, HighChem Ltd.
    Inventors: Ralf Tautenhahn, Timothy J. Stratton, Robert Mistrik
  • Publication number: 20200378983
    Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, the elapsed search time can be monitored. If the elapsed search time of the identification of the candidate peptide is completed before reaching a maximum value, then the mass spectrometer can perform further actions.
    Type: Application
    Filed: May 30, 2019
    Publication date: December 3, 2020
    Applicant: Thermo Finnigan LLC
    Inventor: Derek J. Bailey
  • Publication number: 20200381231
    Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, a candidate peptide score representing a confidence of a match between the product ion spectrum and a theoretical mass spectrum stored in the mass spectral database is generated. A failing score can be promoted to a passing result based on attributes of the candidate peptide.
    Type: Application
    Filed: May 30, 2019
    Publication date: December 3, 2020
    Applicant: Thermo Finnigan LLC
    Inventor: Derek J. Bailey
  • Patent number: 10832897
    Abstract: A method of analyzing a sample, the method includes separating precursor ions from the sample into narrow mass range groups based on mass-to-charge ratio; fragmenting the ions from each group to create groups of fragment ions; and mass analyzing fragment ions from each group of fragment ions using a long transient time mass analyzer, wherein the separation and fragmentation are decoupled from the mass analyzing and the cycle time of the high transient mass analyzer is greater than about five times longer than the cycle time of a narrow mass range scan time, and wherein the separation and fragmentation has a high duty cycle and the mass analyzing has a high duty cycle.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 10, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: Viatcheslav V. Kovtoun
  • Patent number: 10823714
    Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: November 3, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Scott T. Quarmby
  • Patent number: 10802003
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: October 13, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: James M. Hitchcock, George B. Guckenberger
  • Patent number: 10804088
    Abstract: A mass spectrometry method comprises: generating ions; directing the ions through an ion optical component within a first chamber having a first vacuum pressure, the ion optical component maintained at a first electrical potential; transferring the ions through an ion guide within a second chamber having a second vacuum pressure less than the first vacuum pressure, the ion guide maintained at a second electrical potential, wherein a difference between the first and second potentials imparts kinetic energy that causes collision-induced ion fragmentation within the second chamber that removes adduct species; and transferring the ions into another ion guide within a third chamber having a third vacuum pressure less than the second vacuum pressure, the other ion guide maintained at a third electrical potential, wherein a difference between the third and second potentials reduces a portion of the imparted kinetic energy of the ions passing into the third chamber.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: October 13, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Michael P. Goodwin, Michael W. Senko, Graeme C. McAlister
  • Patent number: 10784093
    Abstract: A system and method for processing long scan data from a mass spectrometer is described. The long scan data is broken into multiple discrete subsets and each of the multiple subsets are padded by adding additional strings of data on either end of the subset. Each of the multiple subsets is deconvolved and overhang errors are corrected for on each deconvolved subset. A deconvolved full data set is then assembled from the deconvolved subsets.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: September 22, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: Ping F. Yip
  • Patent number: 10784095
    Abstract: A mass spectrometer is described that includes a multipole configured to pass an ion stream, the ion stream comprising an abundance of one or more ion species within stability boundaries defined by (a, q) values. A detector formed by a plurality of dynodes is configured to detect the spatial and temporal properties of the abundance of ions, where each dynode arranged such that it is struck by ions in a known spatial relationship with the ion stream. The detector also includes a plurality of charged particle detectors, each associated with one or more of the plurality of dynodes. A processing system is configured to record and store a pattern of detection of ions in the abundance of ions by the dynodes in the detector.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: September 22, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby
  • Patent number: 10755914
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10753915
    Abstract: A method for analyzing and quantifying a panel of drugs in a clinical sample comprises: trapping a first portion of drug parent compounds and their metabolites on a first chromatographic column; trapping a second portion of the drug parent compounds and their metabolites on a second chromatographic column; separately eluting the first and second portions of the drug parent compounds and their metabolites from the first and second chromatographic columns; detecting concentrations of each of the drug parent compounds and metabolites eluted from each of the first and second chromatographic columns with a detector; and summing the detected concentration of each drug parent compound together with the detected concentrations of all of its respective analytes so as to derive a respective total concentration of each drug in the sample.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Joseph Herman, Sarah J. Fair, Dayana Argoti
