Patents Assigned to Trustee
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Publication number: 20240013409Abstract: A method for multiple object tracking includes receiving, with a computing device, a point cloud dataset, detecting one or more objects in the point cloud dataset, each of the detected one or more objects defined by points of the point cloud dataset and a bounding box, querying one or more historical tracklets for historical tracklet states corresponding to each of the one or more detected objects, implementing a 4D encoding backbone comprising two branches: a first branch configured to compute per-point features for each of the one or more objects and the corresponding historical tracklet states, and a second branch configured to obtain 4D point features, concatenating the per-point features and the 4D point features, and predicting, with a decoder receiving the concatenated per-point features, current tracklet states for each of the one or more objects.Type: ApplicationFiled: May 26, 2023Publication date: January 11, 2024Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Colton Stearns, Jie Li, Rares A. Ambrus, Vitor Campagnolo Guizilini, Sergey Zakharov, Adrien D. Gaidon, Davis Rempe, Tolga Birdal, Leonidas J. Guibas
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Patent number: 11865167Abstract: The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.Type: GrantFiled: April 12, 2019Date of Patent: January 9, 2024Assignees: Novartis AG, The Trustees of the University of Pennsylvania, University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Jennifer Brogdon, Laura Alexandra Johnson, Carl H. June, Andreas Loew, Marcela Maus, John Scholler, Hideho Okada
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Patent number: 11871607Abstract: A first product may be provided that comprises a substrate having a first surface, a first side, and a first edge where the first surface meets the first side; and a device disposed over the substrate, the device having a second side, where at least a first portion of the second side is disposed within 3 mm from the first edge of the substrate. The first product may further comprise a first barrier film that covers at least a portion of the first edge of the substrate, at least a portion of the first side of the substrate, and at least the first portion of the second side of the device.Type: GrantFiled: March 15, 2022Date of Patent: January 9, 2024Assignees: Universal Display Corporation, The Trustees of Princeton UniversityInventors: Prashant Mandlik, Ruiqing Ma, Jeffrey Silvernail, Julia J. Brown, Lin Han, Sigurd Wagner, Luke Walski
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Patent number: 11869633Abstract: The present disclosure provides methods for accurately predicting the dynamics of symptom response to drugs or other interventions for the treatment of major depressive disorder or other psychological conditions. These methods can allow for a shortening of the time period necessary for the evaluation of a drug or other therapeutic intervention. These predictive methods are based on measured and/or self-reported symptom severity measures at two or more points in time. These measures are then discretized into symptom classes (e.g., low, moderate, severe) and the symptom classes are then applied to the predictive model to predict the progression of symptoms and/or the effectiveness of a drug or other therapeutic intervention.Type: GrantFiled: December 14, 2018Date of Patent: January 9, 2024Assignee: The Board of Trustees of the University of IllinoisInventors: Ravishankar Krishnan Iyer, Arjun Prasanna Athreya, Richard Merle Weinshilboum, Liewei Wang, William Victor Bobo, Mark Andrew Frye
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Patent number: 11865187Abstract: A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain.Type: GrantFiled: August 6, 2020Date of Patent: January 9, 2024Assignee: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, William Thomas Rothwell, Christian Hinderer
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Patent number: 11871233Abstract: A single-antenna device includes a single antenna, at least one processor, and at least one memory. The single-antenna device is operable to receive a signal including at least one frame. Each of said frame includes a repeating portion. The single-antenna device determines a difference of phase and amplitude of the repeating portion and further determines whether the signal is transmitted from a trusted source based at least in part on the difference of phase and amplitude of the repeating portion.Type: GrantFiled: April 26, 2019Date of Patent: January 9, 2024Assignee: Trustees of Dartmouth CollegeInventors: Timothy J. Pierson, Ronald Peterson, David F. Kotz
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Patent number: 11865166Abstract: Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.Type: GrantFiled: August 29, 2017Date of Patent: January 9, 2024Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and BiologyInventors: David Weiner, Alfredo Perales Puchalt, Jian Yan, Anna Maria Slager
