Patents Assigned to Trustee
  • Optical systems and methods for intraoperative detection of CSF leaks
    Patent number: 12121220
    Abstract: A multi-wavelength surgical system is provided using an endoscope sensitive in the short-wave infrared region which allows exploration of different areas of the skull base for CSF leaks. The device includes an LED box with multiple wavelengths including allowing excitation of ICG with 785-808 nm, enhancing the water absorption from 1200-1550 nm and above 1800 nm and incorporating white light to allow for surgical navigation. Because CSF is 99% water having a large absorption in the SWIR band around 1200-1550 nm and above 1800 nm, the system and method should be an effective means of diagnosis without the need for intrathecal fluorescein.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of the Leland Stanford, Jr. University
    Inventors: Tulio A. Valdez, Mahbuba Tusty, David Huland, Oliver Bruns
  • Human alpha-folate receptor chimeric antigen receptor
    Patent number: 12122829
    Abstract: The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having ?-folate receptor (FR?) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FR? binding domain is fully human, thereby preventing a host immune response.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: October 22, 2024
    Assignees: The Trustees of the University of Pennsylvania, Fondazione IRCCS Istituto Nazionale Dei Tumori
    Inventors: Daniel J. Powell, Jr., Mariangela Figini, Silvana Canevari
  • Systems and methods for endoluminal valve creation
    Patent number: 12121404
    Abstract: A device for manipulating tissue at a vessel includes an elongated member having a proximal end and a distal end, a guide member at the distal end of the elongated member, the guide member having a blunt distal tip for engagement against an interior wall of the vessel, and a tissue cutting device at the distal end of the elongated member, wherein the tissue cutting device has a sharp tip that is proximal to the blunt distal tip of the guide member.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Fletcher T. Wilson, Rhunjay James Yu
  • Systems and methods for fusing EEG and fMRI through hierarchical deep transcoding
    Patent number: 12125593
    Abstract: The present subject matter relates to techniques for hierarchical deep transcoding. The disclosed system can include a processor that can be configured to receive a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and reconstruct a latent source space from the fMRI data and/or the EEG data by decoding the EEG data and/or the fMRI data to a latent source space. The fMRI data and the EEG data can be simultaneously acquired.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: October 22, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul Sajda, Xueqing Liu
  • Bacterial DNA gyrase inhibitors and methods of use thereof
    Patent number: 12121528
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: October 22, 2024
    Assignee: The Florida International University Board of Trustees
    Inventors: Fenfei Leng, Eddy Alfonso, Zifang Deng
  • High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
    Patent number: 12121597
    Abstract: Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: King C Li, Jeffrey S Moore
  • Method of redirecting t cells to treat HIV infection
    Patent number: 12122820
    Abstract: The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific scFvs CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with HIV infection.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: October 22, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James L. Riley, Rachel Leibman, Aimee S. Payne, Christoph T. Ellebrecht, Michael C. Milone
  • Sensorized shoelace-tensioning system and method
    Patent number: 12121366
    Abstract: The present disclosure relates to systems and devices for measuring motion of a shoe and tension in the shoelace of the shoe.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: October 22, 2024
    Assignee: The Board of Trustees of The University of Alabama
    Inventors: Xiangrong Shen, Edward Sazonov, Md Rejwanul Haque
  • Articulating Chair
    Publication number: 20240342025
    Abstract: An articulating chair and a method of using same, include at least one actuator, a programmable controller, and movable upper back, lower back and seat bottom sections. In another aspect, an articulating wheelchair and a method of using same, include a seat bottom section, a lower frame to which the seat bottom section is coupled, floor-contacting wheels rotatably coupled to the lower frame, an upper back section, a lower back section, a back frame to which the upper back section and the lower back section are movably coupled, electromagnetic actuators coupled to the back sections, a battery mounted to at least one of the frames, and a programmable controller connected to the actuators and the battery.
    Type: Application
    Filed: June 25, 2024
    Publication date: October 17, 2024
    Applicant: Board of Trustees of Michigan State University
    Inventors: Tamara Reid BUSH, Justin SCOTT
  • POLY(ETHYLENE BRASSYLATE-CO-DIOXANONE) COPOLYMERS, METHOD OF SYNTHESIS AND BIOMEDICAL DEVICES MADE THEREFROM
    Publication number: 20240343859
    Abstract: Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.
    Type: Application
    Filed: April 5, 2024
    Publication date: October 17, 2024
    Applicants: University of Rhode Island Board of Trustees, Yale University
    Inventors: Matthew Kiesewetter, Kassie Picard, Jinal Pothupitiya, W. Mark Saltzman
  • ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS
    Publication number: 20240343697
    Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Application
    Filed: March 27, 2024
    Publication date: October 17, 2024
    Applicants: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, The Board of Trustees of the University of Illinois
    Inventors: Alejandro VILLAGRA, Alan P. KOZIKOWSKI, Sida SHEN
  • Systems and Methods for Predicting and Treating Neurological Condition Relapses
    Publication number: 20240341607
    Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.
