Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.

Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.

Abstract: An acoustic biometric touch scanner device and method is disclosed. In one aspect, an acoustic fingerprint sensing device includes an array of ultrasonic transducers configured to transmit an ultrasound signal having a frequency in a range from 50 megahertz (MHz) to 500 MHz. The acoustic fingerprint ultrasonic transducers include a piezoelectric film. The acoustic fingerprint sensing device further includes a receiving surface configured to receive a finger. The acoustic fingerprint sensing device further includes a processor configured to generate an image of at least a portion of a fingerprint of the finger based on a reflection of the ultrasound signal from the finger.

Abstract: Containers including internal mixers and actuators assemblies and related methods are generally described. In some embodiments, a container may include a mixer and an actuator, at least one of which may be located inside of the container. The actuator may actuate the mixer to induce flow within the container and mix the contents of the container with a low volumetric footprint and high mixing efficiency. In some embodiments, the actuator may be configured to deform the mixer, which may include one or more features which may be deformed out of plane in a Kirigami or Origami fashion. The actuator and mixer may be arranged in series or in parallel. The actuator may be used without a mixer to induce flow within the container. The actuator may be driven pneumatically, hydraulically, electrically, and/or in any other suitable manner.

Abstract: Aspects of the disclosure relate to methods and compositions useful for treating retinitis pigmentosa. In some aspects, the disclosure provides compositions and methods for delivering an interfering RNA to a subject in order to reduce expression of one or both alleles of an endogenous RHO gene (for example a mutant rho allele associated with retinitis pigmentosa) in a subject. In some embodiments, a replacement RHO coding sequence that is resistant to the interfering RNA also is delivered to the subject.

Abstract: In one aspect, the disclosure relates to multiplexable, non-nuclease CRISPR editors comprising RNA aptamer sequences configured to bind to endogenous effector molecules. The disclosed CRISPR editors are small in size and can be delivered by a single adeno-associated virus capsid. Also disclosed are a method for intracellular evolution of aptamers, a method for introducing a genomic modifying event to a host cell using the disclosed CRISPR editors, and a host cell modified by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an engineered nucleic acid sequence encoding an anti-Her2 antibody (i.e., trastuzumab) comprising heavy chain and light chain operably linked to regulatory control sequences which direct expression of trastuzumab in a target cell, and an AAV 3? ITR. Also provided are a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, nucleic acid molecule, packaging host cells, rAAV production system, and a method of treating HER2-positive metastatic cancer in the brain, optionally a metastatic breast cancer in the brain.

Abstract: Systems and methods are provided for simultaneous beamforming at two close frequency bands. Rotman-lens-based beamforming modules with low size, weight, and power (SWaP) can be used. A stacked array Rotman lens module can use a low cost feeding type of layer-to-layer energy transitions, and the stacked module can be capable of simultaneous beamforming at two close frequency bands.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract: Segmentation or other classification of digital pathology images with a deep learning model allows for sophisticated spatial features for cancer diagnosis to be extracted in an automated, fast, and accurate manner. A tiered analysis of tissue structure based in part on deep learning methods is provided. First, tissues depicted in a digital pathology image are segmented into cellular compartments (e.g., epithelial and stromal compartments). Second, the heterogeneity in the different cellular compartments are examined based on a clustering algorithm. Tissue can then be characterized in terms of inertia (or other spatial measures or features), which can be used to recognize disease. In some instances, multidimensional inertia (i.e., inertia computed in different cellular compartments or clustered components) can be used as an indicator of disease and its outcome.

Abstract: A rice cultivar designated Taurus is disclosed herein. The present invention provides seeds, plants, and plant parts derived from rice cultivar Taurus. Further, it provides methods for producing a rice plant by crossing Taurus with itself or another rice variety. The invention also encompasses any rice seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into Taurus through the introduction of a transgene or by breeding Taurus with another rice cultivar.

Abstract: Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided.

Abstract: A speaker verification system includes an ultrasonic microphone generating electrical sound signal from an audio signal corresponding to both ultrasonic frequency sound and sub-ultrasonic frequency sound. A liveness detection module generates a high frequency energy distribution based on the electrical sound signal. The liveness module generates a verification result based on the high frequency energy distribution. A speaker verification module verifies the audio signal based on the high frequency energy distribution signals and a neural network architecture.

Abstract: Embodiments of the present disclosure pertain to methods of capturing one or more ions from an environment by associating the environment with a composition that includes a metal-organic framework. The association results in the capture of the one or more ions by the metal-organic framework. The metal-organic frameworks may include a plurality of metals and a plurality of triphenylene-based ligands that interconnect the plurality of the metals. The methods of the present disclosure may also include a step of detecting one or more captured ions. Additional embodiments of the present disclosure pertain to the compositions for capturing one or more ions from an environment.

Abstract: A system for co-transmitting discrete power and data over a common high frequency channel includes a power transmitting node, a power receiving node, a data transmitting node, a data receiving node, a power transmitting switch, a power receiving switch, a data transmitting switch, a data receiving switch, a primary power switch, a secondary power switch, a common high frequency channel, a first control unit, and a second control unit. When the primary power switch, power transmitting switch, and power receiving switch are in an activated state, a power signal is transmitted over the common high frequency channel from the power transmitting node to the power receiving node. When the secondary power switch, data transmitting switch, and data receiving switch are in an activated state, a data signal is transmitted over the common high frequency channel from the data transmitting node to the data receiving node.

Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.

Abstract: The present disclosure provides methods and systems for improved rehabilitation of ankle motion by visually-driven priming of motor movement. The methods and systems include a sensor configured to measure ankle angle. The generated signal may be used to determine a maximal range of angles the user is capable of generating in order to calibrate the system. Subsequently, the signal from the sensor may be used to display the user location relative to an indication used to prime the motor movement. User performance may be tracked and performance-based awards given to increase rehabilitative outcome. The method and systems may encourage increased patient compliance by providing a comfortable, effective mode of ankle rehabilitation.

Abstract: A smart object may be used to monitor physiological parameters of a user. The object has at least one capacitive sensor to sense a change in capacitance when a tissue of the user comes into contact with the at least one capacitive sensor. The change in capacitance can be used to detect physiological parameters of a user such as heart rate, inter-beat interval and respiratory rate. The smart object may also be used with another smart object to determine the identity of the user or other physiological parameters of the user such as blood pressure.

Abstract: The present disclosure describes systems and methods for implementing input-adaptive neural networks. Several approaches and systems are presented for creating flexible and computationally-efficient deep neural networks that adapt their complexity based upon input data such as video streams. The approach may use fine-grained design and an automatic approach for generating optimal network architectures based on early-exit mechanisms. A neural network modified according to such principles can be implemented in various devices including mobile vision systems such as smartphones, drones, and head-mounted augmented reality devices.

Abstract: The disclosed systems for automated building construction may include upright supports, a support platform coupled to and vertically movable relative to the upright supports, and a bridge platform coupled to and horizontally movable along the support platform. A track may be mounted on the bridge platform, and a robotic arm may be coupled to and movable along the track. The robotic arm may be configured to retrieve structural insulated panels and to position the structural insulated panels to construct at least a portion of a building. Various other related systems and methods are also disclosed.