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Patent number: 11865218Abstract: An embodiment may involve obtaining a three-dimensional image map of m surfaces within an environment, wherein the surfaces are associated with importance weights that represent how frequently the surfaces are expected to be touched; determining a set of n vantage points for a light source within the environment; calculating an m×n irradiance matrix for each of the surfaces when the light source is in each of the vantage points, wherein each entry in the m×n irradiance matrix is determined by: (i) rasterizing the three-dimensional image map, (ii) identifying a set of visible surfaces, and (iii) calculating an amount of light-based power that would reach each of the visible surfaces; determining a set of n dwell times for the vantage points; and providing instructions, to a disinfecting agent, to traverse at least a subset of the vantage points, pausing at and illuminating at least some.Type: GrantFiled: October 30, 2020Date of Patent: January 9, 2024Assignee: The Board of Trustees of the University of IllinoisInventors: Kristoffer Karl Hauser, Joao Marcos Correia Marques, Zherong Pan
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Patent number: 11871190Abstract: A method for separating sound sources includes digitizing acoustic signals from a plurality of sources with a plurality of microphone arrays, wherein each of microphone arrays includes one or more microphones, wherein at least one of the microphone arrays may be asynchronous to another one of the microphone arrays or may be moving with respect to another one of the microphone arrays. Spatial parameters are estimated of the digitized acoustic signals. The method includes estimating time-varying source spectra for the sources from the digitized acoustic signals as a function of the digitized acoustic signals and data received from at least one other microphone array. Source signals are estimated for one or more of the sources by filtering the digitized acoustic data digitized at the respective microphone array using the spatial parameters of the digitized acoustic data and the time-varying source spectra from all or a subset of the microphone arrays.Type: GrantFiled: July 2, 2020Date of Patent: January 9, 2024Assignee: The Board of Trustees of the University of IllinoisInventors: Andrew C. Singer, Ryan M. Corey
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Patent number: 11867794Abstract: An apparatus for detecting and recording insect flying activities, such as outside a bee hive, with a Doppler radar is described. Also described is a system including a plurality of apparatuses for detecting and recording insect flying activities, such as outside a bee hive, with a Doppler radar.Type: GrantFiled: July 5, 2019Date of Patent: January 9, 2024Assignee: University of Maine System Board of TrusteesInventors: Nuri W. Emanetoglu, Herbert Aumann
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Patent number: 11864554Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.Type: GrantFiled: October 17, 2022Date of Patent: January 9, 2024Assignees: The Curators of the University of Missouri, The Trustees of Columbia University in New YorkInventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
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Patent number: 11870459Abstract: Described is a decoder suitable for use with any communication or storage system. The described decoder has a modular decoder hardware architecture capable of implementing a noise guessing process and due to its dependency only on noise, the decoder design is independent of any encoder, thus making it a universal decoder. Hence, the decoder architecture described herein is agnostic to any coding scheme.Type: GrantFiled: April 8, 2021Date of Patent: January 9, 2024Assignees: Massachusetts Institute of Technology, National University of Ireland Maynooth, Trustees of Boston UniversityInventors: Amit Solomon, Muriel Medard, Kenneth R. Duffy, Rabia Tugce Yazicigil Kirby, Vaibhav Bansal, Wei An
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Patent number: 11870216Abstract: An on-chip laser includes a gain portion, a mirror in communication with the gain portion, a waveguide in communication with the gain portion, and a resonator optically coupled to the waveguide at an optical coupling. The resonator has a circular shape. The waveguide and the resonator are separate from the gain portion.Type: GrantFiled: September 28, 2018Date of Patent: January 9, 2024Assignee: The Trustees of Columbia University in the City of New YorkInventors: Brian Stern, Xingchen Ji, Michal Lipson
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Patent number: 11866725Abstract: The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be characterized by the following features: (a) including a cytomegalovirus (CMV) promoter; (b) including a polynucleotide encoding a partial gag protein that includes a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA; (c) not including a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag; (d) not including an SV40 origin of replication and/or an f1 origin of replication; (e) including a cPPT sequence that contains splice site; (f) including an EF1alpha promoter with intact splice donor and acceptor sites; and (g) including hepatitis B PRE with mutation in start codon of X protein ORF.Type: GrantFiled: November 23, 2021Date of Patent: January 9, 2024Assignees: Novartis AG, The Trustees of the University of PennsylvaniaInventors: Vladimir Slepushkin, Dmitriy Lukashev
