Abstract: Materials such as poly(vinylidene fluoride) (PVDF) and lithium cobalt (III) oxide (LCO) are recovered and recycled from cathode films isolated from end-of-life batteries, including lithium-ion batteries. Cathode films are immersed in solution including N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidine (NMP), a tetrahydrofuran (THF):NMP mixture, or a THF:DMF mixture. The solution is able to dissolve PVDF, which can then be separated from LCO and a conductive substrate component of the cathode films via alumina column separation. A PVDF product can be precipitated and recovered, while the LCO and conductive substrate can be recovered directly from the alumina column separator. Both the PVDF and LCO are of suitable quality for use in new cathode films. Such recovery is shown to be achievable even at low solid to liquid ratio during the dissolution process.
Type:
Grant
Filed:
October 13, 2021
Date of Patent:
October 29, 2024
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Lauren Elizabeth Marbella, Amrita Sarkar, Richard May
Abstract: Biosensors capable of detecting certain biomarkers (e.g., platelet-derived growth factor-BB (PDGF-BB)), as well as methods of fabricating the same and methods of using the same, are provided. The biosensors can be disposable and/or label-free. Electrochemical bipolar exfoliation can be used to exfoliate, reduce, and deposit (in a single step) graphene nanosheets on a desired substrate (e.g., an electrode). Affinity aptamers can be immobilized on the graphene nanosheets disposed on the substrate.
Type:
Grant
Filed:
June 9, 2022
Date of Patent:
October 29, 2024
Assignee:
The Florida International University Board of Trustees
Inventors:
Shahrzad Forouzanfar, Iman Khakpour, Nezih Pala, Chunlei Wang
Abstract: Imidazole-containing polymer membranes and resins are described herein. Methods of their preparation and use are also described herein. The methods of using the membranes and resins include reducing acids from liquid phases.
Type:
Grant
Filed:
August 24, 2021
Date of Patent:
October 29, 2024
Assignee:
The Board of Trustees of the University of Alabama
Inventors:
Jason Edward Bara, Steven Thomas Weinman
Abstract: The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein.
Type:
Grant
Filed:
April 22, 2016
Date of Patent:
October 29, 2024
Assignees:
The Trustees of the University of Pennsylvania, Novartis AG
Abstract: An image sensor capable of recording both spectral and polarization properties of light using a single chip device includes an at least 2048 by 2048 array of superpixels. Each superpixel includes an array of spectral pixels, and an adjacent array of polarization pixels. Each spectral pixel includes a spectral filter and a stack of photodiodes, where each photodiode has a different quantum efficiency and is, therefore, sensitive to a different wavelength of light passed by the spectral filter. Each polarization pixel includes a polarization filter and a stack of photodiodes, similar to the spectral pixel photodiode stacks.
Type:
Grant
Filed:
August 15, 2022
Date of Patent:
October 29, 2024
Assignee:
The Board of Trustees of the University of Illinois
Abstract: A search engine server includes a communication interface through which to receive a multi-modal query from a browser of a client device, the multi-modal query including at least a first image of an item. A processing device, coupled to the communication interface, is to: execute a neural network (NN) regressor model on the first image to identify a plurality of second items that are similar to and compatible with the item depicted in the first image, wherein a set of images correspond to the plurality of second items; generate structured text that explains, within one of a phrase or a sentence, why the set of images are relevant to the item; and return, to the browser of the client device via the communication interface, a set of search results comprising the set of images and the structured text.
Type:
Grant
Filed:
March 24, 2020
Date of Patent:
October 29, 2024
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
David A. Forsyth, Ranjitha Kumar, Krishna Dusad, Kedan Li, Mariya I. Vasileva, Bryan Plummer, Yuan Shen, Shreya Rajpal
Abstract: Embodiments herein describe systems and methods to determine nucleic acid thermodynamics and uses thereof. Many embodiments utilize a sequencing chip, such as an Illumina flow cell as a high-throughput platform for performing massively parallel melt curve determination. In many embodiments, nucleic acid molecules possessing a region that forms a secondary structure are affixed to a sequencing chip and hybridized with one or more labeled oligonucleotides. As the secondary structure denatures, changes in fluorescence can be measured to determine a melt curve of specific sequences.
