Abstract: The present disclosure is directed to method of treating water/wastewater using a plasmon-enhanced catalytic ozonation process. Water/wastewater often contains numerous pollutants, some of which are particularly difficult and inefficient to remove and require energy-intensive treatment such as advanced oxidation processes. The present plasmonic metal nanostructured catalyst is configured to interact with electromagnetic radiation through excitation of localized surface plasmon resonance, leading to accelerated ozone decomposition and reactive species generation. The reactive species oxidizes water pollutants, resulting in a water treatment process that avoids excessive energy input and creation of toxic byproducts. In an exemplary application of the plasmon-enhanced catalytic ozonation process, the atrazine degradation rate is increased compared to conventional ozonation and catalytic ozonation processes, owing to the plasmonic effects of Ag in the plasmonic metal nanostructured catalyst.

Abstract: A green-engineered mulch product and methods for making same are disclosed. The mulch product includes a coating of aluminum-based water treatment residuals which makes the product “green.” Furthermore, coating aluminum-based water treatment residuals on mulch eliminates the problem of the low hydraulic conductivity of aluminum-based water treatment residuals and makes it feasible to utilize its pollutant removal potential without requiring any modification to existing best management practices or additional maintenance.

Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Abstract: Systemic lupus erythematosus (SLE) can be diagnosed by affixing a plurality of light sources and a plurality of light detectors against the subject's body near a joint, and sequentially transmitting light from each of the plurality of light sources into the subject's body. Signals are acquired from each of the plurality of light detectors. The rise time of the acquired signals that occurs in response to an inflation of a pressure cuff is determined, and an indication of whether the joint is affected by SLE is made based on the determined rise time. In some embodiments, a plateau time of the acquired signals is also acquired, and the indication of whether the joint is affected by SLE is made based on the determined rise time and the determined plateau time.

Abstract: A device includes a pair of substrate layer corresponding to a carrier substrate, an intermediary layer disposed on the pair of substrate layers, a cavity region disposed between the pair of substrate layers underneath the intermediary layer, a piezoelectric layer including a lithium-based film disposed on the intermediary layer, and a plurality of interdigital transducer electrodes disposed on the piezoelectric layer. The plurality of interdigital transducer electrodes includes an outer signal electrode, an inner signal electrode, an outer ground electrode and an inner ground electrode.

Abstract: A digital-to-analog converter that outputs an analog value representing a digital value includes a decoding stage and an interpolation stage. The decoding stage defines upper and lower bounds and the interpolation stage outputs an interpolated value that is between the upper and lower bounds. The upper and lower bounds are based on a most-significant portion of the digital value. The interpolation stage selects the interpolated value based on the least-significant portion of the digital value.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.

Abstract: An apparatus includes a printed circuit board (PCB), a power component disposed on the PCB, the power component to generate heat, and a multilayered coating disposed over the power component and at least a portion of the PCB to dissipate heat from the power component, the multilayered including: an electrical insulation layer comprising a non-polar compound and disposed on the power component and the at least a portion of the PCB; a chromium layer disposed on the electrical insulation layer; and a copper layer disposed on the chromium layer that is at least 10 microns (?m) thick, the copper layer conformally adhered to a top of the power component and to the PCB.

Abstract: Compositions and methods for treating aggregation-associated diseases are disclosed. In particular, compositions comprising the nascent polypeptide-associated complex (NAC) and the apical domain of CCT1 as well as peptide fragments thereof and fusion proteins containing NAC and CCT1 peptides can be used to suppress pathological protein aggregation and are useful for treatment of diseases associated with polyQ aggregation, amyloid beta aggregation, and alpha-synuclein aggregation.

Abstract: Technology is provided for controlling the motion of soft growing robots during retraction to prevent uncontrollable buckling or bending. A double walled flexible tubular robot is provided with an inside wall, an outside wall, and a folded tip. A retraction device located at the folded tip has a routing aperture sized to encompass the inside wall and for routing the inside wall through the retraction device. The retraction device further has a retraction mechanism inside the retraction device to controllably retract material of the inside wall through the routing aperture in the direction away from the folded tip, thereby decreasing the outside wall, creating more inside wall, and as such shortening the length of the flexible robot. This technology enables behaviors, such as (1) growing in one direction, and then retracting and growing in a different direction, and (2) retracting through a confined space without applying force to the environment.

