Abstract: Provided herein are synthetic peptides with enhanced antimicrobial and antibiofilm characteristics, and are biocompatible with mammalian cellular systems. The disclosed synthetic antimicrobial moieties include a mastoparan peptide having SEQ ID NO:1 and a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues, wherein the pentapeptide motif is conjugated the N-terminus of the mastoparan peptide. Also provided are compositions comprising the synthetic peptides, as well as methods of treating a microbial infection or removing a biofilm using the peptides.
Type:
Grant
Filed:
September 14, 2022
Date of Patent:
October 15, 2024
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez, Gislaine G. O. Silva, Octavio L Franco
Abstract: Nonlinear on-chip optical devices using AlScN are described herein. In one aspect, an optical component having nonlinear characteristics can include a first substrate defining a refractive index; and a nonlinear layer, the nonlinear layer disposed on the first substrate, the nonlinear layer comprising an amount of scandium (Sc), and the nonlinear layer defining a refractive index that is higher than the refractive index of the first substrate.
Type:
Grant
Filed:
July 29, 2022
Date of Patent:
October 15, 2024
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Valerie J. Yoshioka, Jian Lu, Zichen Tang, Jicheng Jin, Roy H. Olsson, III, Bo Zhen
Abstract: A scan multiplier system for optical scanning includes an inertial scanning unit for receiving an incident beam and scanning the incident beam to generate a scanned beam defining a scanned line rate. A scan multiplier unit receives the scanned beam from the inertial scanning unit, the scan multiplier unit including one or more optical elements for redirecting the scanned beam back toward the inertial scanning unit, the inertial scanning unit receiving the reflected beam from the optical element and generating a rescanned beam, the rescanned beam defining a rescanned line rate different from the scanned line rate. The scan multiplier system can be used with a laser scanning microscope system, such as a two-photon microscope system, a confocal microscope system, or other such microscope system.
Abstract: Method for treating pancreatic cancer using des-methyl pateamine A (DMPatA) or a pharmaceutically acceptable salt thereof, or des-methyl des-amino pateamine A (DMDAPatA) or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
April 4, 2024
Publication date:
October 10, 2024
Applicants:
Baylor University, The Trustees of Columbia University in the City of New York
Inventors:
Daniel Romo, Kenneth G. Hull, Haoran Xue, Mingzhao Zhu, Susan E. Bates, Maryam Safari, Antonio Fojo
Abstract: Articles and methods involving fluidic devices are generally provided. In some embodiments, a fluidic device comprises a first layer comprising a central region in fluidic communication with an environment external to the fluidic device. The first layer may also comprise a first channel and a second channel in fluidic communication with the central region and extending radially outwards therefrom. The first and second channels may comprises first and second sample regions from which first and second samples can be removed from the fluidic device. In some embodiments, a fluidic device comprises a first layer and a second, filtration layer configured to separate blood cells from plasma positioned between the environment external to the fluidic device and the first layer.
Type:
Application
Filed:
June 13, 2024
Publication date:
October 10, 2024
Applicant:
Trustees of Tufts College
Inventors:
Charles R. Mace, Jessica E. Schilling, Syrena C. Fernandes, Keith Baillargeon
Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
Abstract: Methods for more secure mobile network communications are disclosed. Specifically, details involving natural language processing (NLP) based auto formal modeling of protocols and specifications with large language models (NLP) are provided. Methods for formal and fuzzing amplification for fuzz testing to detect vulnerabilities are also disclosed. Furthermore, solutions are provided to identified vulnerabilities in existing 5G infrastructures. Also disclosed is a digital twin fuzzing framework.
Type:
Application
Filed:
April 5, 2024
Publication date:
October 10, 2024
Applicant:
The Trustees of The Stevens Institute of Technology
Abstract: Methods for more secure mobile network communications are disclosed. Specifically, details involving natural language processing (NLP) based auto formal modeling of protocols and specifications with large language models (NLP) are provided. Methods for formal and fuzzing amplification for fuzz testing to detect vulnerabilities are also disclosed. Furthermore, solutions are provided to identified vulnerabilities in existing 5G infrastructures. Also disclosed is a digital twin fuzzing framework.
Type:
Application
Filed:
April 5, 2024
Publication date:
October 10, 2024
Applicant:
The Trustees of The Stevens Institute of Technology
Abstract: Systems and methods for evaluating historical trends in real estate prices are provided. Systems and methods provide an understanding of historical price trends and assist in a property evaluation or appraisal, as well as allowing for an analysis of comparables in estimating a reasonable offer for a property on the market. Given a timespan of interest, a locale, and a category of properties of interest, an objective historical trend in values can be computed by first evaluating the ratios between the realized prices of transactions and objective governmental assessment of the properties at some fixed point of time. Then, for each period the ratios of all transactions in that period can be averaged, followed by comparing said averages between different time periods.
Type:
Application
Filed:
April 6, 2023
Publication date:
October 10, 2024
Applicant:
The Florida International University Board of Trustees
Abstract: In various embodiments, lentiviral vectors expressing FoxP3 using the endogenous gene elements to regulate physiologic gene expression of FoxP3 are provided herein as well as uses of such vectors.
Type:
Application
Filed:
June 26, 2024
Publication date:
October 10, 2024
Applicants:
The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Donald B. KOHN, Maria Grazia RONCAROLO, Roger Paul HOLLIS, Katelyn E. MASIUK, Rosa BACCHETTA
Abstract: The present invention provides compositions and methods for detecting and isolating disseminated tumor cells (DTCs) from breast cancer in a bone marrow aspirate of a subject. The invention further provides methods of treating breast cancer in the subject.
