Patents Assigned to Trustee
  • Patent number: 12133771
    Abstract: This disclosure relates to combined frequency and angle compounding for speckle reduction in ultrasound imaging. Such combined frequency and angle compounding can result in a multiplicative speckle reduction compared to using either frequency compounding or angle compounding alone. Compounding methods of this disclosure can make use of the full aperture of the ultrasound probe when acquiring individual images, hence there can be no compromise in resolution. In disclosed embodiments, ultrasound images can be obtained while an ultrasound probe is moving and the relative position and orientation of the ultrasound images can be determined from a measurement of the position and orientation of the ultrasound probe. Certain embodiments can correct for the movement and distortion of an object being imaged during the image acquisition.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: November 5, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, THORLABS, INC.
    Inventors: Yilei Li, Steven Chu, Noah Yuzo Toyonaga, James Y Jiang, Alex E. Cable
  • Patent number: 12133892
    Abstract: Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: November 5, 2024
    Assignees: Memorial Sloan Kettering Cancer Center, The Trustees of Dartmouth College
    Inventors: Samuel F. Bakhoum, Bassem I. Zaki, Duane A. Compton
  • Patent number: 12134757
    Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.
    Type: Grant
    Filed: September 26, 2022
    Date of Patent: November 5, 2024
    Assignees: Southwest Research Institute, The Trustees Of The University Of Pennsylvania
    Inventors: Jian Ling, Kreg A. Zimmern, Michael C. Milone
  • Patent number: 12133762
    Abstract: A system for patient cardiac imaging and tissue modeling. The system includes a patient imaging device that can acquire patient cardiac imaging data. A processor is configured to receive the cardiac imaging data. A user interface and display allow a user to interact with the cardiac imaging data. The processor includes fat identification software conducting operations to interact with a trained learning network to identify fat tissue in the cardiac imaging data and to map fat tissue onto a three-dimensional model of the heart. A preferred system uses an ultrasound imaging device as the patient imaging device. Another preferred system uses an MRI or CT image device as the patient imaging device.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: November 5, 2024
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Jon Klingensmith, Colin Gibbons, Michaela Kulasekara, Vu Quang Dinh
  • Patent number: 12133855
    Abstract: Disclosed are compounds of formula (I) below: wherein each of the variables A, B, X, W, V, R1-R5, and m is defined herein. Also disclosed are pharmaceutical compositions containing a nanocomplex, wherein the nanocomplex is formed of one of the compounds, and a protein, a nucleic acid, or a small molecule; and methods of treating a medical condition with one of the pharmaceutical compositions.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 5, 2024
    Assignee: Trustees of Tufts College
    Inventors: Qiaobing Xu, Yamin Li
  • Patent number: 12136620
    Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: November 5, 2024
    Assignees: The Board of Trustees of the University of Illinois, X-Celeprint Limited
    Inventors: John A. Rogers, Ralph Nuzzo, Matthew Meitl, Etienne Menard, Alfred Baca, Michael Motala, Jong-Hyun Ahn, Sang-Il Park, Chang-Jae Yu, Heung Cho Ko, Mark Stoykovich, Jongseung Yoon
  • Patent number: 12136914
    Abstract: A control circuit is provided for a field-effect transistor with a floating source node. The control circuit includes: a charge storage device electrically connected between a gate of the field-effect transistor and a DC power supply; a gate control circuit electrically connected between the charge storage device and the gate of the field-effect transistor; and a charge control circuit electrically connected between the DC power supply and the charge storage device. The gate control circuit is configured to receive a gate control signal and operates to turn on the field-effect transistor during on time of the gate control signal and turn off the field-effect transistor during off time of the gate control signal. The charge control circuit is also configured to receive the gate control signal and operates to charge the charge storage device with power from the DC power supply during off time of the gate control signal.