Abstract: Dynamic windows with adjustable tint give users greater control over flow of light and heat. Reversible metal electrodeposition dynamic windows include (i) a transparent or translucent conductive electrode; (ii) an electrolyte solution in contact with the electrode, the electrolyte solution comprising metal cations that are reversibly electrodeposited onto the transparent electrode upon application of a cathodic potential; and (iii) a counter electrode. The electrolyte solution advantageously includes a small amount of an additive (e.g., an inhibitor, an accelerator, a leveler, or an organic or inorganic molecule that similarly serves to enhance the surface morphology of the metal cations during reversible metal electrodeposition onto the transparent electrode). Such enhancement of surface morphology during the reversible electrodeposition of the metal tinting layer over the electrode enhances one or more of color neutrality, transmittance characteristics of visible wavelengths (e.g.

Abstract: SNAIL provides cost-efficient detection of specific nucleic acids in single cells, and may be combined with flow cytometry to simultaneously analyze large numbers of cells for a plurality of nucleic acids, e.g. at least one, to up to 5, up to 10, up to 15, up to 20 or more transcripts can be simultaneously analyzed, at a rate of up to about 50, 100, 250, 500 or more cells/second. The methods require only two primers for amplification, and may further include a detection primer.

Abstract: Methods and systems for detecting cell states in a biological sample are disclosed. Methods and systems for predicting a therapeutic response, a severe immune-related adverse event (irAE), a symptomatic irAE, and an irAE grade of a subject to be administered an immunotherapy treatment based on cell states detected from a single biological sample from the subject are also disclosed.

Abstract: Disclosed is a method for forming selenoneine or analogs thereof. The method may include phosphorylating sodium selenide to a selenophosphate, using adenosine triphosphate (ATP) and at least a first protein, generating a selenosugar by converting the selenophosphate using at least a second protein in the presence of a common sugar donor, and forming selenoneine or an analog thereof by combining the selenosugar with N,N,N-trimethyl-L-histidine or analogs thereof using at least a third protein. The method may include combining SenA, SenB, and SenC in an aqueous buffer at neutral pH and ambient temperature, and allowing SenA, SenB, and SenC to form selenoneine or an analog thereof in the presence of ATP, a common sugar donor, and sodium selenide.

Abstract: The present invention relates to compositions and methods comprising a retinoic acid receptor inhibitor, a retinoic X receptor inhibitor or an inhibitor of an enzyme in the retinoic acid biosynthesis pathway for treatment of a patient having a solid tumor. In some embodiments, the solid tumor is a sarcoma.

Abstract: Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.

Abstract: Provided are metal-air scavenger systems that use metal surfaces to harvest energy for powering microelectronic devices; such devices can be attached to exposed metal surfaces and then generate power by electrochemically oxidizing the metal surface. The disclosed devices can be configured to effect relative motion between the device and the metal, thus allowing the device to utilize an entire metal surface to generate power and also allowing the device to feed metal to itself to generate power.

Abstract: In one aspect of the invention, a microcapsule includes a film encapsulating a material. The film is formed by complexation of at least two mutually attractive components initially present in an aqueous dispersion comprising a continuous phase and a dispersed phase. The at least one first component is initially present in the continuous phase and the at least one second component is initially present in the dispersed phase. According to another aspect of the invention, provided is a process for forming microcapsules including the step of injecting a dispersed phase having at least a first component into a continuous phase having at least a second component, where the first component and the second component are mutually attractive, such that a film is formed by complexation of the first charged component and the second charged component.

Abstract: In some embodiments, the present disclosure provides methods including the steps of (i) providing silk fibroin material comprising substantially amorphous structure, and (ii) applying at least one of elevated temperature and elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material. In some embodiments, the present disclosure also provides silk fibroin articles made in accordance with the methods disclosed herein.

Abstract: A novel method and a related system are configured to place measured trajectories into a voxel space, which moves with respect to a particle detector system. The trajectories are measured in a detector reference frame. The voxel space, typically fixed with respect to the object being imaged, is tracked optically with markers and a camera system. A decipherable correlation is established between a set of markers and a set of detector elements. This correlation provides coordinate transformation definitions to place the trajectories into the voxel space in medical imaging, treatment planning, and/or therapeutic applications. The novel method provides a clever process to register an optical tracking system with a particle detector system, which improves quality assurance, accuracy, speed, and operating cost efficiencies of ion, particle, and/or radiation-based imaging, treatment planning, or therapies. This novel method may be utilized in proton imaging, helium imaging, other ion-based imaging, or x-ray imaging.