Type:
Grant
Filed:
June 8, 2018
Date of Patent:
October 8, 2024
Assignee:
The Trustees of the University of Pennsylvania
Abstract: An apparatus for sensing a target analyte includes a sensing material of a baseline composition. The sensing material is in electrical communication with an alternating energy input across the sensing material at a first frequency. The sensing material is configured to be placed within an environment such that an exposed state is in communication with a concentration of a target analyte proximate the sensing material, and wherein the target analyte changes at least one compositional property of the baseline composition. An impedance detection device is connected to a sensing circuit and receives an output from the sensing material, the output exhibiting a respective impedance value of the sensing material corresponding to the input for the first frequency. The respective impedance value is dependent upon the concentration of the target analyte in the environment and the first frequency.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
October 8, 2024
Assignees:
The Board of Trustees of the University of Alabama, The U.S. Army, Edgewood Chemical and Biological Center
Inventors:
Adam Hauser, Jennifer Rose Soliz, Smriti Ranjit
Abstract: Systems and methods for deep brain stimulation using kinematic feedback in accordance with embodiments of the invention are illustrated. One embodiment includes a deep brain stimulation system, including an implantable neurostimulator, a first inertial measurement unit (IMU), a second IMU, and a controller, where the controller is communicatively coupled to the implantable neurostimulator, the first IMU, and the second IMU, and where the controller is configured to obtain kinematic data from the first IMU and the second IMU, identify an abnormal movement event based on the kinematic data, and modify deep brain stimulation provided by the implantable neurostimulator based on the identified abnormal movement event.
Type:
Grant
Filed:
February 1, 2022
Date of Patent:
October 8, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, University of Washington
Inventors:
Helen Bronte-Stewart, Yasmine Kehnemouyi, Matthew Petrucci, Jeffrey Herron, Johanna O'Day
Abstract: Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.
Type:
Grant
Filed:
November 3, 2023
Date of Patent:
October 8, 2024
Assignees:
The Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
Inventors:
Zurab Siprashvili, Ngon T. Nguyen, M. Peter Marinkovich, Jean Tang, Alfred T. Lane, Paul A. Khavari
Abstract: Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.
Type:
Grant
Filed:
May 19, 2017
Date of Patent:
October 8, 2024
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
Inventors:
David Weiner, Emma Reuschel, Bernadette Ferraro, Ahmed S. I. Aly
Abstract: A method of fabricating a superconducting device includes determining a target transition temperature and utilizing a predefined quantitative relationship between superconducting transition temperature and an order parameter for at least one superconducting material composition is utilized to select a superconductor material composition that is capable of providing a target transition temperature. Process parameters may be controlled to form a superconductor device comprising at least one superconductor material having a material composition providing the target transition temperature.
Type:
Grant
Filed:
November 29, 2022
Date of Patent:
October 8, 2024
Assignee:
The Board of Trustees of Western Michigan University
Inventors:
Robert A. Makin, III, Steven Michael Durbin
Abstract: The present invention relates to canine antibodies, binding polypeptides, and scFvs specific for canine cytotoxic T lymphocyte associated protein 4 (CTLA-4).
Type:
Grant
Filed:
October 20, 2023
Date of Patent:
October 8, 2024
Assignees:
The Trustees of the University of Pennsylvania, Vetigenics, Inc.
Inventors:
Nicola J. Mason, Donald L. Siegel, Nicholas Chester
Abstract: Functional human cortico-spinal-muscle assembled spheroids are generated by in vitro culture. Complete cortico-spinal-muscle spheroids (hCS-hSC-hSkM) are assembled from component cultured cell systems, where each cultured cell system is designed to provide specific sets of neural and/or muscle cells, and which components are functionally integrated in the assembled spheroid.
Type:
Grant
Filed:
June 20, 2019
Date of Patent:
October 8, 2024
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Devices and methods for smartphone impostor detection using behavioral and environmental data are provided. Impostors are attackers who take control of an electronic device (e.g., a smartphone) and gain access to confidential and private information of a legitimate user. Embodiments described herein propose a defense-in-depth mechanism to detect impostors quickly with simple deep learning algorithms, which can achieve better detection accuracy than previous works. Embodiments then consider protecting the privacy of the behavioral and/or environmental data (e.g., collected by one or more sensors) of a user by not exposing it outside the protected device. A recurrent neural network (RNN)-based deep learning algorithm is proposed which uses only sensor data of the legitimate user to learn their normal behavior. Prediction error distribution (PED) is used to enhance the detection accuracy.
Abstract: A system for using wireless signals to detect objects of a certain type, such as concealed weapons, leverages the fact that different objects have different resonance characteristics. The system transmits wireless signals of different frequencies, and returns from such signals are measured. The return of a signal from an object at a resonant frequency of the object will be stronger than a return of a signal from the object at a non-resonant frequency. The system analyzes the returns in an effort to determine when a return is sufficiently large to indicate that it was reflected from an object of interest. When an object of interest is detected, the system adjusts a characteristic of the system, such as antenna orientation or pulse shape, based on an estimated location of the object, and then runs a test to confirm the detection of the object, thereby eliminating at least some false positives.
Type:
Grant
Filed:
June 25, 2020
Date of Patent:
October 8, 2024
Assignee:
Board of Trustees of The University of Alabama, for and on behalf of the University of Alabama in Huntsville