Abstract: Compositions and methods for treating metabolic diseases in a subject are provided. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a GLP-1 receptor agonist fusion protein and regulatory sequences which direct expression thereof.

Abstract: Disclosed herein are apparatus for a cooler device includes a manifold constructed at least partially of silicon oxide. The manifold includes an array of inlet channels and an array of outlet channels. Each inlet channel has a first depth. The array of outlet channels are interlaced with the array of inlet channels, Each outlet channel has a second depth that is larger than the first depth. Each of the array of outlet channels has a pair of sidewalls separating each outlet channel from adjacent inlet channels of the array of inlet channels.

Abstract: Disclosed are methods, systems, device, and other implementations, including a method (performed by, for example, a hearing aid device) that includes obtaining a combined sound signal for signals combined from multiple sound sources in an area in which a person is located, and obtaining neural signals for the person, with the neural signals being indicative of one or more target sound sources, from the multiple sound sources, the person is attentive to. The method further includes determining a separation filter based, at least in part, on the neural signals obtained for the person, and applying the separation filter to a representation of the combined sound signal to derive a resultant separated signal representation associated with sound from the one or more target sound sources the person is attentive to.

Abstract: A method of evaluating a package durability includes extracting, using a package evaluation system, a plurality of customer reviews for a specific product from a user-identified website. Each customer review includes data that is used to express a customer's experience with the specific product. The method includes identifying one or more packaging related reviews based on a packaging list profile and the plurality of customer reviews; predicting whether each of the one or more packaging related reviews is a negative review or a positive review; and determining whether the package meets an assurance level based on a percentage of failure rate. The assurance level indicates whether the package provides an acceptable level of performance. The method includes providing a notification of a determination of whether the package meets the assurance level.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A method for analyzing a sample collected from a surface, the method comprising placing at least a portion of a substrate having a pressure sensitive adhesive layer containing the sample in a holder, adding a spray solvent to the sample-containing pressure sensitive adhesive layer, and analyzing the sample contained in the pressure sensitive adhesive layer and the spray solvent using paper spray mass spectrometry.

Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

Abstract: The invention provides a customizable seating support for a seat base that is particularly useful for supporting a physically disabled person in a chair, such as a wheelchair. The seating support includes a posterior portion and a pair of thigh supports that are connected to the posterior portion, via a multi-directional connection, so that the position of at least one thigh support is independently adjustable to tilt upwardly or downwardly or to pivot outwardly relative to the posterior portion to an abducted position. In some embodiments, at least one of the thigh supports may be configured to pivot inwardly relative to the posterior portion to an adducted position.

Abstract: A gel electrolyte composite containing a nonvolatile electrolyte and a zwitterionic polymer scaffold in which the non-volatile electrolyte is a non-lithium-containing ionic liquid, a sodium-containing ionic liquid, or a lithium-containing ionic liquid and the zwitterionic polymer scaffold is formed from one or more zwitterionic monomers only or both one or more zwitterionic monomers and one or more non-zwitterionic monomers. The zwitterionic polymer scaffold contains 8 mol % or higher of zwitterions relative to the total content of the gel electrolyte composite when the nonvolatile electrolyte is a non-lithium-containing ionic liquid, and contains 1 mol % or higher of zwitterions relative to the total content of the gel electrolyte composite when the nonvolatile electrolyte is a sodium-containing ionic liquid or a lithium-containing ionic liquid. Also disclosed are a method of preparing the above-described gel electrolyte composite and an electrochemical energy storage device containing same.

Abstract: A method and apparatus for correcting an error in depth information estimated from a two-dimensional (2D) image are disclosed. The method includes diagnosing an error in depth information by inputting a color image and depth information estimated using the color image to a depth error detection network, and determining enhanced depth information by maintaining or correcting the depth information based on the diagnosed error.

Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.

