Abstract: The present invention provides a compound having the structure: wherein D, E and F are each independently NR1, CR2R3 or CR6R7, wherein one of D, E and F is NR1 and the remaining two are CR2R3 or CR6R7, wherein R1 is H or -(alkyl), and wherein R2, R3, R6 and R7 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl or -alkylaryl; X1 is C or N; X2 is O, S, N, NR14 or CR15, wherein R14 is H, -(alkyl) or -cycloalkyl, wherein R15 is H, -(alkyl) or -cycloalkyl, and wherein X2 is other than N when X1 is N; ? and ? represent a bond that is present or absent, and wherein either ? or ? is present, wherein when ? is present, then X1 is C and X2 is O, S or NR14, or when ? is present, then X1 is N and X2 is N or CR15; R4, R5, R8 and R9 are each independently H, -(alkyl), -(alkenyl), -(alkynyl), -cycloalkyl, -alkylcycloalkyl, -aryl, heteroaryl, -alkylaryl, —OH, —O(alkyl), —OAc, —S(alkyl), —NH2, —NH(alkyl), —N(alkyl)2, —COOH, —CO2(alkyl), —CONH2, —CONH(alk

Abstract: Disclosed is a method for wet chemical functionalization of single crystal diamond surfaces that involves gentle reaction conditions. This method enables a wide range of functional groups and molecules to be tethered to the diamond surface. The method is compatible with the formation of stable nitrogen vacancy centers with long spin coherence times within nanometers of the diamond surface.

Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: Provided herein are engineered nucleic acid sequences encoding AAVhu68 which provide improved yields of packaged AAVhu68 viral particles. Also provided is a packaging host cell comprising the engineered nucleotide sequence and methods of using same to product recombinant AAVhu68 vectors useful for gene delivery. Further provided are production cell supernatants comprising improved yields of recombinant AAV vectors having AAVhu68 capsids produced using the nucleotide sequences provided herein.

Abstract: Disclosed herein are therapeutic conjugates having an extended circulating serum half-life. The therapeutic conjugates comprise a drug moiety linked to a half-life extension moiety via an enzyme-cleavable linker. Methods of using the therapeutic conjugates are also provided.

Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.

Abstract: A method for identifying brain-state dependent functional areas of unitary pooled activity (FAUPAs) using a statistical model that does not require a priori knowledge of the activity-induced ideal response signal time course is provided. A system for identifying a functional network in a brain of a living object includes a FAUPA identifier configured to identify FAUPAs by analyzing a plurality of images of the brain over a predetermined period. The plurality of images include a plurality of voxels, and the FAUPA identifier analyzes each voxel of the plurality of voxels in relation to one or more surrounding voxels of each voxel until each voxel of the plurality of voxels is evaluated. A brain network identification module configured to construct the functional network based on the identified FAUPAs that are functionally connected. A display module configured to display images of the brain depicting the FAUPAs included in the functional network.

Abstract: The present invention includes compositions and methods for an HLA-A2 specific chimeric antigen receptor (CAR). In certain embodiments the HLA-A2 specific CAR is expressed on a T regulatory cell. In certain embodiments, the HLA-A2 specific CAR protects transplanted tissue from rejection.

Abstract: We provide a wide-field time-resolved imaging apparatus using resonant drive. We also identify ideal configurations of electro-optic (EO) modulator crystals for wide-field imaging. These techniques enable compact and low-cost LIDAR imaging devices. Resonant drive affords modulation of various EO modulators at high voltage by means of resonant voltage enhancement. Further, it enables operation of imaging modulators at high frequencies which would otherwise not be possible with conventional pulsed drivers—this leads to improved LIDAR accuracy and dynamic range. Resonant drive uniquely enables Pockels cell LIDAR beyond normal flash mode by allowing for multiple pulses or multiple cycles of amplitude modulated illumination to be present simultaneously in a scene. This corresponds to illumination and modulation waveforms having a defined phase relationship where time-of-flight is encoded in the phase of the returning light waveform.

