Patents Assigned to Thermo Finnigan LLC
  • Patent number: 11469088
    Abstract: A signal processing assembly for a detector includes a signal amplifier, a control unit, and an offset control module. The signal amplifier is configured to receive an input signal from the detector assembly and to provide an output signal. The control unit is configured to compare a first data point from the output signal with a signal range, and to generate an input bias control signal based upon the comparison. The offset control module is coupled with the control unit and configured to receive the input bias control signal. The offset control module includes a power supply operatively coupled with an input of the signal amplifier, and the offset control module is configured to generate and apply an adaptive input offset signal at the input of the signal amplifier based upon the input bias control signal.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: October 11, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Hongxuan Zhang, Scott T. Quarmby
  • Patent number: 11456166
    Abstract: Control of an amplitude of a signal applied to a component of a mass spectrometer is described. In one aspect, a mass spectrometer includes a component and a resonant circuit to generate a radio frequency (RF) signal applied to the component. An amplitude control circuit can be inductively coupled with inductors of the resonant circuit to selectively discharge energy from the resonant circuit and, therefore, adjust the amplitude of the signal in particular situations.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: September 27, 2022
    Assignee: Thermo Finnigan LLC
    Inventor: Johnathan Wayne Smith
  • Patent number: 11454617
    Abstract: An exemplary chromatographic alignment system accesses a target file including data representative of a plurality of chromatographic features detected from a first sample and a reference file including data representative of a plurality of chromatographic features detected from a second sample. The system identifies, based on the target and reference files, a distinct retention time offset value for each chromatographic feature included in a first subset of the plurality of chromatographic features detected from the first sample. The system determines, based on the identified distinct retention time offset values for the chromatographic features included in the first subset and on a machine learning model, a distinct predicted retention time offset value for each chromatographic feature included in a second subset of the plurality of chromatographic features detected from the first sample.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: September 27, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Iman Mohtashemi, Matthew Kump
  • Patent number: 11450520
    Abstract: Apparatus and methods for performing charge detection mass spectrometry are disclosed. An analyte ion is injected into an electrostatic trap, which has electrodes shaped and arranged to establish a trapping field that causes the analyte ion to undergo harmonic motion along a longitudinal axis. A time-varying signal is generated by a detector representative of the harmonic motion. A data system processes the time-varying signal to derive the frequency of ion motion and the amplitude at the harmonic motion frequency, and determines the mass-to-charge ratio (m/z) of the ion based on the derived frequency and the charge from the derived amplitude. The product of the experimentally determined m/z and charge yields the mass of the analyte ion. The electrodes preferably include an elongated inner electrode surrounded by an outer electrode, forming an orbital or non-orbital electrostatic trap.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 20, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Michael W. Senko, Jesse D. Canterbury
  • Publication number: 20220268797
    Abstract: An autosampler for sampling liquids is disclosed. The autosampler may comprise a holder for holding at least one vial, a syringe for withdrawing a liquid sample from the at least one vial, an actuator for actuating the syringe, a housing for accommodating the syringe and the actuator, and a magnifying lens attached to the housing to facilitate visual inspection of the syringe during use. The magnifying lens may be accommodated in a door of the housing, behind or integrated in a transparent section of the door. The autosampler may be used in conjunction with a chromatograph, such as a gas chromatograph, a liquid chromatograph, or an ion chromatograph.
    Type: Application
    Filed: February 24, 2021
    Publication date: August 25, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventors: George B. GUCKENBERGER, Giuliano ANTONINI, Riccardo FACCHETTI
  • Patent number: 11393666
    Abstract: A system comprises: first and second mass spectrometers; at least one liquid chromatograph configured to simultaneously supply a first stream of chromatographic eluate derived from a sample to the first mass spectrometer and a second stream of chromatographic eluate to the second mass spectrometer; and a computer or electronic controller electronically coupled to both of the first and second mass spectrometers and comprising computer-readable instructions operable to: input a mass spectrometric analysis of a chromatographic fraction of the sample obtained by the first mass spectrometer; determine whether an additional mass spectrometric analysis of the chromatographic fraction of the sample is required, based on the mass spectrometric analysis of the chromatographic fraction obtained by the first mass spectrometer; and, if the determination is affirmative, cause the second mass spectrometer to perform, after a time delay, the additional mass spectrometric analysis of the chromatographic fraction of the sample
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: July 19, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventor: Bennett S. Kalafut
  • Publication number: 20220213880
    Abstract: A method comprises: heating a flow of coolant liquid by passing the flow through one or more fluidic tubing lines, channels or conduits that are in thermal contact with a housing of a vacuum pump; apportioning the flow of heated coolant liquid between a bypass fluid tubing line and a channel within a wall of a vacuum chamber; recombining the first and second partial flows of the heated coolant liquid; passing the recombined flow of the coolant liquid through a heat exchanger that cools the coolant liquid; and recirculating the cooled coolant liquid through the one or more fluidic tubing lines, channels or conduits that are in thermal contact with the vacuum pump housing, wherein the apportionment of the flow of the heated coolant liquid is automatically performed under the control of an electronic controller or computer in response to a temperature measurement received by the electronic controller or computer.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Applicant: Thermo Finnigan LLC
    Inventors: Jaime A. CARRERA, Dustin J. KREFT
  • Patent number: 11380531
    Abstract: A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 5, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Michael W. Senko, Philip M. Remes
  • Publication number: 20220199392
    Abstract: An ion separation apparatus comprises: (a) first and second ion carpets, each comprising: a substrate having first and second faces; and a set of electrodes disposed on or beneath the first face, wherein a configuration of a first plurality of the set of electrodes defines at least one group of circle sectors; (b) an ion exit aperture passing through one ion carpet; and (c) one or more power supplies configured to provide radio frequency voltages to a first subset of the electrodes of each ion carpet, to provide electrical potential differences across electrodes of the first subset of electrodes of each ion carpet, and to provide time-varying voltages to the first plurality of electrodes of each ion carpet that migrate through the sectors as a traveling wave, wherein the ion carpets are disposed parallel to one another with a gap therebetween, the first faces facing one another across the gap.
