Abstract: The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe3)(PEt3)2Cl, which exhibits superior performance compared to other analogs.

Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding an antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding an antigen, adjuvant, or a combination thereof.

Abstract: Antenna arrays with three-dimensional (3D) conformal radiating elements are provided, as well as methods of manufacturing and methods of using the same. An array can include a ground plane and a plurality of unit cells disposed thereon. Each unit cell can include a 3D conformal radiating element. The 3D conformal radiating elements can be, for example, patches (e.g., circular 3D patches), dipoles, or loops, and each radiating element is conformal on a hemispherical shape.

Abstract: The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Abstract: Cold-sprayed aluminum capacitors on lead frame metal foils are provided for applications in 3D power package integration. This additive manufacturing process allows pre-patterned low-temperature processing of aluminum electrodes on metal lead frames, insulated metal substrates or even heat-spreaders and cold-plates. Cold-sprayed capacitors can eliminate several process integration and reliability issues that are associated with traditional discrete surface-assembled capacitors.

Abstract: Exemplary computer-accessible medium, systems, and methods are described herein which can provide an excited fluorescence radiation. In accordance with certain exemplary embodiments of the present disclosure, an excited fluorescence radiation can be provided using a beam of a probe so as to excite a molecule to an excited state for a fluorescence emission to effectuate the excited fluorescence radiation. The molecule can be detected based on the fluorescence emission. For example, the beam of the probe can be either the near-infrared spectrum or the visible light spectrum.

Abstract: Dual-polarized ultrawideband antennas and antenna arrays are provided. Fully inverted-L elements (FILEs) can be used as the radiating element in a unit cell antenna, which can be repeated to form an array. The dual-polarized FILE unit cell can include two L-bent elements, which tightly couple to a common shorted via as well as to each other. The same shorted via can be utilized to suppress the well-known common mode resonance.

Abstract: An internal-ion gated electrochemical transistor is provided. In some embodiments, the internal-ion gated electrochemical transistor comprises: a gate electrode, a source electrode, and a drain electrode; a channel formed between the source electrode and the drain electrode, wherein the channel comprises a conducting polymer, wherein the channel serves as a reservoir of positively charged mobile ions; and an ion membrane between the channel and the gate electrode, wherein: in an off state, at least a subset of the positively charged mobile ions are ionically bonded to negatively charged ions of the conducting polymer, and wherein in an on state, at least a subset of the positively charged mobile ions are unbonded from the negatively charged ions of the conducting polymer to induce a current within the channel, and wherein at least one of the off state and the on state is actuated by application of a voltage to the gate electrode.

Abstract: This invention relates generally to covalently crosslinked colloidal cellulose nanocrystals (xCNC) and methods of preparation and use thereof. The colloidal cellulose nanocrystals (CNCs) are covalently crosslinked in aqueous suspension to generate a network showing tunable physicochemical properties. The xCNC structures are tunable in terms of their physicochemical properties and arrangement within the hydrogel network. The covalent crosslinking of solitary sulfonated (—OSO3) CNCs can be accomplished without prior hydroxyl replacement or functionalization.

Abstract: The present invention relates to antibodies, binding polypeptides, and scFvs specific for fibroblast activation protein (FAP) capable of cross reacting with canine, mouse, and human FAP.

Abstract: A hadron therapy system that provides 3D scanning and rapid delivery of a high dose. Such systems can include a hadron source and accelerator with an RF energy modulator and an RF deflector that operate in combination to provide 3D scanning of a targeted tissue. The systems can include a permanent magnet quadrupole for magnification of the beam. The systems can include high energy hadron sources that utilize a multi-cell, multi-klystron design that achieves scanning of high energy hadron beams, for example a fixed energy of 200 MeV protons. Such systems can provide full irradiation of a liter scale tumor within one second or less.

Abstract: Methods and apparatus for direct detection of chemical reactions are provided. Electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. The charge perturbation caused by the polymerase reaction can uniquely identify a DNA sequence. The polymerization process generates local perturbations of charge in the solution near the electrode surface and induces a charge in a polarazible gold electrode. This event is detected as a transient current by a voltage clamp amplifier. Detection of single nucleotides in a sequence can be determined by dispensing individual dNTPs to the electrode solution and detecting the charge perturbations. Alternatively, multiple bases can be determined at the same time using a mix of all dNTPs with subsequent analysis of the resulting signal.

Abstract: A transparent solar panel includes a transparent substrate and a transparent photoactive material. An average photosynthetic transmittance (APT) of the entire transparent solar panel is greater than or equal to about 45%. The transparent solar panel is configured to transmit light to a region containing a plant at a daily light integral (DLI) of greater than or equal to about 10 mol·m?2·d?1. The transparent solar panel may be a transparent photovoltaic (TPV) or a transparent luminescent solar concentrator (TLSC).

Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.

Abstract: The present disclosure relates to genetically modified plants including one or more edited open reading frames (uORFs) in endogenous nucleotide sequences encoding photosystem II subunit S (PsbS), zeaxanthin epoxidase (ZEP), or violaxanthin de-epoxidase (VDE). The present disclosure further relates to methods of producing the genetically modified plants, as well as to isolated constructs and expression cassettes for use in producing the genetically modified plants. In addition, the present disclosure relates to transient screening methods to study gene expression.

Abstract: The present disclosure provides compounds of Formula (I) and (II), which may be ROCK2 inhibitors. The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, and methods of treating or preventing diseases and disorders associated with ROCK2 (e.g., fibrotic disease, autoimmune disease, inflammatory-fibrotic condition, inflammatory condition, edema, ophthalmic disease, cardiovascular disease, central nervous system disorder, cancer) by administering to a subject in need thereof the compounds or pharmaceutical compositions.

Abstract: The approach disclosed herein is a process for non-equilibrium chemical and materials processing using the combination of non-equilibrium plasma, non-equilibrium multi-functional catalysis, a precisely programed heating and quenching (PHQ), and supersonic reaction quenching to dynamically change the chemical equilibrium and increase the yield and selectivity of the products. An important feature of the disclosed approach is to realize an efficient and high selectivity synthesis method of chemicals and materials by using non-chemical equilibrium, non-equilibrium catalysts, and non-equilibrium of excited states via active control of molecule excitation by low temperature hybrid plasma, dynamics of chemical reactions by programed heating and supersonic quenching, and the design of non-equilibrium catalysts by thermal shocks and plasma coupling to enable distributed and electrified chemical synthesis of hydrogen, ammonia, valued carbon and other chemical products at atmospheric conditions.

Abstract: Immunogenic compositions that include a full-length influenza A virus matrix 2 (M2) protein, an amphipathic molecule, and at least one phospholipid, which assemble to form a nanodisc, are described. Use of the immunogenic compositions, for example as a universal influenza virus vaccine, is described.

Abstract: Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn.

Abstract: Methods of performing experimental treatments on a cohort of subjects are provided. A predictive model can be utilized to predict progression of a medical disorder or relevant imaging biomarker. The predicted medical disorder progression can be utilized as a control to determine whether an experimental treatment has an effect on the progression of the medical disorder. In some instances, the enrollment of subjects within a control group for clinical experiment is eliminated or reduced.