  • Patent number: 10748756
    Abstract: A system comprises an electrostatic trapping mass analyzer and an information processor configured to receive a transient signal from the electrostatic trapping mass analyzer at a maximum resolution, the information processor comprising instructions operable to: partition the transient signal into segments and, while a quality metric is either less than a pre-determined minimum threshold or greater than a pre-determined maximum threshold value, to perform the steps of: (i) defining a test transient as being equal to either a first one of the segments or a previously defined transient with an appended signal segment; (ii) generating a spectrum of component frequencies by calculating a mathematical transform of the test transient; and (iii) determining the quality metric from the spectrum of component frequencies; and set an instrumental resolution to be employed for subsequent mass spectral data acquisitions in accordance with a length of the most-recently-defined test transient.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: August 18, 2020
    Assignee: Thermo Finnigan LLC
    Inventor: Thomas D. McClure
  • Patent number: 10748752
    Abstract: A method is disclosed for analyzing ions by mass spectrometry by repeatedly executing a data acquisition cycle to acquire product ion data across a precursor mass range of interest. The data acquisition cycle comprises performing, for each of a plurality of isolation windows having different mass ranges, steps of (i) isolating precursor ions within the mass range of the isolation window, (ii) fragmenting the isolated precursor ions to generate product ions, and (iii) mass analyzing the product ions. The step of mass analyzing the product ions includes concurrently mass analyzing product ions corresponding to N isolation windows, N being an integer greater than or equal to one, wherein N is changed at least once across the data acquisition cycle.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: August 18, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: James S. Chang
  • Patent number: 10718745
    Abstract: A system for analyzing a sample includes a chromatographic device, an electrospray source, and a mass resolving device. The chromatographic device is configured to separate components of the sample as a function of retention time within a chromatographic column. The electrospray source is configured to direct a first portion of a flow from the chromatographic device via a waste outlet to a pressurized waste reservoir, direct a second portion of the flow to an electrospray ionization outlet to form a spray, and charge and desolvate the spray to form ions of the components of the sample. A flow rate of the second portion of the liquid flow is substantially determined by a pressure of the pressurized waste reservoir. The mass resolving device configured to receive the ions and characterize the mass-to-charge ratio of the ions.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 21, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Gary A. Schultz, R. Paul Atherton, Eloy R. Wouters
  • Patent number: 10679841
    Abstract: A method of operating a quadrupole mass filter is disclosed. A first set of RF and resolving DC voltages are applied to electrodes of a quadrupole mass filter to selectively transmit first ions having a first mass-to-charge ratio (m/z). A second set of RF and resolving DC voltages are applied to electrodes of the quadrupole mass filter to selectively transmit second ions having a second m/z. Detection of the second ions is initiated after completion of a settling time. The settling time is determined in accordance with the relationship: Eq. 1, where ts is the settling time, (m/z)1 is the first mass-to-charge ratio, (m/z)2 is the second mass-to-charge ratio and A, B and C are empirically derived coefficients.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: June 9, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Harald Oser, Qingyu Song, Mikhail V. Ugarov
  • Patent number: 10672597
    Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: June 2, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Edward B. McCauley, Scott T. Quarmby
  • Patent number: 10663430
    Abstract: A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separator configured to separate ions received from the source based on the mobility in a gas; a plurality of ion channels arranged adjacent to the plurality of exit apertures of the mobility separator such that ions from the mobility separator are directed to different channels according to their respective mobility; a mass analyzer configured to determine the mass-to-charge ratio of the ions; and a controller. The controller is configured to identify retention time windows with minimum overlap of ions with similar mobility and sets of ions within the retention time windows; adjust mobility separation parameters for specific sets of ions to optimize separation of compounds; and quantify a plurality of target analytes.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: May 26, 2020
    Assignee: Thermo Finnigan LLC
    Inventor: Mikhail V. Ugarov