Abstract: Disclosed are a method of encoding and decoding an audio signal and an encoder and a decoder performing the method. The method of encoding an audio signal includes identifying an input signal, and generating a bitstring of each encoding layer by applying, to the input signal, an encoding model including a plurality of successive encoding layers that encodes the input signal, in which a current encoding layer among the encoding layers is trained to generate a bitstring of the current encoding layer by encoding an encoded signal which is a signal encoded in a previous encoding layer and quantizing an encoded signal which is a signal encoded in the current encoding layer.

Abstract: A co-therapeutic regimen comprising AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDS gene and two or more immunosuppressants is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating Hunter syndrome and the symptoms associated with Hunter syndrome.

Abstract: A sensor can selectively detect quantum signatures in charge transfer processes via a tunneling current. In one aspect, the sensor can include a metal electrode having a first surface and a second surface. The sensor can also include an insulator film having a first thickness, a first surface area and a first surface chemistry. The insulator film can be coupled to the metal electrode via the first surface. The sensor can also include a functionalization film having a second thickness, a second surface area and a second surface chemistry. The functionalization film can be coupled to the metal electrode via the second surface. The insulator film and the functionalization film are configured to separate the metal electrode from an electrochemical solution comprising the analyte.

Abstract: A method for MR imaging includes acquiring with an MR imaging apparatus undersampled k-space imaging data having one or more temporal dimensions and two or more spatial dimensions; transforming the undersampled k-space imaging data to image space data using zero-filled or sliding window reconstruction and sensitivity maps; decomposing the image space data into a compressed representation comprising a product of spatial and temporal parts, where the spatial part comprises spatial basis functions and the temporal part comprises temporal basis functions; processing the spatial basis functions and temporal basis functions to produce reconstructed spatial basis functions and reconstructed temporal basis functions, wherein the processing iteratively applies conjugate gradient and convolutional neural network updates using 2D or 3D spatial and 1D temporal networks; and decompressing the reconstructed spatial basis functions and reconstructed temporal basis functions to produce a reconstructed MRI image having one or

Abstract: Provided herein are genetically modified Issatchenkia yeast and fermentation methods for producing succinic acid.

Abstract: Temperature measurements are critical in gas turbine engine design but difficult to obtain due to the extreme environment. Temperature indicating paints (thermal paints) have been used for decades to map maximum temperature fields on superalloy components but have numerous weaknesses. Disclosed herein are novel glass ceramic thermal paints that undergo viscous flow sintering to indicate temperatures up to 1000° C., with high resolution (±5° C.), by an optical transition. Disclosed paint formulations are designed to adhere to Nickel-based superalloys or SiC—SiC ceramic matrix composites (CMC) by closely matching coefficients of thermal expansion and may function for times above 60 hours. By utilizing automation and a UV:VIS spectrometer, quantitative temperature maps can be generated for easy comparison to theoretical models. A transient sintering energy model is disclosed to recover full thermal history information.

Abstract: An electrochemical device includes an anode having sodium or lithium; a cathode having a carbonaceous material; a separator; and an electrolyte that includes a metal halide, a fluorinated electrolyte compound, and thionyl chloride; wherein the electrochemical device is a primary battery or a secondary battery.

Abstract: According to various embodiments, a cellular architecture for enhanced privacy regarding identity and location of a computing device is disclosed. The architecture includes a privacy gateway connected to the core packet forwarding gateway, where the privacy gateway is configured to authenticate the computing device while hiding the identity of the computing device by verifying authentication tokens that represent units of access. The architecture further includes an over-the-air (OTA) gateway configured to select an international mobile subscriber identity (IMSI) from a pool of valid IMSIs and deliver the selected IMSI to a subscriber identity module (SIM) card of the computing device, where the SIM card periodically shuffles the pool of valid IMSIs.

Abstract: Systems and methods for structuring unstructured data according to a data object structure that enables fast query look-ups across a variety of space and time dimensions. Furthermore, many embodiments optimize the storage of the data objects using a set of compression techniques that configure the data types used for the data objects based on properties of the stored data. Furthermore, many embodiments provide are able to service query look-up requests without having to deserialize data within the byte stream format as stored in memory by encoding information that provide memory locations for requested data, thereby allowing for the immediate retrieval of the data as it is stored in the persistent memory.