Type:
Application
Filed:
August 29, 2022
Publication date:
October 24, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Hannah K. Wayment-Steele, Eesha Sharma, Rhiju Das, William J. Greenleaf, Anthony Ho, Winston Becker, Yuxi Ke
Abstract: Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
Type:
Application
Filed:
June 26, 2024
Publication date:
October 24, 2024
Applicant:
The Trustees of Princeton University
Inventors:
Cliff BRANGWYNNE, Yongdae SHIN, Dan BRACHA
Abstract: A synthetic or recombinant human lecithin cholesterol acyltransferase (LCAT) variant is provided which comprises an LCAT enzyme having a substitution at position 114 based on the residue numbering of wild-type (WT) human LCAT [SEQ ID NO:1], wherein said variant is characterized by one or more of: (i) an esterification rate higher than the esterification rate of WT human LCAT; and/or (ii) an association with higher density lipoprotein levels as compared to subjects having WT LCAT. Also provided are vectors encoding the variant, compositions containing same, and methods of using the variant proteins and vectors for treatment of a variety of disorders associated with defective wt LCAT.
Type:
Application
Filed:
December 21, 2023
Publication date:
October 24, 2024
Applicant:
The Trustees of the University of Pennsylvania
Inventors:
Daniel Rader, Devin Christopher, Anna P. Tretiakova
Abstract: Systems, devices, and methods for performing peripheral vascular imaging are provided. A continuous wave, non-contact, near-infrared optical scanner (NIROS) can utilize at least one near-infrared (NIR) light. The diffuse reflected NIR signal(s) can be obtained from the surface of the tissue of the mammal being imaged. The signal(s) can be optically filtered and can be detected by an NIR-sensitive image sensor. A graphical user interface (GUI) can be used to automate the acquisition of the spatio-temporal diffuse reflected maps from the NIROS device.
Type:
Application
Filed:
April 24, 2023
Publication date:
October 24, 2024
Applicant:
The Florida International University Board of Trustees
Inventors:
Anuradha Godavarty, Joshua Daniel Hutcheson, Daniela Leizaola, Kevin Leiva, Valentina Dargam
Abstract: Chronic non-healing wounds represent a major source of morbidity for patients, and a significant economic burden. Current wound care treatments are passive and are unable to adapt to changes in the wound environment in real time. By integrating multimodal sensors and adding stimulators in a bandage, physiological monitoring is possible and provides an opportunity for active intervention into the complex wound environment. Here, we develop a battery-free flexible bioelectronic system consisting of wirelessly powered, closed-loop, autonomous sensing and stimulation circuits with tissue-interfacing tough conducting hydrogel electrodes for robust signal transduction, on-demand adhesion, and detachment.
Type:
Application
Filed:
August 26, 2022
Publication date:
October 24, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Disclosed herein are a neuromorphic nerve device including an artificial proprioceptor device and an artificial synapse, and a neuromorphic prosthetic device using the same. The neuromorphic nerve device in accordance with the present disclosure is simple in structure, is drivable with low power, and excellent in stretchability, so that a robot made of a soft material similar to a human or an animal can be made, and a neuromorphic prosthetic device that is comfortable for a user to wear can be made possible.
Type:
Application
Filed:
April 20, 2023
Publication date:
October 24, 2024
Applicants:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Tae-Woo LEE, Yeongjun LEE, Zhenan BAO, Yuxin LIU
Abstract: A purified surface region of a semiconductor includes a treated surface and comprises a crystalline metal oxide containing an impurity species (e.g., an isotopic impurity or a chemical impurity). The crystalline metal oxide comprises a depletion region extending to a first depth from the treated surface, and an accumulation region adjacent to the depletion region and extending to a second depth greater than the first depth. A concentration of the impurity species is lower in the depletion region than in the accumulation region. An electronic component comprising the purified surface region may be used for thermal management, quantum computing, sensing, and/or light detection.
Type:
Application
Filed:
April 18, 2024
Publication date:
October 24, 2024
Applicant:
The Board of Trustees of the University of Illinois
Abstract: A retina clip in accordance with embodiments of the invention are illustrated. One embodiment includes a retina clip including an outer ring having a means of retention against the retina, and an inner platform configured to hold a payload against the retina of an eye, where the inner platform is suspended from the inner ring via several springs. In many embodiments, the springs are flexures. The springs can be modified to generate a desired deflection based on a given payload attached to the inner platform. In numerous embodiments, the payload is a microelectrode array used as part of a retinal prosthetic.