    Type: Application
    Filed: December 1, 2021
    Publication date: June 23, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventor: Michael W. SENKO
  • Publication number: 20220181131
    Abstract: A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions.
    Type: Application
    Filed: November 30, 2021
    Publication date: June 9, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventors: Johnathan W. SMITH, Scott T. QUARMBY
  • Patent number: 11346824
    Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: May 31, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Scott T. Quarmby
  • Patent number: 11336290
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole based on an amplifier RF input signal. An analog-to-digital converter (ADC) can generate a digital representation of the RF signal. A controller circuit can receive the digital representation and adjust an amplitude of the amplifier RF input signal based on differences between an amplitude of a fundamental frequency of the RF signal being different than an expected amplitude.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: May 17, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
  • Publication number: 20220122827
    Abstract: A signal processing assembly for a detector includes a signal amplifier, a control unit, and an offset control module. The signal amplifier is configured to receive an input signal from the detector assembly and to provide an output signal. The control unit is configured to compare a first data point from the output signal with a signal range, and to generate an input bias control signal based upon the comparison. The offset control module is coupled with the control unit and configured to receive the input bias control signal. The offset control module includes a power supply operatively coupled with an input of the signal amplifier, and the offset control module is configured to generate and apply an adaptive input offset signal at the input of the signal amplifier based upon the input bias control signal.
    Type: Application
    Filed: October 19, 2020
    Publication date: April 21, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventors: Hongxuan ZHANG, Scott T. QUARMBY
  • Patent number: 11293898
    Abstract: Using ion mobility separation to improve a duty cycle of a mass spectrometer is described. In one aspect, a mass spectrometer can use an ion-mobility spectrometer to allow for more multiply-charged ions to transmit through than singly-charged ions. This results in a mass analyzer to perform a mass analysis with more multiply-charged ions.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: April 5, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Satendra Prasad, Eloy R. Wouters, Jean-Jacques Dunyach
  • Patent number: 11293422
    Abstract: A system comprises: a vacuum chamber disposed within a housing and having a vacuum port; a vacuum pump within the housing and having a gas inlet port that is fluidically coupled to the vacuum port; and a fluid circuit that comprises: one or more fluidic tubing lines, channels or conduits in thermal contact with a housing of the vacuum pump; a liquid pump fluidically coupled to an inlet of the one or more fluidic tubing lines, channels or conduits; and a heat exchanger having a heat exchanger inlet and a heat exchanger outlet, wherein the heat exchanger inlet is fluidically coupled to an outlet of the one or more fluidic tubing lines, channels or conduits and the heat exchanger outlet is fluidically coupled to the liquid pump. The fluid circuit may also include a portion that is in thermal contact with the vacuum chamber.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: April 5, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Jaime A. Carrera, Dustin J. Kreft
  • Patent number: 11282685
    Abstract: A tuning system may acquire, from a mass spectrometer during a batch of one or more analytical runs performed with the mass spectrometer, tune data associated with an operating characteristic of the mass spectrometer. The tuning system may determine, based on the tune data, a value of an operating parameter configured to adjust the operating characteristic of the mass spectrometer and set the operating parameter to the determined value.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: March 22, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, Giacinto Zilioli, Charles H. Vogt, Dustin J. Kreft, Nathaniel L. Sanders, George B. Guckenberger, John G. Voss
  • Patent number: 11270874
    Abstract: Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: March 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby, Dustin J. Kreft, Michael W. Senko
  • Publication number: 20220065828
    Abstract: A connector for a gas chromatography (GC) column includes a receiving portion coupled to a ferrule receiving conical surface and a column holding portion. The column holding portion includes a column guide tube and a column retention spring to fix the axial position of the column and a compression spring to bias the column guide tube towards the ferrule receiving conical surface. When connected, a ferrule is compressed between the ferrule receiving conical surface and the column guide tube.
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Applicant: THERMO FINNIGAN LLC
    Inventors: Adam Durgin BRYANT, Riccardo FACCHETTI
  • Patent number: 11262334
    Abstract: A liquid chromatography monitoring system comprises a computer or electronic controller comprising computer-readable instructions operable to: (a) draw a fluid into a syringe pump; (b) configure a valve so as to fluidically couple the pump to either a fluidic pathway through a fluidic system or to a plug that prevents fluid flow; (c) cause the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determine a profile of the variation of the measured pressure; (e) compare the determined profile to an expected profile that depends upon the fluid; and (f) provide a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: March 1, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventors: Tao Song, John E. Brann, Joseph John Takarewski, Jr., Eric A. France
  • Patent number: 11255828
    Abstract: A device for a gas chromatograph (GC) system includes an injector connected to an inlet gas line and a conduit assembly. The inlet gas line is configured to pressurize an input end of a column and to deliver a split or purge flow. The conduit assembly includes a conduit surrounding the input end of the analytical column and coupled to a carrier gas line and a controller. The inlet gas line and the carrier gas line connect to a common gas source. The controller, connected to the conduit, has a first mode delivering a flow of carrier gas which is less than the column flow during an injection period to effect a sample transfer to the column and a second mode delivering a flow of carrier gas greater than the column flow following an injection period to prevent the split or purge flow from entering the column.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: February 22, 2022
    Assignee: THERMO FINNIGAN LLC
    Inventor: Edward B. McCauley