Abstract: A metallic glass coating material is composed of an alloy of Fe, B, and one of the metals Nb, Mo, Zr, or W. The ratios of Fe, B, and the metal are predetermined using machine learning predictions and high-throughput experiments. In one example, the material is an alloy of Fe, Nb, Mo and B, of the form Fex(Nb, Mo)yBz, where x is in the range 18-28, y is in the range 35-45, and z is in the range 32-42. In another example, the material may be the alloy Fe23(Nb, Mo)40B37. The alloy may be doped with Zr and/or W, where the Zr and/or W comprises at most 10% of the alloy.

Abstract: Compositions and methods are provided for treating ocular disorders in a subject are provided. In one aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding CNGA3. In another aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding CNGB3. In another aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding REP-1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate.

Abstract: Mechanisms for defending a computing system from attack are provided. The mechanisms include: maintaining a round counter that tracks a round number for a local host; determining a location in a graph for each of a plurality of hosts including the local host; determining monitor hosts of the plurality of hosts that are monitoring the local host; determining monitoree hosts of the plurality of hosts that are being monitored by the local host; sending a message to each of the monitor hosts identifying a value of the round counter; forwarding a first set of heartbeat messages from previous monitoree hosts to the monitor hosts; attempting to receive messages from the monitoree hosts; determining whether any messages were not received from the monitoree hosts; and in response to determining that one or more messages were not received from the monitoree hosts, generating an alert.

Abstract: Improved heat exchangers according to several embodiments are provided. The heat exchangers provide improved heat transfer for air flow in wet and dry operating conditions, while minimizing pressure drop across the heat exchanger in some applications. According to one embodiment, an improved heat exchanger includes a plurality of metal foam fins between adjacent heat exchange conduits, the heat exchange conduits being arranged parallel to each other to define parallel flow paths between an inlet header and an outlet header. The metal foam fins occupy a cross-flow region between adjacent conduits, the fins having a fixed angular orientation or being rotatable in unison to vary the thermal capacitance of the heat exchanger.

Abstract: According to certain aspects, an electric-propulsion thruster is used as part of a base or platform which also includes a power converter, having a plurality of inductors and other electrical components, and a printed circuit board (PCB). The PCB includes a layer at which the other electrical components and printed circuit inductor traces, for the plurality of inductors, are secured. The electric-propulsion thruster includes a housing (e.g., as part of the base or platform) providing a cavity and having at least one structurally-rigid side wall along the cavity, where the PCB is integrated with the electric-propulsion thruster for a compact arrangement which can be used to propel the apparatus. Such a compact design might be used as an important part of thruster spacecraft architecture such as micro-satellites (e.g., CubeSats).

Abstract: Photoredox catalysis has emerged as a powerful strategy for C—O cross-coupling reactions. We herein report a new class of tridentate pyridinophane ligands RN3 that allow for detailed mechanistic studies of the photocatalytic C—O coupling reaction. The derived (RN3)Ni complexes are active C—O cross-coupling photocatalysts under mild conditions and without an additional photocatalyst. We also utilized the RN3 ligands to study the essential but so far putative steps involving paramagnetic Ni species in a proposed catalytic cycle: the oxidative addition of an aryl bromide to a Ni(I) species, the ligand exchange at a Ni(III) center, and the C—O reductive elimination from a Ni(III) species.

Abstract: A recombinant adeno-associated virus (rAAV) vector comprising an AAVhu68 capsid produced in a production system comprising a nucleotide sequence of SEQ ID NO: 1, or a sequence at least 75% identical thereto which encodes SEQ ID NO:2. The AAVhu68 capsid comprises subpopulations of highly deamidated asparagine residues in asparagine-glycine pairs in the amino acid sequence of SEQ ID NO: 2. Also provided are compositions containing the rAAV and uses thereof. Additionally, rAAV having an engineered AAV capsid comprising at least one subpopulation of vp1 or vp2 proteins having a Val at amino acid position 157 with reference to the AAVhu68 vp1 numbering are provided.

Abstract: Enzymes and methods are described herein for manufacturing terpenes, including terpenes.

Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

Abstract: Many embodiments describe a scalable scheme for performing quantum computation in a synthetic time dimension which uses a single coherently controlled atom. Quantum operations applied to the atomic qubit can be teleported onto the photonic qubits via projective measurement, and arbitrary quantum circuits can be compiled into a sequence of these teleported gates. The synthetic time dimension can negate the need for many identical quantum emitters to be integrated into a photonic circuit, and the single atom may provide effective all-to-all connectivity between photonic qubits.