Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.

Abstract: The invention relates to a peptide comprising the following amino acid sequence Thr-Phe-Leu-Lys (SEQ ID NO: 17) or Thr-Phe-Leu-Lys-Cys (SEQ ID NO: 1), useful as a CCR2 non-competitive antagonist peptide.

Abstract: The invention concerns peptides useful as MAP kinase/ERK pathway-specific inhibitors relative to a given substrate in a given subcellular compartment.

Abstract: A device for electro-optical sampling of a microwave frequency signal is disclosed. In one aspect, the device includes a microwave transmission line for transmitting a microwave signal, the microwave line including an interruption zone configured to be rendered conducting under the effect of an optical control signal so as to carry out a function of optically controlled interrupter switch. The device also includes, in the interruption zone, a layer of nanostructured semiconductor material, including a periodic or quasi-periodic tiling of nanostructures. The layer of nanostructured semiconductor material is placed, at the level of the interruption zone, in suspension or on a dielectric material of lower refractive index than the refractive index of the semiconductor material, the layer of nanostructured semiconductor material being able to carry out the function of optically controlled interrupter switch.

Abstract: The present invention relates to a method for preparing a fibrillar collagen matrix, which is advantageously transparent or composite, suitable for being used as a biomaterial, in particular as a corneal substitute.

Abstract: A method for determining electrical parameter values of the transistors of an analog circuit of a system on chip includes breaking the circuit down into a set of blocks connected to one another; establishing the wiring diagram of said circuit; defining a set of electrical constraints that are specific to said circuit, blocks and transistors of each block; defining electrical parameters of the circuit, block and transistors; selecting for each transistor of the circuit an operator for calculating the electrical parameter values of said transistor; generating structured diagrams of each block of the circuit from the defined constraints and the chosen operators; assembling said structured diagrams of blocks into a general diagram of the circuit; identifying whether there is any conflict; and, if so, emitting an alarm signal.

Abstract: The invention relates to a microfluidic system for controlling a concentration profile of molecules capable of stimulating a target, for example formed by an assembly of living cells, this system comprising: —a microfluidic device (1) comprising at least one microfluidic channel (4) equipped with at least one inlet orifice (21) and with at least one outlet orifice (22) for at least one fluid; —at least one means for supplying the microfluidic channel (4) with at least one fluid comprising molecules capable of stimulating the target; —at least one chamber (8) or another microfluidic channel comprising a base (6) intended to receive the target; and —at least one microporous membrane (5) separating the chamber (8) or the other microfluidic channel from the microfluidic channel (4), said microporous membrane (5) being positioned away from the base (6) so that when the supply means provides the microfludic channel (4) with said at least one fluid flowing in laminar flow in contact with the microporous membrane (5)

Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumor or a lymphoid tumor in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumor or a lymphoid tumor.

Abstract: A chimeric peptide construct having a cell penetrating peptide linked to a pro-apoptotic peptide. The construct can be used for treating a tumor in combination with an anti-tumor agent. Also disclosed is a method for treating a tumor with the chimeric peptide construct and a chemotherapeutic agent.

Abstract: Device for the representation, in a frequency-wave number reference frame f-k, of the propagation of an ultrasound wave in a dihedral guide (1), which comprises ultrasound emitters (2) referenced by “Ej” with j an integer varying between 1 and N, N a strictly positive integer and ultrasound receivers (3) referenced by “Ri” with i an integer varying between 1 and M, M a strictly positive integer, the receivers being disposed spatially over a first segment of a straight line according to a regular pitch “A”, which comprises means for processing the signal received by the receivers, originating from the emitters, and in which the processing means comprise means for calculating a modified discrete spatial Fourier transform, for a spatial integration variable “x”, centered in the middle of said first segment and running through the receivers in the direction of increasing x, and for a wave vector k(x) equal to a product k.

Abstract: The invention relates to the use of at least one chelating agent, including an iron chelating agent, in order to stimulate the growth of magnetotactic bacteria.

Abstract: A cell-penetrating peptide is described. Also described is a pro-apoptotic agent including the cell-penetrating peptide and a pro-apoptotic peptide linked thereto. The pro-apoptotic agent is useful for inhibition of in vitro cell proliferation and for treatment of tumors.

Abstract: An implant and guide are described, together with methods for configuring the same. The implant and guide are for maxillofacial osteosynthesis and may be provided as a kit. Three-dimensional models of the pre- and post-operative anatomy are used to define attachment points. These attachment points are used to define a structure for the implant and the guide.

Abstract: This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.

Abstract: The endovascular prosthesis includes a first expandable framework and a first jacket for the first framework, the first framework and the first jacket forming a first channel when the first framework is in the expanded state. The first framework and the first jacket each have at least one opening, which openings are arranged substantially opposite one another and through which a sleeve is received, the sleeve having a first end and a second end, the perimeter of the first end being attached to the perimeter of the opening of the first jacket, while the second end extends inside the first channel.

Abstract: A continuous-time sigma delta radio frequency modulator is provided, including at least two LC resonators coupled in parallel by a coupling capacitive element, producing an at least 4th-order bandpass filter, a frequency response of the bandpass filter presenting at least two poles that can be brought closer together or moved further apart depending on the capacitive element value; a feedback loop for shaping the quantization noise with a predetermined noise transfer function; and an adder for receiving: at one of its inputs an analog signal; and at its other input a signal provided by the feedback loop; and the output of which is linked to the input of the bandpass filter, the feedback loop including a finite impulse response filter, the coefficients of which being calculated to obtain a noise transfer function which maximizes the signal-to-noise ratio in a signal bandwidth while ensuring the stability of the feedback loop.

Abstract: The present invention relates to methods and devices for observing the cell division, in particular the cytokinetic ring, methods for preparing such devices, methods for studying modifications of cell division, and methods for screening compounds of interest which enhance or inhibit cell division.

Abstract: A system for simulation of a contact with a surface by tactile stimulation including a surface that will come into contact with the digital pulp of a user's finger. The system includes means of displacing the surface along first and second directions (X, Y) orthogonal to each other and approximately tangent to the digital pulp of the finger. The displacement means are controlled as a function of the simulation to be generated, in which the displacement means are electromagnetic actuators.

Abstract: The present invention concerns an in vitro method for diagnosing a myeloid tumor or a lymphoid tumor in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumor or a lymphoid tumor.

Abstract: The invention relates to a haptic controller comprising a base (2), at least one maneuvering body (8) which is movably mounted on the base such that it can be moved under the action of a user, mechanical connection means (4, 15) comprising at least one deformable abutment consisting of an elastomer material between the maneuvering body and the base, and suitable for exerting a monotonous, non-linear resistive effort against an actuating effort of the maneuvering body, at least one sensor (12) placed in the haptic controller in such a way as to generate a signal representative of said actuating effort, and associated built-in or remote means (18) for processing the signal generated by the sensor, in order to supply an output signal for controlling at least one characteristic of a sound.