    Type: Application
    Filed: April 23, 2024
    Publication date: October 17, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Keith Sudheimer
  • Genetic toolbox for metabolic engineering of non-conventional yeast
    Patent number: 12116580
    Abstract: The present disclosure provides polynucleotides and vectors for the genomic engineering and editing of non-conventional yeasts such as Issatchenkia orientalis. The polynucleotides and vectors can be used as tools that are efficient to alter the expression of one or more gene products in the yeast, and specifically to induce the production of organic acids or other bioproducts of interest in the yeast.
    Type: Grant
    Filed: February 20, 2021
    Date of Patent: October 15, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Huimin Zhao, Mingfeng Cao, Vinh Tran, Zia Fatma
  • Blockchain-based voting system
    Patent number: 12118828
    Abstract: A control system for conducting an election may include a voter client configured to be used by a voter to cast a vote for a candidate, a registrar server, and a moderator server. The moderator server may be configured to obscure the identity of the voter. The registrar server may be configured to randomly assign a ballot to the obscured voter. The registrar server may be configured to encrypt the ballot. The moderator server may be configured to transmit the encrypted ballot to the voter client. The voter client may be configured to decrypt the encrypted ballot to recover the ballot. The voter client, in response to the voter selecting a desired candidate, may be configured to generate a ballot associated with a vote. The voter client may be configured to encrypt the ballot using a public key of the registrar server and a public key of the moderator server.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: October 15, 2024
    Assignee: Board of Trustees of Michigan State University
    Inventors: Jian Ren, Ehab Zaghloul, Tongtong Li
  • Functional ultrasound imaging of the brain using deep learning and sparse data
    Patent number: 12115024
    Abstract: A method for ultrasound power Doppler image reconstruction includes obtaining sparse sequences of compound frames of ultrasound data; inputting the sparse sequences into a convolutional neural network; and generating as output from the convolutional neural network a reconstructed time series of power Doppler images corresponding to the sparse sequences. The convolutional neural network is trained using a custom loss function to learn a reconstruction function using ground truth images from high-quality in vivo images.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: October 15, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tommaso Di Ianni, Raag D. Airan
  • Protein surface recognition via chemically enhanced phage display
    Patent number: 12116698
    Abstract: Low molecular weight molecules able to penetrate cells and tissues and having high specificity and affinity for the surfaces of proteins. Methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers, infectious diseases, and diseases and disorders associated with aberrant protein expression using same. A method for selecting a therapeutic peptide for binding to an isolated and/or purified protein of interest by screening a phage display library containing phage particles with phage display peptides which have at least one APBA modified cysteine residue. The APBA modified cysteine residues bind to surface lysine residues on the isolated and/or purified protein of interest by dynamic covalent conjugation to form iminoboronates.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 15, 2024
    Assignee: The Trustees of Boston College
    Inventor: Jianmin Gao
  • Coaxial phase change material heat sink for electric charging cable
    Patent number: 12119146
    Abstract: A heat sink apparatus having a pair of casings hinged in a clamshell arrangement and configured to contain a portion of an electric charging cable, the casings each having an inner space which contains a phase change material for absorbing heat generated during current flow through the electric charging cable.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: October 15, 2024
    Assignees: The Board of Regents of the University of Oklahoma, The University of Connecticut, The Board of the Trustees of the Leland Stanford Junior University
    Inventors: Hamidreza Shabgard, Amir Faghri, Kenneth Goodson, Mehdi Asheghi
  • Disrupting tumor tissues by targeting fibroblast activation protein (FAP)
    Patent number: 12116418
    Abstract: The present invention relates to compositions and methods comprising a chimeric antigen receptor (CAR) capable of binding fibroblast activation protein (FAP) for use in treating diseases, disorders or conditions associated with the expression of FAP on canine, mouse, or human tumor-associated cells.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: October 15, 2024
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Steven A. Albelda, Ellen Puré, Leslie Todd
  • Aqueous two-phase system for the separation and recovery of mammalian cells from contaminated cultures
    Patent number: 12115471
    Abstract: A method is directed to separating contaminants from mammalian cells in an aqueous multiphase system, and includes loading a container with a liquid having a top liquid phase and a bottom liquid phase. A cover medium is inserted in the container with a mixture of cultured mammalian cells and contaminants. The container is incubated and centrifuged for respective periods of time. In response to the centrifuging, the cells are separated from the contaminants in accordance with the respective density of the cells, the contaminants, and each liquid phase, resulting in the cells being located at a liquid-to-liquid interface between the top liquid phase and the bottom liquid phase and the contaminants being located at the bottom of the container.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: October 15, 2024
    Assignee: Trustees of Tufts College
    Inventors: Charles R. Mace, Christopher Luby
  • Surgical navigation with stereovision and associated methods
    Patent number: 12114988
    Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.
    Type: Grant
    Filed: May 31, 2023
    Date of Patent: October 15, 2024
    Assignee: The Trustees of Dartmouth College
    Inventors: David W. Roberts, Keith D. Paulsen, Alexander Hartov, Songbai Ji, Xiaoyao Fan