Patents Assigned to Thermo Finnigan LLC
  • Patent number: 11837451
    Abstract: A method for cleaning an electrospray emitter of a mass spectrometer comprises the steps of: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude, |V|, of a voltage applied between a counter electrode and the electrospray emitter; and (b) changing the mode of operation of the electrospray emitter from the dripping mode or the pulsating mode of operation to the stable jet mode of operation by increasing the magnitude, |V|, of the applied voltage; wherein the repetitions are performed at a predetermined frequency that depends on one or more of liquid flow rate, an emitter internal diameter, and liquid properties.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: December 5, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua A. Silveira, Michael L. Poltash, Wei Wei, Eloy R. Wouters
  • Publication number: 20230369036
    Abstract: A method of performing mass spectrometry includes accessing a series of mass spectra of detected ions derived from components eluting from a chromatography column; obtaining, based on the series of mass spectra, an elution profile including a plurality of detection points representing intensity of at least a set of the detected ions as a function of time; and determining, based on a set of detection points included in the plurality of detection points, a predicted next detection point of the elution profile to be obtained based on a next mass spectrum to be acquired subsequent to acquisition of the series of mass spectra.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 16, 2023
    Applicant: Thermo Finnigan LLC
    Inventors: Philip M. REMES, Jesse D. CANTERBURY
  • Patent number: 11810773
    Abstract: A mass spectrometry method comprises: introducing a first packet of ions into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the introducing of the first packet, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; introducing a second packet of ions into the mass analyzer through the set of lenses, wherein, during the introducing of the second packet, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: November 7, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Jesse D. Canterbury, Michael W. Senko
  • Publication number: 20230352287
    Abstract: Disclosed herein are systems and methods for a mass spectrometer having a multipole configured to pass an ion stream, and a detector configured to detect the properties of the abundance of ions represented by data points. The mass spectrometer also includes a processing system that is configured to obtain a plurality of paired data points (e.g., detector data points and RF amplitude data points), and identify, based on centroiding a portion of the plurality of paired data points, at least one characteristic of a peak and determine, based on the at least one characteristic of the peak, a preferred peak shape.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 2, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventor: Johnathan W. SMITH
  • Patent number: 11802856
    Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: October 31, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Joshua T. Maze, Scott T. Quarmby
  • Publication number: 20230338649
    Abstract: Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes evaluation logic to identify a first syringe has a bent needle, a bent plunger, a blocked needle, or a stuck plunger; syringe logic to switch from the first syringe to a second syringe; and reporting logic to notify a user of a syringe problem.
    Type: Application
    Filed: April 25, 2022
    Publication date: October 26, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventors: Xin ZHENG, Deven L. SHINHOLT
  • Patent number: 11791144
    Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: October 17, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Bennett S. Kalafut, Joshua A. Silveira, Abhishek Joshi, Eloy R. Wouters
  • Publication number: 20230314372
    Abstract: A system for analyzing a sample includes a source configured to generate ions from constituent components of the sample; a mobility separator configured to separate ions received from the source based on the mobility in a gas; a ion storage array configured to store ions from the mobility separator as a plurality of mobility fractions; a mass filter configured to select ions within a mass-to-charge window; a mass analyzer configured to determine the mass-to-charge ratio of the ions; and a controller. The controller is configured to identify an ion mobility fraction and a mass-to-charge window to select for a charge state or ion class; utilize the mass filter to select ions from the ion storage array within the mass-to-charge window corresponding to a charge state or ion class; and analyze the selected ions with the mass analyzer.
    Type: Application
    Filed: April 5, 2022
    Publication date: October 5, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventor: Mikhail V. UGAROV
  • Patent number: 11769655
    Abstract: A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The targeted MS3 analysis is performed during an acquisition segment scheduled based on an expected retention time of the isobaric tag-labeled target analyte. The method further includes performing, during the acquisition segment, a plurality of MS2 analyses of product ions derived from components included in the multiplex sample and eluting from the column. The method further includes determining, based on MS3 mass spectra acquired by the targeted MS3 analysis and MS2 mass spectra acquired by the plurality of MS2 analyses, a relative quantity of the isobaric tag-labeled target analyte in the multiplex sample.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Philip M. Remes
  • Patent number: 11767938
    Abstract: A compression fitting includes a nut with a threaded end for receiving a threaded tube and a receiving end for holding a plunger head; and a plunger with an inner bore for receiving a capillary tube and the plunger head for engaging a ferrule positioned within the receiving end between the plunger head and the threaded tube, the plunger slidingly engaged with the nut to force the ferrule from the nut.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: September 26, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: George B. Guckenberger, Adam D. Bryant
  • Patent number: 11754062
    Abstract: A method comprises: heating a flow of coolant liquid by passing the flow through one or more fluidic tubing lines, channels or conduits that are in thermal contact with a housing of a vacuum pump; apportioning the flow of heated coolant liquid between a bypass fluid tubing line and a channel within a wall of a vacuum chamber; recombining the first and second partial flows of the heated coolant liquid; passing the recombined flow of the coolant liquid through a heat exchanger that cools the coolant liquid; and recirculating the cooled coolant liquid through the one or more fluidic tubing lines, channels or conduits that are in thermal contact with the vacuum pump housing, wherein the apportionment of the flow of the heated coolant liquid is automatically performed under the control of an electronic controller or computer in response to a temperature measurement received by the electronic controller or computer.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: September 12, 2023
    Assignee: THERMO FINNIGAN LLC
    Inventors: Jaime A. Carrera, Dustin J. Kreft
  • Patent number: 11756780