Type:
Application
Filed:
April 22, 2024
Publication date:
October 24, 2024
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Eduardo Jose Chichilnisky, Ruwan Amila Silva, Martin Breidenbach, Knut Skarpaas, VIII, Marco Oriunno
Abstract: Systems and methods for energy storage and energy recovery are provided. An electrical-to-electrical energy storage system includes a thermochemical energy storage device, a blower, a compressor, a turbine, and an electrical generator. The TCES device includes a vessel, a porous bed, and a heater. The porous bed is disposed within an interior volume of the vessel. The porous bed comprises a reactive material. The reactive material is configured to release oxygen upon being heated to a reduction temperature, and generate heat when exposed to oxygen. The heater is in thermal contact with the reactive material. The blower is configured to remove oxygen from the interior volume. The compressor is configured to flow oxygen into the interior volume. The turbine is configured to receive a heated, oxygen-depleted gas from the interior volume. The generator is configured to be powered by the turbine to generate electricity.
Type:
Grant
Filed:
August 28, 2023
Date of Patent:
October 22, 2024
Assignee:
Board of Trustees of Michigan State University
Inventors:
James F. Klausner, Joerg Petrasch, Kelvin Randhir, Nima Rahmatian
Abstract: Systems and methods for tethering a fiber optic cable to an apparatus such as an unmanned underwater vehicle (UUV) or remotely operated vehicle (ROV). The cable is a bare or tight-buffered optical fiber surrounded by a braided sheath, and is constructed so that loads experienced by the cable are not transferred from the sheath to the optical fiber. This construction enables the cable to have good tensile strength but be sufficiently lightweight so that a commercial fishing reel or any similarly scaled lightweight/portable winch system can be used, instead of large specialized deployment equipment. A tube is inserted between the sheath and the optical fiber a certain distance from the end of the cable, and then the cable and tube are inserted into a housing which attaches to the apparatus and potted using an epoxy resin.
Type:
Grant
Filed:
February 22, 2022
Date of Patent:
October 22, 2024
Assignees:
University of Rhode Island Board of Trustees, Nautilus Defense LLC
Inventors:
Brennan T. Phillips, James B. Owens, Jr.
Abstract: An energy absorbing apparatus includes particles with nanopores in a liquid. A further aspect employs a reusable energy absorbing apparatus including gas-liquid interactions in nanopores. Another aspect of the present apparatus uses oversolubility of gas in a solution to enhance bubble nucleation in hydrophobic nanopores or nanochannels, which suppresses gas outflow while promoting liquid outflow from particles. Still another aspect includes anions within an aqueous electrolytic solution, containing nanoporous material therein.
Type:
Grant
Filed:
October 12, 2021
Date of Patent:
October 22, 2024
Assignee:
Board of Trustees of Michigan State University
Abstract: Various embodiments may involve obtaining an image of at least a section of a manufactured part; determining, based on executing a neural network on the image, that the manufactured part was not fabricated according to a specification for the manufactured part, wherein the neural network was trained to associate images of manufactured parts with corresponding indicators of specifications for the manufactured parts; and, in response to determining that the manufactured part was not fabricated according to the specification, generating an electronic alert indicating that the manufactured part was improperly fabricated.
Type:
Grant
Filed:
April 8, 2024
Date of Patent:
October 22, 2024
Assignees:
Sybridge Technologies U.S. Inc., The Board of Trustees of the University of Illinois
Inventors:
William Paul King, Sameh Tawfick, Miles Bimrose, Charles Wood, Davis McGregor
Abstract: The subject invention provides compositions and methods for isolating exosomes from, for example, biological fluid samples, cell cultures and/or cultured medium. Provided are Absolute Precipitation of Exosomes (APEX) reagents and precipitation techniques to isolate exosomes from various EV subsets, cells, dead cells, and/or cell debris. Advantageously, APEX is a rapid, effortless, inexpensive, high-recovery method to extract exosomes. This method is also faster and purer at isolating exosomes from other precipitation techniques.
Type:
Grant
Filed:
January 11, 2024
Date of Patent:
October 22, 2024
Assignee:
The Florida International University Board of Trustees
Inventors:
Andrea D. Raymond, Madhavan P. Nair, Arti Vashist, Mickensone Andre