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: November 5, 2024
    Assignee: Board of Trustees of Michigan State University
    Inventors: Kevin David Moran, Guoming George Zhu
  • Patent number: 12133516
    Abstract: A trap accessory for attachment to a marine trap that facilitates release of by-catch. A buoyant recovery buoy is operably attached to a trap frame secured to the marine trap. Components for operably attaching the recovery buoy to the trap frame include a latch and attachment components, of which at least one of these components is a Degradable Metal (DM). The DM maintains the integrity of the trap and trap accessory for a pre-determined time, typically 1 year or less. When one or more of the DM components are sufficiently degraded, the recovery buoy is released to open a slot through which animals can escape. A buoy line connected to the trap frame maintains connection between the marine trap and the recovery buoy, which assists in recovery of the marine trap.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: November 5, 2024
    Assignee: The Florida International University Board of Trustees
    Inventors: Mark Butler, Norman Munroe
  • Patent number: 12135246
    Abstract: A wirelessly powered resistive sensor is presented. The sensor includes: an antenna; a parametric resonator and a resistive loop circuit. The parametric resonator is configured to receive a pumping signal from the antenna and operable to oscillate at two frequencies. The resistive loop circuit is inductively coupled to the parametric resonator, such that oscillation frequency of the parametric resonator changes (e.g., linearly) with changes in resistance of the resistance loop circuit. The resistance of the resistor in the resistive loop circuit approximately equals the impedance of the resistive loop circuit at one resonance frequency of the parametric resonator. The resistive sensor may further include a resonator enhancer circuit arranged adjacent to the parametric resonator and operates to resonate at frequency of the pumping signal.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: November 5, 2024
    Assignee: Board of Trustees of Michigan State University
    Inventors: Chunqi Qian, Wei Qian
  • Patent number: 12133893
    Abstract: A stable injectable collagen-based hydrogel delivery platform and method is provided to obtain the viscosity, post-injection stability and mechanical properties needed of an injectable collagen matrix via incorporating alginate and calcium sulfate (CaSO4) into the matrix. The hydrogel (Alg/Col hydrogel) is shear-thinning, injectable through commercially available needles and stable right after injection.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: November 5, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yunzhi Yang, Seyedsina Moeinzadeh
  • Patent number: 12135266
    Abstract: Systems and methods for determining the yield stress of a non-Newtonian fluid in real time are provided. A pressure loss and/or liquid rise technique, an ultrasonic technique, and/or a penetrometer technique can be used to determine the yield stress of a non-Newtonian fluid. The ultrasonic technique can include a longitudinal wave approach and/or a shear wave approach. The methods and systems are non-invasive and only require slight modifications to the piping containing the non-Newtonian fluid in order to measure the yield stress.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: November 5, 2024
    Assignees: The Florida International University Board of Trustees, Savannah River Nuclear Solutions, LLC
    Inventors: Dwayne E. McDaniel, Ahmadreza Abbasi Baharanchi, Michael Poirier, Shervin Tashakori
  • Publication number: 20240361522
    Abstract: A dual ring resonator including a base substrate, and a silicon oxide layer positioned on the base substrate having a first waveguide, a primary ring resonator optically coupled to the first waveguide, a second waveguide, and a secondary ring resonator optically coupled to the primary ring resonator and the second waveguide. The dual ring resonator further includes at least one heater disposed partially on the primary ring resonator, and a trench within at least the silicon oxide layer and surrounding at least a portion of the first waveguide and the second waveguide.
    Type: Application
    Filed: April 28, 2023
    Publication date: October 31, 2024
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the Leland Stanford Junior University, Toyota Jidosha Kabushiki Kaisha
    Inventors: Ercan M. Dede, Sean P. Rodrigues, Jiahui Wang, Shanhui Fan
  • Publication number: 20240361665
    Abstract: The present disclosure provides a new visible light swept source that enables ultrafast visible light OCT to operate at a faster rate to reduce the motion artifacts and increase the field of view without sacrificing image quality. The new visible light swept source further provides for improved roll-off performance and mitigation of influence of RIN and wash-out effect for wide-field imaging. With a much-improved increase in imaging speed, increased signal-to-noise ratio (SNR), and increased imaging depth, visible light swept-source OCT (vis-ss-OCT) has the capability to perform more accurate functional and structural imaging.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Applicants: Northwestern University, The Board of Trustees of The Leland Stanford Junior University
    Inventors: Hao F. ZHANG, Cheng SUN, Tingwei ZHANG, Roman V. KURANOV, David Andrew MILLER
  • Publication number: 20240358719
    Abstract: Methods and formulations of treatment for menstrual complications, gestational complications, and to prolong gestation are described. Treatments include administration of a compound related to regulation of gestational progress or uterine contractions.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 31, 2024
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Trustees of Boston University
    Inventors: Liang Liang, Michael P. Snyder, Cristina M. Alvira, David N. Cornfield, Lihua Ying, John K. Snyder
  • Publication number: 20240360576
    Abstract: Disclosed is a technique for reducing CO2 to oxalate utilizing a copper-free, nickel-enhanced electrocatalyst (such as a nickel-enhanced (Cr2O3)3(Ga2O3) electrocatalyst) that can be used for producing, e.g., 1-butanol, in exceedingly high yields. Disclosed herein are various synthetic methodologies for introducing nickel into the electrocatalysts, and described is the characterization, and optimization of the Ni enhanced electrocatalysts for the reduction of CO2 to 1-butanol with a maximum faradaic efficiency ?max of 64%, at an overpotential of 900 mV (?1.48 V vs Ag/AgCl), and having an onset overpotential of 320 mV. The product selectivity is potential dependent with other C2+ products such as 3-hydroxybutanal, (?max 63%) at an overpotential of 890 mV (?1.4 V vs Ag/AgCl); acetic acid with ?max 18% at an overpotential of 390 mV (?1.0 V vs Ag/AgCl); and acetone with ?max 10% at an overpotential of 620 mV (?1.2 V).