    Abstract: A first multipole assembly includes a first plurality of rod electrodes arranged about an axis and configured to confine ions radially about the axis. A second multipole assembly disposed adjacent to the first multipole assembly includes a second plurality of rod electrodes arranged about the axis and configured to confine the ions radially about the axis. An orientation of the first multipole assembly about the axis is rotationally offset relative to an orientation of the second multipole assembly about the axis.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: September 12, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Harald Oser, Raman Mathur
  • Patent number: 11749519
    Abstract: A space-time buffer includes a plurality of discrete trapping regions and a controller. The plurality of discrete trapping regions is configured to trap ions as individual trapping regions or as combinations of trapping regions. The controller is configured to combine at least a portion of the plurality of trapping regions into a larger trap region; fill the larger trap region with a plurality of ions; split the larger trap region into individual trapping regions each containing a portion of the plurality of ions; and eject ions from the trapping regions.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: September 5, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, Michael W. Senko
  • Patent number: 11728153
    Abstract: A multipole ion guide includes a plurality of electrodes disposed about a longitudinal axis of the device so as to define an ion transmission volume for transmitting ions along a length of the device between opposite inlet and outlet ends. An electronic controller is operably connected to an RF power source and to at least some of the electrodes and is configured to apply at least an RF potential to the electrodes. During use the electrodes generate an RF-only field along a first portion of the device and an axial DC field along a second portion of the device. Ions are focused radially inward toward the longitudinal axis of the device by the RF-only field within the first portion of the device prior to and/or subsequent to experiencing the axial DC field within the second portion of the device.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 15, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Paul I. Hendricks, Harald Oser
  • Patent number: 11721538
    Abstract: A method includes obtaining a first mass spectrum; selecting a first peak of the first mass spectrum; isolating precursor ions in an isolation window including the first peak; fragmenting and analyzing the isolated ions to obtain a second mass spectrum; performing a real-time search of the second mass spectrum for both the target precursor and near isobaric precursors ions that are co-isolated with the target precursor in an isolation window; adding the precursor ions that produced an identification during the real-time search to the exclusion list; selecting a second peak present in the first mass spectrum and not on the exclusion list; and fragmenting and analyzing ions of the second peak to obtain a third mass spectrum.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: August 8, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Graeme C. McAlister
  • Publication number: 20230230823
    Abstract: A mass spectrometer support apparatus includes a deconvolution logic and a centroider logic. The deconvolution logic is configured to deconvolve a mass spectrum measured by a mass spectrometer using an approximate peak shape. The centroider logic is configured to integrate the deconvolved spectrum and populate a sparse vector of peak locations.
    Type: Application
    Filed: January 18, 2022
    Publication date: July 20, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventor: Johnathan W. SMITH
  • Publication number: 20230230824
    Abstract: A mass spectrometer support apparatus includes a peak shape logic to determine one or more peak shapes using a calibration mass spectrum and known peak locations; and a tuning logic to adjust instrument parameters to achieve a selected peak width. A method for tuning a quadrupole-based mass spectrometer includes determining one or more peak shapes using a calibration mass spectrum and known peak locations; and adjusting instrument parameters to achieve a selected peak width.
    Type: Application
    Filed: January 18, 2022
    Publication date: July 20, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventor: Johnathan W. SMITH
  • Publication number: 20230187192
    Abstract: A method of data-independent mass spectrometric analysis of compounds of a compound class of interest comprises: determining or retrieving a distribution, over a mass-to-charge (m/z) ratio range of interest, of a number of primary ion species of members of said compound class having m/z ratios within each respective one of a plurality of m/z sub-ranges of the m/z ratio range of interest; defining m/z positions of a set consisting of a number, nsb, of finite-width bins, within the m/z ratio range of interest, the set of bins excluding m/z sub-ranges within the m/z ratio range of interest that encompass fewer than a threshold number, tsb, of the primary ion species, wherein the defining based on the determined or received distribution; and performing a plurality of tandem mass analyses, each tandem mass analysis pertaining to primary ion species within a respective one of the defined bins.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 15, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventor: Philip M. REMES
  • Publication number: 20230178349
    Abstract: A method comprises: obtaining, from a series of mass spectra including a most recent mass spectrum and a plurality of previously-acquired mass spectra, an elution profile comprising a plurality of detection points each representing intensity of ions accumulated over an accumulation time and detected by a detector as a function of time; classifying, based on a subset of detection points included in the plurality of detection points, a current signal state of the elution profile; and setting, for a next acquisition of a mass spectrum, the accumulation time based on the classified current signal state of the elution profile.
    Type: Application
    Filed: February 1, 2023
    Publication date: June 8, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventors: Philip M. REMES, Jesse D. CANTERBURY
  • Publication number: 20230178356
    Abstract: A mass spectrometry method comprises: introducing a first packet of ions into an electrostatic trap mass analyzer through a set of electrostatic lenses, wherein, during the introducing of the first packet, either the lenses are operated in a first mode of operation or an injection voltage of a first pre-determined magnitude is applied to an electrode of the mass analyzer; mass analyzing the first ion packet using the mass analyzer; introducing a second packet of ions into the mass analyzer through the set of lenses, wherein, during the introducing of the second packet, either the lenses are operated in a second mode of operation or an injection voltage of a second pre-determined magnitude is applied to the electrode of the mass analyzer; and mass analyzing the second packet of ions using the electrostatic trap mass analyzer.
    Type: Application
    Filed: January 24, 2023
    Publication date: June 8, 2023
    Applicant: THERMO FINNIGAN LLC
    Inventors: Jesse D. CANTERBURY, Michael W. SENKO