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Publication number: 20240002474Abstract: Systems and methods to assess insulin resistance are described. Further, compounds and methods for treatment of insulin resistance or hyperglycemia are described. In some instances, immunoglobins of an individual are utilized in an insulin-stimulated mitochondrial function assay, which can be utilized to determine insulin resistance. In some instances, glycosylation, including sialylation, of immunoglobins of an individual are assessed, which can be utilized to assess insulin resistance. In some instances, immunoglobins, such as immunoglobin G, are utilized as a treatment for insulin resistance or hyperglycemia.Type: ApplicationFiled: November 16, 2021Publication date: January 4, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael P. Snyder, Andrew Lipchik, Justin Annes, Sooyeon Lee, Anil Narasimha
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Publication number: 20240003021Abstract: The system includes electrolyzers to generate acidic and alkaline effluent streams from saltwater. The electrolyzer include stacked pairs of porous anodes and cathodes that define feed channels into which reactants, e.g., hydrogen and brine, can be pumped to undergo an oxidation-reduction reaction. The porous cathode carries out the HER to generate H2, which floats upwards to the porous anode, where it is oxidized through the HOR. The reaction can thus progress in a self-maintaining manner. The HER creates an alkaline product stream with increased basicity, and the HOR an acidic product stream with increased acidity, compared to the inlet stream. Streams are pumped through the porous electrodes and the electrolyzer to sweep effluent through separate channels before they can combine. The alkaline product stream can have an alkalinity sufficient to drive metal ion precipitation in raw saltwater prior to feeding to the electrolyzer to reduce fouling/degradation of electrolyzer electrodes.Type: ApplicationFiled: November 16, 2021Publication date: January 4, 2024Applicant: The Trustees of Columbia University in the City of New YorkInventors: Daniel Esposito, Quinten van Hinsberg
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Publication number: 20240002685Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.Type: ApplicationFiled: September 19, 2023Publication date: January 4, 2024Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Pengfei Zhang, Longyu Li, Qianming Lin
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Publication number: 20240000758Abstract: The present disclosure provides methods of increasing mitochondrial biogenesis, function, or both in a tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating diseases, disorders, or conditions associated with dysfunctional mitochondria and/or increased oxidative stress including mitochondrial diseases.Type: ApplicationFiled: October 22, 2021Publication date: January 4, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Helen M. BLAU, Adelaida Rosa PALLA, Meenakshi RAVICHANDRAN
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Publication number: 20240002864Abstract: Systems and methods for enhancing mRNA translation are disclosed. Some embodiments describe expression constructs for producing a peptide and include a translational enhancer. Additional embodiments describe methods for producing a peptide using a construct including a translational enhancer.Type: ApplicationFiled: May 11, 2021Publication date: January 4, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Maria Barna, Kathrin Leppek
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Publication number: 20240006129Abstract: Transparent UV-absorbing solar cells are promising for the applications of powering electrochromic windows that regulate the transmission of visible and near-infrared photons for natural lighting and heating purposes, respectively. Current technologies focus on using organic solar cells for the application due to their narrow excitonic absorption and tunable bandgaps. However, transparent organic solar cells have drawbacks including the stability issue and thickness-induced problems, such as low yield rate and limited power conversion efficiency. Disclosed herein is the co-deposition of two or more materials by thermal evaporation to make visibly transparent inorganic perovskite films. By tuning the halide compositions, the inorganic perovskite films show absorption range in UV and near-UV region, which is well-suited to the application. Its high conductivity and absorbance enable it to be around 400 nm thick for devices, which is critical to improve the yield rate and efficiency.Type: ApplicationFiled: October 11, 2021Publication date: January 4, 2024Applicant: The Trustees of Princeton UniversityInventors: Tianran LIU, Xiaoming ZHAO, Lynn LOO