    Type: Application
    Filed: April 29, 2024
    Publication date: October 31, 2024
    Applicant: The Trustees of Princeton University
    Inventors: Andrew B. Bocarsly, Steven Cronin, Stephanie Dulovic, Kai Filsinger, Josef Lawrence
  • Publication number: 20240359009
    Abstract: Systems and methods for calibration of retinal prosthetics in accordance with embodiments of the invention are illustrated. A closed loop calibration process is described whereby a multi-electrode stimulation regime can be calibrated to a given user's retina. Multi-electrode stimulation can provide increased stimulation selectivity, but significantly increases complexity. Systems and methods described herein provide computational steps that significantly reduce the amount of trials and computation required in order to achieve clinically viable selectivity, making closed-loop calibration of retinal prosthetics possible in significantly less time than open-loop calibration.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eduardo Jose Chichilnisky, Praful K. Vasireddy, Nishal Pradeepkumar Shah
  • Publication number: 20240358529
    Abstract: Prosthetic arm controller systems, as disclosed and discussed herein, include: a first controller unit that is placed or located inside a shoe or a sock of a user or that is integrated into a foot sleeve that slides on to the foot of a user, wherein the first controller unit comprises at least two interactive buttons that the user can engage, a second controller unit that is removably clipped or otherwise removably attached to the side or top of the shoe or the sock, wherein the second controller unit comprises at least one microcontroller with at least one integrated gyroscope, at least one accelerometer, and an onboard wireless protocol antenna that wirelessly communicates at least one command to a prosthetic arm from the first controller unit or the second controller unit, and wherein the at least one command comprises at least one grip command, at least one rotate command, at least one bend command, or a combination thereof.
    Type: Application
    Filed: April 29, 2024
    Publication date: October 31, 2024
    Applicant: The Trustees of the California State University
    Inventors: Peter L. Bishay, Jack Wilgus
  • Publication number: 20240361313
    Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.
    Type: Application
    Filed: December 8, 2023
    Publication date: October 31, 2024
    Applicant: Trustees of Boston University
    Inventors: Derin Sevenler, M. Selim Ünlü
  • Publication number: 20240358865
    Abstract: The present disclosure is generally directed to quinolinyl and pyridinyl containing compounds targeting on alpha-synuclein for neurological diseases. These compounds, particularly radiolabeled versions of these compounds, can be particularly useful in PET scans targeting diseases such as Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA).
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Applicants: Washington University, The Trustees of the University of Pennsylvania, University of Pittsburgh – Of the Commonwealth System of Higher Education
    Inventors: Zhude Tu, Yanbo Yu, Lin Qiu, Paul Kotzbauer, Robert Mach, Chester Mathis
  • Patent number: 12131867
    Abstract: A dielectric nanolayer capacitor comprises a nanoscale dielectric layer between a cathode layer and an anode layer. When exposed to a high electric field of at least about 0.5 GV/m at a temperature of about 200 K or less, the nanoscale dielectric layer includes an amount of trapped charge sufficient to form a Coulomb barrier for suppressing leakage current. A method of charging a dielectric nanolayer capacitor includes cooling a nanolayer capacitor comprising a nanoscale dielectric layer between a cathode layer and an anode layer to a temperature of about 200 K or less, and applying a high electric field of at least about 0.5 GV/m to the nanolayer capacitor to inject electrons into the nanoscale dielectric layer. While the nanolayer capacitor remains cooled to the temperature, the electrons are trapped in the nanoscale dielectric layer and form a Coulomb barrier to suppress leakage current.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: October 29, 2024
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Alexey Bezryadin, Eduard Ilin, Irina Burkova